IRANIAN POLYMER JOURNAL
·
2022
·Vol. 31
·期 11
·1347-1359
·
IF 2.485
Wu Xiaoli,Cao Jianfei,Liang Haotian,Tang Hailong,Liao Yijun,Meng Guolong,Huang Wanxia
An effective 2D thermal-conductive filler was prepared by coating glass flakes with silver (Ag-coated-glass flakes) through the electroless plating method for the first time. The XRD, XPS and SEM results showed that the silver completely covered the glass flake, and the silver volume could be controlled by the silver nitrate concentration. When the Ag-coated glass flakes was introduced to polyaspartic acid resin (PAE) matrix, the measurement results indicated that the thermal conductivity of the Ag-coated glass flakes/PAE composite was gradually enhanced with increasing loading of (Ag-coated glass flakes) as well as the volume of Ag on the surface of glass flake. The high thermal conductivities of 0.61–1.15 Wm −1 K −1 were achieved for 1.41–4.58% (vol) (Ag-coated glass flakes/PAE composites. The improvement was ascribed to its formation of continuous and effective 3D heat transfer channels by Ag-coated-glass flakes in PAE matrix. Furthermore, the introduction of low loading of Ag-coated glass flakes into PAE exhibited an enhancement effect on the impact strength. The impact strengths for 2.16% (vol) Ag-coated glass flakes-2 and Ag-coated glass flakes-4 filled PAE composites were increased by 30.5% and 20.3% as compared with pure PAE resin. Besides, the introduction of Ag-coated glass flakes enables the composites with obvious improvements of the degradation temperature, heat deformation, Vicat softening temperature. Therefore, the results of this study suggested an alternative method to fabricate high thermal conductive PAE-based composites with decent toughness and thermal stability. Graphical abstract
研究领域:
材料科学
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纳米技术
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DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 24
·13474-13481
·
IF 2.936
Bin Chen,Jingyu Li,Tong Liu,Zhendong Dai,Haichao Zhao
In this work, a secondary amine-capped polyaspartic ester (PAE-D230) was synthesized using diethyl maleate and amine-terminated polyether (D230) via Michael addition reaction. By modulating the molar ratio of preliminary amine containing D230 and secondary amine-capped PAE-D230 during the curing process with epoxy precursor E44, we obtained epoxy shape memory polymers with tunable Tgs(−12–20 °C), controllable mechanical properties with tensile stress from 0.8 to 14.1 MPa, tensile modulus from 0.7 to 872.0 MPa, and elongation at break from 45.2 to 195.1%. The influence of the composition of curing components on the thermal properties, thermomechanical, mechanical properties, shape memory effect were systematically studied by DSC, TGA, DMA, tensile-stress measurements.
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
Coatings
·
2023
·Vol. 13
·期 7
·1162
·
IF 3.4
Yizhi Du,Lina Hu,Liting Dong,Shuming Du,Dong Xu
This study aims to solve the icing problem of wind turbine blades in low-temperature environments and to improve the power generation efficiency of wind turbines. In this study, modified TiO2particles (500 nm), butyl acetate solvent, polyaspartic acid ester polyurea (PAE polyurea), and Crestron N75 curing agent were mixed and sprayed on the epoxy resin board surface. Static icing test, dynamic icing test, wear resistance test, and icing adhesion strength test studies were carried out to evaluate the anti-icing performance of the coating as well as its mechanical stability. The results showed that the mechanical stability and anti-icing performance of the coating were relatively optimal when the ratio of modified TiO2particles to PAE polyurea was 1.5. Under this ratio, the static contact angle of the coating was 161.4°, and the rolling angle was 4.7°. The main reason for the superhydrophobic performance after 250 wear cycles was that the TiO2particles were encapsulated by PAE polyurea. The static contact angle of the coating was still greater than 150° after eight icing–de-icing cycles. This paper provides a simple method to prepare a robust superhydrophobic coating and promotes the application of superhydrophobic coatings in the field of passive anti-icing of wind turbine blades.
