Materials Today Advances
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2023
·
IF 10
Xiao Gong,Wenjing Li,Yongzhong Wu,Xiaoyan Li,Yan Ma,Hangxiang Wang,Min Wu
Carbon nanodots (CDs) have received huge attention of researchers due to their good optical properties. However, CDs generally suffer from severely fluorescence self-quenching once they are aggregated or in solid state, limitating their applications in light-emitting devices. In this work, we report a rational strategy for synthesis of yellow fluorescent carbon nanodots (Y-CDs)-based microparticles with a high solid-state photoluminescence quantum yield (32.02%). It is the first report on designing a lamellar structured matrix to disperse CDs to realize long-wavelength solid fluorescence. The matrix is confirmed as p-phenylenediamine dihydrochloride by X-ray diffraction (XRD). 3-glycidyloxypropyltrimethoxysilane (KH-560) acts as a bridge to connect CDs to the matrix based on epoxy-amine reaction and silane hydrolysis condensation for uniform dispersion of CDs and high solid-state luminescence can be easily achieved. Meanwhile, through adjusting the amount of KH-560, the morphology of Y-CDs-based microparticles can be controlled from cube to layered structure and the fluorescence intensity can be significantly improved. Importantly, the optimal Y-CDs particles can be combined with blue chips (450 nm) to fabricate high-performance white light-emitting diodes (WLEDs) without using commercial phosphor, and the constructed WLEDs exhibit a high color rendering index (CRI) of 84.2.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
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IF 8.456
Ming Shi,Hao Zhang,Ting Song,Xiaofang Liu,Yunfen Gao,Jianhua Zhou,Yan Li
Hydrogel-based wound dressings provided a moist microenvironment and local release of bioactive molecules. Single drug loading along with fast release rates and usually in hydrogel sheets limited their performance. Hence, uniform alginate/CaCO3 composite microparticles (∼430 μm) with tunable compositions for sustainable release of drug and pH-sensitivity were successfully fabricated using microfluidic technology. Due to the presence of CaCO3 and the strong interactions with alginate molecules, lyophilized composite microparticles reverted to hydrogel state after rehydration. Regardless of microparticle states (hydrogel or lyophilized) and pH values (6.4 or 7.4), in vitro release rates of model drug were inversely related with CaCO3 concentrations and much lower than that for pure alginate microparticles. The release rate at pH 6.4 (simulating wound microenvironment) was always slower than that at pH 7.4 for the same type of microparticles. Rifamycin and basic fibroblast growth factor (bFGF) were independently encapsulated into AD-5-R and AD-40-F to achieve a fast release of rifamycin and a slower, more sustained release of bFGF, respectively; CD-F-R was a mixture of AD-5-R and AD-40-F at weight ratio 1/1. For AD-5-R and CD-F-R, inhibition zones of S. aureus were observed until day 5, showing a sustained antibacterial property. On the basis of in vitro wound healing model of NIH-3T3 cell micropattern on glass coverslips with a hole array, it was found that AD-40-F and CD-F-R significantly promoted cell proliferation and migration rates. In a full-thickness skin wound model of rats, CD-F-R microparticles significantly accelerated wound healing with higher granulation tissue thickness and better bioactivity to stimulate angiogenesis than the control group. Furthermore, CD-F-R microparticles demonstrated a good biocompatibility and biodegradability in vivo. Taken together, CD-F-R composite microparticles may ideally meet the requirements for different stages during wound healing and demonstrated a good potential to be used as dressing materials.
研究领域:
生物材料学
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药剂学
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组织工程学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 31
·6439-6447
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IF 4.726
Ai-Zheng Chen,Yong-Qiang Kang,Shi-Bin Wang,Na Tang,Xiao-Qian Su
The co-delivery of siRNA and therapeutic agents provides an effective method for cancer chemotherapy by avoiding drug resistance during the treatment. With a combination of ionic gelation and supercritical fluid technology, nanoparticle-embedded composite microparticles (CMPs) co-loaded with siRNA and paclitaxel (siRNA-PTX-CMPs) were successfully prepared. The results show that CMPs embedded with nanoparticles with a diameter of 50–100 nm exhibited a spherical shape and core–shell structure with a mean diameter of 323 nm. The encapsulation efficiency of siRNA in chitosan nanoparticles (CS NPs) was 96.97%. The drug load and encapsulation efficiency of PTX-loaded CMPs (5% dosage) were 1.40% and 27.95%, respectively; both these increased with an increase in dosage. It was found that no change had occurred in the functional groups of the components during the supercritical process, while the physical form of PTX had shifted to an amorphous state. In the cell experiments, the CMPs clustered around the nucleus after being taken up by the Bcap-37 cells. The results of the antitumor effect experiments revealed that the co-loaded siRNA-PTX-CMPs achieved a significantly better synergistic effect than single dosages, which indicated that the co-delivery system developed by the supercritical process could have potential in the application of cancer chemotherapy.
研究领域:
药剂学
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肿瘤学
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药物递送系统
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生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Tianyuan Xu,Lu Fan,Li Wang,Haozhen Ren,Qingfei Zhang,Weijian Sun
Drug delivery systems based on hydrogel microcarriers have shown enormous achievements in tumor treatment. Current research direction mainly concentrated on the improvement of the structure and function of the microcarriers to effectively deliver drugs for enhanced cancer treatment with decreased general toxicity. Herein, we put forward novel hierarchical mesoporous silicon nanoparticles (MSNs) and bovine serum albumin (BSA) composite microparticles (MP MSNs@DOX/FU ) delivering doxorubicin (DOX) and 5-fluorouracil (FU) for effective tumor therapy with good safety. The DOX and FU could be efficiently loaded in the MSNs, which were further encapsulated into methacrylate BSA (BSAMA) microparticles by applying a microfluidic technique. When transported to the tumor area, DOX and FU will be persistently released from the MP MSNs@DOX/FU and kept locally to lessen general toxicity. Based on these advantages, MP MSNs@DOX/FU could observably kill liver cancer cells in vitro, and evidently suppress the tumor development of liver cancer nude mice model in vivo. These results suggest that such hierarchical hydrogel microparticles are perfect candidates for liver cancer treatment, holding promising expectations for impactful cancer therapy.
研究领域:
药剂学
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肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science Advances
·
2025
·Vol. 11
·期 12
·
IF 12.5
Zhonglin Fang,Xinyuan Yang,Luoran Shang
Oral delivery of probiotics has shown promising effects in modulating the gut microbiota and treating ulcerative colitis (UC). However, the therapeutic efficacy is restricted by gastrointestinal assaults, poor mucosal adhesion, and single therapeutic modality. Here, we developed acid-resistant, gut-environment–responsive composite microparticles based on microfluidic electrospray for the oral codelivery of probiotic [Lactobacillus acidophilus (LA)] biofilm and postbiotics (indole-3-propionic acid). Montmorillonite was selected for supporting biofilm formation due to its cation-exchange capability and clearly defined biosafety. The montmorillonite-LA biofilm was effectively protected by the microparticles and markedly improved the intestinal retention. Upon oral administration, the composite microparticles notably alleviated colitis in mice, including reducing the inflammatory response, improving intestinal barrier function, and modulating the gut microbiota. Consequently, the composite microparticles show high potential for enhancing probiotic delivery efficacy and present a promising strategy for UC treatment.
研究领域:
药学
·
生物医学工程
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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