GREEN CHEMISTRY
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2025
·
IF 9.2
Xiaopeng Shi,Haotong Lin,Qi Ouyang,guanqun luo,Xianghong Lu,Jianbing Ji,Kaige Wang
Although bio-oil from biomass pyrolysis can be hydrotreated or cracked into transportation fuel, economic and energy challenges remain. One strategy is to cogeneration of oxygen-containing biochemical with high value in biorefinery. Here, we developed a simple separation method with combination of distillation and chemical extraction to produce a stream of phenolic compounds mixture, potential of which as sustainable biodiesel antioxidants was explored. The study revealed that higher distillation temperatures (>250 ℃) contributed to the enrichment of methoxyphenols, binary phenols and ternary phenols. The presence of electron-withdrawing groups at the ortho and para positions of phenolic hydroxyl groups was found to enhance antioxidant activity. An increase in the number of phenolic hydroxyl groups also significantly improved antioxidant performance. Certain extracts with maximum amount of pyrogallol and exhibited comparable antioxidation performance, as compared to commercial antioxidants. Acetic acid, cyclopentanone, furfural, and benzyl ether exhibited a certain negative effect on antioxidant activity. Based on these findings, a graded utilization strategy for pyrolysis bio-oil was developed, and the economic feasibility was comprehensively evaluated. The minimum sales price of the biodiesel antioxidant was calculated to be $1,072.98 per ton, which is significantly lower than the market price of commercial antioxidants, indicating the economic potential of this strategy.
研究领域:
生物化学
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能源工程
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环境科学
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产品关联
DOI
高影响因子
ACS Omega
·
2021
·
IF 3.512
Nina Bao,Marwan M. A. Rashed,Bianling Jiang,Kefeng Zhai,Zisheng Luo
In this paper, the gas-assisted combined with glycerol extraction (GAGE) for polyphenol recovery from lotus seedpods (LSPs) was modeled and optimized. Box–Behnken design was applied to optimize the total polyphenol content (TPC) of LSP along with enhancing antioxidant activities using response surface methodology based on the TPC extraction yield (%), which was affected by glycerol concentration, time, temperature, and glycerol-to-solid ratio. The optimal conditions for the LSP extract were glycerol-to-solid ratio, 42 mL/g; time, 50 min; concentration of glycerol, 45%; and temperature, 70 °C. Ultra-high-pressure liquid chromatography integrated with triple-time-of-flight mass spectrophotometry (UPLC-Triple-TOF/MS) analysis revealed nine biologically active polyphenols. Furthermore, Fourier-transform infrared spectroscopy and scanning electron microscopy results demonstrated the effect and influence during extraction. The findings suggested that GAGE is a potential, green, and high-efficiency alternative that could be used to recover polyphenols from plant source byproducts.
研究领域:
植物化学
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食品科学
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环境科学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2024
·
IF 4.9
Wenjing Ma,Mingjun Tang,Siying Li,Yongqun Ma,Min Ling,Wenqian Sheng
This study explored the extraction of polyphenols from Juniperus chinensis Roxb. using natural deep eutectic solvents (NADES), emphasizing the role of hydrogen bonding strength in enhancing extraction efficiency. Choline chloride-fructose emerged as the most effective NADES after evaluating the correlation between hydroxyl stretching vibrations and polyphenol yield. Using the response surface methodology, the optimal extraction process (liquid to solid ratio 50.6 mL/g, extraction temperature 41.1 °C, extraction time 29.8 min, ultrasonic time 14.9 min) was determined to have a yield of 27.90 ± 0.14 mg/g, more than double that of water extraction. Choline chloride-fructose showed a more pronounced disruptive effect on plant powders. Additionally, compared to water extracts, the extracts using choline chloride-fructose exhibited higher antioxidant potential and quercitrin content. Overall, this study explores the correlation between hydrogen bond strength and extraction yield, while optimizing a green and efficient alternative process for polyphenol extraction from plants. These findings align with green chemistry principles, contributing to the development of sustainable and environmentally friendly extraction methods.
