Scientific Reports
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2025
·Vol. 15
·期 1
·1-11
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IF 3.9
Zhang Liwen,Zhao Jinhong,Zhang Jie,Lou Bang,Li Huijie,Guo Fangyuan,Yang Gensheng,Hong Weiyong
The convergence of advanced materials science and additive manufacturing technologies has revolutionized medical applications ranging from orthodontic devices to patient-specific bone fixation systems. Despite these advancements, the clinical translation of 3D-printed orthopedic implants remains constrained by suboptimal biocompatibility of conventional manufacturing materials. This study systematically evaluates dental resin-based composites as alternative biomaterials for bone fixation devices, hypothesizing that their rapid photopolymerization kinetics, mechanical robustness, and inherent biocompatibility can address current limitations. Through stereolithography technology, ceftriaxone sodium-loaded bone fixation devices were developed with customized geometries tailored to diverse anatomical requirements. Material optimization revealed that a 7:3 ratio of ethoxylated bisphenol A dimethacrylate (BPA2EODMA) to triethylene glycol dimethacrylate (TEGDMA) achieved optimal mechanical performance. Cytocompatibility assessment using L929 fibroblasts demonstrated > 70% cell viability, confirming minimal cytotoxicity. The drug-eluting implants exhibited potent antimicrobial efficacy in 8-h elution assays, showing inhibition rates of 49.14 ± 4.89% ( Staphylococcus aureus ), 48.38 ± 5.88% ( Escherichia coli ), and 26.79 ± 2.69% ( Candida albicans ). These results validate the dual functionality of antibiotic-loaded dental resin constructs, positioning them as promising candidates for patient-specific orthopedic solutions that simultaneously address mechanical stability, osseointegration, and infection prevention.
研究领域:
生物医学工程
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材料科学
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药理学
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骨科
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PubMed
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2018
·Vol. 97
·期 3
·709-716
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IF 1.265
Wei Wang,Dapeng Hu,Yanqiu Pan,Hengle Li,Guohua Chen
Initially unsaturated material frozen with prefabricated porosity was prepared to experimentally investigate its effect on freeze-drying of liquid material. Ceftriaxone sodium, a kind of commonly used antibiotic, was selected as the primary solute in an aqueous solution. The liquid nitrogen ice cream-making method was employed to prepare frozen materials with different initial porosities. Results showed that freeze-drying was significantly enhanced with the initially unsaturated frozen material and substantial drying time was saved compared with conventional freeze-drying. Drying time for the unsaturated sample (0.3 of saturation or 0.67 of initial porosity) was more than 20 % shorter than that required for the saturated one (1.0 of saturation without initial porosity). SEM images displayed that the dried products of the unsaturated frozen material had a pierced solid skeleton and uniform pore space with a fine and tenuous structure compared with those of the saturated one. The freezing rate exhibited little influence on the freeze-drying process. Annealing can be moderately beneficial to shortening the drying time and further improving the energy utilization. An appropriate increase in operating temperature was able to enhance the freeze-drying rate while changes in chamber pressure had a negligible effect on the process.
研究领域:
制药工程
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生物医学工程
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Journal of Cleaner Production
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2023
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IF 11.1
Haoran Chen,Zongping Wang,Yuxin Huang,Junchi Wei,Gang Guo,Lei Miao
Ceftriaxone sodium (CTX) is a typical β-lactam antibiotic in pharmaceutical wastewater. Although traditional biological treatments are low-cost and eco-friendly, antibiotics usually inhibit microorganisms , resulting in limited treatment performance. The biological co-metabolism process provides carbon sources and energy for microorganisms through co-substrate addition, thereby producing enzymes or cofactors to enhance the degradation of refractory pollutants. Therefore, the present study aimed to investigate the degradation performance of CTX through anaerobic biological co-metabolism. A simple co-metabolic substrate (i.e., glucose, 80 mg L −1 ) was added into an anaerobic-activated sludge system, and its mechanism was explored in terms of the variations in extracellular polymeric substances , microbial structure, and resistance genes. Additionally, the possible degradation pathways of CTX were described. The results showed that the degradation efficiency of CTX (200 mg L −1 ) was only about 35% within 8 h in the control group, while it increased to 67.6% in the experimental group with glucose. Chloroflexi , Actinobacteria , Bacteroidetes ADurb.Bin123, and Bacteroidales were the predominant bacterial species in the system. Additionally, the types of enzymes and the relative abundance of β-lactam resistance genes in the co-metabolic system significantly increased by 7 and 0.77%, respectively. Furthermore, nine primary anaerobic CTX biodegradation products were detected, indicating the existence of three possible degradation pathways. Overall, the study results provide a novel approach to treating CTX-containing wastewater.
