MACROMOLECULAR RESEARCH
·
2013
·Vol. 21
·期 12
·1338-1348
·
IF 1.639
Xu Yiting,Xie Jianjie,Chen Lingnan,Yuan Conghui,Pan Yinyin,Cheng Ling,Luo Weiang,Zeng Birong,Dai Lizong
A novel organic/inorganic hybrid amphiphilic random copolymer poly(methacrylate isobutyl POSS- co -N-isopropylacrylamide- co -oligo(ethylene glycol) methyl ether methacrylate- co -2-vinylpyridine), poly(MAPOSS- co -NIPAM- co -OEGMA- co -2VP), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The self-assembly behavior of random copolymers in aqueous solution was investigated by dynamic light scattering (DLS) as well as transmission electron microscopy (TEM). The results indicate the novel random copolymer in water could self-assemble into spherical aggregates and the self-aggregate size displays a remarkable dependence on pH. The stimuli-responsive characteristics of these assembles were tested by means of UV-vis spectra, DLS and TEM. There is a critic Zn 2+ concentration over which the aggregates can be coordinated into well-define spherical aggregate clusters. The critic Zn 2+ concentration can be tuned finely through adjusting solution concentration or 2VP amount. Results from UV-vis and DLS reveal that the copolymer solutions exhibit a sharp and intensive lower critical solution temperature (LCST). Some factors such as the solution concentration, molecular weight, pH and copolymer generation, which could affect the cloud point, were studied systematically. The essentially predetermined LCST can be achieved by altering the content of 2VP or pH. In addition, these novel hybrid aggregates can undergo an association/disassociation cycle with the heating and cooling of solution and the degree of reversibility shows a strong concentration dependence. As a novel organic-inorganic hybrid material which can respond to multiple external stimuli including temperature, pH, metal ions with sharp stimuli-responsive behaviors, it is potentially used for biomedicine, catalysis, diagnostics, bioseparations, biosensors and for fundamental investigation.
研究领域:
材料科学
·
高分子化学
·
生物医药
✓ 已验证
产品关联
DOI
高影响因子
Biomass Conversion and Biorefinery
·
2023
·
IF 4
Cai Jinyun,Zhong Haiyi,Tang Weihao,Wen Fangzhou,Lv Yingbin,Huang Xinghai,Luo Jianwei,Li Peiyuan
Safety, non-toxic, and degradable ammonium alginate with polyvinyl alcohol were selected as substrates for the preparation of AA/PVA hydrogel by simple co-blending and cyclic freeze-thaw methods. Curcumin as the model drug was encapsulated to obtain AA/PVA/Cur hydrogel. The resulting hydrogels were characterized using various techniques to confirm the success of preparation, including FTIR, SEM, XRD, TGA, and rheometer. In addition, multiple stimuli-responsive behaviors of hydrogels were studied in depth. For one thing, AA/PVA hydrogel showed dual response shape memory properties which could be fixed in a temporary shape in Ca 2+ or low temperature and followed recovery to the original shape with more than 90% recovery rate in Na + (Na 2 CO 3 and EDTA.2Na) or high temperature respectively, confirming that the hydrogels have ion- and temperature-responsive behaviors. For another, the drug-loaded hydrogel AA/PVA/Cur exhibited different drug release properties under different pH stimulation conditions, where curcumin could reach nearly 90% release under alkaline conditions after 6 h, whereas the release rate was only nearly 20% under acidic conditions. AA/PVA/Cur hydrogel had antibacterial and antioxidant effects, especially under alkaline conditions. Thereinto, the antibacterial rate of Escherichia coli and Staphylococcus aureus reached over 90%, respectively. Among the four antioxidant systems, up to 98.5%, ABTS radical scavenging rate was prominent. In conclusion, multiple stimulus-response properties of AA/PVA hydrogel exhibit a unique three-dimensional network structure capable of drug loading, combined with various properties such as good hydrophilicity, biocompatibility, biodegradability, non-cytotoxicity, and hemocompatibility, which have potential applications in medical and pharmaceutical fields.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Wen Yang,Fangbing Liu,Ran Li,Xiaoji Wang,Wentao Hao
