CHINESE JOURNAL OF POLYMER SCIENCE
·
2014
·Vol. 33
·期 1
·173-183
·
IF 1.42
Zhao Zheng-bai,An Shuang-shuang,Xie Hai-jiao,Jiang Yong
A series of multicomponent hydrogels were prepared by the copolymerization of hydrophobic silicon-containing monomer 3-bis(trimethylsilyloxy) methylsilylpropyl glycerol methacrylate (SiMA) with the solvent-responsive monomers 2-hydroxyethyl methacrylate (HEMA) and N -vinyl pyrrolidone (NVP) and thermosensitive monomer N , N -dimethyl acrylamide (DMA). 2-Hydroxy-2-methyl phenyl acetone (D-1173) was chosen as UV initiator and five different dienes/triene monomers were selected as crosslinking agent in order to select the best crosslinker. The ethanol extraction experiments as well as the FTIR, DSC and TG results showed that the copolymerization was effective. The optical, permeability, and mechanical analysis results demonstrated that the obtained hydrogels were highly transparent with good oxygen permeability and mechanical properties. And the impact of crosslinker on the mechanical properties of the hydrogels was also discussed in detail. The basic results demonstrated that the obtained hydrogels had good stimuli-responsive effects to both pH value and solvent.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2016
·
IF 0.62
Zheng-Bai Zhao,Hai-Jiao Xie,Yan-Li Li,Yong Jiang
In this article, the multicomponent hydrogel was prepared by the copolymerization of the hydrophobic silicon-containing monomer tris(trimethylsiloxy)-3-methacryloxypropyl-sliane (TRIS) with the hydrophilic monomers 2-hydroxyethyl methacrylate (HEMA) and N-vinyl pyrrolidone (NVP). The ethanol extraction experiments as well as the FTIR, DSC results showed that the copolymerization was effective. The silicone hydrogel that had hydrophilic and hydrophobic phases could be loaded with hydrophilic drug (FITC) and hydrophobic drug (Nile Red) simultaneously. The drug release properties of the hydrogel were studied by taking advantage of its innate stimuli-responsiveness to solvent and pH. The release behaviors of hydrophilic and hydrophobic drugs were found to be solvent dependent. And the release behavior of hydrophilic drug was also pH sensitive. With the characteristics above, the silicone hydrogels can be good candidates for specified materials and may have broad applications in responsiveness, drug release, contact lens, etc.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
·
2025
·Vol. 15
·期 7
·2933
·
IF 13.3
Xiaoxiao Ma,Xiaohui Zhu,Sheng Lv,Chunyan Yang,Zihao Wang,Meilan Liao,Bohao Zhou,Yiming Zhang,Shiyu Sun,Ping Chen,Zhonghua Liu,Haiyan Chen
Background: The timely management of large-scale wounds and the regeneration of skin appendages constitute major clinical issues. The production of high-precision and customizable artificial skin via 3D bioprinting offers a feasible means to surmount the predicament, within which the selection of bioactive materials and seed cells is critical. This study is aimed at employing skin stem cells and multicomponent hydrogels to prefabricate artificial skin through 3D bioprinting, which enables the regeneration of skin and its appendages. Methods and Results: We employed gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA) as bioactive materials, in conjunction with epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs), to fabricate artificial skin utilizing 3D bioprinting. The photosensitive multicomponent hydrogel, comprising 5% GelMA and 0.5% HAMA, demonstrated excellent printability, suitable solubility and swelling rates, as well as stable mechanical properties. Moreover, this hydrogel exhibited exceptional biocompatibility, effectively facilitating the proliferation of SKPs while maintaining the cellular characteristics of both SKPs and Epi-SCs. The transplantation of this artificial skin into cutaneous wounds in nude mice led to complete wound healing and functional tissue regeneration. The regenerated tissue comprised epidermis, dermis, hair follicles, blood vessels, and sebaceous glands, closely resembling native skin. Remarkably, the artificial skin demonstrated sustained tissue regeneration capacity even after 12 h of in vitro culture, facilitating comprehensive functional skin regeneration. Conclusions: Our research presented a skin repair strategy for prefabricated cell-loaded artificial skin, thereby successfully facilitating the regeneration of the epidermis, dermis, hair follicles, blood vessels, and sebaceous glands within the wound.
研究领域:
组织工程
·
再生医学
·
生物材料科学
·
干细胞研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）