研究领域:
植物化学
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食品科学
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绿色化学
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Weilong Peng,Lijun Wang,Xiaoguang Wang,Yaya Wang,Weimei Wang,Junjie Huang,Ruigang Zhou,Chaoyang Chen,Ruonan Bo,Mingjiang Liu,Jingui Li
A novel method for extracting polyphenols from Moringa oleifera Lam. ( M. oleifera ) using natural deep eutectic solvents (NADES) has been developed, with extraction conditions optimized via an artificial neural network-genetic algorithm (ANN-GA) to maximize efficiency. Traditional extraction methods for polyphenols from M. oleifera leaves, such as ethanol extraction, are often associated with low efficiency, environmental concerns, and high operational costs. Furthermore, the empirical selection of solvents and extraction conditions is time-consuming and lacks precision. In this study, 28 NADES were employed to predict the solubility of polyphenol molecules through a conductor-like screening model for realistic solvents (COSMO-RS) model. Based on the results, eight highly effective NADES combinations were selected and experimentally verified. The betaine-maleic acid (Bet-MA) combination with the ultrasonic-assisted extraction showed the highest extraction rate of M. oleifera leaves polyphenol (MOLP), which was 1.56 times that of ultrasonic-assisted ethanol solvent. Simplex centroid mixture design (SCMD) and two-level factor experiments were conducted to optimize the ratio of betaine, maleic acid, and water and identify the most influential extraction factors on MOLP yield. The ANN-GA model was further applied to refine the extraction conditions and analyze their interactions on MOLP content. Additionally, antioxidant assays demonstrated that MOLP extracted with the Bet-MA solvent displayed significant antioxidant activity. In conclusion, this study demonstrates that COSMO-RS and ANN-GA may serve as powerful tools for solvent selection and extraction process optimization, offering a green and efficient approach for polyphenol extraction from M. oleifera leaves. The findings highlight the potential of NADES-based extraction methods for broader applications in the extraction of various bioactive substances, contributing to the development of sustainable and environmentally friendly extraction technologies.
研究领域:
植物化学
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食品科学
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环境科学
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产品关联
DOI
高影响因子
Journal of Berry Research
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2021
·Vol. 11
·期 2
·349-362
·
IF 2.352
Song Haizhao,Shen Xinchun,Chu Qiang,Zheng Xiaodong
BACKGROUND:Red raspberry (Rubus idaeus L.), a natural dietary source of (poly)phenols, has been used as medicine for centuries. OBJECTIVE:The purpose of this study is to determine the effect of a red raspberry (poly)phenolic extract (RPE) on diet-induced obesity, hepatic steatosis and insulin resistance, and elucidate the underlying molecular mechanisms. METHODS:Male specific pathogen-free C57BL/6J mice were randomly divided into three groups (n = 12 per group), and fed with low-fat diet (10% fat energy), high-fat diet (HFD, 45% fat energy), or HFD supplemented with RPE of 150 mg/kg body weight by intragastric administration for 14 weeks. Obesity-related biochemical indexes and hepatic gene expression levels were determined. The statistical analyses were conducted using one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test. RESULTS:The body weight gain, steatosis grade scores and insulin resistance index in the RPE group decreased by 34.48% (P = 0.00), 58.82% (P = 0.00), and 53.77% (P = 0.00), respectively, compared to those in the HFD group. Moreover, RPE supplement significantly changed the expression profile of the genes involved in lipid metabolism and fibroblast growth factor 21 signaling pathway. CONCLUSIONS:This study demonstrated that RPE protected from diet-induced obesity and related metabolic disorders by improving the lipid metabolism and fibroblast growth factor 21 resistance.
