FOOD CHEMISTRY
·
2024
·
IF 8.5
Xiaomeng Li,Mengyao Wu,Minquan Xia,Mohamed Salama,Haoyang Sun,Lixian Ding,Xi Huang,Dewei Shu,Zhaoxia Cai
This work presents a novel use of fibrous egg white protein (FEWP) in food preservation and nutraceutical applications. In this study, food-grade FEWP was used as an encapsulating material, along with chitosan (CS), to stabilize emulsions. The emulsion system was then used as a delivery system to improve the stability of retinyl acetate (RA). The structural and functional properties, as well as the stability and rheological behavior of the FEWP/CS copolymer, was investigated. The stability of RA-enriched emulsions was also evaluated. FEWP and CS stabilized emulsions exhibited smaller particle sizes and enhanced stability against different ionic strengths and storage periods. Additionally, RA-encapsulated emulsions stabilized by FEWP:CS (25:1 w /w) effectively inhibited apple browning. This study presents a promising strategy for delivering antioxidant components, highlighting its potential in food preservation and nutraceutical applications.
研究领域:
食品科学
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营养学
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材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2019
·
IF 4.213
Xue-Han Xu,Tie-Jun Yuan,Pei-Wu Ye,Mao-Ze Wang,Hui-Jian Ma,Zhi-Hong Jiang,Yong-Pin Zhang,Li-Hua Peng
Skin is the first protection of human body. It is always challenged by a range of external factors, resulting in the wounds of skin. Hydrogel, as a dressing with multiple advantages, causes increasing interests or the applications in wound treatment. However, the function and importance of micro-environment of wound region are frequently neglected. In this study, we successfully developed a chemokine loaded biomimetic hydrogel as a functional reservoir to stimulate the rapid in situ recruitment of BMSCs for fast wound repair and regeneration. The biomimetic hydrogel was fabricated by using the Polyvinyl alcohol (PVA) combined with chitosan (CS) as the hybrid materials. The fabricated hydrogel possesses many features such as the porous structure, high swelling rate and moisture retention property. More importantly, the incorporated chemokine could be released with a sustained manner from the hydrogel and recruited the bone marrow mesenchymal stem cells (BMSCs) significantly both in vitro & in vivo . Moreover, the hydrogel was demonstrated to be highly biocompatible to the skin tissue without any side effect or irritation observed. Topical delivery of chemokine by the biomimetic PVA/CS hybrid material based hydrogel is demonstrated as a promising carrier to accelerate wound repair and regeneration without inducing scar formation and any other negative complications. The PVA/CS/SDF-1 hydrogel was shown a novel therapeutic system for wound therapy.
研究领域:
生物医学工程
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组织工程
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伤口愈合
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生物材料
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Long Li,Xianguo Wang,Dan Li,Jinfa Qin,Ming Zhang,Kaijie Wang,Jinping Zhao,Li Zhang
The complexity of cardiovascular disease requires that the materials for preparing vascular grafts possess good biocompatibility, high mechanical property, and even some excellent additional properties. In this study, polycaprolactone (PCL) with good mechanical property and natural source silk fibroin (SF) were electrospun into PCL/SF nanofibers to obtain the nanofibrous substrate. With the addition of SF, the mechanical property of PCL/SF nanofibrous mats was maintained to a certain extent. While, the hydrophilicity of PCL/SF nanofibrous mats was greatly improved which is more suitable for immersive layer-by-layer assembly (LBL). The oppositely charged heparin (Hep) and chitosan (CS) were alternatively deposited on the surface of PCL/SF nanofibers via LBL. After implanting human umbilical vein endothelial cells (HUVEC) on the LBL-structured nanofibrous mats for 48 h, it was confirmed that the CS/Hep bilayers enhanced the biocompatibility of the nanofibers. Furthermore, the results of the antibacterial test showed that the antibacterial effects of the LBL-structured nanofibrous mats for Escherichia coli and Staphylococcus aureus were both achieved 95% when the number of Hep/CS bilayer was 10. It can be demonstrated that the LBL-structured nanofibrous mats with improved biocompatibility and reduced infectivity had been prepared successfully, and can be potentially used in vascular grafts.
