Separation Science Plus
·
2024
·
IF 1.3
Boyu Chen,Shengkai Liu,Hongxin Zhi,Jin Huang,Han Song,Jiashen Fan,Yujie Fu,Zhiguo Liu
Green extraction of the active lignans from Schisandra chinensis has received considerable attention due to their promising applications in the biomedical field. In this study, microwave-assisted deep eutectic solvent method was used to simultaneously extract five lignans: Schizandrol A, Schizandrol B, Schisantherin A, Schisandrin A and Schizandrin B. The extraction parameters were optimized according to the calculated comprehensive score obtained from the analytic hierarchy process combined with the entropy weight method. The optimal extraction conditions were that the molar ratio of choline chloride and glycolic acid is 4:1, water content is 30% (V/V), solid–liquid ratio is 1:20 (W g :V mL ), extraction time is 20 min, and extraction temperature is 70°C, under which the extraction rate of the five lignans were 10.89, 8.616, 4.019, 4.893, and 5.318 mg/g. These results confirmed that our extraction method is efficient and feasible for green extraction of lignans from S. chinensis .
研究领域:
药学
·
分析化学
·
绿色化学
✓ 已验证
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2021
·
IF 4.076
Haoyu Peng,Ningning Tian,Changyou Yu,Ye Gao,Kangli Li,Hui Yan,Pengwei Zhao,Songgu Wu,Mingyang Chen,Junbo Gong
The experimental metastable zone widths of PE–DPE–H2O systems were measured by a polythermal method, and the nucleation behavior of pentaerythritol (PE) and the influence of dipentaerythritol (DPE) on the critical nucleus parameters were analyzed on the basis of modified Sangwal’s model and classical nucleation theory, respectively. The results reveal that the dissolved DPE molecules can significantly increase the nucleation solid–liquid interfacial energy γ from 3.93 to 5.51 mJ/m2, increasing the critical nucleus size rcrit and free energy ΔGcrit, and inhibit the nucleation process.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Haichao Cao,Yue Chen,Zhigang Qian,Tingjie Huang,Nan Zou,Daxia Zhang,Wei Mu,Beixing Li,Feng Liu
The foliar loss of pesticides causes serious utilization decline and environmental risk. On the basis of biomimetics, pesticide-loaded microcapsules (MCs) with spontaneous deformation on foliar micro/nanostructures, like the snail suction cup, are prepared by interfacial polymerization. By controlling the usage or types of small alcohols in the MC preparation system, the flexibility of MCs is tunable. Through the investigation of emulsions and MC structures, we discover that the migration and distribution of small alcohols driven by amphiphilicity affect the process of interfacial polymerization between polyethylene glycol and 4,4-methylenediphenyl diisocyanate. By hydrophobic modification of the polymer and competition for oil monomers of small alcohols, the thickness and compactness of shells are reduced, whereas the density of the core is increased. As a result of the regulation in structures, the flexibility of MCs is improved significantly. In particularly, the MCs-N-pentanol (0.1 mol kg–1) with the best flexibility show strong scouring resistance on varied foliar structures, sustained release property on the air/solid interface, and persistent control effect against foliar diseases. The pesticide-loaded soft MCs provide an effective way to improve pesticide foliar utilization.
