COLLOIDS AND SURFACES B-BIOINTERFACES
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2023
·
IF 5.8
Zhongfei Gao,Qinbing Qi,Rongkai Li,Chengbo Li,Xianrui Xie,Guige Hou
Uncontrolled bleeding and bacterial infections cause severe damage to the wounds and remain a clinical challenge. Here, we developed a nanofiber/sponge bilayered composite membrane (QCP) containing quaternized silicone (QP12) and quaternized chitosan (QCS12) by joint approaches of electrospinning and freeze-drying and investigated their potential for wound dressing. The QCP was composed of a sponge (QCC) containing collagen (COL) and QCS12 and a nanofibrous membrane (MQP) containing poly-ε-caprolactone (PCL) and QP12. The QCP composite membrane possessed feasible permeability (0.22 ± 0.01 g/(cm 2 ·24 h)), available thermal stability , suitable mechanical properties with natural skin, and in vivo hemostatic efficiency. The bonds of the N -quaternary and Schiff base endow composite membranes with significant anti-microbial invasion, potentially enhancing the wound healing process with an eligible microenvironment. Meanwhile, QCP evinced fine hemocompatibility, low cytotoxicity, negligible skin irritation, and other desirable biosafety as an excellent wound dressing. QCP promoted collagen deposition and re-epithelization to accelerate healing and suppress scars in the full-thickness acute wound models. Furthermore, the evaluation in the chronic skin incision model of diabetes mellitus manifested high healing efficiency with a certain resistance to bacterial infection of the composite membrane. Taken together, the QCP composite membrane may be a potential antibacterial and hemostatic wound dressing.
研究领域:
生物医学工程
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材料科学
·
创伤修复
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2019
·
IF 3.073
Meng Li,Mengjie Sun,Wenya Liu,Xu Zhang,Cuiming Wu,Yonghui Wu
Composite anion exchanges membranes are prepared by incorporating quaternized graphene oxide (QGO) within poly(vinyl alcohol) (PVA) or the mixture of PVA and quaternized polyethyleneimine (QPEI), followed by cross-linking with formaldehyde. The PVA-QGO series of membranes have low ion exchange capacities (IECs) of 0.10–0.37 mmol/g and low water uptakes ( W R ) of 16.1%–22.0%, leading to high area resistances (>60 Ω cm 2 ). The PVA-QPEI-QGO series of membranes show much lower area resistances of 2.47–6.04 Ω cm 2 , which is ascribed to the improved IECs (0.86–1.37 mmol/g) and W R (46.8%–71.4%). Both series of membranes show higher alkali resistance than commercial membrane AMV. Their weight losses are in the range of 0.5%–8.9% after immersion in 60 °C 2 mol/L NaOH alkaline solution for 32 days, while the value of AMV membrane is 19.2%. When utilized for electrodialysis (ED) application to recover NaOH from NaOH/Na 2 WO 4 mixture, the prepared membranes exhibit high selectivity, as evidenced by the low leakage ratio of Na 2 WO 4 . The leakage ratio of the optimized composite membrane to WO 4 2− is only 5.1%, while the leakage ratio of AMV membrane is up to 61.4%. To explore this reason, the composite membranes are selected for the ED separation of monovalent ions. The separation efficiency ( S ) of the optimized membrane is 83.9%, which is similar to the value of commercial anion selective membrane NEOSEPTA® ACS (88.7%), confirming further the selectivity of the composite membranes.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2022
·Vol. 307
·期 3
·2100787
·
IF 4.402
Dawei Dong,Minghua Zhang,Yafei Xiao,Zhaojie Yang,Ke Wang,Minmin Fan
Anion exchange membrane (AEM) is essential for the development of alkaline anion exchange membrane fuel cells, and its performance largely depends on its internal microstructure. Herein, to improve the performance of AEM, quaternized branched polyethyleneimine modified nitrogen-doped graphene quantum dots (QBPEI@N-GQDs) are introduced to quaternized polysulfone (QPSU) polymer matrix to prepare a series of QPSU/QBPEI@N-GQDs (QQ-n-N-GQDs) composite AEMs. Due to the uniform distribution of hydrophilic QBPEI@N-GQDs, an obvious hydrophilic/hydrophobic microphase separation structure is formed inside the QQ-n-N-GQDs composite AEMs. Compared with the pristine QPSU AEM, the QQ-0.7%-N-GQDs AEM shows slightly higher water uptake (WU) and swelling ratio (SR), as well as much higher ionic conductivity (76.18 mS cm −1 at 80 °C for QQ-0.7%-N-GQDs AEM versus 46.14 mS cm −1 at 80 °C for pristine QPSU AEM) and better maximum power density of single fuel cell (85.2 mW cm −2 for QQ-0.7%-N-GQDs AEM versus 46.3 mW cm −2 for QPSU AEM). Moreover, the chemical stability of QQ-n-N-GQDs composite AEMs has not been significantly adversely affected by the introduction of QBPEI@N-GQDs.
