WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 6
·1-20
·
IF 3.8
Akbari Mohammad Zahir,Xu Yifeng,Liang Chuanzhou,Lu Zhikun,Shen Siyuan,Peng Lai
This study aimed to accelerate photocatalytic treatment of sulfamethoxazole (SMX) and cefixime (CFM) and alleviate the toxicity of photocatalysis effluents to improve further biodegradability. An efficient and fast reactive photocatalyst (Fe 2 O 3 /ZnO@VC) was synthesized, characterized and applied for photocatalytic removal of the targeted compounds. Results further confirmed the complete removal of SMX (1 mgL -1 ) within 30-min photocatalytic treatment. Acidic condition favored SMX removal due to the formation of negative ions, which were attracted by the surface of the catalyst comprising positive charge in pH values below the point of zero charge. The ideal degradation environment for CFM (1 mgL -1 ) was at neutral pH, and 97.2±0.1% of CFM was degraded over 60-min. A quenching test revealed that superoxide radial ( • O 2 − ) and e − played a major role in the photocatalytic degradation of SMX, while hydroxyl radical ( • OH) showed an identical effect during photocatalytic treatment of CFM. The degradation efficiency of SMX was marginally reduced in synthetic wastewater (SWW) and CFM in tap water (TW) due to the quenching effects of phosphates and carbonates anions in SWW and chloride ions in TW, respectively. As a result of the excellent mineralization properties of the photocatalyst, the photocatalysis effluents were highly detoxified, reaching 93.5±11.8% and 87.0±5.1% for SMX and CFM, respectively. Graphical Abstract
研究领域:
环境科学
·
化学工程
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 6
·2827
·
IF 4.6
Arshad Mahmood,Laraib Khan,Muhammad Ijaz,Imran Nazir,Mahrukh Naseem,Muhammad Azam Tahir,Muhammad Naeem Aamir,Masood Ur Rehman,Mulazim Hussain Asim
Background: Cefixime (CFX) belongs to a group of third-generation cephalosporin antibiotics with low water solubility and low intestinal permeability, which ultimately leads to significantly low bioavailability. Aim: This study aimed to increase solubility, improve drug release, and intestinal permeability of CFX by loading into SEDDS. Methods: Suitable excipients were selected based on drug solubility, percent transmittance, and emulsification efficiency. Pseudo-ternary phase diagram was fabricated for the identification of effective self-emulsification region. The best probably optimized formulations were further assessed for encumbered drug contents, emulsification time, cloud point measurement, robustness to dilution, mean droplet size, zeta potential, polydispersity index (PDI), and thermodynamic and chemical stability. Moreover, in vitro drug release studies and ex vivo permeation studies were carried out and apparent drug permeability Pappof different formulations was compared with the marketed brands of CFX. Results: Amongst the four tested SEDDS formulations, F-2 formulation exhibited the highest drug loading of 96.32%, emulsification time of 40.37 ± 3 s, mean droplet size of 19.01 ± 1.12 nm, and demonstrated improved long-term thermodynamic and chemical stability when stored at 4 °C. Release studies revealed a drug release of 97.32 ± 4.82% within 60 min in simulated gastric fluid. Similarly, 97.12 ± 5.02% release of CFX was observed in simulated intestinal fluid within 120 min; however, 85.13 ± 3.23% release of CFX was observed from the marketed product. Ex vivo permeation studies displayed a 2.7-fold increase apparent permeability compared to the marketed product in 5 h. Conclusion: Owing to the significantly improved drug solubility, in vitro release and better antibacterial activity, it can be assumed that CFX-loaded SEDDS might lead to an increased bioavailability and antibacterial activity, possibly leading to improved therapeutic effectiveness.Keywords:oral bioavailability;cefixime;self-nanoemulsifying drug delivery system (SEDDS);permeation enhancement
研究领域:
药剂学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Rui Tian,Jiamin Chai,Yuhui Yang,Rui Zhang,Hua Yang,Xuehua Sun,Haoyu Li
The confinement effect of silica nanoparticles (SNPs) can significantly enhance the fluorescence and sensing performance of metal nanoclusters. In this study, silver nanoclusters (Ag NCs) were encapsulated within silica nanoparticles (SNPs) via a reverse microemulsion method to form a silver nanoclusters/silica nanoparticles (Ag NCs/SNPs) composite. The composite exhibited superior fluorescence properties compared to bare Ag NCs. It was found that cefixime (Cfx) could effectively quench the fluorescence of Ag NCs/SNPs (λex = 265 nm; λem = 298 nm). Based on this, a novel fluorescence method was developed for the detection of Cfx. Under optimal conditions, the probe showed a linear response to Cfx concentrations ranging from 0.77 to 24.4 µmol L−1, with a limit of detection (LOD) of 0.37 µmol L−1 (LOQ = 1.23 µmol L−1). The method demonstrates high selectivity for Cfx against common interferents. When applied to the analysis of pharmaceutical samples and human serum sample, the method yielded satisfactory recovery rates of 92.57–109.83% and 93.73–102.05%, respectively, with relative standard deviations (RSD) below 6.51%. These results confirm that the proposed sensing system is robust and reliable, indicating its great potential for application in pharmaceutical quality control and the detection of Cfx in biological samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2024
