MACROMOLECULAR CHEMISTRY AND PHYSICS
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2018
·Vol. 219
·期 8
·1700558
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IF 2.492
Hengchang Liu,Yujun Feng
Multicompartment micelles (MCMs), whose cores have at least two compartments, show potential applications in various areas, but the synthesis of polymers for preparing MCMs is usually tedious and time-consuming. In this work, two well-defined telechelic fluorocarbon-terminated triblock copolymers, F 8 -PEO 100 -PPO 65 -PEO 100 -F 8 (F 8 -F127-F 8 ) and F 8 -PEO 132 -PPO 50 -PEO 132 -F 8 (F 8 -F108-F 8 ), are synthesized via a single-step coupling reaction of Pluronics F127 or F108 with perfluoro-1-octanesulfonyl fluoride and characterized by Fourier-transform infrared and NMR spectroscopies, as well as gel permeation chromatography and surface tensiometry. Both of these fluorocarbon-terminated Pluronics can self-assemble into spherical MCMs with Janus-core in aqueous solution, as evidenced by transmission electron microscopy imaging. Since the lipophilic block (PPO) and fluorophilic segments (F 8 ) are separated by the hydrophilic blocks (PEO), these fluorocarbon-terminated Pluronics will loop to give rise to flower-like MCMs, and the calculations based on thermodynamics and dynamics support the formation of such unique aggregates. A “pre-self-assembly” mechanism is proposed to explain the formation process of flower-like MCMs with Janus-core prepared by these telechelic fluorocarbon-terminated triblock copolymers.
研究领域:
材料科学
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化学工程
·
纳米技术
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Duo Wei,Nuoqing Yin,Dehua Xu,Lingling Ge,Rong Guo
Multicompartments in complex emulsions, which mimic the organelles of living cells, can spontaneously sequester reactants/products and confine spatially incompatible compounds. This provides opportunities to control spatiotemporal reaction processes and to be a sustainable and high-efficiency platform for biphasic reactions even under stirring-free and ambient temperatures. We introduce a new multicompartment droplet microreactor based on one-step prepared complex emulsions. An organic/aqueous addition reaction between oil-soluble stilbene and water-soluble N-bromosuccinimide is employed as a model biphasic reaction. The conversion in the proposed complex droplet microreactor achieves a rate about 25 times higher than that in a traditional triphasic batch system. Over a 10 times threshold of the reaction rate is finely tuned by rationally engineering diverse droplet morphologies. Reversible in situ control of the reaction kinetics is achieved based on the reversible topology transition manipulated by the surfactant composition and temperature, with no need for adding any extra substance. Furthermore, reaction kinetics are precisely regulated by the droplet size and the shape of the two inner lobes. After rapid demulsification, over 86% of the target product is spontaneously enriched in one separated phase with a maximum purity of 98% following solvent removal. The byproduct succinimide and the solvent fluorocarbon phase are fully recycled to avoid potential pollution problems.
研究领域:
化学工程
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生物化学
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材料科学
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产品关联
DOI
高影响因子
Small
·
2024
·
IF 13
Kunlin Chen,Jingyu Chen,Changyue Xu,Haie Zhu,Jing Hu,Kejing Yu
High-performance color-changing compounds, recognized as prominent smart materials, dynamically alter their color in response to external environmental stimuli. However, existing compounds exhibit limited responsiveness and color diversity, presenting challenges in the development of textiles responsive to multiple stimuli. This research introduces a novel design for dual-responsive color-changing microcapsules, employing a Pickering emulsion template method. The larger compartment encloses photosensitive dyes, whereas the smaller one contains thermochromic phase-change colorants. Adjusting the density of nanocapsules in the smaller compartment on the microcapsule surface enables a spectrum of colors, including red, yellow, blue, and green, triggered by light and heat. When incorporated into textiles, these microcapsules bestow adaptive color-changing attributes and infrared stealth capabilities onto the fabrics. Additionally, by modulating the color via surface micro/nanostructures, textile surfaces can exhibit hydrophobic and oleophobic properties. Such enhancements extend the textiles’ potential applications in areas like anti-counterfeiting and military operations.
研究领域:
材料科学
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纺织工程
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智能材料
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产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2017
·
IF 2.572
Baolin Wang,Meidi Wang,Ming-Wei Chang,Zesshan Ahmad,Jie Huang,Jing-song Li
Multi-compartment fibers with well-defined regions and functional media hosting potential provide co-encapsulation opportunities for a variety of bio-molecules, drugs and even nutrients. In this research, fibers possessing multiple compartments were prepared using the single-step electrospinning method and a modified non-concentric multi-needle. Polyvinyl pyrrolidone (PVP) was used as the fiber shell material, while ketoconazole (KCZ, model drug) and Sudan Red (model probe) were encapsulated as two separate segments running along the fiber length. Multi-compartment fiber morphology and structure were examined using optical and electron microscopy. The effect of flow rate on fiber morphology was also investigated and the release of encapsulated KCZ and Sudan Red was examined using UV spectroscopy. The results present an efficient and promising method to engineer multi-compartment fibers in a single step for several biomedical applications in lieu .
