Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 6
·1-11
·
IF 23.2
Ma Hongze,Shi Zhengyang,Yang Honghong,Yuan Wei,Liang Gemeng,Zou Jinshuo,Qian Cheng,Shen Zhaocun,Sui Kunyan
Information leakage and counterfeiting are critical global issues threatening human security and social stability. Advanced flexible anti-counterfeiting technologies are urgently needed, as flexible wearables are becoming more and more significant. In this study, we report a straightforward and efficient wet spinning technique to prepare lanthanide-alginate hybrid fibers with multicolor-emitting capabilities for flexible anti-counterfeiting. Lanthanide ions are able to coordinate with sodium alginate to endow the hybrid fibers with good molding properties, thermal stability, and homogenicity. These hybrid fibers can emit red, orange, and green fluorescence depending on the ratios of doped lanthanide elements under 254 nm UV light. The fluorescence lifetime of these hybrid fibers is longer than that of commonly used organic dyes. Notably, their fluorescence can be quenched in acidic environments or by Fe 3+ ions, which is ascribed to the weakened coordination strength between 2,2′-bipyridine with the lanthanide elements. More importantly, the hybrid fibers can be woven into various flexible anti-counterfeiting patterns. Our study demonstrates the significant flexible anti-counterfeiting potential of lanthanide-doped fibers due to their low cost, ease of fabrication, and flexibility. Graphical The multicolor-emitting lanthanide-alginate hybrid fibers with multi-stimuli responsiveness are produced through a simple wet spinning process and can be woven into various patterns for flexible anti-counterfeiting.
研究领域:
材料科学
·
光学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Fanqi Meng,Lei Chen,Haoran Chen,Meili Shen,Guangyi Wang,Yulei Chang
Combined phototherapy with other therapeutic strategies can improve the therapeutic outcomes of tumors and reduce the side effects. However, shaping multiple modalities for combination therapy remains challenging. Herein, multiple stimuli-responsive drug-loaded micelles are presented, which are self-assembled from cypate-conjugated pH-sensitive poly(ethylene glycol)–poly(2-(diisopropylamino) ethyl methacrylate)–poly(2-aminoethyl methacrylate hydrochloride) and redox-responsive poly(glycidyl methacrylate)–poly(propylene sulfide) copolymer and loaded with chemo agents doxorubicin (DOX) and sorafenib (SRF, also a ferroptosis inducer) for enhanced tumor therapy. The DOX and SRF chemo drugs were encapsulated into the hydrophobic core of PPS and PDPA to enable multiple stimuli-responsive controlled drug delivery. In vivo and in vitro experiments are carried out to investigate the potential application for controlled drug release and systemic chemo-phototherapy. This study highlights the rational design of cypate-based drug-loaded micelles, offering multiple stimuli-responsive drug releases and synergistic photo-, ferro-, and chemotherapy in colorectal cancer.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2025
·
IF 5.2
Ke Wang,Xiaofang Liu,Ziyan Li,Fan Zhao,Guiyan Liu,Yongfei Zeng
A new family of multistimuli-responsive acrylamide-based homopolymers with different end pendant substituents were prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization. They include three types of multistimuli-response: temperature/pH/CO2-response, temperature/pH/redox-response, and temperature/pH/light-response. When the terminal substituent was ethyl and tetrahydropyran, P(Et-N-AM) and P(THP-N-AM) exhibited lower critical solution temperature (LCST) behavior in water, which can be adjusted by degree of polymerization (DP) and concentration of polymer, additives, pH, and the injection of CO2/N2 to the solution. When the terminal substituents were phenyl, ferrocene, and azobenzene, P(Ph-N-AM), P(Fc-N-AM), and P(Azo-N-AM) were insoluble in water due to the increase of hydrophobicity, but the upper critical solution temperature (UCST) was exhibited in the mixed solution of nBuOH/water and can be adjusted by the addition of acid or base. P(Fc-N-AM) was also redox-responsive, and its UV/vis absorption peaks changed with the addition of FeCl3/VC. P(Azo-N-AM) was also light-responsive, and under UV/blue light radiation, the characteristic peaks of its UV/vis absorption spectrum changed reversibly. In addition, the three homopolymers were amphiphilic, which can self-assemble in solution, and the obtained micelles were also responsive. Finally, nile red (NR) was used as a hydrophobic drug model, and the controlled release behavior of NR-loaded micelles of P(Fc-N-AM) and P(Azo-N-AM) under different stimuli was investigated. This work has greatly enriched the family of multistimuli-responsive poly(N-substituted acrylamide)s, and the synthetic steps of homopolymers were simple; the responsive behavior was sensitive, and the species were rich. It provides a reference for the design of novel stimuli-responsive polymers and has a good application prospect in self-assembly, drug release, and other fields.
