SOCIAL SCIENCE & MEDICINE
·
2012
·
IF 2.699
Michelle Hannah Smirnova
The logic and cultural myths that buttress the cosmeceutical industry construct the older woman as a victim of old age, part of an “at-risk” population who must monitor, treat and prevent any markers of old age. A content and discourse analysis of 124 advertisements from the US More magazine between 1998 and 2008, revealed three major themes working together to produce this civic duty: (1) the inclusion of scientific and medical authorities in order to define the cosmeceutical as a ‘drug’ curing a disease, (2) descriptions of the similarities (and differences) between the abilities of cosmeceuticals and cosmetic surgery to restore one’s youth, and (3) the logic equating youth with beauty, femininity and power and older age with the absence of these qualities. Together these intersecting logics produce the “will to youth”—the imperative of the aging woman to promote her youthful appearance by any and all available means. Further, by using images and references to fantasies and traditional fairytales, cosmeceutical advertisements both promise and normalize expectations of eternal youth of the aging woman.
研究领域:
社会学
·
医学
·
生物学
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DOI
PubMed
高影响因子
Revue Francaise d Allergologie
·
2021
·
IF 0.288
H. Rezapour,M. Fereidouni,Z. Asadi,M. Saharkhiz,M. Ayadilord,S. Mahmoudzadeh,M.R. Shadmand Foumani Moghadam,G.A. Ferns,A. Bahrami
The prevalence of allergic disorders has been increasing globally, and it may be useful to identify the modifiable factors associated with it. Diet has been identified as one possible lifestyle factor implicated in the pathogenesis of allergic diseases. The goal of this study was to evaluate the associations between dietary patterns and the presence of allergies in a group of young women in eastern Iran. In all, 181 female students were enrolled. Screening for presence of allergic diseases, including allergic rhinitis (AR), asthma and eczema, was performed by an expert allergist. Information about dietary intake was collected using a validated 65-item food frequency questionnaire. Exploratory factor analysis was used to evaluate the relationships between food/nutrition variables. Serum immunoglobulin (Ig)E levels were significantly higher in the group in the third tertile (highest adherence) for a Western dietary pattern compared to the group in the first tertile (lowest adherence). The multivariate odds ratio for presence of allergic rhinitis (AR) was 2.5 (95% CI:1.1-5.1) for the highest compared to lowest tertile of the Western dietary pattern score. However, no significant relationship was found between a traditional dietary pattern and AR, asthma or eczema. Our findings indicate a potential role in the development of AR of the Western dietary pattern, which is characterized by high intake of dairy products, snacks, nuts and sugar. Since diet is a modifiable factor, the relationship between AR and a Western dietary pattern may have clinical implications, particularly in subjects with other risk factors for developing AR. Résumé La prévalence des troubles allergiques a augmenté à l’échelle mondiale, et il peut être utile d’identifier les facteurs modifiables qui y sont associés. L’alimentation a été identifiée comme un facteur de style de vie possible impliqué dans la pathogenèse des maladies allergiques. Le but de cette étude était d’évaluer les associations entre les habitudes alimentaires et la présence d’allergies dans un groupe de jeunes femmes de l’est de l’Iran. Au total, 181 étudiantes se sont inscrites. La présence de maladies allergiques dont la rhinite allergique (RA), l’asthme et l’eczéma a été identifiée par un allergologue expert. Les informations sur l’apport alimentaire ont été recueillies à l’aide d’un questionnaire de fréquence alimentaire validé de 65 éléments. Une analyse factorielle exploratoire a été utilisée pour évaluer les relations entre les variables alimentaires/nutritionnelles. Les taux sériques d’immunoglobulines (Ig) E étaient significativement plus élevés dans le groupe du troisième tertile (adhérence la plus élevée) pour un régime alimentaire occidental par rapport au groupe du premier tertile (adhérence la plus faible). L’odds ratio multivarié d’avoir une rhinite allergique (RA) était de 2,5 fois (IC à 95 % : 1,1 à 5,1) pour le tertile le plus élevé par rapport au tertile le plus bas du score de modèle alimentaire occidental. Mais, aucune relation significative n’a été trouvée entre un régime alimentaire traditionnel et la RA, l’asthme ou l’eczéma. Nos résultats indiquent un rôle potentiel du modèle alimentaire occidental, caractérisé par sa teneur élevée en produits laitiers, en collation, en noix et en sucre, dans le développement de la RA. Étant donné que le régime alimentaire est un facteur modifiable, la relation entre la RA et un modèle alimentaire occidental peut avoir des implications cliniques, en particulier chez ceux qui ont d’autres facteurs de risque de développer une RA.
