Nanoscale
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2024
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IF 5.8
Caicheng Song,Yiwen Guo,Tianwei Wang,Kun Liu,Pin-Yi Zhao,Ying Liu,He Huang,Rongwen Lu,Shufen Zhang
Functional mesoporous carbon nanomaterials with large pores and small particle sizes have broad accessibility, but remain challenging to achieve. This study proposed a dual-template synergistic assembly strategy to facilely synthesize extra-small nitrogen-doped mesoporous carbon nanospheres with large pores in a low-cost manner. Directed by the synergistic effect of the combination of surfactants, sodium oleate (anionic surfactant) and triblock copolymer-P123 (nonionic surfactant) were selected as templates to construct nanomicelles (nanoemulsions), which were co-assembled with melamine-based oligomers to form composite nanomicelles, thus obtaining nitrogen-doped mesoporous polymer nanospheres (NMePS) and then nitrogen-doped mesoporous carbon nanospheres (NMeCS). Based on Schiff base chemistry, the melamine-based oligomers with self-assembly capability were synthesized as precursors, which is different from the conventional synthetic route of melamine–formaldehyde resin. The key parameters involved in the route were investigated comprehensively and correlated with the characterization results. Furthermore, the 50 nm-scale particle size and the large mesoporous size of 5.5 nm of NMeCS can facilitate effective mass transport, coupled with their high nitrogen content (15.7 wt%), contributing to their excellent performance in lithium-ion batteries.
研究领域:
材料科学
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能源化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2017
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IF 3.615
Yajun Du,Lingping Cheng,Long Chen,Yunchao He,Yaling Wu,Shanshan He,Yanxiong Ke
Sub-2 μm large-pore monodispersed mesoporous silica spheres (MMSS) were synthesized by using mixed non-ionic surfactants of dodecylamine (DDA) and dodecylamine polyoxyethylene ether (AC1210) as templates through an alkali-catalyzed silica sol–gel technique combined with the template method. Methanol-H 2 O volume ratio on morphology was researched in detail. In addition, by using hydrothermal treatment , the average pore size of MMSS could be enlarged to 11 nm from 4.4 nm. The mesoporous silica particles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), laser particle size analyzer, X-ray diffraction, N 2 physisorption technique. The synthesized sub-2 μm monodispersed mesoporous silica microspheres were successfully functionalized by dimethyloctadecylchlorosilane and used as a packing material in high performance liquid chromatography (HPLC).
研究领域:
材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2018
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IF 3.716
Qishu Qu,Yang Si,Han Xuan,Kehua Zhang,Xiaoming Chen,Yi Ding,Shaojie Feng,Han-Qing Yu,M. Asiri Abdullah,Khalid A. Alamry
Monodispersed core-shell silica spheres with fibrous shell structure and tunable pore size were prepared by using a one-pot oil-water biphase method. The pore size could be tuned from 7 nm to 37 nm by using organic solvents with different polarities as oil phase. The spheres synthesized by using benzene as organic solvent had the maximum pore size of 37 nm and possessed a surface area of 61 m 2 g −1 . The obtained wide pore core-shell silica spheres were applied for rapidly separating small molecules, peptides, small proteins, and large proteins with molecular weight up to 200 kDa. Since the pore size of the core-shell silica spheres was sufficiently large for the free access of all the solutes, sharp and symmetric peaks were obtained. The separation performance was as high as 264,531 plates m −1 for fluorene. The great efficient separation demonstrates that the wide pore core-shell silica spheres have a great potential for rapid analysis of both small and large solutes with high performance liquid chromatography.