研究领域:
材料科学
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能源科学
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DOI
高影响因子
Micro & Nano Letters
·
2018
·Vol. 13
·期 7
·1011-1016
·
IF 0.841
Bin Zhang,Yujie Jiang
This work reports a novel environmentally friendly antibacterial and hydrophobic polyester [polyethylene terephthalate (PET)] fibre finished with ZnO containing quaternary ammonium compounds (QACsZnO). The results show that the QACsZnO can be coated onto the PET fibre surface, imparting perdurable antibacterial activity. It was found that the hydrophobicity and mechanical properties were improved greatly after the PET fibre was finished with QACsZnO. Additionally, the QACsZnO-finished PET fibre exhibited good antibacterial activities against Staphylococcus aureus , Escherichia coli and Bacillus subtilis . Moreover, QACsZnO-finished PET fibre was still capable of restoring its hydrophobicity, and it did not induce damage after dry-cleaning. These remarkable features of QACsZnO-finished PET fibre that were suitable for development of multi-function and textile applications on the market had increased dramatically.
研究领域:
材料科学
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纺织工程
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微生物学
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Shuangshuang Wang,Jixuan Song,Yuchao Li,Xingchuan Zhao,Lin Chen,Guang Li,Liping Wang,Zhengfeng Jia,Xiangcai Ge
An environmentally benign and convenient approach to impart titanium (Ti) surfaces with antibacterial functionalities was described in this work. Polydopamine (PDA) was first deposited onto an alkali activated Ti substrates. Then 2-bromoisobutyryl bromide (BIBB) was immobilized on the surface of PDA coated Ti. Finally, the BIBB functionalized Ti initiated the polymerization of N, N -diethylaminoethyl methacrylate (DEAEMA) and N, N -dimethylaminoethyl methacrylate (DMAEMA) to obtain Ti@PDA-g-polymer brushes by activators regenerated by electron transfer atom transfer radical polymerization (ARGET-ATRP). The prepared PDEAEMA and PDMAEMA brushes on Ti surfaces would be subsequently quaternized by using 1-bromooctane, which would impart the obtained products with quaternary ammonium groups. The surface compositions of the functionalized Ti were characterized by X-ray photoelectron spectroscopy (XPS). The hydrophilic/hydrophobic properties of the functionalized Ti surfaces were determined by static water contact angle measurements, and morphologies were characterized by scanning electron microscope (SEM). Antibacterial abilities of quaternized PDEAEMA and PDMAEMA coated Ti were evaluated by the contact killing test, in which live/dead cell staining method was employed. The results showed that the quaternized polymer decorated Ti exhibited good bactericidal effects against Escherichi coli ( E. coli ), and its inhibition rate of E. coli were observed to be nearly 90%.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2014
·Vol. 49
·期 9
·3391-3399
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IF 2.305
Jie Zhiqiang,Zhang Bing,Zhao Lianhong,Yan Xiufang,Liang Jie
A novel regenerable antimicrobial silica gel was prepared by a dehydration between silanols of silica gel and hydrolyzed 3-chloropropyltrimethoxysilane, a quaternization between grafted hydrolyzed 3-chloropropyltrimethoxysilane and (5,5-dimethylhydantoinyl-3-ylethyl)-dimethylamine (DHEDA), and a chlorination of amide groups of DHEDA. The as-prepared antimicrobial silica gel was characterized by FT-IR and X-ray photoelectron spectroscopy. Antimicrobial tests showed that the as-prepared antimicrobial silica gel was capable of about a 6-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 10 min of contact. Interestingly, more than 2 × 10 4 CFU/mL of Escherichia coli O157:H7 could be almost inactivated under flowing water condition. Furthermore, the as-prepared antimicrobial silica gel exhibits good regenerability and storage stability.
研究领域:
材料科学
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微生物学
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DOI
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Manli Sun,Hong Li,Kexin Wang,Chao Hu,Xincheng Jiang,Wei Ding,Yuxin Zhang,Huaili Zheng
The regrowth of pathogenic bacteria in municipal sludge poses a significant environmental and health risk. Starch-derived polymers (St-g-PDMC) grafted with quaternary ammonium monomers have demonstrated dual functions of flocculation and bacterial inactivation. However, the mechanisms remain unclear, particularly the interplay between flocculation and bactericidal processes, hindering the optimization and application of such bactericidal flocculants. To directionally modulate the synergy between two functions, this study explored the structure-property relationship of St-g-PDMC with varying charge density (CD), chain length (CL), and chain density (CN) by adjusting the grafting ratio of monomers. The results revealed that polymers with high CD and CL effectively enhanced the efficiency, achieving an E. coli removal of 96.11% and bactericidal efficiency of 99.56%. Mechanism analysis revealed that the bactericidal process competed for active sites, weakening the flocculation dominated by charge neutralization, while high-molecular-weight intracellular substances synergistically enhanced adsorption bridging. The optimized polymer mitigated competition and promoted synergy, exhibiting enhanced diffusion, adsorption, and the ability to alter membrane permeability, as confirmed by molecular dynamics simulations. Finally, a polynomial model was developed to accurately predict the flocculation efficiency and optimal dosage, facilitating the application of quaternized bactericidal flocculants in complex aquatic environments by testing in real water.