研究领域:
营养学
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过敏性疾病研究
·
公共卫生
✓ 已验证
DOI
高影响因子
Cell Death Discovery
·
2023
·Vol. 9
·期 1
·1-11
·
IF 7
Yang Liu,Du Xing,Wang Siqi,Lin Chenggang,Li Qiqi,Li Qifa
Follicular atresia triggered by granulosa cell (GC) apoptosis severely reduces female fertility and accelerates reproductive aging. GC apoptosis is a complex process regulated by multiple factors, regulatory axes, and signaling pathways. Here, we report a novel, small regulatory network involved in GC apoptosis and follicular atresia. miR-187, a miRNA down-regulated during follicular atresia in sows, maintains TGFBR2 mRNA stability in sow GCs by directly binding to its 5’-UTR. miR-187 activates the transforming growth factor-β (TGF-β) signaling pathway and suppresses GC apoptosis via TGFBR2 activation. NORHA, a pro-apoptotic lncRNA expressed in sow GCs, inhibits TGFBR2-mediated activation of the TGF-β signaling pathway by sponging miR-187. In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX. Our findings define a simple regulatory network that controls GC apoptosis and follicular atresia, providing new insights into the mechanisms of GC apoptosis, follicular atresia, and female fertility.
研究领域:
生殖生物学
·
分子生物学
·
内分泌学
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产品关联
DOI
PubMed
高影响因子
AMERICAN SOCIOLOGIST
·
2002
·Vol. 33
·期 3
·21-57
·
IF 0
Richardson Barbara
Best known as the first woman graduate from MIT, and the founder of Home Economics, Ellen Swallow Richards was a Progressive Era reformer who applied social science research techniques to problems of concern to early sociologists. As a mentor to many women who joined the “Cultural” and “Pragmatic” feminists of Hull House, her secular theories of “Oekology” and “Euthenics” challenged many of the models of social change prevalent in the Cambridge and Chicago academic communities. Her most radical contribution as a feminist was her assertion that women’s unpaid labor in the home played a vital economic role in maintaining capitalism and was the ultimate source of their second-class citizenship. She shared a belief in democracy and education as a feminist “Pragmatist,” and laid the groundwork for the contemporary “Ecofeminist” movement. Although she was a biochemist by training, she engaged several genera-tions of women in the application of scientific methods to the solution of contemporary social problems. As a political organizer, much of her legacy is reflected in the accomplishments of the reform organizations she was instrumental in founding.