研究领域:
营养学
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代谢学
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分子生物学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Yuanbin Li,Siyuan Chen,shanshan Li,Zhenyuan Wang,Chengyu Wu,Jichuan Zhang,Junzi Dong,Jiaheng Zhang
Bioactive constituents in Camellia sinensis (white tea) provide dermatoprotective benefits, but conventional extraction methods are often inefficient and cumbersome. Research on green extraction techniques for white tea and their effects on skin-related bioactivities remains limited. This study therefore established Natural Deep Eutectic Solvents (NaDESs) as a sustainable extraction platform for white tea bioactives and evaluated the multifunctional skincare properties of the resulting extracts. An optimized L-proline/xylitol NaDES significantly enhanced polyphenol extraction efficiency over traditional solvents. the NaDES-derived extract exhibited superior antioxidant and anti-photoaging effects due to its higher polyphenol content, while also inhibiting advanced glycation end-products (AGEs) formation—demonstrating anti-glycation potential. In conclusion, NaDES represents an advanced plant extraction solvent, and the derived white tea extract shows promise as a multifunctional skincare ingredient (antioxidant, anti-photoaging, anti-glycation) for cosmetic and food applications.
研究领域:
植物化学
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化妆品科学
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皮肤科学研究
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绿色化学
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食品科学
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生物技术
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产品关联
DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 2
·214
·
IF 5.1
Mengge Duan,Yuting Wang,Shiyu Chen,Jiawen Lu,Ruihong Dong,Qiang Yu,Jianhua Xie,Yi Chen
Bisphenol A (BPA) and diisobutyl (DIBP) phthalate are widely used as typical plasticizers in food packaging. Plasticizers can be released from polymers, migrate into food, and be ingested by humans, leading to various health problems. However, little research has investigated the combined toxicity of BPA and DIBP, particularly their intestinal toxicity. Our goal is to analyse the combined toxicity of BPA (50 mg/kg) and DIBP (500 mg/kg) on the intestines of KM mice. Additionally, we tried to find natural products that can inhibit or prevent the combined toxicity of BPA and DIBP. The results indicated that the combination of BPA and DIBP exposure resulted in a reduction of beneficial flora, an increase in D-Lac levels (136 ± 14 μmol/L), an increase in intestinal permeability, activation of the notch pathway, and a decline in intestinal stem cells (ISCs) to goblet cells, compared to single-exposure sources. Nevertheless,Rubus chingiiHu phenolic extract (RHPE) (200, 400 and 600 mg/kg) ameliorated the BPA and DIBP-induced intestinal microbiota disruption and intestinal mucosal barrier impairment by inhibiting the overactivation of the notch pathway. The results of this study highlight the potential risks to human health posed by the combination of BPA and DIBP and may help explain the potential pathways of enterotoxicity caused by combined ingestion.
研究领域:
毒理学
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胃肠病学
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微生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Foods
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2025
·Vol. 14
·期 4
·619
·
IF 5.1
Kaijie Shang,Zhiheng Zhao,Hua Chen,Xiaonan Bian,Xianquan Zhong,Xiaoping Hu,Xue Lin,Lu Wang
The consumption of wampee has traditionally been utilized to alleviate gastrointestinal inflammation and associated disorders; however, its exact mechanism has remained unknown. The aim of this study was to elucidate the therapeutic efficacy and underlying mechanism of wampee polyphenol extract (WPE) in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). The findings revealed that WPE alleviated diverse symptoms of UC, regulated various inflammatory cytokines, and effectively protected the colon tissue structure and barrier integrity, thereby inhibiting LPS translocation. Moreover, WPE restored the richness and diversity of gut microbiota and optimized its structure at the phylum and genus levels, causing a notable improvement in short- chain fatty acid (SCFA) metabolism, particularly acetic acid, propionic acid, and butyric acid. Consequently, WPE was demonstrated to effectively suppress the LPS-induced TLR4-p38 MAPK/NF-κB signaling pathway by modulating gut microbiota and SCFA metabolism. These findings provided a theoretical basis for the use of wampee as a potential functional natural food for UC.