研究领域:
材料科学
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生物材料
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组织工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Biointerphases
·
2024
·Vol. 19
·期 2
·
IF 1.6
Zhang Yeshan,Han Xue,Zhao Jun,Gan Menglan,Chen Yaya,Zhang Jinxia,He Yu,Wu Mingkai,Liu Hai
Bletilla striata polysaccharide (BSP) and chitosan (CS) were chemically cross-linked using oxalyl chloride to prepare a composite hemostatic sponge (BSP-CS), and the process parameters were optimized using the Box–Behnken design (BBD) with response surface methodology. To optimize the performance of the hemostatic sponge, we adjusted the ratio of independent variables, the amount of oxalyl chloride added, and the freeze-dried volume. A series of evaluations were conducted on the hemostatic applicability of BSP-CS. The characterization results revealed that BSP-CS had a stable bacteriostatic effect on Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa within 72 h, and the bacteriostatic rate was above 30%. The CCK-8 cytotoxicity test demonstrated that BSP–CS had a certain effect on promoting cell proliferation of L929 cells. In the mouse tail-cutting experiment, the hemostasis time of BSP–CS was 463.0 ± 38.16 s, shortened by 91.3 s on average compared with 554.3 ± 34.67 s of the gauze group. The blood loss of the BSP–CS group was 28.47 ± 3.74 mg, which was 34.7% lower than that of the control gauze group ( 43.6 ± 3.83 mg). In the in vitro coagulation experiment, the in vitro coagulation index of the BSP–CS group was 97.29 % ± 1.8 % , which was reduced to 8.6% of the control group. The CT value of the BSP–CS group was 240 ± 15 s, which was 155 s lower than that of the gauze group ( 355 ± 31.22 s). All characterization results indicate that BSP–CS is an excellent hemostatic material.
研究领域:
材料科学
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生物医学工程
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药剂学
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止血
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DOI
PubMed
高影响因子
Scientific Reports
·
2022
·Vol. 12
·期 1
·1-13
·
IF 4.996
Luo Meng,Lin Juntao,Zhou Xinhua,Pu Xia
This study provides a promising controlled release form of nuclear polyhedrosis virus (NPV) for targeted control of lepidopteran pests. However, the application of NPV is limited due to its sensitivity to UV inactivation. This study investigated the anti-UV properties of microcapsules of SeMNPV occlusion bodies (OBs) encapsulated by calcium alginate (CA), and also the influence of the modification of CA by chitosan (CS), whey protein (WP), and polydopamine (PDA). These capsules were used to deliver, in a controlled release manner virions under alkaline pH conditions. Characterization of the structure, morphology, particle size, encapsulation efficiency, contact angle, insecticidal activity, UV resistance and in vitro release of the microcapsules was conducted. The modified microcapsules had better sphericity, and were devoid of SeMNPV OBs on the surface. The encapsulation rate was 84.76 ± 0.59%. PDA@CA-NPV had the highest wettability and the contact angle was 74.51 ± 0.53°. The 50% lethal concentration values (LC 50 ) of CA-NPV, CS@CA-NPV, WP@CA-NPV and PDA@CA-NPV were 11.5, 10.7, 10.5 and 1.2 times that of SeMNPV OBs alone. The modified microcapsules all improved the anti-UV performance of the virus, and PDA@CA-NPV was the most UV-resistant. Using qPCR, it was observed that under alkaline conditions, a large number of virions were released from PDA@CA-NPV, CA-NPV and SeMNPV OBs. Microencapsulated virus under alkaline conditions did not change the release pattern of virions.