研究领域:
社会学
·
女性研究
·
环境科学
·
公共健康
·
教育学
·
应用社会科学
✓ 已验证
DOI
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Cong Ma,Kaiqin Hu,Xueke Zhang,Yaru Yu,Zuying Xu,Tian Ma,Hongzhen Ruan,Yingying Zhang,Jiajia Wang,Xinyu Yue,Chunmei Liang,Huifen Xiang,Rui Guo,Yunxia Cao,Zhiming Ding
Arsenic is a pollutant that can cross the placenta; however, research on the effects of arsenic exposure during pregnancy on the fertility of female offspring is limited. To address this gap, we developed a mouse model to investigate the relationship between arsenic exposure during pregnancy and fertility in female offspring. Our fertility assessment revealed that gestational exposure to 1 mg/kg arsenic or higher (10 mg/kg) resulted in reduction in litter size, ovarian volume, and multistage-follicle number in female offspring. By assessing the in vitro developmental capacity of oocytes and zygotes, we confirmed that the reduced fertility was due not to impaired oocyte quality but rather to a reduction in oocyte quantity. Arsenic exposure impedes synapsis formation in MPI and compromises homologous recombination-mediated repair of double-strand breaks, resulting in fewer crossovers. This disruption activates the pachytene-checkpoint, hindering the progression of the MPI and resulting in the elimination of defective oocytes through p-Chk2 activation. Our study reveals for the first time the detrimental effects of arsenic exposure during pregnancy on the fertility of female offspring, underscoring the urgent need to prevent such exposure to safeguard reproductive health.
研究领域:
生殖生物学
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毒理学
·
遗传学
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产品关联
DOI
PubMed
高影响因子
Cell Metabolism
·
2023
·
IF 29
Di Li,Ting Sun,Yongqing Tong,Juan Le,Qian Yao,Jun Tao,Hang Liu,Woer Jiao,Yufeng Mei,Jingru Chen,Zhongchun Liu,Gaohua Wang,Yan Li
Estradiol decline can result in depressive disorders in females; nevertheless, the causes of this decline are unclear. In this study, we isolated estradiol-degrading Klebsiella aerogenes from the feces of premenopausal females with depression. In mice, gavaging with this strain led to estradiol decline and depression-like behaviors. The gene encoding the estradiol-degrading enzyme in K. aerogenes was identified as 3β-hydroxysteroid dehydrogenase (3β-HSD). Heterologously expressing 3β-HSD resulted in Escherichia coli obtaining the ability to degrade estradiol. Gavaging mice with 3β-HSD-expressing E. coli decreased their serum estradiol levels, causing depression-like behaviors. The prevalence of K. aerogene and 3β-HSD was higher in premenopausal women with depression than in those without depression. These results suggest that the estradiol-degrading bacteria and 3β-HSD enzymes are potential intervention targets for depression treatment in premenopausal women.
研究领域:
微生物学
·
神经科学
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内分泌学
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产品关联
DOI
PubMed
高影响因子
STEROIDS
·
2022
·
IF 2.76
Yaqin Jia,Zhe Wang,Yuyi Feng,Meixian Wang,Lili Jiang,Zhijun Yu,Xiaoguang Shao,Guiyuan He,Yong Liu
Quantification of endogenous steroids and their precursors is essential for diagnosis of a wide range of causes for female infertility. However, immunoassays often overestimate concentrations due to assay interference by other endogenous steroids, especially at low concentrations. In addition, it still lacks of diagnostic reference intervals for five sex steroid hormones, including estradiol (E 2 ), 11-deoxycorticosterone (DOC), 17-hydroxyprogesterone (17-OHP 4 ), pregnenolone (P 5 ) and progesterone (P 4 ), which are crucial for distinguishing between normal individuals and female infertility. Therefore, we developed and validated a reliable and rapid ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous determination and quantification of five sex hormones, giving the reference intervals to accurately evaluate and diagnose female infertility. Our results showed that the developed UPLC-MS/MS assay was fast, high throughput, reproducible, specific, accurate, highly sensitive, and fully validated for simultaneous determination of P 5 , P 4 , 17-OHP 4 , DOC and E 2 in human follicular fluid. The simple sample preparation procedure in the current study gave reproducible and consistent recoveries. The validation results show that the UPLC-MS/MS assay has acceptable accuracy and precision at low concentrations, which permits their use in clinical study. In addition, our data gave the concentration range of five steroid hormones quantification in patients with female infertility and normal individuals. Our data can be used to accurately evaluate and diagnose female infertility.
