Flexible Electronics and Materials for Synchronized Stimulation and Monitoring in Multi-Encephalic Regions
Simultaneous neuron stimulation and biophysiological sensing in multi-encephalic regions can lead to profound understanding of neural pathways, neurotransmitter transportation, and nutrient metabolism. Here, a flexible electronic device with tentacle-like channels radiating from a central wireless circuit is presented. The device is constructed by different organic and inorganic materials that have been made into thin-film or nanoparticle formats. All channels have been equipped with flexible components for distributed and synchronized opto-electrical stimulation, biopotential sensing, and ion concentration monitoring. They can be implanted into different brain regions through adaptive bending and individually addressed to follow programmable working sequences. Experimental results conducted in vitro and in vivo have demonstrated the capability in generating optical or electrical stimulation, while sensing 16-channels biopotential and concentration of Ca 2+ , Na + , and K + ions in distributed regions. Behavior and immunohistochemistry studies suggest potential applications in regulating brain functions for freely moving animals. In combination with various functional materials, the device can serve as a comprehensive research platform that can be modularized to accommodate different needs for brain studies, offering numerous possibilities and combinations to yield sophisticated neuromodulation and behavior regulation.
危险品化学品经营许可证（带存储）