研究领域:
材料科学
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分析化学
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生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2025
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IF 2.3
Chang Guanglei,Yang Miaomiao,Xu Zhaobin,Wang Xinling,Li Wenyao,He Meixia,Zhang Jintao,Xu Yuanzhi,Wang Lulu,Zhang Liguo
The performance of chromatographic media affects the efficiency of purification. In this study, based on a T-type microfluidic droplet generation system, agarose microspheres with large pore size and high load were prepared by adjusting the viscosity of a 4% agarose solution to 70 mPa·s at high temperature. Optical microscopy revealed that the self-made agarose microspheres had a good spherical structure with an average particle size of 82.81 μm and a CV value of 0.0576. Subsequently, the stability and mechanical strength of the self-made agarose microspheres were improved by cross-linking and activation with epichlorohydrin. After the cross-linking and activation, the agarose microspheres were grafted with Protein A to make it have specific adsorption capacity for IgG. The adsorption capacity of the self-made agarose microspheres grafted with Protein A for IgG was 87 mg/g. In the complex serum environment, the agarose microspheres grafted with Protein A still maintained good IgG adsorption capacity and selectivity, demonstrating their potential in practical applications. This study demonstrates the great potential of microfluidic technology in the design and preparation of bio-separation media. By precisely controlling the particle size and pore size of the microspheres, the purification efficiency and selectivity can be significantly improved, providing a new solution for the efficient purification of bio-products. Graphical abstract
研究领域:
生物分离
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生物技术
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS & DESIGN
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2019
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IF 5.77
Tingting Cheng,Siqi Li,Lan Xu,Adnan Ahmed
A modified electrospinning (MES), which consists of a copper mesh collector and an air pump placed behind it, was presented to fabricate nanofiber membranes (NFMs) with controllable large pore sizes by adjusting the MES parameters, such as copper mesh size, air velocity, applied voltage, flow rate and collecting distance. The controllable preparation mechanism of NFMs with large pore sizes was systematically investigated by experimental research and theoretical analysis. And the effects of the copper mesh grid dimensions, air velocity, applied voltage, flow rate and collecting distance on the pore sizes of NFMs were demonstrated. The results showed that NFMs with large pores produced successfully by the MES, and the pore sizes were all micrometer scale. And the optimal average pore size reached 14.45 μm 2 at the grid size of copper mesh of 4 mm×4 mm, the air velocity of 5 m/s, the applied voltage of 12 kV, the flow rate of 1.0 mL/h and the collecting distance of 18 cm.
研究领域:
材料科学
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生物医学工程
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纳米技术
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组织工程
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过滤材料
✓ 已验证
DOI
高影响因子
FUEL
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2024
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IF 6.7
Jia-Qi Wu,Lu-lu Ma,Zhuang-Zhuang Li,Xin Li,Si-Wen Li,Chang Li,Rong-Xi Li,Jian-She Zhao
A kind of large-aperture mesoporous silica spheres (HMSNS) has been innovatively synthesized via “Stöber- Phenolic resin” assistance, mainly attributed to the similarity on reaction conditions between the Stöber method and phenolic resin polymerization, as well inspired by the idea of obtaining large-aperture carbon spheres by simple etching and removing templates. To develop the high efficiency heterogeneous catalyst for oxidative desulfurization of fuel, the P-Mo-V type polyoxometalate as active sites, which was considered to own great influence on catalytic performance, was dispersedly immobilized onto HMSNS under the chemical bonding, named PMo 10 V 2 /APTES-HMSNS. The PMo 10 V 2 /APTES-HMSNS possessed the ultra-deep ODS performance under the optimal reaction conditions. It is worth mentioning that the 20-Mo 10 V 2 /APTES-HMSNS could catalyze the degradation for the four sulfur-containing components simultaneously, as high as 86.84 %, 99.99 %, 97.84 % and 91.35 % for benzothiophene (BT), dibenzothiophene (DBT), 4-methyl-dibenzothiophene (4-MDBT) and 4,6-dimethyl-dibenzothiophene (4,6-DMDBT). In addition, 20-PMo 10 V 2 /APTES-HMSNS displayed an outstanding reusability at least 8 times and the plausible ODS mechanism has been proposed.
研究领域:
材料科学
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催化化学
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环境化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2018
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IF 3.862
Weixia Xu,Xiaofeng Gao,Pengjin Ge,Fuquan Jiang,Xiaokun Zhang,Jingjing Xie
Multidrug resistance (MDR), as a major obstacle in cancer therapy, has resulted in over 90% of cancer chemotherapeutic failure. Mesoporous silica nanospheres (MSNs) have been demonstrated to be tuned with large pore sizes, mediating the MDR-reversal effects. However, the study that surface functionality of the large pore sized-MSNs affects the MDR-overcoming effects hasn’t been extensively studied. In this study, we developed a new dendrimer-like MSNs delivery system based on a rational synthesis strategy and further modified MSNs with various surface functionalities to evaluate their roles in overcoming cancer MDR. Our results showed that the small particle sized-MSNs could be fabricated with dendrimer-like internal structure, resulting in the large pore size of 9 nm. Surface functionality of MSNs, especially hydroxylation and carboxylation, largely improved the intra-nuclear delivery and therapeutic efficiency of DOX for MCF7/ADR cells, which was not up to inhibiting P-gp expression but significantly increasing the intracellular drug accumulation of over 90% even under the strong drug efflux. This study indicates that surface functionality design strategy may display the potential of the large pore sized-MSNs as the efficient chemotherapeutic carriers to combat MDR.
研究领域:
纳米技术
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药学
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癌症治疗
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）