研究领域:
生殖医学
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内分泌学
·
临床化学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-11
·
IF 5.3
Li Heming,Tu Yuxin,Xie Wen,Shi Xinye,Zhang Qiuting,Lin Juan,Zhong Yanhui,Lin Zian,Cai Zongwei
Solid-phase microextraction (SPME) coupled with electrospray ionization mass spectrometry (ESI-MS) was developed for rapid and sensitive determination of endogenous androgens. The SPME probe is coated with covalent organic frameworks (COFs) synthesized by reacting 1,3,5-tri(4-aminophenyl)benzene (TPB) with 2,5-dioctyloxybenzaldehyde (C8PDA). This COFs-SPME probe offers several advantages, including enhanced extraction efficiency and stability. The analytical method exhibited wide linearity (0.1–100.0 µg L −1 ), low limits of detection (0.03–0.07 µg L −1 ), high enrichment factors (37–154), and satisfactory relative standard deviations (RSDs) for both within one probe (4.0–14.8%) and between different probes (3.4–12.7%). These remarkable performance characteristics highlight the reliability and precision of the COFs-SPME-ESI-MS method. The developed method was successfully applied to detect five kinds of endogenous androgens in female serum samples, indicating that the developed analytical method has great potential for application in preliminary clinical diagnosis. Graphical abstract
研究领域:
分析化学
·
生物分析化学
·
质谱分析
·
生物医学分析
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产品关联
DOI
PubMed
高影响因子
Science of Advanced Materials
·
2022
·Vol. 14
·期 2
·263-271
·
IF 1.067
Fan Jing,Wu Dan,Zhao Depeng,Hu Rui,Fu Zhihong,Li Xuemei
In this study, a novel small molecule estradiol guanidine derivative (Guanidoestradiol, GDT) for female reproductive system targeting and nitric oxide (NO) release has been constructed by conjugating 17β-estradiol and L-arginine through an esterification reaction. After
intraperitoneal administration in female mice, the serum Griess assay and immunohistochemical analysis of ovary and uterus were performed. GDT effectively increased NO concentration in the blood and produced some bio-effects that are beneficial to the reproductive system. The specific advantages
are as follows: (1) the introduction of guanidine groups and amino groups improves the water solubility and bioavailability of estradiol and is expected to exert other biofunctions; (2) the estradiol residue of GDT gives the NO donor the ability for ovarian and uterine targeting; (3) combined
administration of estradiol and NO to the uterus and ovary promoted endometrial thickening and expression of vascular proliferation markers; (4) the abundance of iNOS in tissues was reduced after treatment with NO donors. We suggest that Guanidoestradiol is a promising small-molecule drug
to enhance normal endometrial and ovarian function and may play a role in promoting reproduction.
研究领域:
药理学
·
生殖生物学
·
内分泌学
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2023
·
IF 6.8
Jiani Sun,Lei Gan,Siji Lv,Tao Wang,Chaoqun Dai,Jing Sun
Endocrine-disrupting chemicals (EDCs) have been reported to affect populations by disrupting the human endocrine system. Di-(2-ethylhexyl) phthalate (DEHP) is an EDC that is present in various consumer products. Exposure to DEHP could contribute to reproductive system dysfunction, with subsequent adverse female reproductive outcomes. Granulosa cells (GCs) play essential roles in ovarian function and fertility. To further reveal the underlying mechanism by which DEHP impairs female fertility and affects the normal function of GCs, in vivo and in vitro experiments were performed. Transcript sequencing was used to identify genes that were differentially expressed in GCs after DEHP treatment. SLC39A5 was shown to be overexpressed in the DEHP group compared to the normal control group. DEHP treatment and overexpression of SLC39A5 activated NF-κB-related factors, followed by an increase in the transcript expression level of NLRP3. NLRP3 inflammasomes play crucial roles in pyroptosis by acting as sensors. Pyroptosis is a type of inflammation-related cell death associated with various diseases, including ovarian cancer and polycystic ovary syndrome. Activation of NF-κB contributed to the upregulation of pyroptosis in GCs, while pyroptosis factors were downregulated after the inhibition of NF-κB with JSH-23. The same phenomenon was also observed in a mouse model in which DEHP-treated mice had higher expression levels of NF-κB and pyroptosis markers in GCs. Moreover, this phenomenon could be partially reversed by the NF-κB inhibitor JSH-23. DEHP treatment also disrupted the normal expression of ovarian function-related genes and inhibited the proliferation of GCs. Reproductive system impairment was observed in mice exposed to DEHP. DEHP-treated mice had a lower body weight, smaller reproductive organs, fewer healthy follicles, and diminished ovarian reserve. Thus, DEHP contributes to ovarian dysfunction by inducing pyroptosis via the SLC39A5/NF-κB/NLRP3 axis in GCs.