研究领域:
农学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2016
·Vol. 92
·期 7
·1801-1808
·
IF 2.738
Qinli Liu,Ting Yan,Zhao Jiang,Tao Fang
BACKGROUND The biodiesel by-product, crude glycerol including lower alcohols, could be used as the feedstock for producing monoacyglycerols (MAGs), which are commonly used as non-ionic surfactants and emulsifiers. In this work, lower alcohols (methanol, ethanol and isopropanol) in sub- and supercritical states were used as the solvents for MAG production. RESULTS Isopropanol is the best solvent for obtaining high monooleate (MOG) yield compared with methanol and ethanol. Moreover, the sub- and super-critical isopropanol shows better performance than the normal NaOH catalyzed or non-solvent process. The reaction loading of a batch reactor has a complicated effect on the yield. The maximum MOG yield can always be obtained at 60% loading. The square root modified quadratic model was utilized to analyze the relationship and to optimize reaction temperature (220–260 °C), reaction time (30–150 min), and isopropanol (0–4 mL). In the optimum condition (260 °C, 150 min, 4 mL of isopropanol), a high MOG yield of 67.8% can be obtained, well in agreement with the predicted value. CONCLUSION Isopropanol at sub- and super-critical state greatly improved the mass transfer between the immiscible reactants (triglyceride and glycerol). Compared with some methods with chemical catalyst, the method without any catalyst obtained higher MOG yield. © 2016 Society of Chemical Industry
研究领域:
生物化学
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
Journal of Energy Storage
·
2024
·
IF 8.9
Xuanxuan Wang,Yuting Wu,Chuan Li,Yuanwei Lu,Cancan Zhang,Ming Hong
As one of classic organic compounds, pentaerythritol (PE) has been reported to have two phase-change processes with one solid-solid transition and other solid-liquid transition. To utilize these two phase-change enthalpies and avoid the liquid leakage over heat storage process, this work for the first time proposes to encapsulate PE with use of silicon dioxide (SiO 2 ) as a shell substance through a so-called so-gel technology. The microstructure characterization and thermoproperties as well as the cycling performance of the PE- SiO 2 composite are detailedly investigated. The results showed that PE could be successfully covered by SiO 2 to form a spherical core-shell structure. Such an encapsulation has a mean size of 0.3 μm and an encapsulated rate of over 77.8 %. Due to the involvement of two phase-transition stages, the latent heat of the PE- SiO 2 composite reached to 255 kJ/kg, which is higher than other organic microencapsulations. In addition, the thermal conductivity is largely enhanced by adjusting the ratio of SiO 2 . For a given SiO 2 ratio of 77.8 %, the thermal conductivity of PE-SiO 2 composite is 0.93 W/m·K, 36.8 % higher than that of pristine PE. Apart from these, the results also indicated that the composite achieves excellent thermal cycling performance. After one hundred repeated heating-cooling cycles, the latent heat of the PE- SiO 2 composite decreases by less than 5 %, demonstrating that this composite material has a large potential for application in the field of thermal energy storage at low and medium temperatures.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
ENERGY
·
2023
·
IF 9
Chu Huang,Haixi Zhu,Yinjie Ma,Jiaqiang E
Immersion cooling is an effective way to control the thermal load of high-power-density energy storage devices. Developing high-efficiency coolants is the core problem and research hotspot to improve immersion cooling performance. In this study, a novel ester coolant, pentaerythritol esters, for battery immersion cooling systems (BICS) was proposed by experiment, and its thermal properties were comparatively studied with other coolants. The effect of coolant flow rate and discharge rate on the thermal performance of BICS was studied. An increase in the discharge rate results in an increase in the maximum battery pack temperature and temperature non-uniformity. However, at a 3-C discharge rate, pentaerythritol esters with a flow rate of 0.015 kg/s can keep the temperature difference of the battery pack below 0.7 K. When the flow rate increases from 0.003 kg/s to 0.045 kg/s, the temperature rise of the battery pack can be reduced by 61%. For all coolants, when the flow rate increases from 0.025 kg/s to 0.045 kg/s, the power consumption increases by 2.3 times. Compared with mineral oil, at a flow rate of 0.045 kg/s, pentaerythritol esters can reduce power consumption by 55.4%. Combined with its renewable, biodegradable features, the novel pentaerythritol ester is a perfect option for the battery immersion coolant.
研究领域:
能源工程
·
材料科学
·
热力学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Zixin Qi,Zhaofeng Zhang,Tianyu Ren,Nan Jiang,Mengfan Wang,Shengping You,Wei Qi,Rongxin Su
Because of the high complexity of the product and the similar physicochemical properties between G and S counterparts, the separation of aromatic monomers is one of the greatest challenges in the lignin chemical valorization, which limits its further utilization and conversion. In this study, the preparation method of the dihydroconiferyl alcohol & dihydrosinapyl alcohol-enriched oil and high purity dihydrosinapyl alcohol from reductive catalytic fractionation products catalyzed by Pd/C was first reported. Moreover, a purification process with alkali extraction - organic solvent extraction - dichloromethane reverse extraction - crystallization in the KOH ethanol solution as the main unit operation was designed. As a result, a monomer-enriched oil in which dihydroconiferyl alcohol (G-3OH) and dihydrosinapyl alcohol (S-3OH) could totally account for more than 83% was obtained, and S-3OH with a purity of 90.2% was separated by crystallization. In addition, this purification process was scaled up to 10 times. The monomer-enriched oil with a G-3OH and S-3OH content of 87.2% was obtained. The recoveries of G-3OH and S-3OH were 81.0% and 91.5%, respectively. The purity of S-3OH was 89.4%, and the recovery was 51.6%. The integrated process realizes the effective separation of the reductive depolymerization products of lignin, which can provide technical support for its industrial production.