研究领域:
环境科学
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微生物学
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DIAMOND AND RELATED MATERIALS
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2024
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IF 4.3
Jingle Zhang,Huihu Wang,Yangliu Ou,Hao Tu,Ziguan Zhang,Chenhuinan Wei,Xing Xiang,Ming Bao
As the overuse of antibiotics increasingly contaminates the environment, one of modern chemistry's objectives is to identify high-performance photocatalytic materials to degrade antibiotics. This study initially utilized NH 4 Cl as a gas template to synthesize porous lamellar g-C 3 N 4 (CNS) through a high-temperature calcination process. Building upon this, a homojunction catalyst, CNS/g-C 3 N 5 (S-CN), was developed via a secondary sintering technique using different amount of 3-amino-1,2,4-triazole addition to evaluate its efficacy in activating peroxymonosulfate (PMS) for degrading the antibiotic ceftriaxone sodium. Under neutral conditions, the photocatalytic system composed of S-CN catalysts prepared by 50 mg of 3-amino-1,2,4-triazole addition and PMS (S 3 -CN/PMS) exhibited degradation rates that were 3.37 and 8.11 times higher than those of the CNS/PMS and g-C 3 N 5 /PMS, respectively. At a pH of 8, the S 3 -CN/PMS system attained a 99.7 % degradation efficiency within 75 min. Based on results from UV–visible diffuse reflectance spectroscopy (DRS), transient photocurrent response, electrochemical impedance spectroscopy (EIS), photoluminescence spectroscopy and radical scavenging experiments, this high efficiency is attributed to a homojunction Z-type charge transfer mechanism that enhances the separation of photogenerated carriers. Furthermore, the study found that the optimal PMS addition was 20 mg and the optimal pH was 8. Chloride ions promoted the reaction, while other ions decreased the reaction rate. In conclusion, this paper provides valuable insights for the morphological modification of carbon nitride homojunction materials and the efficient activation of PMS for pollutant degradation.
研究领域:
环境科学
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材料科学
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化学工程
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Jie Chen,Jiafeng Wan,Chi Li,Yuhan Wei,Haolin Shi
Fe 0 -Fe 3 O 4 nanoparticles and cerium dioxide hollow spheres as efficient heterogeneous electro-Fenton reagents were rationally designed to be embedded in porous carbon derived from skimmed cotton for the electrocatalytic degradation of ceftriaxone sodium. Skimmed cotton porous carbon material has a hollow tubular structure, and cerium dioxide is dispersed on the surface of the carbon material in a hollow sphere structure of uniform size. Fe 0 -Fe 3 O 4 nanoparticles were wrapped in irregular particle shapes on the surface of cerium dioxide hollow spheres, and the remaining part was laid flat on the surface of porous carbon material. The as-synthesized Fe 0 -Fe 3 O 4 /CeO 2 /C showed excellent degradation efficiency of 95.59 % for ceftriaxone sodium within 120 mins and obtained a COD removal rate of 95.21 % at 240 mins. The zero-valent iron as a reducing agent effectively accelerated the Fe 3+ /Fe 2+ cycle, allowing the composites to exhibit higher catalytic activity and further reducing the possibility of secondary contamination. Moreover, the existence of cerium dioxide further promoted the redox cycle of Ce 4+ /Ce 3+ and accelerated the electron transfer in the interface of the catalyst. The synergistic effect of iron and cerium greatly facilitated the production of hydroxyl radicals and increased the yield of hydroxyl radicals in the reaction system.
研究领域:
环境科学
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材料科学
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化学工程
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PubMed
高影响因子
CHEMOSPHERE
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2024
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IF 8.1
Xinyue Feng,Haolin Shi,Wei Liu,Fangwei Ma,Pan Liu,Jiafeng Wan
This study demonstrated the design and fabrication of flower-like Ni/Mn-MOFs materials, and three-dimensional ultrathin flower-like Ni/Mn/MC microspheres were fabricated by embedding metal or metal oxide nanoparticles into a porous carbon skeleton via high-temperature pyrolysis at 600 °C and used for the electrocatalytic degradation of ceftriaxone sodium. This unique ultrathin porous flower-like structure can expose more active sites, provide rapid ion/electron transfer, and improve electrocatalytic activity. Meanwhile, the excellent electrical conductivity of the carbon skeleton, as well as the rational composition and synergistic effect of the two components, can promote the generation of active radicals (•OH and •O 2 − ) in the reaction system, which accelerates the electrochemical degradation process and improves the electrocatalytic degradation performance. The results showed that the Ni/Mn/MC-5:1 composite prepared when the molar ratio of Ni: Mn was 5:1 exhibited the best electrocatalytic degradation performance for the degradation of sodium ceftriaxone. The composites showed 98.2% degradation of ceftriaxone sodium in 120 min and maintained sound degradation after 20 cycles. Therefore, we concluded that this novel multicomponent composite has good electrocatalytic activity and stability for the degradation of antibiotic wastewater.