研究领域:
毒理学
·
生殖生物学
·
分子生物学
·
内分泌学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Quan-Kuo He,Chang-Long Xu,Yan-Ping Li,Zhi-Ran Xu,Yu-Shen Luo,Si-Cheng Zhao,Hai-Long Wang,Zhong-Quan Qi,Yu Liu
Captan is a non-systematic fungicide widely used in agricultural production, and its residues have been found in the environment and daily diet. Previous studies confirmed that captan exerts several toxic effects on tissues, but its effect on the mammalian female reproductive system is unclear. In current study, we reported that captan affected mouse ovarian homeostasis and disrupted female hormone receptor expression, leading to impaired follicular development. Ovarian follicles from the captan exposure group showed an increased level of inflammation, endoplasmic reticulum stress and apoptosis. In addition, captan exposure disrupted oocyte development. Transcriptomic analysis indicated that captan changed multiple genes expression in oocytes, including autophagy and apoptosis. Further molecular testing showed that captan induced oxidative stress and mitochondrial dysfunction, as indicated by the increased level of reactive oxygen species , disrupted mitochondrial structure and distribution, and depolarized membrane potential. Furthermore, captan triggered DNA damage, autophagy and early apoptosis, as shown by the enhanced levels of γ-H2AX, LC3, and Annexin-V and increased expression of related genes. Taken together, these results indicated that captan exposure impairs ovarian homeostasis and subsequently affects oocyte development.
研究领域:
毒理学
·
生殖生物学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Dacheng Yang,Yanhong Ran,Xusheng Li,Xinwei Jiang,Jiali Chen,Jianxia Sun,Lingmin Tian,Katia Teerds,Weibin Bai
Cadmium (Cd) is an environmental pollutant and endocrine disrupter , abundantly present in water, food, and soil. Accumulation of Cd in the body can negatively affect female reproduction; especially the uterus is exceptionally sensitive to the toxic actions of Cd. The anthocyanin cyanidin-3- O -glucoside (C3G) is a naturally occurring phenolic compound in fruits and plants that can antagonize the toxic effects of Cd. This capacity makes C3G a possible candidate to prevent Cd-induced female infertility. The present study aimed to investigate: 1) whether C3G intake could prevent Cd-induced female reproductive toxicity, and 2) the underlying mechanisms responsible for this protective effect. The results of our study indicated that Cd exposure did not affect ovarian function, but induced hypertrophy of the uterine endometrium. Oral intake of C3G markedly reduced the effects of Cd exposure on the thickness of the uterine epithelium cells. Transcriptomic analysis of the endometrium revealed that C3G intake had anti-estrogenic effects, attenuating Cd-induced endometrial epithelial cell proliferation by inhibiting estrogen-responsive genes, enhancing epithelial progesterone receptor expression, and regulating Klf4 expression. The current findings implicate that C3G has the potential to be used as a dietary supplement based on its capacity to intervene in Cd-induced female reproductive toxicity.
研究领域:
毒理学
·
生殖生物学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）