研究领域:
材料科学
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可再生能源工程
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表面化学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-11
·
IF 5.3
Zhou Wenxiu,Lv Xiaoyuan,Zhang Shengman,Gao Zhenye,Li Bingjie,Wang Xin
A novel in-tube solid-phase microextraction coupled with an ultra-high performance liquid chromatography-mass spectrometry method has been established for simultaneous quantification of three crucial brain biomarkers N -acetylaspartic acid (NAA), N -acetylglutamic acid (NAG), and N -acetylaspartylglutamic acid (NAAG). A polymer monolith with quaternary ammonium as the functional group was designed and exhibited efficient enrichment of target analytes through strong anion exchange interaction. Under the optimized conditions, the proposed method displayed wide linear ranges (0.1–80 nM for NAA and NAG, 0.2–160 nM for NAAG) with good precision (RSDs were lower than 15%) and low limits of detection (0.019–0.052 nM), which is by far the most sensitive approach for NAA, NAG, and NAAG determination. Furthermore, this approach has been applied to measure the target analytes in mouse brain samples, and endogenous NAA, NAG, and NAAG were successfully detected and quantified from only around 5 mg of cerebral cortex, cerebellum, and hippocampus. Compared with existing methods, the newly developed method in the current study provides highest sensitivity and lowest sample consumption for NAA, NAG, and NAAG measurements, which would potentially be utilized in determining and tracking these meaningful brain biomarkers in diseases or treatment processes, benefiting the investigations of pathophysiology and treatment of brain disorders. Graphical abstract
研究领域:
分析化学
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神经化学
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生物医学
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DOI
PubMed
高影响因子
Scientific Reports
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2023
·Vol. 13
·期 1
·1-8
·
IF 4.6
Xin Jia-Xiang,Yang Guang,Zhang Huojun,Li Jianqi,Fu Caixia,Wang Jiachen,Tong Rui,Ren Yan,Wei Da-Xiu,Yao Ye-Feng
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have made great successes in clinical diagnosis, medical research, and neurological science. MRI provides high resolution anatomical images of tissues/organs, and MRS provides information of the functional molecules related to a specific tissue/organ. However, it is difficult for classic MRI/MRS to selectively image/probe a specific metabolite molecule other than the water or fat in tissues/organs. This greatly limits their applications on the study of the molecular mechanism(s) of metabolism and disease. Herein, we report a series of molecularly targeted MRI/MRS methods to target specific molecules. The optimal control method was used to efficiently prepare the singlet spin orders of varied multi-spin systems and in turn greatly expand the choice of the targeted molecules in the molecularly targeted MRI/MRS. Several molecules, such as N -acetyl- l -aspartic acid (NAA), dopamine (DA), and a tripeptide (alanine-glycine-glycine, AGG), have been used as targeted molecules for molecularly targeted MRI and MRS. We show in vivo NAA-targeted 1 H MRS spectrum of a human brain. The high-resolution signal of NAA suggests a promising way to study important issues in molecular biology at the molecular level, e.g., measuring the local pH value of tissue in vivo, demonstrating the high potential of such methods in medicine.
研究领域:
医学影像学
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分子生物学
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DOI
PubMed
高影响因子
Food & Function
·
2024
·
IF 5.1
Yajie Ma,Fan Zhang,Yujun Xie,Luyao An,Bo-Li Zhang,Bo-Yang Yu,Renshi Li
Asparagi Radix is a healthy food type with medicinal and edible homology, which is now widely used for improving pulmonary inflammation in clinical. However, the lung-protective effect and the active constituents of Asparagi Radix have yet to be elucidated. Herein, the potential pulmonary protective effect of oligosaccharides was investigated. We firstly identified eighteen oligosaccharides with different degrees of polymerization from Asparagi Radix using HPLC-QTOF MS. Oligosaccharides were found to be simultaneously determined in 20 batches of Asparagi Radix collected from various regions in China by HILIC-ELSD, and oligosaccharides stably exist in this herb. In the present study, we found that AROS significantly reduced NO production, and effectively down-regulated the mRNA expression of IL-6, IL-1β and TNF-α in RAW 264.7 cells, thereby reducing the inflammatory response induced by LPS. AROS also inhibited LPS-stimulated intracellular ROS production. A murine model of lipopolysaccharide (LPS)-induced acute lung injury was used to evaluate the in vivo anti-inflammatory and lung protective efficacy of AROS. AROS could ameliorate the damage of the pulmonary cellular architecture pathological injury and lung edema. AROS significantly decreased the levels of cytokines IL-6, TNF-α and IL-1β, as well as the levels of MPO and MDA, and superoxide dismutase consumption in vivo. This effect of oligosaccharides could explain the traditional usage of Asparagus cochinchinensis as a tonic medicine for respiratory problems and oligosaccharides from Asparagi Radix used as a natural ingredient could play an important role in protecting from lung injury.