研究领域:
生物技术
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昆虫学
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材料科学
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病毒学
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产品关联
DOI
PubMed
高影响因子
MEASUREMENT
·
2025
·
IF 5.6
Jiangrong Hou,Liang Guo,Bingzhi Yan,Shuxian Gao,Chuxiao Sun,Yanpei Xu,Qi Wang
This paper introduces a wireless passive humidity sensor based on a molybdenum disulfide (MoS 2 ) nanoflower and chitosan (CS) composite material, designed to address the limitations of traditional humidity sensors, including weak response, complex structure, and high cost, particularly in extreme humidity environments. The innovative MoS 2 /CS composite dielectric layer was developed by leveraging the high specific surface area and active sites of MoS 2 , in conjunction with the hydrophilicity and biocompatibility of CS. Experimental results demonstrate that an optimized composite material ratio (MoS 2 :CS = 1:20) yields an ultra-high sensitivity (660 kHz/%RH), faster response/recovery time (70 s/120 s), The device demonstrates a strong linear response within a humidity range of 40 %–60 %RH, evidenced by a linearity value of 0.98779. However, between the humidity range of 60 %–95 %RH, the resonant frequency exhibits a quintic relationship with humidity. In this range, the linearity R 2 value is 0.99656. and minimal hysteresis (approximately 3 %) across a broad humidity range (40 %–95 % RH). Furthermore, the chemical-physical synergistic adsorption mechanism of the composite material was elucidated using characterization methods such as FTIR, XPS, and SEM. Chemical adsorption (hydrogen bonding and coordination bonding) predominates at low humidity, while physical adsorption (swelling and interlayer hydration) is more prevalent at high humidity. The sensor offers several advantages, including low cost, long-term stability (no drift for 30 days), and environmental compatibility, thereby providing a high-performance solution for the Internet of Things and closed monitoring systems. This also expands the potential application of two-dimensional materials and biopolymers in the field of wireless sensing.
研究领域:
传感器与传感技术
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材料科学
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无线传感器网络
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环境监测
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纳米材料
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物联网（IoT）
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 31
·e52720
·
IF 3.057
Xiaolong Wang,Weiguang Gong,Xin Meng,Chenyang Li,Jin Gao
Biobased flame retardant (FR) has attracted great interest owing to its green and degradable properties similar to polylactic acid (PLA). In this work, with ammonium polyphosphate (APP) as the core, chitosan (CS) and halloysite (HNT) as the shell, a biobased FR (APP@CS@HNT) with a core-shell structure was prepared through the self-assembly method. The flame retardancy of PLA composites has been improved with the addition of the FR (APP@CS@HNT). With the loading of 17 wt% APP@CS@HNT, the PLA composite shows a high limiting oxygen index value (29.4%) and achieves vertical burning (UL-94) test V0 rating. Compared with pure PLA, the cone calorimetry test indicates that the peak heat release rate (PHRR) and total heat release decrease from 299.88 to 152.29 kW/m 2 and from 102.0 to 71.2 MJ/m 2 , respectively. The addition of APP@CS@HNT can also improve the smoke suppression performance of PLA composites. Such enhanced flame retardancy is mainly attributed to APP@CS@HNT prompting the PLA matrix to produce more continuous and denser carbon layers at a lower temperature to form physical barriers.
研究领域:
材料科学
·
高分子科学
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消防安全工程
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纳米技术
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环境科学
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 46
·51360
·
IF 3.125
He Yang,Zhifang Ma,Xinghua Guan,Zehong Xiang,Yue Ke,Yu Xia,Zhirong Xin,Qiang Shi,Jinghua Yin
Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3-Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross-linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA-based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency.
研究领域:
材料科学
·
生物医学工程
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止血
·
生物相容性
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产品关联
DOI
高影响因子
Advanced Science
·
2023
·Vol. 10
·期 9
·2206242
·
IF 15.1
Xueyu Dou,Hufei Wang,Fei Yang,Hong Shen,Xing Wang,Decheng Wu