Multiresponsive fluorescent supramolecular materials are quite interesting, for they combine the multiresponsiveness of supramolecules and the high sensitivity of fluorescent materials. Different from the multiresponsive supramolecular materials based on host–guest interactions, in this report, a supramolecular ionic network was fabricated by 1-(2-aminoethyl)piperazine and citric acids via ionic interactions. Despite the fact that there are no conventional chromophores, the obtained supramolecular ionic material can emit strong fluorescence. Most interestingly, the thin film of this supramolecular ionic material can change its fluorescent intensity in response to four external stimuli, including humidity, triethylamine, acetic acid, and temperature. Beneficial to the supramolecular ionic structure, this multiresponsive fluorescent sensor is self-healable. It is found that a new route has been opened to prepare the multiresponsive fluorescent sensors.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Yan Li,Jin Jia,Hua Yu,Shan Wang,Zhao-Yuan Jin,Yu-Hao Zhang,Hong-Zhi Ma,Kai Zhang,Kai Ke,Bo Yin,Ming-Bo Yang
Elastomer fiber mat sensors, which are capable of perceiving mechanical stimuli, temperature, and vapor of chemicals, are highly desirable for designing wearable electronics and human–robot interfacing devices due to good wearability, skin affinity, and durability, and so on. However, it is still challenging to fabricate multiresponsive flexible wearable sensors with three-dimensional (3D) architecture using simple material and structure design. Herein, we report an all-in-one multiresponsive thermoplastic polyurethane (TPU) nanofiber mat sensors composed of crimped elastomer fibers with deposited platinum nanoparticles (PtNPs) on the fiber surface. The 1D TPU nanofibers could be transferred to nanofibers with different 3D nanofiber architectures by controllable macromolecular chain relaxation of aligned elastomer polymers upon poor solvent annealing. The conductive networks of PtNPs on wavy TPU fibers enable the sensor susceptible to multiple stimuli like strain/pressure, humidity, and organic vapors. Besides, the 3D nanofiber architectures allow the strain sensor to detect wider tensile strain and pressure with higher sensitivity due to delicate fiber morphology and structure control. Therefore, this work provides new insights into the fabrication of multifunctional flexible sensors with 3D architecture in an easy way, advancing the establishment of a multiple signal monitoring platform for the health care and human–machine interfacing.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Xueting Lu,Yunli Liu,Dongxu Lu,Anqiu Xu,Yuexin Cao,Xiacong Zhang,Wen Li,Afang Zhang
Helical polymers with dynamic chirality are interesting not only for understanding the relationship between polymer structure and chiral conformation but also for developing responsive chiral polymeric materials. We report here the synthesis and characterization of a homologous series of dendronized poly(phenylacetylene)s (PPAs) via both macromonomer and grafting-to routes. These copolymers consist of achiral units carrying dendritic oligoethylene glycol (OEG) pendants and chiral units of dynamic imines formed from aldehydes and amino acids, which combine the constitutional dynamic chemistry (Schiff base) in the pendants with the conformational dynamic PPA backbones. Dendritic OEG pendants endow these copolymers with characteristic thermoresponsive behavior. The principles for modulating the helicity of these dendronized copolymers were examined, and factors including molecular structures (copolymer compositions and pendant linkage via ester or amide), solution pH, and thermally induced phase transitions have been investigated. These copolymers adopt tailored helicities in the presence of additional amino acids through multiple interaction balances between the copolymers and the amino acids. We believe that the methodology developed in this work will pave a convenient way to afford optically inactive copolymers or active polymers with featured dynamic helicity.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Chen Su,Jia Liu,Zhuoran Yang,Lei Jiang,Xiufeng Liu,Wei Shao
Carboxymethyl cellulose (CMC)/pPoly-N-isopropylacrylamide (PNIPAM) hydrogels were prepared using nanoclay as physical cross-linker by UV irradiation . PNIPAM/CMC hydrogels exhibit 3D network structures with high porosity. PNIPAM/CMC hydrogels exhibit not only high water absorption capacity , but also temperature, pH and salt mutiple-responsive swelling performance. Besides, they exhibit reversible swelling behavior in alternate de-ionized water and NaCl solution. Moreover, the fabricated PNIPAM/CMC hydrogels display great compression mechanical property. Then, tetracycline hydrochloride (TCH) was loaded into the PNIPAM/CMC hydrogels to endow their antibacterial ability. TCH loaded PNIPAM/CMC hydrogels exhibit excellent antibacterial activity against E. coli and B. subtilis and good biocompatibility . Thus, the PNIPAM/CMC composite hydrogels with triple stimuli-responsive swelling performances reported herein have great potentials in many biomedical applications .
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）