研究领域:
高分子化学
·
材料科学
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2018
·Vol. 14
·期 39
·8044-8050
·
IF 3.709
Yangyang Xu,Suya Fu,Feiyang Liu,Haiyin Yu,Jiangang Gao
Herein, a novel supramolecular gel was fabricated through the bi-component co-assembly strategy of commercially available 10,12-pentacosadiynoic acid (PCDA) and laboratory-synthesized amphiphilic co-gelator N-(2-(1H-imidazol-4-yl)ethyl)stearamide (IMSA), which contains one imidazole head group and a long alkyl chain tail, by synergetic noncovalent interactions. Upon irradiation of normal 254 nm UV light, blue polydiacetylene (PDA) could be obtained by topo-polymerization of the PCDA monomers in the gel phase. This PDA-based supramolecular gel is able to respond to various environmental stimuli and shows a blue-to-red chromatic transition, which could be observed by the naked eye. Specifically, upon exposure to heat, pH, metal cation and organic solvent stimuli, the PDA gel displays thermochromism, halochromism, ionochromism and solvatochromism, respectively. More interestingly, the differences of the above-mentioned stimuli-induced color transition of the blue PDA supramolecular gels could be characterized by UV-Vis absorption spectra and Raman spectra, therefore illuminating a bright application prospect in the area of chemosensing.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2018
·
IF 3.741
Kun Wang,Hao Lu,BeiBei Liu,Jiping Yang
Polyurethanes STMPU and HTMPU containing AIE fluorogens in the soft segments and hard segments, respectively, have been synthesized and characterized. Both two resulting polyurethane solutions exhibited an aggregation-enhanced emission (AEE) feature. Then two kinds of polyurethane films were prepared and their multi-stimuli-responsive properties were explored. Interestingly, the fluorescence emission of two polyurethane films were decreased in high temperature, and polyurethanes with different structures have different temperature-dependent fluorescent behaviors. Meanwhile, weak emission was obtained when acetone was dripped onto the two polyurethane films. Moreover, the fluorescence of the polyurethane STMPU film was greatly enhanced with the increase of tensile stress (at ε < 0.3), suggesting its potential application in multifunctional fluorescent probes.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2022
·
IF 5.122
Chen Wang,Qing Yan,Sheng Wang,Derong Cao
A novel donor-acceptor Stenhouse adducts (DASAs) derivative ( DASA-IDN ) was constructed by introducing phenanthroimidazole (PI), tetraphenylethylene (TPE), triphenylamine (TPA) moieties into the DASAs molecular system. The multi-stimuli response process, photochromic and fluorescence properties of DASA-IDN were investigated. When irradiated with visible light, the color of DASA-IDN solution fade quickly and the fluorescence lighted up rapidly. Heating under darkroom could restore it to the initial state. Moreover, solid film of DASA-IDN have been achieved and utilized for information storage. Remarkably, DASA-IDN exhibited versatile switching behavior in response to acid, base and light, turning it into an efficient multi-stimuli responsive molecule.
研究领域:
有机化学
·
材料科学
·
光化学
✓ 已验证
DOI
高影响因子
Advanced Optical Materials
·
2024
·Vol. 12
·期 23
·2400839
·
IF 8
Xiao-Feng Wang,Rui-Lian Lin,Wen-Qi Sun,Jing-Xin Liu,Li-Xin Xu,Carl Redshaw,Xing Feng
Multistimuli-responsive color-changing materials have potential applications in areas such as chemical sensing and anti-counterfeiting. In this work, a fluoro-phenyl-acetyl-substituted viologen derivative (FPAV·Cl 2 ) is synthesized, which can form a supramolecular inclusion complex with cucurbit[7]uril (Q[7]) via self-assembly. Significantly, the resulting inclusion complex FPAV 2+ @Q[7] in the solid-state exhibits visual color changes in response to multiple external stimuli including light, heat, and vapors of ammonia and organic amines. The electron spin resonance (ESR) and ultraviolet–visible (UV–vis) spectra analysis reveals that the photochromic, thermochromic, and vapochromic behavior of FPAV 2+ @Q[7] is due to the generation of FPAV +• free radicals resulting from electron transfer. Furthermore, in the solid-state, FPAV 2+ @Q[7] shows controllable fluorescence regulated by its chromic process. Based on the multi stimuli-responsive color-changes and fluorescence properties of FPAV 2+ @Q[7], its practical applications in erasable inkless printing, multiple anti-counterfeiting processes, visible ammonia/organic amines detection, and information encryption are demonstrated. The supramolecular strategy of encapsulating viologen derivatives into macrocycles provides a general method for fabricating multi stimuli-responsive chromic materials with multiple practical applications.