研究领域:
环境科学
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材料科学
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化学工程
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PubMed
高影响因子
CHEMOSPHERE
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2022
·
IF 8.943
Jianhua Yang,Lu Fang,Zhengkui Li,Guanhua Meng,Yong Jia,Yongbin Jiang,Jianjun Lian,Xinhong Gan
At present, the researches on photocatalysis were mainly focused on the design, improvement and development of catalysts, and less attention was paid to the existing characteristics of environmentally persistent free radicals (EPFRs) during the process of photocatalytic oxidation. In this study, A flower-like Z-type heterojunction ZnO/ZnIn 2 S 4 (ZnO/ZIS) and typical antibiotic ceftriaxone sodium (CS) were taken as study objects, concentrating on the generation characteristics of EPFRs during the degradation of CS by ZnO/ZIS, and clarifying the degradation mechanism of CS in which EPFRs participated. The results showed that the degradation efficiency of 10 mg/L CS by 0.40 g/L ZnO/ZIS reached 85.3% in 150 min under the irradiation of 500 W xenon lamp . It was clear that ·O 2 − and h + play major roles in CS degradation by ZnO/ZIS under visible light, and ·OH plays an auxiliary role. Furthermore, the formation mechanism of EPFRs during photocatalytic degradation processes of CS by ZnO/ZIS were first investigated thoroughly via experimental analysis and density functional theory (DFT) calculations. The concentration level of EPFRs centered on oxygen atoms is 10 11 spin/mm 3 , which were generated in the process of degradation of CS by ZnO/ZIS under visible light. The production of EPFRs chiefly includes two procedures: chemical adsorption and transfer of electrons. The adsorption energy of precursor P8 on ZnIn 2 S 4 side is −1.91 eV, the electrons transferred from precursor P8 and P11 to ZnO/ZnIn 2 S 4 heterojunction. Surprisingly, EPFRs have little negative effects on the degradation process of CS by ZnO/ZIS. The study was not only a key field in the development of photocatalysis technology , but also a new way to study the removal mechanism of antibiotics.
研究领域:
环境科学
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材料科学
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化学工程
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PubMed
高影响因子
NANOTECHNOLOGY
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2024
·Vol. 35
·期 48
·485706
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IF 2.9
Dong Wang,Shaobo Yang,Song Yan,Yaxin Gu,Yi Fang,Chaochao Cao,Chengchun Tang
Antibiotics can easily enter the water environment through direct or indirect approach, causing environmental pollution and endangering the health of organisms. Therefore, development of highly efficient adsorbent materials to adsorb and remove antibiotics is necessary. Here, cobalt oxide and nickel oxide are uniformly and tightly bonded on the surface of porous boron nitride fibers (PBNFs-NiCo), increasing the number of functional groups (B–O and N–H) and hydrogen bond receptors within PBNFs. The total pore volume and specific surface area of resulting PBNFs-NiCo can reach up to 0.48 cm3 g−1 and 720.3 m2 g−1, respectively. Encouraged by the unique micromorphology and chemical composition mentioned above, PBNFs-NiCo exhibits excellent ceftriaxone sodium (CS) adsorption ability, showing the adsorption capacity and removal efficiency up to 410.9 mg g−1 and 96.5%, respectively. Chemical adsorption plays an important role in their adsorption behavior, abiding by Langmuir adsorption theory and pseudo-second-order kinetic equation. Importantly, PBNFs-NiCo exhibits fascinating adsorption effects in surroundings with pH ranging from 4 to 6, 25 °C and varying salt concentrations. This work would establish a practical and feasible foundation for the practical application of PBNFs-NiCo for CS adsorption in aqueous solution.