研究领域:
生物质化学
·
林产化工
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 2
·194
·
IF 3.164
Feng Ye,Qiufeng Ye,Haihua Zhan,Yeqian Ge,Xiaotao Ma,Yingying Xu,Xu Wang
Zinc orotate (ZnOr2), which is a new kind of poly(vinyl chloride) (PVC) stabilizer, is prepared in this work through the precipitation method, and its impact on the thermal stability of PVC is measured by thermogravimetric analysis (TG), Congo red test, and discoloration test. The results exhibit that the thermal stability of PVC is positively enhanced after the addition of ZnOr2. In contrast with a commercial thermal stabilizer, zinc stearate (ZnSt2), a noteworthy improvement was observed that ZnOr2could postpone the “zinc burning” of PVC. This is principally ascribed to the Or anion in the structure of ZnOr2being able to absorb the HCl released by PVC, and to supersede unstable chlorine atoms in the structure of PVC. In addition, blending ZnOr2with calcium stearate (CaSt2) in diverse mass ratios can significantly accelerate the thermal stability of PVC. Optimum performance was achieved with a CaSt2:ZnOr2ratio of 1.8:1.2. Moreover, an outstanding synergistic effect can be observed when CaSt2/ZnOr2is coupled with other commercial auxiliary stabilizers. The initial color and long-term stability of PVC including CaSt2/ZnOr2is significantly increased when pentaerythritol (PER) is added, while dibenzoylmethane (DBM) can only improve its long-term thermal stability.Keywords:poly(vinyl chloride);zinc orotate;dibenzoylmethane;thermal stabilizer;pentaerythritol;synergistic effect
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 22
·e202401172
·
IF 1.9
Miao Mi,Jie Xiong,Suhong Zhang,Yidong Zhang,Xin Chen,Rong Shao,Wei Xu,Jianfei Ding
Graphical Compared to SnCl 2 and HZSM-5, SnCl 2 @HZSM-5 was a mesoporous composite, which had the most amount of total and weak acidity, and the weakest acid strength. More total acid content is beneficial to increase pentaerythritol conversion, and the weak acid can improve the selectivity of PETS, and weak acid strength is beneficial to inhibit the formation of carbon deposits. Therefore, SnCl 2 @HZSM-5 showed the highest pentaerythritol conversion, PETS selectivity and catalytic stability. The mesoporous HZSM-5 and SnCl 2 @HZSM-5 mesoporous composite were prepared by two-step crystallization and wet impregnation method, respectively. The catalytic esterification performances of SnCl 2 , HZSM-5 and SnCl 2 @HZSM-5 were compared. SnCl 2 @HZSM-5 had the most amount of total and weak acidity, and the weakest acid strength. More total acid content was beneficial to increase pentaerythritol conversion, and the weak acid could improve the selectivity of PETS, and weak acid strength was beneficial to inhibit the formation of carbon deposits. Brönsted and Lewis acid sites were present simultaneously on the SnCl 2 @HZSM-5 catalyst. Moreover, some extra Brönsted acid sites were created on the SnCl 2 @HZSM-5 catalyst, because the interaction of SnCl 2 with HZSM-5 may result in the exchange of Sn 2+ with protons. Both acid sites could catalyze the esterification reaction, and the Brönsted acid site was more beneficial to increasing PETS selectivity. Therefore, SnCl 2 @HZSM-5 showed the highest pentaerythritol conversion, PETS selectivity and catalytic stability. The generation of coke and the leaching of Sn were the main cause of catalyst deactivation. Under the optimized process conditions: 105 °C, 4.7 molar ratio of stearic acid and pentaerythritol, 1.2 wt % catalyst amount and 2.5 wt % SnCl 2 loading, after 3 h reaction time, the pentaerythritol conversion, PETS selectivity and yield was 99.3 %, 97.2 % and 96.5 %, respectively.