·
IF 4.1
Yi Zheng,Hanyu Yang,Qiang Yang,Yingying Li,Pran Gopal Karmaker,Xiupei Yang
Antibiotics play an important role in human life, but the abuse of antibiotics not only damages people's health but also poses a potential threat to the environment. Hence, the development of a rapid and efficient antibiotic detection method has profound significance. Herein, a novel terbium-based metal-organic framework (Tb-MOF) [Tb 2 (0.5BPDC) 4 (BPDC)(DMF) 2 .DMF] was prepared by a one-step solvothermal method . The framework structure of the synthesized Tb-MOF remained stable not only under different acidic and alkaline environments but also under different organic reagents. In view of the quenching effect of cefixime (CFX) on the fluorescence of Tb-MOF, a method for the detection of CFX was constructed with a linear range of 0.1–150 μM and a detection limit of 31.55 nM. The quenching mechanism was revealed by ultraviolet–visible absorption spectroscopy (UV–vis), fluorescence lifetime and density functional theory (DFT) to be attributed to the internal filtration effect (IFE) and photoinduced electron transfer (PET). Tb-MOF was applied to the quantitative analysis of CFX in environmental water samples and tablets, and the recovery rate was 98.4%–104.8%, which verified its practicability. Therefore, the prepared Tb-MOF is a potential fluorescence sensing platform for rapid and sensitive detection of CFX in actual samples.
研究领域:
分析化学
·
环境科学
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2023
·
IF 2.3
Kong Ruiping,Xu Lingwei,Zhu Li,Sun Yongrong
In an endeavor to ameliorate the solubility and subsequent oral bioavailability of Cefixime (CEF), a drug noted for its deficient water solubility, the formulation of ternary inclusion complexes was executed utilizing hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD), in conjunction with N-methyl-D-glucaminet (MG). This development was realized through the application of a mechanochemistry technique, acknowledged for its “green” credentials. The complexes' physicochemical attributes were meticulously examined through various analytical techniques: Fourier-transform infrared spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (XRD), and Scanning Electron Microscopy (SEM). Notably, the ternary complexes exhibited an uplift in apparent drug solubility, especially when juxtaposed with binary complexes. A prominent augmentation was perceived in the stability constant (Kc) and complexation efficiency (CE) when MG was integrated into the ternary complexes with HP-β-CD or SBE-β-CD. Further exploratory molecular docking and molecular dynamics studies underscored MG’s role in augmenting complex stability by serving as a bridge between CEF and cyclodextrins (CDs). The parallel artificial membrane permeability assay (PAMPA) indicated a conspicuous enhancement of CEF permeability in the ternary complexes relative to the control–free CEF. The particle size and zeta potential of the mechanochemically processed ternary complexes in liquid form were assessed using Dynamic Light Scattering (DLS). Moreover, in vivo evaluations revealed the ternary complexes to manifest notably superior oral bioavailability when compared to unadulterated CEF. Lastly, through the rapid storage assay, a heightened physicochemical stability was observed in the mechanochemically synthesized CEF ternary supramolecular inclusion complexes, compared to the pure drug, intimating a pioneering approach for the oral delivery of CEF, ensuring improved bioavailability. Graphical abstract
研究领域:
药剂学
·
药物化学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Youheng Pan,Tianyi Zhang,Yanyun Jin,Shixin Li,Jiandong Hu,Lanlan Li
The escalating global threat of antibiotic contamination in food and environmental matrices necessitates rapid, sensitive detection solutions. Current analytical methods suffer from limitations in multiplexing capability, portability, and sensitivity for trace antibiotic residues. Here, we report a high-performance electrochemical sensor based on a dual-metal iron/nickel metal-organic framework (Fe/Ni-MOFs/CNTs/rGO) nanocomposite supported by carbon nanotubes/reduced graphene oxide, for the simultaneous detection of furazolidone (FZD), chloramphenicol (CAP), and dimetridazole (DMZ). This sensor exhibits excellent detection performance, with a wide linear range (0.5–250 μM for FZD, 0.4–1036.8 μM for CAP, 0.2–576 μM for DMZ), and extremely low detection limits—(LOD) (0.08, 0.03, and 0.01 μM, respectively). Moreover, the recovery rate in complex matrices (eggs, milk, and lake water) exceeds 95 %, demonstrating excellent anti-interference ability. This work elucidates electron-coupled proton transfer mechanisms enabling portable antibiotic detection, bridging lab-scale innovation to practical monitoring solutions.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Hazardous Materials Advances