研究领域:
超分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2025
·
IF 2.7
Wentao Hao,Chenchen Ke,Xianxiang Pan,Tengfei Qi,Wenping Wang,Wenjuan Li,Wen Yang
Fluorescent supramolecular materials have attracted a lot of attention over the past few decades. However, those can respond to multiple stimuli are not often reported, especially for the nonconventional fluorescent materials. Here, a supramolecular material is reported that can respond to temperature/electrical heating, humidity, volatile acids/organic amines, and mechanical strain. This material is prepared by physical mixing oligomeric polyethyleneimine (o-PEI) and oligomeric polyacrylic acid (o-PAA). Although they are almost non-fluorescent, their combination produces bright fluorescence, and the emission bands shift to longer wavelengths as the amount of o-PAA increases. Calculations based on Density Functional Theory (DFT) show that there are strong noncovalent interactions between o-PEI and o-PAA, resulting in through-space conjugation and cluster-triggered emission. By studying the relationship between emission intensity, temperature, and molecular motion, the dependence of emission intensity on relaxation time is established, which will provide insight into the luminescence origin of nonconventional fluorescent materials. In addition, this material shows good self-healing ability. The luminescence, responsiveness and self-reparability are all related to the strong but reversible noncovalent bonds that link the o-PEI and o-PAA. This work not only highlights the value of supramolecular polymers, but also enriches the research of nonconventional fluorescent materials.
研究领域:
材料科学
·
化学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Chenyu Liu,Hengjun Zhou,Simiao Yu,Hailiang Chen,Ning Wang,Weihe Yao,An-Hui Lu,Weihong Qiao
Controlled-release drug carriers in cancer therapy are the most ideal way to reduce toxicity and improve drug efficacy . Since light stimulation is precise and operable, most multi-stimulation response carriers utilize phototherapy to enhance release efficiency. However, phototoxicity severely limits the application of phototherapy. Herein, we designed and synthesized a Cou-ONB lipid with sensitive fluorescence feedback and multi-stimulus response. COBL liposomes prepared from Cou-ONB lipids will passively aggregate at the tumor and guide phototherapy by fluorescence. More importantly, it can reflect the drug release effect in vivo through its own sensitive fluorescence changes, further enabling precise phototherapy and reducing phototoxicity. In this paper, the multi-stimulus superimposed response and precise fluorescence-guided performance of COBL liposomes were investigated at the molecular, liposome, cellular, and animal levels. Finally, tumor treatment experiments showed that the d -COBL-UV group had the best tumor suppression effect (5.3-fold). This paper highlights a real-time fluorescence-guided multi-stimulus superposition strategy and provides a design idea to precisely implement exogenous stimuli by displaying the degree of drug release, aiming to achieve less toxic and more efficient cancer therapy through timely and precise multi-stimulation. Statement of significance Multi-stimulus responsive drug carriers have been extensively developed in the last decade. Visual guidance is an important tool to achieve precision medicine and precise control of drug release. However, the available visualization materials are more aimed at directing stimulation at the optimal moment. There is little discussion on when to stop exogenous stimulation and how to minimize the damage of stimulation to the patient. Here, we provide a Cou-ONB lipid that not only responds to multiple stimuli, but also provides sensitive feedback on its own dissociation with a fluorescent signal so that physicians can adjust exogenous stimuli in a timely manner. This paper provides insights to facilitate precision drug delivery systems, providing viable design ideas for precise, efficient, and less toxic cancer therapies.