Double-network (DN) hydrogels consisting of noncovalent interacting networks are highly desired due to their well-controlled compositions and environmental friendliness, but the low water resistance always impairs their mechanical strength. Here, an anti-swelling hydrogel possessing the core/shell architecture through rational regulation of multiple weak noncovalent interactions is prepared. A composite hydrogel consists of chitosan (CS) and poly( N -acryloyl 2-glycine) (PACG), readily forming the shell-structured DN hydrogel after soaking in a FeCl 3 solution because of in situ formation of chain entanglements, hydrogen bonds, and ionic coordination. The produced DN hydrogels exhibit excellent anti-swelling behaviors and mechanical durability for over half a year, even in some strict situations. Taking the merits of noncovalent bonds in adjustability and reversibility, the swelling property of these hydrogels can be easily customized through control of the ion species and concentrations. A dynamically reversible transition from super-swelling to anti-swelling is realized by breaking up and rebuilding the metal-coordination complexes. This facile but efficient strategy of turning the noncovalent interactions and consequently the mechanics and anti-swelling properties is imperative to achieve the rational design of high-performance hydrogels with specific usage requirements and expand their applicability to a higher stage.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
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DOI
PubMed
高影响因子
Bioactive Materials
·
2024
·
IF 18
Shunlai Shang,Kaiting Zhuang,Jianwen Chen,Ming Zhang,Shimin Jiang,Wenge Li
Mesenchymal stem cell derived exosomes (MSC-Exos) demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties. Chitosan (CS) exhibits excellent biocompatibility and accelerates cellular migration, adhesion, and proliferation. The ions released from bioactive glass (BG) and titanium dioxide (TiO 2 ) nanoparticles exhibit sustained angiogenic and antibacterial potency. In this study, CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan (CMCS), chitosan nanoparticles (CS-NPs), BG, and TiO 2 nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects, diabetic wounds, and burn skin injury due to burns. In vitro analysis indicated that the hydrogel exhibits excellent cell compatibility, stimulates endothelial cell adhesion and proliferation, and presents anti-inflammatory, angiogenic, and antibacterial activities. In vivo, the composite hydrogel dressing accelerated a wound healing acceleration effect, stimulated angiogenesis, and increased collagen deposition and the expression of anti-inflammatory factors. This innovative composite hydrogel dressing as a potential clinical therapy, utilizing bioactive materials , holds promise as a potential clinical therapy that aims to facilitate the regeneration of acute and chronically damaged skin tissue.
研究领域:
生物医学工程
·
组织工程
·
伤口愈合
·
纳米技术
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Caiyun Zheng,Jinxi Liu,Que Bai,Yanxiao Quan,Zihao Li,Wenting Chen,Qian Gao,Yanni Zhang,Tingli Lu
Powder hemostatic particles have no limitation on wound type and a wide application prospect in the treatment of wound hemostasis. In this study, bioactive glass-based membrane-like structure camouflage composite particles ( [email protected] /CS) were prepared by Layer-by-layer (LBL) method to coat bovine serum albumin (BSA) and chitosan (CS) on the surface of the synthesized macroporous and mesoporous bioactive glass (MBG). The results showed that [email protected] /CS particles significantly improved the coagulation effect of MBG and could activated both endogenous and exogenous physiological coagulation pathways. [email protected] /CS had the excellent water absorption quality and could immediately release Ca 2+ to participate in the coagulation pathway. The main hemostatic mechanism of [email protected] /CS was that the membrane-like of BSA/CS could form a fibrin network by aggregating erythrocytes and activating platelets, thus rapidly aggregating coagulation factors. In addition, [email protected] /CS particles had a significant hemostatic effect on surface bleeding (tail-amputation model) and internal bleeding (liver injury model) in SD rats, which could shorten the bleeding time and reduce the amount of blood loss effectively. This research work stated that the MBG-based membrane-like structure camouflage composite particles might be with the potential applications as a hemostasis biomaterial for the emergency bleeding.
研究领域:
材料科学
·
生物医学工程
·
止血
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2022
·
IF 15.304
Yingping Zhang,Yue Wang,Lin Chen,Jun Zheng,Xiaojing Fan,Xinglian Xu,Guanghong Zhou,Niamat Ullah,Xianchao Feng
Great challenges remain in the effective control of irregular and incompressible deep wound bleeding and the promotion of wound healing after bacterial infection. In this study, cryogels were prepared using an ice template based on chitosan (CS), oxidized gallic acid (OGA) and hemin (HE), which are all green edible materials. The cryogels exhibit rapid blood-triggered shape recovery and a high swelling ratio. The cryogels with 5 mg mL −1 HE (Gel-CS/ [email protected] ) exert excellent photothermal effects. Additionally, the cryogels have excellent cytocompatibility and blood clotting abilities. In the mouse liver injury model and mouse tail amputation model, Gel-CS/ [email protected] presents better hemostasis properties than gauze and a gelatin sponge. Moreover, Gel-CS/ [email protected] displays excellent healing performance as a wound dressing. Overall, we provide a simple and effective strategy to prepare cryogels for controlling wound bleeding and promoting wound healing.
研究领域:
材料科学
·
生物材料
·
生物医学工程
·
止血
·
伤口愈合
·
抗菌材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）