·
2026
·
IF 9.1
Arif Nawaz,Jalwa Afreeq,Zhao Linke,Adnan Khan,Haifa Zhai,Nisar Ali,Rayya Ahmed Al Balushi,Mohammad M. Al-Hinaai,Thuraya Al-Harthy
Construction of solar energy harvesting chalcogenides heterojunctions could reign as photocatalysts due to significant chemical modulation and transformations with light irradiation. However, for significant utilizations of light, band gap engineering, charge carrier separation/transfer, and stability of selenides are leftovers challenges. Inspired by this, in the forefront a novel promising, eco-friendlier, and efficient visible light responsive piezoelectric built-in interface (ZnSe@Sb 2 Se 3 ) heterojunction was successfully constructed. Characterizations as HR-TEM, SEM, Raman, XPS, XRD, etc. confirmed the optimized coupling of Sb 2 Se 3 /ZnSe built-in interfaces. The shape, crystallinity and d-spacing of synthesized heterojunction deduced from HR-TEM, SAED, SEM and XRD are in agreement and further strengthen the confirmation of optimized heterojunction formation. The resulted intimate heterojunction were applied for photocatalysis of cefixime (Cf) and Cr 6+ reduction. The piezo induce carriers acts as a center to stabilize intrinsic point defects and dangling bonds at grain boundaries hence improve photocatalytic performance. The X-ray photoelectron study and experimental results reveal the great photocatalytic potential of heterojunction reflected by higher redox capacity and extraordinary light harvesting of the built-in interface, synergizing piezo-photo charge carrier separation/transfer via S-scheme charge transfer. It is revealed that the hole in heterojunction was generating reactive oxygen species (ROS), primarily responsible for the photocatalysis of contaminants. These statistical parameters demonstrate the suitability of the proposed model and experimental data.
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2025
·
IF 10.5
Xiansu Liu,Hanwen Ren,Biao Wang,DongDong Zhao,Haolin Xiao,Qunfeng Tang,Hongli Huang,Feijun Zhao,Zhencheng Chen
Ceftriaxone sodium, a widely used third-generation cephalosporin antibiotic, poses significant health risks when residues accumulate in clinical or environmental settings. However, conventional detection techniques, including high-performance liquid chromatography and capillary electrophoresis, are limited by complex procedures, poor sensitivity, and a lack of real-time capability. To address these challenges, we report a sensitivity-enhanced electrochemiluminescence (ECL) microfluidic device for the rapid and label-free detection of ultra-low concentrations of ceftriaxone. Au 25 (Capt) 18 gold nanoclusters were served as a novel ECL luminophore to boost detection sensitivity, while a 3D-printed circulating microfluidic channel was designed to enrich ceftriaxone via inertial centrifugation. The device achieved a wide detection range of 4–400 μg/mL, a low detection limit of 0.522 μg/mL, and an average recovery of 99.1% in real sample tests. This integrated platform offers a promising strategy for simple, sensitive, and on-site monitoring of ceftriaxone contamination.
研究领域:
分析化学
·
环境科学
·
医学检验
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Tongtong Ma,Qiao Huang,Lei Yuan,Shugang Yan,Yalin Mo,Yibin Ying,Yingchun Fu,Jinming Pan
Sensor array offers significant potential for rapid, high-throughput antibiotic detection. However, cross-reactivity-based sensor arrays often lack accuracy, despite comprehensive data analysis; while traditional high-affinity-based sensors based on antibodies/aptamers frequently suffer from complicated design and poor robustness. Here, a filterable paper-based fluorescent metal–organic frameworks (MOFs) sensor array is developed for one-to-one recognition and quantification of multiple antibiotics. Three representative MOFs are designed to exceptional affinity and specificity for the target antibiotic. A filtration-assisted detection enhances sensitivity, achieving parts-per-billion (ppb)-level detection in mixed solutions. The proposed approach integrates recognition and signal generation, streamlined 10-min process. The robustness of the MOFs also enables direct detection in raw samples containing organic solvents, which is not achievable by conventional methods. Notably, the sensor array can be easily incorporated into a smartphone-based portable device, coupled with a user-friendly image analysis applet for one-step extraction and quantitative detection in chicken samples. Leveraging MOFs’ versatility, this method can be extended to simultaneously detect a broad range of antibiotics, offering the potential for universal, high-throughput accurate detection of various chemical targets.
