FOOD HYDROCOLLOIDS
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2024
·
IF 11
Fang Xie,Mingzhu Liu,Xiaofang Feng,Zhijun He,Qianqian Chen,Jiaojiao Zhou,Jie Cai
The development of biomass hydrogel coatings is significant for fruit preservation. This paper presents the facile development of a multifunctional polysaccharide-based hydrogel produced from quaternized chitin (QC) and tannic acid (TA) by in situ rapid cross-linking with high-density hydrogen bonding using the sample mixing method. The Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) spectra, and thermogravimetric analysis (TGA) proved that QC-TA hydrogel was formed by physical interactions (hydrogen bonding, electrostatic interaction, etc.). Moreover, the cross-linking density of the QC-TA hydrogels was analyzed by rheological property measurements and scanning electron microscope (SEM) morphology observations. This polysaccharide-based hydrogel, QC-TA, was evaluated as an edible coating for perishable food items, demonstrating significant improvements in physic-chemical properties, oxidation resistance, and antimicrobial activity against key pathogens ( E. coli , S. aureus , and C. albicans ). Notably, the hydrogel formed a protective film that effectively shields fruits from mechanical damage, maintaining freshness and extending shelf life, and also featuring with easy cleaning. Applied to cherry tomatoes, the QC-TA coating ensured a smooth, uniform surface, reducing dehydration and flavor loss while inhibiting microbial growth. These findings underscore the potential of employing polyphenol induced polysaccharide forming green hydrogel coatings as an economical, efficient strategy for enhancing the quality and safety of perishable foods, representing an advancement in the field of sustainable food packaging.
研究领域:
食品科学
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生物材料学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Tenghe Zhang,Yingying Guo,Yu Chen,Xu Peng,Sara Toufouki,Shun Yao
A quaternized chitosan (QCS)@poly(ionic liquid) (PIL) hydrogel adhesive was prepared by in-situ ultraviolet (UV)-induced copolymerization of 1-vinyl-3-butyl imidazolium bromide ([BVIm][Br]) and methacryloyloxyethyl trimethylammonium chloride (DMC) in QCS aqueous solution without using any crosslinkers, which was stably crosslinked by reversible hydrogen bonding together with ion association and exhibited excellent adhesion, plasticity, conductivity and recyclability properties. Moreover, its thermal/pH-responsive behaviors and intermolecular interaction mechanism of thermal-triggered reversible adhesion were discovered, meanwhile good biocompatibility, antibacterial properties, repeated stickiness and degradability were also proved. The results showed that the newly developed hydrogel could make various tissues, organic, inorganic or metal materials adhered tightly within 1 min; after 10 binding-peeling cycles, the adhesive strength to glass, plastic, aluminum and porcine skin still remained beyond 96 %, 98 %, 92 % and 71 % of the original, respectively. The adhesion mechanism involves ion dipole interaction, electrostatic interaction, hydrophobic interaction, coordination, cation-π interaction, H-bonding and van der Waals force. For above merits, the new tricomponent hydrogel is expected to be applied in biomedical field to achieve adjustable adhesion and on-demand peeling.
研究领域:
材料科学
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生物医学工程
·
化学工程
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产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2020
·
IF 7.053
Xiangwei Zhu,Jianjun Chen,Yuxi Hu,Ni Zhang,Yuqing Fu,Xiaoqiang Chen
Carboxymethyl cellulose (CMC) is an economical and easily available cellulose derivative that ionizes in water and is used in several charge-related interfacial applications. However, compared with other chemically functionalized cellulose derivatives, such as cellulose nanocrystals, the development of CMC-based (CMC as the major ingredient) O/W emulsions remains unexplored. In this study, we synthesized a CMC and quaternized chitosan (QCS) complex for the preparation of Pickering emulsions . Partially protonated CMC was complexed with QCS, followed by neutralization at pH 7 to obtain the CMC/QCS (CQ) particles. The prepared CQ-stabilized emulsion showed a gel-like rheological behavior and exhibited emulsion stability against several environmental stresses, including pH, salt, temperature, and long-term storage. The curcumin was then encapsulated in the CQ-stabilized emulsion and displayed a reduced degradation rate. This study provides a new route for the development of a Pickering emulsion delivery system with improved stability, sustainability and reduced complexity.