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
·
2017
·Vol. 174
·期 8
·672-688
·
IF 5.491
Hang Zeng,Yiming Jiang,Pan Chen,Xiaomei Fan,Dongshun Li,Aiming Liu,Xiaochao Ma,Wen Xie,Peiqing Liu,Frank J Gonzalez,Min Huang,Huichang Bi
Background and Purpose Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here we have evaluated the anti-cholestasis effects of Schisandrol B (SolB), a bioactive compound isolated from Schisandra sphenanthera . Experimental Approach Hepatoprotective effect of SolB against intrahepatic cholestasis, induced by lithocholic acid (LCA), was evaluated in mice. Metabolomic analysis and gene analysis were used to assess involvement of pregnane X receptor (PXR). Molecular docking, cell-based reporter gene analysis and knockout mice were used to demonstrate the critical role of the PXR pathway in the anti-cholestasis effects of SolB. Key Results SolB protected against LCA-induced intrahepatic cholestasis. Furthermore, therapeutic treatment with SolB decreased mortality in cholestatic mice. Metabolomics and gene analysis showed that SolB accelerated metabolism of bile acids, promoted bile acid efflux into the intestine, and induced hepatic expression of the PXR-target genes Cyp3a11, Ugt1a1 , and Oatp2, which are involved in bile acid homeostasis. Mechanistic studies showed that SolB activated human PXR and up-regulated PXR target genes in human cell lines. Additionally, SolB did not protect Pxr -null mice from liver injury induced by intrahepatic cholestasis, thus providing genetic evidence that the effect of SolB was PXR-dependent. Conclusion and Implications These findings provide direct evidence for the hepatoprotective effects of SolB against cholestasis by activating PXR. Therefore, SolB may provide a new and effective approach to the prevention and treatment of cholestatic liver diseases.
研究领域:
肝病学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
FITOTERAPIA
·
2012
·
IF 1.848
Cong Liu,Yun-Feng Cao,Zhong-Ze Fang,Yan-Yan Zhang,Cui-Min Hu,Xiao-Yu Sun,Ting Huang,Jia Zeng,Xu-Ran Fan,Mo Hong
Deoxyschizandrin and schisantherin A are major bioactive lignans isolated from Fructus schisandrae which has been widely used as a tonic in traditional Chinese medicine for many years. Inhibition of UDP-glucuronosyltransferases (UGTs) by herbal components might be an important reason for clinical herb–drug interaction. The aim of the present study is to investigate the inhibitory effect of deoxyschizandrin and schisantherin A on major UGT isoforms. Recombinant UGT isoforms were used as enzyme source, and a nonspecific substrate 4-methylumbelliferone (4-MU) was utilized as substrate. The results showed that 100 μM of deoxyschizandrin and schisantherin A exhibited strong inhibition on UGT1A3, and negligible inhibition on other tested UGT isoforms. Furthermore, deoxyschizandrin and schisantherin A were demonstrated to inhibit UGT1A3 in a concentration-dependent manner, with IC 50 value of 10.8 ± 0.4 μM and 12.5 ± 0.5 μM, respectively. Dixon and Lineweaver–Burk plots showed that inhibition of UGT1A3 by deoxyschizandrin was best fit to competitive inhibition type, and inhibition kinetic parameter (K i ) was calculated to be 0.48 μM. Inhibition of UGT1A3 by schisantherin A gave the best fit for types of noncompetitive inhibition, and the results showed K i to be 11.3 μM. All these experimental data suggested that herb–drug interaction might occur when deoxyschizandrin or schisantherin A containing herbs were co-administered with drugs which mainly undergo UGT1A3-mediated metabolism. However, given that many in vivo factors could influence the in vitro – in vivo extrapolation (IVIVE), these in vitro inhibitory parameters should be considered with caution.
研究领域:
中药学
·
生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2020
·Vol. 10
·期 1
·1-7
·
IF 3.998
Wang Xueni,Liao Xiuling,Zhang Yimin,Wei Linyao,Pang Yuzhou
Schisandrin B (SchB) is the highest content of biphenyl cyclooctene lignans in Schisandra chinensis . It has been reported to have a variety of pharmacological effects, including anti-inflammatory, anti-oxidant, anti-cancer, heart protection, liver protection. In this study, we found that SchB can promote the proliferation of MC3T3-E1 subclone 14 cells. Meanwhile, we found that SchB can regulate the BMP2-SMADs signaling pathway by increasing gene and protein expression of those relative biomolecules. Furthermore, SchB can raise the RUNX2 and SP7 expression in both mRNA and protein levels. Since the role of BMP2-SMADs-RUNX2-SP7 signaling axis in osteoblast proliferation and differentiation has been well documented. The present experimental findings indicate that SchB could promote the proliferation and differentiation of osteoblasts through BMP2-SMADs-RUNX2-SP7 signaling axis.
研究领域:
药理学
·
细胞生物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）