研究领域:
营养学
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胃肠病学
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免疫学
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微生物学
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药理学
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产品关联
DOI
PubMed
高影响因子
MOLECULAR NUTRITION & FOOD RESEARCH
·
2024
·Vol. 68
·期 8
·2300643
·
IF 4.5
Xiaobo Wei,Ni Ma,Wen Yang,Jinhu Tian,Huiyan Liu,Haitian Fang
Scope Polyphenols are the major active substances in red jujube fruit, and their anti-inflammatory and antioxidant activities suggest their potential utility in the prevention of ulcerative colitis (UC). Methods and results In this study, the effect of polyphenol extracts from red jujube ( Ziziphus jujuba Mill. “Junzao”) (PERJ) on the dextron sulfate sodium (DSS)-induced UC mice is investigated. The result shows that PERJ effectively improves clinical symptoms, including food and water intake, the disease activity insex (DAI) and spleen index, and routine blood levels, and alleviates the shortening of the colon, in mice with DSS-induced UC. Meanwhile, PERJ remarkably decreases the expression of proinflammatory factors. Moreover, PERJ repairs intestinal barrier damage by increasing the expression level of mucin 2 and mucin 3, and the result is also confirmed in the histological assessment. Besides, the expression levels of Nod-like receptor family pyrin domain-containing 3 (NLRP3) and mitogen-activated protein kinase cascade (MAPKs) signaling pathway-related proteins are inhibited by the PERJ administration. Finally, 16S rRNA sequencing analyses reveal that PERJ reverses intestinal microbiota dysbiosis by enhancing the abundance of Firmicutes and decreasing that of Proteobacteria and Bacteroidetes . Conclusion PERJ probably inhibits the development of UC by suppressing the NLRP3 and MAPKs signaling pathways and regulating gut microbiota homeostasis, and can be considered as a potential resource for preventing UC.
研究领域:
药理学
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免疫学
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微生物学
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胃肠病学
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产品关联
DOI
PubMed
高影响因子
iMeta
·
2024
·
IF 23.7
Shi Zhong,Yu-Qing Sun,Jin-Xi Huo,Wen-Yi Xu,Ya-Nan Yang,Jun-Bo Yang,Wei-Jie Wu,Yong-Xin Liu,Chong-Ming Wu,You-Gui Li
Inflammatory bowel disease (IBD) is a significant global health concern. The gut microbiota plays an essential role in the onset and development of IBD. Sanghuangporus (SH), a traditional Chinese medicinal mushroom, has excellent anti-inflammatory effects and is effective at modulating the gut microbiota. Despite these attributes, the specific anticolitic effects of SH and the mechanisms through which the gut microbiota mediates its benefits remain unclear. Herein, we demonstrated that polyphenol-rich extract from SH effectively alleviated the pathological symptoms of dextran sodium sulfate (DSS)-induced colitis in mice by modulating the gut microbiota. Treatment with SH distinctly enriched Alistipes , especially Alistipes onderdonkii , and its metabolite 5-hydroxyindole-3-acetic acid (5HIAA). Oral gavage of live A. onderdonkii or 5HIAA potently mitigated DSS-induced colitis in mice. Moreover, both 5HIAA and SH significantly activated the aromatic hydrocarbon receptor (AhR), and the administration of an AhR antagonist abrogated their protective effects against colitis. These results underscore the potent efficacy of SH in diminishing DSS-induced colitis through the promotion of A. onderdonkii and 5HIAA, ultimately activating AhR signaling. This study unveils potential avenues for developing therapeutic strategies for colitis based on the interplay between SH and the gut microbiota. Graphical Sanghuangporus is a medical mushroom with potent anticolitic effects. It modulates the gut microbiota and specifically enriches Alistipes onderdonkii , which can produce 5-hydroxyindole-3-acetic acid, thus activating the aryl hydrocarbon receptor pathway and ameliorating colitis. Highlights Sanghuangporus (SH) polyphenol extract potently alleviated symptoms of colon colitis in dextran sodium sulfate-induced colitis mice. The gut microbiota especially Alistipes onderdonkii mediates the anticolitic effect of SH. The SH-enriched microbial metabolite 5-hydroxyindole-3-acetic acid exhibited an anticolitic effect via the activation of the aryl hydrocarbon receptor. The “gut microbiota-metabolites-signaling pathway” provides an effective perspective for the study of complex Chinese medicine systems.