研究领域:
药理学
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免疫学
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肺科学
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分子生物学
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
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2024
·
IF 6.7
Zisheng Ju,Xiangyu Guo,Linsen Li,Yao Tang,Mantang Qiu,Wenpeng Zhang,Zheng Ouyang,Qiang Ma
Point-of-care testing (POCT) involves administering rapid on-site analysis to provide fast biochemical testing results. POCT reduces delays in clinical decision-making and eliminates the need to transport and prepare clinical samples for immediate diagnosis or clinical intervention by healthcare professionals. Herein, a novel methodology integrating thin-layer chromatography-based two-dimensional separation with miniature mass spectrometry was developed for rapid on-site clinical analysis. As a proof-of-concept demonstration, γ-aminobutyric acid, 2-hydroxyglutarate, and N-acetyl-l-aspartic acid, which are widely known as biomarkers for brain gliomas, were selected as model analytes for method development and validation. The proposed approach exhibited satisfactory analytical performance, with 1 ng/mL limits of detection, 2 ng/mL limits of quantitation, and recoveries in the range of 85.9–107.2%. Additionally, on-TLC derivatization and reactive spray ionization strategies were utilized to enhance the mass spectrometric signals compared to underivatized analysis. This method was applied to analyze clinical samples, showcasing its attractive potential outside the laboratory.
研究领域:
医学诊断
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分析化学
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临床检验
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DOI
PubMed
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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2023
·
IF 6.2
Fen Xiong,Kaiyuan Jiang,Yali Wu,Cong Lou,Chengjie Ding,Wenli Zhang,Xi Zhang,Chen Li,Hong Zheng,Hongchang Gao
Intermittent fasting (IF) is an ecological strategy to control various metabolic disorder symptoms, but its protective effect on type 1 diabetes (T1D)-induced cognitive dysfunction and the underlying mechanisms remain poorly defined. Herein, we examined the efficacy of IF in altering the behaviors and brain metabolome in T1D mice and investigated the potential molecular mechanisms. We demonstrated that IF remarkably improved frontal cortical-dependent memory in T1D mice and reduced the loss of neuronal cells. Metabolomics and targeted mass spectrometry assays showed that IF reprogrammed the composition of the frontal cortical metabolome in T1D mice, including activating the aspartate and glutamate pathway and reversing glycerophospholipid and sphingolipid depositions. Mechanistically, IF attenuated the levels of oxidative stress proteins, like NOX2, NOX4, 8-OHdG, and 4-HNE, and inhibited the levels of pro-apoptotic factors Bax and cleaved Caspase-3, ultimately improving the memory ability of T1D mice. In vitro studies confirmed the protective effect of the supplemented N -acetylaspartate, a pivotal metabolite involved in IF-regulated T1D-induced cognitive dysfunction, in high glucose-stimulated SH-SY5Y cells by eliminating toxic lipids accumulation, oxidative stress, and apoptosis. To conclude, the frontal cortical metabolites mediated the protective effects of IF against T1D-induced cognitive dysfunction by attenuating oxidative stress and apoptotic signaling. Thus, IF can be a potential therapeutic strategy for T1D-induced cognitive dysfunction.
研究领域:
神经科学
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代谢疾病
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糖尿病研究
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认知科学
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DOI
PubMed
高影响因子
TOXICOLOGY MECHANISMS AND METHODS
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2021
·
IF 2.987
Lirui Hou,Fang Liu,Chong Zhao,Lihong Fan,Hongbo Hu,Shutao Yin
Oxytetracycline (OTC) and Quinocetone (QCT) are antimicrobials, whose residues have been found in food and environment. These two are sometimes used simultaneously in livestock and aquaculture, potentially resulting in the simultaneous consumption of multi-antimicrobials by consumers. However, the combined toxic effects of this phenomenon have yet to be addressed. Since the liver is a major target of both OTC and QCT, we tested their hepatotoxic effect using both cell cultures and animal models. Results showed that the QCT (5–25 μM) or OTC (20–100 μM) treatments alone caused dose-dependent reductions in cell numbers, while their combination strongly further enhanced inhibitory effects. Mechanistically, the combination enhanced the generation of reactive oxygen species (ROS) and activated mitochondrial cell death pathways. It also showed that the combination of OTC (800 mg/kg, i.g., 5d) and QCT (5000 mg/kg, i.g., 5d) resulted in significantly enhanced liver toxicity in C57BL/6N mice, the serum alanine transaminase (ALT) and aspartate transaminase (AST) were significantly increased by the OTC/QCT. These findings indicate the necessity of considering the combined toxicity of these two antimicrobials in safety assessments.