研究领域:
分析化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemical Engineering and Processing-Process Intensification
·
2024
·
IF 3.8
Yanyan Zhao,Rong Huang,Xuhua Liang,Nianwu He,Hongxing Zheng,Mahmoud Sayed
In this work, a physical adsorption strategy including three steps of “turning waste into treasure-removal of pollutants-adsorption mechanism” have been provided to solve the environmental problems caused by spent mushroom substrate and organic pollution simultaneously. A series of environment-friendly Zn 2+ modified activated carbon (AC) with adequate adsorption capacity are prepared by using spent mushroom substrate as raw material. X-Ray Diffraction results indicate weak graphitization of Zn 2+ modified AC sample during the calcination process. FTIR results indicate that the AC adsorbents are inevitably entailed with abundant surface functional groups. Zn 2+ modified AC calcinated at 600 °C (Zn-AC-600) has the bigger BET surface area of 450 m 2 ·g −1 and excellent adsorption property, it can remove about 95, 75, and 88 % of Rhodamine B, Amoxicillin and Cefixime after 120 min adsorption process. While the maximal adsorption capacity q max for Rhodamine B, Amoxicillin and Cefixime towards Zn-AC-600 sample is about 202, 123, and 130 mg·g −1 , respectively. The adsorption process of all pollutants is found to match well with the pseudo-second-order kinetics. Zeta potential measurements reveal that Zn-AC-600 is negatively charged (-23.5 mV), which can absorb Rhodamine B, Amoxicillin, and Cefixime by electrostatic attraction. This work may provide an effective strategy toward beneficial recycling of spent mushroom substrate wastes and remove pollutants from water.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2025
·
IF 4.7
Linfang Wu,Jing Wang,Yonghuan Yan,Lu Wang,Qi Huang,Jinyong Peng,Lili Li
Endometritis is a prevalent condition of the reproductive system that leads to significant tissue damage in the uterus, thereby seriously impacting the health and quality of life of these patients. Hesperidin (HES), a natural flavonoid glycoside, displays various biological activities. Nonetheless, the protective effect of HES treatment against endometritis remains uncertain. In this study, we examined the protective effects of HES on endometritis induced by lipopolysaccharide (LPS) both in vivo and in vitro . In vitro experimental results showed that HES reduced the levels of inflammatory factors, improved mitochondrial morphology, increased mitochondrial activity and inhibited ROS levels; moreover, it activated the AMPK/PGC-1 α signalling pathway in LPS-induced human endometrial endothelial cells (HEECs). AMPK served as a potential target of HES, which was further validated using molecular docking, molecular dynamic simulation, CETSA and SPR. Moreover, in vivo experimental results indicated that HES significantly mitigated the histopathological alterations in the uterus caused by LPS, as well as reduced the levels of inflammatory factors, MPO activity, the expression levels of CD38, and CD138 and activated the AMPK/PGC-1α signalling pathway. Overall, HES mitigated mitochondrial oxidative stress and inflammatory response primarily through activation of the AMPK/PGC-1α signalling pathway, thereby exerting protective effects against endometritis.
研究领域:
药理学
·
免疫学
·
细胞生物学
·
分子生物学
·
妇产科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Chuanqi Zhang,Xiaomei Cheng,Ruirui Zhao,Mengxian Fu,Meifang Wang,Zhiming Chen,Changfang Zhang,Xiangzi Li
The integration of metal–organic framework (MOF) materials with magnetic cores not only serves as an effective adsorbent but also facilitates the recovery post-adsorption. In this study, we synthesized Ni@ZIF-8 composite nanotubes by introducing ZIF-8 onto the surface of Ni nanotubes, which were used as adsorbents for antibiotic removal. The Ni@ZIF-8 composite nanotubes exhibited high-efficiency and recyclable antibiotic adsorption, with the maximum adsorption capacities for tetracycline (TC) and cefixime (CFX) reaching 770.2 and 428.2 mg·g −1 , respectively. The Ni nanotubes, acting as magnetic cores, facilitated magnetic recovery after adsorption. Furthermore, the introduction of ZIF-8 not only increased the surface roughness of the composite but also incorporated a significant number of functional groups. The pseudo-second-order model, Langmuir model and intra-particle diffusion models provided better fits to the isotherm and kinetic data of the two antibiotics. Density functional theory (DFT) calculations results indicate that the π-π interactions dominate the adsorption process of both TC and CFX onto ZIF-8. And the electrostatic potential (ESP) calculations and interaction analysis indicate that the Ni atom enhances the adsorption behavior through π-π interactions between the benzene ring or carbonyl group of the two antibiotics and the imidazole of ZIF-8. This research offers a novel approach for the removal of antibiotics from contaminated water and environmental remediation using magnetic core-MOF composite materials.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）