Analytical Methods
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2021
·Vol. 13
·期 34
·3785-3791
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IF 2.896
Ling Li,Miaomiao Zhang,Ran Li,Huan Jiang,Zhongde Liu
Olaquindox (OLA), a chemically synthesized antibacterial growth promoter, despite being strictly controlled, is illegally used in feed to improve feed conversion efficiency and increase the rate of weight gain for animals. However, it has become clear that OLA has toxic effects on human beings via the transmission of OLA through the food chain. Here, by employing terbium nitrate to provide metal ions and benzene-1,3,5-tricarboxylic acid (H3BTC) as an organic ligand, a simple, rapid, and easy scale-up synthetic method was presented for the fabrication of water-stable and highly luminescent rod-like metal–organic frameworks (Tb–BTC MOFs). Using the Tb–BTC MOFs as a luminescent probe, the luminescence quenching effect was obviously observed upon the addition of OLA, ascribed to the binding of OLA molecules on the surface of Tb–BTC and the existence of an inner-filter effect (IFE) mechanism. The correlation between the luminescence quenching ΔI and the concentration of OLA was found to be linear from 1.0 to 1000.0 μM with a detection limit of 20.6 nM. Furthermore, a Tb–BTC-loaded fiber paper was prepared and it is highly responsive (30 s) and suitable for visual OLA assay. The method described here can be successfully applied to the detection of OLA in animal feed and edible animal tissue samples.
研究领域:
分析化学
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材料科学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2018
·
IF 5.123
Hongwu Wang,Yanqing Liu,Su Yao,Gengxin Hu
In this study, a novel and simple electrochemical sensor (ECS) was fabricated based on super pure single−walled carbon nanotubes (spSWCNTs) modified electrode . The ECS exhibited superior catalytic performance on the electrochemical reduction of olaquindox. A series of experimental parameters were systematically optimized to achieve optimal ECS performance. Compared with the bare gold electrode, the peak current increased 1700 times under the optimal experimental conditions. The ECS exhibited excellent sensitivity for the determination of trace olaquindox. The current response of the modified electrode was linear to the olaquindox concentration in the range of 0.1–500 nM with a detection limit of 30.0 pM (S/N = 3). The ECS was successfully applied for electrochemical recognition of olaquindox in real samples. In addition, the spSWCNTs modified electrode also exhibited remarkable electrocatalytic property in a wide potential range, so it had great potential for sensitive detection of various electroactive compounds.
研究领域:
分析化学
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环境科学
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材料科学
✓ 已验证
DOI
高影响因子
MOLECULES
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2019
·Vol. 24
·期 17
·3041
·
IF 3.06
Yanqing Liu,Gengxin Hu,Hongwu Wang,Su Yao,Yinjian Ye
A hybrid nanocomposite consisting of hydroxylated multi-walled carbon nanotubes (MWCNTs−OH) and cube mesoporous carbon (CMK−8) was applied in this study to construct an MWCNT−OH/CMK−8/gold electrode (GE) electrochemical sensor and simultaneously perform the electro-reduction of olaquindox (OLA) and carbadox (CBX). The respective peak currents of CBX and OLA on the modified electrode increased by 720- and 595-fold relative to the peak current of GE. The performances of the modified electrode were investigated with electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry. Then, the modified electrodes were used for the individual and simultaneous determination of OLA and CBX. The fabricated sensor demonstrated a linear response at 0.2–500 nmol/L in optimum experimental conditions, and the detection limits were 104.1 and 62.9 pmol/L for the simultaneous determination of OLA and CBX, respectively. As for individual determination, wide linear relationships were obtained for the detected OLA with levels of 0.05–500 nmol/L with LOD of 20.7 pmol/L and the detected CBX with levels of 0.10–500 nmol/L with LOD of 50.2 pmol/L. The fabricated sensor was successfully used in the independent and simultaneous determination of OLA and CBX in spiked pork samples.Keywords:CMK−8;MWCNTs−OH;electrochemical sensor;differential pulse voltammetry;simultaneous determination;carbadox;olaquindox
研究领域:
分析化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2021
·Vol. 102
·期 5
·2080-2089
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IF 3.639
Xibin Liao,Yihui Chen,Meikang Lei,Chunyan Hou,Xie Li,Tingting Wang