研究领域:
食品科学
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材料科学
·
药物递送
✓ 已验证
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 23
·5770
·
IF 4.2
Lili Fu,Kun Liu,Jinyu Yang,Yuan Zhao,Zhijun Wang,Dongxu Tang,Yuesheng Li,Huangqin Chen
In this study, a polyvinyl alcohol/polyethylene glycol/hydroxypropyltrimethyl ammonium chloride chitosan (PVA/PEG/HACC) ternary composite hydrogel was synthesized using electron-beam radiation. The materials were thoroughly characterized via Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, Brunauer–Emmett–Teller analysis, gelation fraction tests, and swelling rate tests. Systematic adsorption experiments revealed that the rate of adsorption of calf thymus DNA (ctDNA) by the PVA/PEG/HACC hydrogel reached 89%. The adsorption process followed the Langmuir isotherm and pseudo-second-order kinetic model. This process was mainly characterized by monolayer chemical adsorption, with intraparticle diffusion playing a crucial role. In addition, the process was spontaneous, with higher temperatures enhancing adsorption. The possible adsorption mechanisms included electrostatic interactions, hydrogen bonding, and van der Waals forces. The maximum ctDNA desorption rate was 81.67%. The adsorption rate remained at 71.39% after five adsorption–desorption cycles. The bioactivity of the PVA/PEG/HACC hydrogel was validated by antibacterial, cytotoxicity, and apoptosis tests. The results of this study demonstrated the crucial application potential of adsorbent materials in DNA adsorption and biomedical applications.
研究领域:
材料科学
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生物医学工程
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分子生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 21
·15021-15030
·
IF 3.9
Jingxuan Liu,Hongyu Zhao,Mengyue Wang,Wenzheng Ban,Xi Lu,Bin Yan
In this work, gallic acid was successfully grafted onto quaternary aminated chitosan to prepare a high efficiency cationic flocculant. The mechanism of flocculation and different influencing factors were studied in detail. The prepared flocculant only needs 60 mg L−1 to achieve a 98.7% and 94.5% removal rate on methyl blue (MB) and Congo red (CR), respectively. The high removal rate (93.2%) of a CR-MB mixed dye also confirms the universality of flocculation. In addition, kaolin as a simulated suspended solid was removed at a rate of 97% in the experiment at a dosage of 3 mg L−1. A zeta potential test showed that it worked best when the potential of the flocculation system was zero; this was because an electrostatic balance was reached between the flocculant and pollutant. Importantly, the three-functional molecules can provide more possibilities to form hydrogen bonds with water molecules, which is conducive to the stretching of flocculant molecular chains in salt water. The flocculant maintained a high stability in four different salt environments and has a positive industrial application significance. Furthermore, the flocculation experiment of the actual wastewater of the printing and dyeing plant found that the dye wastewater changed obviously from turbidity to clarification, which proved the practical application potential of the flocculant. This work provides a feasible idea for the preparation of bio-based flocculants.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Yinfeng Tan,Hao Wu,Tianzhi Xie,Lingling Chen,Shuqian Hu,Huafeng Tian,Yutang Wang,Jianguo Wang
Some thermoduric food spoilage bacteria pose great threat to beverage industry . To tackle the challenge, hydroxypropyl trimethyl ammonium chloride chitosan (HTCC) grafted magnetic cellulose beads have been prepared via a dropping technology. Sodium periodate oxidation process was carried out to form dialdehyde functional groups on the regenerated cellulose beads mixed with maghemite nanoparticles . HTCC was anchored on the beads through Schiff base reaction. The structure and properties of HTCC anchored beads were evaluated by Fourier transform infrared (FTIR) spectra, field emission scanning electron microscope (FESEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). Thermal stability of the beads was estimated by thermogravimetric analysis (TGA) and differential thermal gravity (DTG), and the decomposition temperature of the beads were around 200–300 °C. A long-term antibacterial activities of the beads against Alicyclobacillus acidoterrestris were confirmed caused by the covalent bond between HTCC and the beads. The biodegradable HTCC grafted cellulose beads may provide a novel approach for food safety management .