研究领域:
生物医学工程
·
药理学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xiaolei Yue,Chen Dong,Yucheng Wang,Zhishuai Cui,Zhihui Ren,Zheng-Hui Guan
Intelligent actuation materials are widely utilized as parts of soft robots, smart sensors and other applications, due to their response to external stimuli (such as heat, light, magnetism, humidity, etc.). Yet preparing a single polymer material with multi-stimuli responsive functions remains challenging and less explored. Herein, we have explored a novel multi-stimuli responsive intelligent actuating polyurethane material, AzoPU50, through one-pot co-polymerization of 4,4′-bis (6-hydroxy-hexoxy) azobenzene (BHHAB), polyethylene glycol 400 (PEG400) and 4,4′-methylene bis (phenyl isocyanate) (MDI) at a ratio of 1:1:2. This novel material can respond to three types of stimuli to trigger shape deformation movements. The intrinsic microphase separation structure of polyurethane can afford thermal responsive shape memory performances. Furthermore, the variation in the configuration of azobenzene units endows the polyurethane film with good light-responsive deformation. Most importantly, this polyurethane actuator can also achieve humidity-responsive movements including flipping motion on a wet filter paper, bending deformation driven by the palm and finger, etc. In addition, a biomimetic device that integrated the heat, light and humidity stimuli together to imitate human gestures of praise was successfully assembled. This work provides a new strategy for constructing actuators with triple-functions and will pave a way for further development of multi-stimuli-responsive smart actuating devices and other intelligent materials/systems.
研究领域:
材料科学
·
智能材料
·
软体机器人
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 37
·16045-16053
·
IF 3.288
Yang Ma,Mingming Li,Keren Shi,Zhifeng Chen,Baozhong Yang,Deyu Rao,Xiawei Li,Wei Ma,Shaozhang Hou,Guojing Gou,Huiqin Yao
Based on semi-interpenetrating polymer network (semi-IPN) hydrogel films, a multiple stimuli-responsive film system composed of poly(acrylic acid) (PAA) and N,N-diethyl acrylamide (DEA), designated as PAA–PDEA semi-IPN films, was realized on a glassy carbon (GC) electrode surface with a one-step polymerization method. Rutin (RT), an electroactive probe, displayed invertible pH-, thermo- and SO42− concentration–sensitive cyclic voltammogram (CV) behaviors in the film system. This multiply sensitive electrocatalysis of RT at the PAA–PDEA films was employed to further investigate the multiple stimuli-responsive ON–OFF behaviors of RT. The scanning electron microscopy (SEM) images and control experiments showed pH-sensitive ON–OFF properties of RT, which could be ascribed to the protonated/deprotonated carboxylic (–COOH) groups of the PAA component in different pH buffers and the properties of RT itself. However, the confirmation change or phase transition of the PDEA hydrogel film between the coil and globular states led to thermo- and SO42− concentration–sensitive ON–OFF properties. According to these results, a 3-input/3-output logic gate and a 2-to-1 encoder were constructed successfully. This present system was fabricated for the first time, which may offer numerous possibilities for the design of new electrochemical drug sensors, drug-mimicking release processes and other medical applications. Furthermore, it also can contribute to the development of biomolecular or molecular computing.
研究领域:
材料科学
·
生物医学工程
·
电化学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 8
·2764-2771
·
IF 5.7
Xiao-Feng Wang,Chen-Yan Xu,Rui-Lian Lin,Wen-Qi Sun,Ming-Fu Ye,Li-Xin Xu,Jing-Xin Liu
Multistimuli-responsive materials are highly desirable due to their convenient controllability and potential applications in smart window, sensor and bionic manufacturing. Herein, we designed and synthesized a guest molecule 1-[2-(4-fluorophenyl)-2-oxoethyl]-4,4′-bipyridinium dichloride (FOV·Cl2), whose ketone–enol tautomerism (FOV2+ ↔ FHV+) in aqueous solution is governed by pH values. The solid-state inclusion complex formed β-cyclodextrin (β-CD) and FOV2+ (in the ketone form) demonstrated multiple chromic behaviors under the external stimuli of light, heat and vapors of ammonia and some organic amines, which were characterized by UV-vis and ESR spectroscopy. For comparison, the chromic behavior of the solid-state inclusion complex of β-CD with FHV+ (in the enol form) was also investigated. In addition, we found that the fluorescence emission of the inclusion complex FOV2+@β-CD can be reversibly modulated by the photochromic process. The chromic and fluorescent properties of the FOV2+@β-CD endow it with practical utility in inkless printing, ammonia sensing and multiple anti-counterfeiting. This work focused on demonstrating the multistimuli-responsive chromic behaviors of the inclusion complexes and exploring their promising applications.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）