研究领域:
毒理学
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药理学
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细胞生物学
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动物科学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Hang Qu,Xin Gao,Hai-Tian Zhao,Zhen-Yu Wang,Juan-Juan Yi
A new purified polysaccharide (PNP40c-1) with a molecular weight of 2.06 × 10 5 Da was obtained from pine nuts ( Pinus koraiensis Sieb. et Zucc. ). Structural analysis indicated that PNP40c-1 is a homogeneous heteropolysaccharide composed of arabinose, rhamnose and glucose in a molar ratio of 2.98:1.00:0.52. The major backbone consisted of →3,4)- α - l -Ara p (1→, →4)- α - l -Ara p 3Me(1→, →3)- α - l -Rha p (1→ and →6)- β - d -Glc p (1→, and the side chain is β - d -Glc p -(1→ linked at C4-position of →3,4)- α - l -Ara p (1→. In addition, the hepatoprotective effect of PNP40c-1 was investigated by human hepatocyte cell line L02 treated with carbon tetrachloride (CCl 4 ). Results suggested that PNP40c-1 could protect L02 cells from CCl 4 -induced damage by enhancing the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), increasing the level of non-enzymatic antioxidant glutathione (GSH), suppressing lipid perioxidation and further reducing the leakage of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Hence, PNP40c-1 could be a promising functional food to serve as hepatoprotective agent.
研究领域:
生物化学
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药理学
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营养学
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DOI
PubMed
高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2018
·
IF 3.616
Lili Wu,Yulian Chen,Han Liu,Zhikun Zhan,Zhi Liang,Tao Zhang,Zheng Cai,Ling Ye,Menghua Liu,Jie Zhao,Shuwen Liu,Lan Tang
Aggravating effect of probenecid (a traditional anti-gout agent) on emodin-induced hepatotoxicity was evaluated in this study. 33.3% rats died in combination group, while no death was observed in rats treated with emodin alone or probenecid alone, indicating that emodin-induced (150 mg/kg) hepatotoxicity was exacerbated by probenecid (100 mg/kg). In toxicokinetics-toxicodynamics (TK-TD) study, aspartate aminotransferase (AST) and systemic exposure (area under the serum concentration-time curve, AUC ) of emodin and its glucuronide were significantly increased in rats after co-administrated with emodin and probenecid for 28 consecutive days. Results showed that the increased AUC (increased by 85.9%) of emodin was mainly caused by the decreased enzyme activity of UDP-glucuronosyltransferases (UGTs, decreased by 11.8%–58.1%). In addition, AUC of emodin glucuronide was increased 5-fold, which was attributed to the decrease of multidrug-resistant-protein 2 (MRP2) protein levels (decreased by 54.4%). Similarly, in vitro experiments proved that probenecid reduced the cell viability of emodin-treated HepG2 cells through inhibiting UGT1A9, UGT2B7 and MRP2. Our findings demonstrated that emodin-induced hepatoxicity was exacerbated by probenecid through inhibition of UGTs and MRP2 in vivo and in vitro , indicating that gout patients should avoid taking emodin-containing preparations in combination with probenecid for a long time.
研究领域:
药理学
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毒理学
·
药学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2019
·Vol. 411
·期 15
·3361-3372
·
IF 3.286
Zhang Yingyi,Li Liang,Wang Qi,Shen Mei,Han Weili,Yang Xuemei,Chen Lingyun,Ma Ande,Zhou Zhengzheng
Methamphetamine (METH) is one of the most highly addictive illicit drugs abused all over the world. Much evidence indicates that METH abuse leads to major toxicity, medical consequences, and even severe public health consequences. Existing studies usually focus on the pathomechanism of METH-induced toxicity; therefore, data on metabolites and elements correlating with particular toxicity remain scarce. The objective of the present study is to develop appropriate analytical procedures to identify the differential metabolic and elemental biomarkers on METH-induced hepatic injury to rats. The rats were administrated with METH (15 mg/mL/kg, two times per day) via intraperitoneal (i.p.) injections for four consecutive days. The alanine aminotransferase and aspartate aminotransferase activity levels of in the rat serum of the METH group increase significantly compared with those of the control group, suggesting obvious hepatic injury. The results are further confirmed by the histopathological microscopic observation. A total of 18 small molecular metabolites and 19 elements are selected to perform the simultaneous quantification based on the combination of liquid chromatography coupled with tandem mass spectrometry and inductively coupled plasma mass spectrometry. Sample preparation was optimized to cover all the analytes. Both methods are optimized and validated according to developed guidelines such as limits of detection, limits of quantification, linearity, precision, and recovery. All the obtained data are within the satisfactory range. The normalized data were processed according to the partial least squares discrimination analysis (PLS-DA) model. Five differential metabolic and six elemental markers are identified in rat plasma based on the variable importance in projection (VIP) (> 1) and t test results. Overall, the results obtained in this study demonstrate the developed methods are suitable for simultaneous determination of metabolic and elemental markers in the hepatic injury to rats induced by METH.
Graphical abstract
研究领域:
毒理学
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分析化学
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药理学
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病理学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）