研究领域:
微生物学
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免疫学
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药理学
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胃肠病学
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产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 17
·3055
·
IF 5.1
Xianxian Luo,Hao Chen,Jiayi Mi,Xinyan Li,Ziheng Wu,Yan Jiang,Xiufang Dong
Macroalgae are often used to produce sodium alginate, but their by-products have not been fully utilized. This study aimed to optimize the extraction of bound polyphenols (BPs) from Macrocystis pyrifera (L.) residues, analyze the composition of free polyphenols (FPs) and BPs, and evaluate their antioxidant activities and ability to inhibit glycosidase activity. The optimal conditions for extracting BPs achieved by the response surface method were as follows: 50 °C, a solid–liquid ratio of 1:50, an alkaline hydrolysis time of 2.38 h, and a NaOH concentration of 8 mol/L. Polyphenol content determination results indicated that FPs had significantly higher total polyphenols (13.02 ± 0.05 μg GAE/mg) and phlorotannin (3.44 ± 0.04 μg PE/mg) than BPs (6.57 ± 0.07 μg GAE/mg and 1.32 ± 0.20 μg PE/mg). HPLC/ESI-QTOF-MS showed distinct profiles: FPs had one polyhydroxy phenol, nine flavonoids, and four additional compounds, whereas BPs had five flavonoids and four other compounds. Antioxidant activity was found to be higher in FPs than in BPs (DPPH: 3.03 vs. 1.79 μg TE/mg; FRAP: 19.40 vs. 7.43 μg TE/mg). Furthermore, FPs exhibited 4.59- and 11-fold higher inhibition capacity toward α-amylase and α-glucosidase, respectively, compared to BPs. The results provide valuable basic data for the application of macroalgae residues in the marine biological industry and reveal their potential hypoglycemic ability.
研究领域:
海洋生物技术
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食品化学
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天然产物研究
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工艺优化
·
生物活性物质
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Meiqian Wang,Ping Zhan,Jingzhang Geng,Peng Wang,Wanying He,Honglei Tian
The generation of off-flavor during boiling significantly hampers the acceptability and popularity of the greenfin horse-faced filefish (BFF). Adding perilla to Chinese fish dishes can enhance the flavor of fish. A total of 72 volatile compounds were quantified in BFF with different addition of Perilla polyphenol extract (PPE) (i.e., 0, 0.1 %, 0.3 %, 0.5 %, w: w) by headspace solid phase microextraction and gas chromatography-mass spectrometry (HS-SPME-GC-MS). Based on the gas chromatography-olfactometry (GC-O), odor activity value (OAV) and recombination omission testing, ( Z )-4-heptenal, ( E , E )-2,4-heptadienal, ( E , E )-2,4-nonadienal, ( E , E )-2,4-decadienal, heptanal, nonanal, octanal, decanal, ( E )-2-hexenal, ( E )-2-octenal, ( E )-2-nonenal were identified as volatiles contributing to the off-flavor, while linalool and β-ionone exhibited a mitigating effect. Moreover, the antioxidant capacities of PPE assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and thiobarbituric acid reactive substances (TBARs) assays, exhibited a positive correlation with perilla polyphenols contents. Orthogonal partial least square discriminate analysis (OPLS-DA) and partial least-squares regression (PLSR) results indicated a significant relationship between the off-flavor of BFF and lipid oxidation, adding 0.3% PPE resulted in a marked improvement in flavor profile, with a reduction in off-flavors associated with fishy, oily/fatty and marine, while simultaneously enhancing the freshness, herbal flavors, and overall acceptability of the product.
研究领域:
食品科学
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化学
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农业
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营养学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）