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
·
IF 9.9
Liang Zhang,Zhen Ma,Haidong Sun,Rongzi Zhang,Zilong Zhao,Jie Wang,Zhonglin Zhang,Zhong Liu,Jun Li,Xiao Du,Xiaogang Hao
Based on the superior selectivity of bismuth oxybromide (BiOBr) for Br - , the excellent electrical conductivity of carbon nanotubes (CNTs), and the ion exchange capacity of quaternized chitosan (QCS), a three-dimensional network composite membrane electrode CNTs/QCS/BiOBr was constructed, in which BiOBr served as the storage space for Br - , CNTs provided the electron transfer pathway, and QCS cross-linked by glutaraldehyde (GA) was used for ion transfer. The CNTs/QCS/BiOBr composite membrane exhibits superior conductivity after the introduction of the polymer electrolyte, which is seven orders of magnitude higher than that of conventional ion-exchange membranes. Furthermore, the addition of the electroactive material BiOBr improved the adsorption capacity for Br - by a factor of 2.7 in electrochemically switched ion exchange (ESIX) system. Meanwhile, the CNTs/QCS/BiOBr composite membrane displays excellent Br - selectivity in mixed solutions of Br - , Cl - , SO 4 2- and NO 3 – . Therein, the covalent bond cross-linking within the CNTs/QCS/BiOBr composite membrane endows it great electrochemical stability. The synergistic adsorption mechanism of the CNTs/QCS/BiOBr composite membrane provides a new direction for achieving more efficient ion separation.
研究领域:
材料科学
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环境工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xiaohui Wei,Junjie Cai,Chunlai Wang,Kun Yang,Sheng Ding,Feng Tian,Song Lin
It is essential to enhance our antibacterial arsenal in the first-aid hemostatic treatment due to the healing delay and even death from the bacteria-contaminated wounds. Herein, serial quaternized chitosan with varying degrees of substitution (QCS X ) was prepared by glycidyl trimethyl ammonium chloride modification. Then the obtained QCS X was conjugated with dialdehyde cellulose (DAC) through Schiff base reaction to obtain the corresponding composite sponges (2QCS X -DAC). The surface morphology, chemical structures, and physical characters of mechanical measurement, water uptake behavior, porosity, and degradation tests were determined. Furthermore, in vitro and in vivo biological assays were performed. The obtained 2QCS X -DAC sponges exhibit abundant porous structures, moderate mechanical properties, excellent water uptake performance, and effective bactericidal rates against Staphylococcus aureus and Escherichia coli . Moreover, these porous composite sponges have superior blood coagulation abilities with the blood coagulation time reduced by 76.6% and 59.8% compared with blank control and Celox™ as well as low hemolysis rates (<5%). Meanwhile, 2QCS 3 -DAC had benign cytotoxicity of L929 cells in vitro and could accelerate the infected wound healing of rats at the early stage in vivo . Overall, this composite sponge appears to be a viable wound dressing for daily wound care in civilian hospitals and emergency hemostasis on battlefields.
研究领域:
生物医学工程
·
材料科学
·
药学
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DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2020
·Vol. 78
·期 7
·3785-3801
·
IF 2.014
Ma Yu,Wang Lulu,Feng Ruijiang,Wang Jilin,Cai Tianzhou
In this study, we prepared a novel composite membrane (QCS-IRMOF-3) by attaching IRMOF-3 (metal–organic framework materials, formed by coordination of metallic zinc and 2-aminoterephthalic acid) with a free amino group to a quaternized chitosan (QCS) by chemical cross-linking. The successful synthesis of IRMOF-3 was verified by SEM, XRD, and FT-IR. Then, the mechanical properties, swelling properties, ion exchange capacity, hydroxide conductivity and chemical stability of the composite membrane (QCS-IRMOF-3) were also investigated. It was found that the performance of the aforementioned composite membrane was affected obviously by the amount of IRMOF-3 crystals. The composite membrane doped with 15 wt% IRMOF-3 crystals exhibits better overall performance, which included that the tensile strength is 22.4 MPa, water uptake is 78.4%, hydroxide conductivity is 29.9 mS cm −1 at 80 °C, and after immersion in 6.0 mol L −1 KOH solutions at 60 °C for about 240 h, only the conductivity decreased by less than 10%. This result implies that the composite membrane synthesized in this research is promising for application in alkaline polymer electrolyte fuel cells.