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 36
·8467-8475
·
IF 5.344
Hao Shen,Xuelian Zheng,Zixin Zhou,Wenting He,Mengqi Li,Ping Su,Jiayi Song,Yi Yang
Various organelles (e.g., mitochondria and chloroplasts) have a multicompartment structure, providing superior function of material transformation, selective segregation and energy conversion. Enlightened by the elegant evolution of nature, intended isolation of the biochemical process by cooperative multicompartments in cells has become an appealing blueprint to construct bioreactors. In this study, we develop a “soft separation” way to establish a delicate multicompartment multienzyme system (MMS) with polyphenol-encapsulated enzyme–DNA conjugates, which are anchored on magnetic Janus particles, providing a biomimetic catalysis network with the model cascade reactions in confinement. The well-designed MMS exhibits preferable bioactivity benefitting from the dependable DNA bridges and the oriented immobilization of enzymes, while the polyphenol shell further protects the anchored enzymes from exterior attacks, such as heat and enzymatic degradation. Moreover, by applying the MMS as nanomotors, the asymmetrical distribution of enzymes on Janus particles is found to improve mutual elevation between the self-driven locomotion and enzyme-mediated reactions, delivering enhanced dispersal ability and bioactivity. Owing to the excellent enzymatic activity, promoted stability and satisfying biocompatibility, the assembled MMS is proved to be promising for the in vitro and intracellular sensing of glucose, showing significant potential for biochemical analysis applications.
研究领域:
生物化学
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纳米医学
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催化科学
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产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Hai Chen,Xueer Han,Junlu Gao,Xiaoyi Tan,Hongjie Dai,Liang Ma,Yuhao Zhang
Hybrid multicompartment artificial architectures, inherited from different compartmental systems, possess separate microenvironments that can perform different functions. Herein, a hybrid compartmentalized architecture via hybridizing ferritin nanocage (Fn) with non-aqueous droplets using aminated-modified amphiphilic gelatin (AGEL) is proposed, which enables the generation of compartmentalized emulsions with hybrid multicompartments. The resulting compartmentalized emulsions are termed “hybrasome”. Specifically, by chemically attaching ethylenediamine to gelatin, the programmed noncovalent docking of Fn-AGEL nanoparticles is implemented and their interfacial self-rearrangement generates hybrasome with layered physicochemical barriers. Confocal Laser Scanning Microscopy images show that Fn nanocages are deposited on the non-aqueous droplets, separated by gelatin layers. Interfacial adsorption kinetics reveal that lower permeation and rearrangement rates of Fn are responsible for their double-layered structure formation. By choosing oxidized iron nanoparticles and reductant carnosic acid (CA) as models, these two molecules are co-encapsulated separately within the hybrasome, resulting in significant inhibition of the redox reaction. After structural destruction in the intestine, a redox reaction is triggered and leads to the Fe 2+ redox products release, which generates a suitable valence state of iron element for cell absorption. Overall, this approach may open up an avenue for facile construction of hybrid compartmentalized architectures used to co-encapsulate incompatible compounds separately and control the sequential release of targeted components.
研究领域:
生物材料学
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纳米医学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 17
·e202200560
·
IF 4.839
Qihan Zhang,Jun Liu,Yingjie Wu
Graphical An enzyme-driven multicompartmental colloidal motor was synthesized by using a facile microfluidic-based microdroplet technology. The colloidal motor could trigger enzyme cascade reaction in biocompatible fuel to generate local concentration gradient to provide net propulsion force for autonomous movement. Due to the advantages of the multicompartment, the colloidal motor has great potential for co-encapsulation of active species in biomedical applications. Compartmentalization is a crucial natural methodology to enable multiple biocatalytic transformations to proceed efficiently. Herein, we report a biocompatible multicompartmental colloidal motor that can achieve autonomous movement in the biological environment through two-enzyme cascade reactions of immobilized enzymes. The colloidal motors with the heterogeneous multicompartment structure were prepared in one step by microfluidic technology, and the compartmentalized encapsulation of glucose oxidase (GOD) and catalase (CAT) was realized. The fabricated colloidal motor was size controllable by tuning the flow rates of the microfluidic system, and its autonomous movement can be triggered by good responsiveness to the alkaline environment. In glucose medium of pH 7.5, the pH-responsive alginate cores of the colloidal motor swell to facilitate fuel penetration and enzyme-catalyzed reactions. The enzyme cascade between GOD and CAT immobilized in the colloidal motor chamber results in the self-propulsion of the colloid motor in glucose medium. The compartmentalized encapsulation of immobilized enzyme improves the stability of the enzyme and enables multicompartmental colloidal motors to self-propel in an alkaline intestinal environment through an enzyme cascade reaction. These features indicate that such multicompartmental colloidal motors actuated by enzyme cascade reaction in biocompatible fuel have great potential for co-encapsulation and autonomous movement in different applications.
研究领域:
生物医学工程
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材料科学
·
纳米技术
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）