BACKGROUND Carbadox and olaquindox have been banned from feeds since 1998 by the EU because of their mutagenic, photoallergic, and carcinogenic effects. Unfortunately, owing to their outstanding effect, they are frequently abused or misused in animal husbandry. There is an urgent need to develop a sensitive and reliable method for monitoring these drugs in animal feeds. RESULTS This work reported a new method of hydrophilic-interaction-based magnetically assisted matrix solid-phase dispersion (MMSPD) extraction coupled with reversed-phase liquid chromatography–mass spectrometry for simultaneous determination of carbadox and olaquindox in animal feeds. 3-Trimethoxysilylpropyl methacrylate ( γ -MAPS)-modified attapulgite (ATP) was crosslinked with γ -MAPS-modified iron(II,III) oxide (Fe 3 O 4 ), 1-vinyl-3-(butyl-4-sulfonate) imidazolium (VBSIm), acrylamide (AM), and N , N ′-methylene-bis(acrylamide) (MBA) to synthesize ATP@Fe 3 O 4 @poly(VBSIm-AM-MBA) particles. The resultant particles were characterized by scanning electron microscopy, energy dispersive spectrometer, transmission electron microscopy, vibrating sample magnetometer, and Fourier transform infrared spectroscopy. Crosslinking of ATP into the magnetic particles has significantly increased the adsorption capacity of the particles. Under optimum conditions, the limits of detection ( S / N = 3) were 0.3 μg kg −1 and 0.9 μg kg −1 for carbadox and olaquindox respectively. The intra-day and inter-day recoveries of the spiked targets in feed samples were in the range 83.5–98.3% with relative standard deviations of 1.0–8.3%. CONCLUSION With a simplified procedure and a low amount of sample, the proposed hydrophilic-interaction-based MMSPD method is not only useful for the determination of carbadox and olaquindox in feeds but also holds great promise for the analysis of other polar targets in solid or semisolid matrices. © 2021 Society of Chemical Industry.
研究领域:
分析化学
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食品安全
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动物营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
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2022
·
IF 9.231
Zhenhua Wen,Xuelian Hu,Rongfang Yan,Wenxiu Wang,He Meng,Yang Song,Shuo Wang,Xianghong Wang,Yiwei Tang
Olaquindox residues in food from its illegal use has received great attention. Here, an immunoassay strategy integrating an upconversion nanoparticle (UCNP)-based immunochromatographic strip with a fluorescence reader was proposed for the highly selective and sensitive detection of olaquindox. Polyacrylic acid-functionalized UCNPs were synthesized using a simple ligand exchange process and combined with an olaquindox polyclonal antibody to form a fluorescent probe. This approach achieved a sensitive response and specific recognition of olaquindox. A convenient upconversion fluorescence reader was introduced to implement accurate and sensitive quantitative analysis of olaquindox based on the fluorescence intensity of control and test lines on a strip. Under optimal conditions, the method demonstrated a favorable linear range (0–50 ng/mL) and sensitive detection (1.42 ng/mL, S/N = 3). This method was applied successfully to determine olaquindox in fish muscle and water samples, and results were consistent with an HPLC approach, and considered a promising strategy for monitoring olaquindox residuals.
研究领域:
分析化学
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环境科学
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食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Shuang Han,Ruonan Sun,Le Zhao,Chen Yan,Hongtao Chu
Olaquindox (OLA) in food from its illegal use possesses great harmful effects on humans, making it important to develop sensitive, inexpensive, and convenient methods for OLA detection. This study innovatively presented a molecularly imprinted electrochemical sensor based on the synergistic effects of nitrogen-doped graphene quantum dots ( N -GQDs) and a nickel-based metal–organic framework functionalized with silver nanoparticles (Ag/Ni-MOF) for OLA detection. N -GQDs and Ag/Ni-MOF with unique honeycomb structures were sequentially modified on the glassy carbon electrode (GCE) surface to accelerate the electron transfer rate and increase the available region of the electrode. Molecularly imprinted polymers were further grown on the Ag/Ni-MOF/ N -GQDs/GCE by electropolymerization to significantly enhance the selective recognition of OLA. The constructed sensor showed excellent performance for selective OLA determination, with a wide linear range (5–600 nmol·L -1 ) and exceedingly low detection limit (2.2 nmol·L -1 ). The sensor was successfully applied to detect OLA in animal-origin food with satisfactory recoveries (96.22–101.02%).
研究领域:
分析化学
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电化学
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食品安全
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）