研究领域:
材料科学
·
燃料电池技术
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Haihua Luo,Huan Xu,Hongli Zhang,Xiangming Li,Qiong Wu,Tian Gao
Drug-resistant bacterial infections represent a critical global public health challenge, driven largely by the misuse and overuse of antibiotics. Tackling the growing threat of bacterial resistance necessitates the development of innovative antibacterial agents that function independently of traditional antibiotics. In this study, novel antibacterial nano-micelles were rationally designed by conjugating quaternized chitosan with the photosensitizer chlorin e6. These nano-micelles promoted the solubility and stability of chlorin e6 while maintaining robust singlet oxygen generation under 660 nm laser irradiation. The positively charged nano-micelles facilitated strong electrostatic interactions with bacterial surfaces, promoting efficient adhesion and enabling effective photodynamic antibacterial activity mediated by singlet oxygen. In vitro experiments revealed that the nano-micelles exhibited instant and prolonged antibacterial effects, effectively suppressing bacterial proliferation without inducing resistance and disrupting mature biofilms. Furthermore, in conjunction with laser treatment, nano-micelles exhibited remarkable in vivo antibacterial efficacy, significantly accelerating the healing of skin wounds infected with Methicillin-resistant Staphylococcus aureus while maintaining favorable biocompatibility. These findings highlight the potential of the nano-micelles as a promising non-antibiotic antibacterial formulation, offering a powerful strategy to combat drug-resistant bacterial infections and paving the way for their clinical application in infection management.
研究领域:
微生物学
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药理学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Susu Zhang,Congcong Huang,Zengyu Sun,Penghua Jiao,Baoqi Ding,Luyao Ding,Qianfen Qi,Yanzhe Gou,Renlong Zhang,Yanhao He,Wenjun Li,Chunguang Ren,Linlin Wang
Hydrogels with antioxidant and antibacterial activities have received increasing attention in wound healing due to excessive reactive oxygen species (ROS) and bacterial infection are common issues associated with wounds. Herein, we constructed a series of hydrogels with C-phycocyanin (C-PC), quaternized chitosan (QCS) and silk fibroin protein (SF) as matrixes, which with tetrakis hydroxymethyl phosphonium sulfate (THPS) as crosslinking agent to form dynamic covalent bonds with C-PC and SF. The hydrogel exhibited excellent stretchability and compressibility, which with adhesion strength reached 15 ± 3 kPa and rapid self-healing properties. The hydrogel possessed strong antioxidant activity with assessments of DPPH radical-scavenging capacity and total reducing power. In addition, the hydrogel possessed obvious coagulation function and good blood compatibility, which also showed strong antibacterial activity against E. coli and S. aureus . To improve the therapeutic effect, polydeoxyribonucleotide (PDRN) with the ability of promote wound healing was introduced into the hydrogel. The results showed that the hydrogel loading with PDRN possessed high biocompatibility and can promote cell migration. More importantly, the hydrogel loaded with PDRN can effectively promote wound healing by exerting anti-inflammatory and antioxidant effects, which may offer promising potential application value in the field of wound dressing and tissue repair.
研究领域:
生物材料学
·
医学
·
药学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Huiyuan Zheng,Xiaofeng Zhang,Weijiang Wang,Huan Xin,Bin Yu,Lichen Wang,Huiqian Xie,Yage Zhang,Yang Song,Qingming Ma
Complex wound closure scenarios necessitate the development of advanced wound dressings that can effectively address the challenges of filling irregularly shaped wounds and managing fatigue failures encountered in daily patient activities. To tackle these issues, we develop a multifunctional hydrogel from natural polysaccharides and polypeptides with injectability and self-healing properties for promoting full-time and multipurpose wound healing. Synthesized through dynamic Schiff base linkages between oxidized hyaluronic acid (OHA), ε -polylysine ( ε -PL), and quaternized chitosan (QCS), the OHA/ ε -PL/QCS hydrogel can gel rapidly within 50 s. It exhibits notable strong shear-thinning and self-healing behavior, allowing easy injection to fit various wound shapes while maintaining integrity. In rat models of liver and femoral artery injuries, the hydrogel shows significantly reduced bleeding and accelerated hemostasis. The hydrogel can enhance cell proliferation through cell migration and tube formation, stimulate angiogenesis, support collagen deposition, and reduce inflammation. Its superior biocompatibility also supports the safe encapsulation of epidermal growth factor (EGF). In infected full-thickness skin wound models, the OHA/ ε -PL/QCS/EGF hydrogel achieves nearly complete wound closure within 10 days. Overall, this study highlights the outstanding therapeutic potentials of the injectable and self-healing OHA/ ε -PL/QCS hydrogel as a promising solution for fulfilling the multi-purpose, sophisticated needs in complicated wound closure scenarios.
研究领域:
生物材料学
·
医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）