研究领域:
环境科学
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材料科学
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高影响因子
APPLIED SURFACE SCIENCE
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2020
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IF 6.182
Jinhui Yang,Xiaogang Luo
Photocatalytic degradation is a promising method to solve the problem of ceftriaxone sodium wastewater. In this paper, Ag/TiO 2 @C composite materials with different Ag molar contents, where cellulose-derived carbon beads used as the carrier, were successfully prepared by the One-Pot method. In Ag/TiO 2 @C composite photocatalyst, Ag nanoparticles were deposited on TiO 2 particles to form a metal-semiconductor structure, where charge carriers were effectively separated under the Surface Plasmon Resonance effect of Ag nanoparticles, thereby extending the lifetime of charge carriers. Ag/TiO 2 @C has been found of higher photocatalytic degradation performance compared to pure TiO 2 and pure carbon beads. Among all, Ag (0.5%)/TiO 2 @C has the best catalytic performance. According to the Langmuir-Hinshelwood model, the photodegradation rate followed first-order kinetics, with the highest apparent rate of 0.0091 min −1 . According to the results of mass spectrometry, ceftriaxone sodium was degraded into small molecules and eventually degraded into CO 2 , H 2 O, and we proposed possible pathways and photocatalytic mechanism accordingly.
研究领域:
环境科学
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材料科学
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化学工程
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高影响因子
Frontiers in Microbiology
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2019
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IF 4.259
Tan Fang,She Pengfei,Zhou Linying,Liu Yiqing,Chen Lihua,Luo Zhen,Wu Yong
Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound CD437 was found to have potent bactericidal effect on E. faecalis. In addition, CD437 exhibited synergistic effects when administered in combination with gentamicin and additive effects when combined with ceftriaxone sodium. CD437 also inhibited biofilm formation by E. faecalis and exerted bactericidal effect on mature biofilm. Moreover, CD437 exhibited antibacterial and anti-biofilm effects against Staphylococcus. No bactericidal action of CD437 was observed against the gram-negative bacillus, but Pseudomonas aeruginosa biofilm extracellular polymeric substances (EPS) matrix formation was reduced. Overall, these findings indicate that CD437 has the potential to be developed as a novel antibacterial drug.
研究领域:
微生物学
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药理学
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传染病学
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DOI
PubMed
高影响因子
CHEMOSPHERE
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2022
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IF 8.943
Chen Zhang,Yingzhang Shi,Zhiwen Wang,Cheng Liu,Yidong Hou,Jinhong Bi,Ling Wu
ZnIn 2 S 4 ultrathin 2D nanosheets with a positive surface charge are synthesized by a hydrothermal method and different contents of surface S vacancies are induced via heat treatment of as-prepared ZnIn 2 S 4 (ZIS). As the S vacancies contents increased, the photocatalytic degradation efficiency of ceftriaxone (CTRX) sodium is promoted. Especially, ZIS-300 shows the best degradation efficiency (88.8%) for an initial CTRX concentration of 10 mg L −1 in 2 h. It is found that S vacancies cause the electron density of surface metal atoms (Zn, In) to be decreased, which makes the effective adsorption and activation of ceftriaxone anions through electrostatic adsorption interactions. Meanwhile, S vacancies also serve as active centers to promote the absorption of O 2 and gather electrons to form •O 2 − species. The photogenerated holes quickly transfer to the surface of the catalyst to directly degrade the adsorbed CTRX. Thus, the photocatalytic CTRX degradation efficiency is significantly improved. Finally, a possible mechanism for over defective ZIS is proposed. This work provides a feasible strategy for the efficient degradation of antibiotics from the perspective of electrostatic adsorption and molecule activation.
研究领域:
环境科学
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材料科学
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化学
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药学
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DOI
PubMed
高影响因子
ChemNanoMat
·
2026
·Vol. 12
·期 1
·e202500442
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IF 2.6
Jing Hu,Decheng Peng,Yue Liu,Shaogui Wu
Nitrofurantoin (Nit), a widely used antimicrobial agent classified as a Group 3 carcinogen, demands rapid, sensitive detection and practical monitoring for environmental and food safety. This study's unique contribution lies in developing bifunctional nitrogen-doped yellow-green carbon dots (YG-CDs) integrating sensitive Nit detection and oxygen “breathing color” tracking. YG-CDs were synthesized via a one-step solvothermal method using bromothymol blue and 2-mercaptobenzimidazole, with structural/optical characterization via Fourier transform infrared, X-ray photoelectron spectroscopy, UV–vis, and fluorescence spectroscopy; YG-CDs-gelatin composites were fabricated for visualization. Key findings: YG-CDs emit at 555 nm (long-wavelength) with a quantum yield of 26.1%, excellent stability (salt, temperature, UV), and high selectivity/anti-interference for Nit, achieving a detection limit of 2.1 μM and 96.5–100.5% recovery in lake water. The YG-CDs-gelatin composite exhibits oxygen-responsive color shifts (yellow-green to green), enabling instrument-free food freshness monitoring. This work provides a novel, integrated strategy for on-site antibiotic residue detection and intelligent packaging, advancing practical applications in environmental monitoring and food safety.
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高影响因子
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