研究领域:
环境科学
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微生物学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Peng Huawen,Yu Kaicheng,Liu Xufei,Li Jiapeng,Hu Xiangguo,Zhao Qiang
Current polyamide lithium extraction nanofiltration membranes are susceptible to chlorine degradation and/or low permeance, two problems that are hard to reconcile. Here we simultaneously circumvented these problems by designing a quaternized-spiro piperazine monomer and translating its beneficial properties into large-area membranes (1 × 2 m 2 ) via interfacial polymerization with trimesoyl chloride. The quaternary ammonium and spiral conformation of the monomer confer more positive charge and free volume to the membrane, leading to one of the highest permeance (~22 L m −2 h −1 bar −1 ) compared to the state-of-the-art Mg 2+ /Li + nanofiltration membranes. Meanwhile, membrane structures are chlorine resistant as the amine–acyl bonding contains no sensitive N-H group. Thus the high performance of membrane is stable versus 400-h immersion in sodium hypochlorite, while control membranes degraded readily. Molecular simulations show that the high permeance and chlorine resistance, which were reproducible at the membrane module level, arise from the spiral conformation and secondary amine structures of the monomer.
研究领域:
材料科学
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化学工程
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环境科学
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2024
·
IF 8.4
Xinli Zhang,Shoutao Gong,Long Han,Quan Jin,Xiaoming Yan,Gaohong He,Fengxiang Zhang
Polyarylpiperidinium anion exchange membranes (AEMs) have been widely studied in anion exchange membrane fuel cells and alkaline electrolyzed water due to their excellent alkali resistance stability. In this work, we report the design and fabrication of poly(p-triphenylene-piperidinyl) (PTP) AEMs quaternized and cross-linked by bromo-β-cyclodextrin (β-CD-Br 7 ). In this type of membranes, the densely cross-linked and quaternized sites derived from β-CD-Br 7 can help to construct continuous ion transport channels to facilitate ion conduction. Although the ion exchange capacity (IEC) tended to decrease with increasing cross-linking degree, the qPTP-CD 5 membrane with 5 % cross-linking (IEC = 2.3 mmol g −1 ) produced the most significant microphase separation and the highest conductivity (125.6 mS cm −1 at 80 °C). The membrane also exhibited impressive alkaline stability, with 94.6 % conductivity retention in 1 M NaOH at 80 °C after 1000 h and 90.7 % conductivity retention after 1500 h. Finally, the peak power density of the fuel cell assembled with qPTP-CD 5 membranes was 1.216 W cm −2 at 80 °C and there was no significant voltage degradation when operated at 200 mA cm −2 current density for 40 h. This work demonstrates that β-CD can function as a good “platform” for simultaneous cross-linking and quaternization to fabricate high performance AEM.
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Fang Xie,Mingzhu Liu,Xiaofang Feng,Zhijun He,Qianqian Chen,Jiaojiao Zhou,Jie Cai
The development of biomass hydrogel coatings is significant for fruit preservation. This paper presents the facile development of a multifunctional polysaccharide-based hydrogel produced from quaternized chitin (QC) and tannic acid (TA) by in situ rapid cross-linking with high-density hydrogen bonding using the sample mixing method. The Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) spectra, and thermogravimetric analysis (TGA) proved that QC-TA hydrogel was formed by physical interactions (hydrogen bonding, electrostatic interaction, etc.). Moreover, the cross-linking density of the QC-TA hydrogels was analyzed by rheological property measurements and scanning electron microscope (SEM) morphology observations. This polysaccharide-based hydrogel, QC-TA, was evaluated as an edible coating for perishable food items, demonstrating significant improvements in physic-chemical properties, oxidation resistance, and antimicrobial activity against key pathogens ( E. coli , S. aureus , and C. albicans ). Notably, the hydrogel formed a protective film that effectively shields fruits from mechanical damage, maintaining freshness and extending shelf life, and also featuring with easy cleaning. Applied to cherry tomatoes, the QC-TA coating ensured a smooth, uniform surface, reducing dehydration and flavor loss while inhibiting microbial growth. These findings underscore the potential of employing polyphenol induced polysaccharide forming green hydrogel coatings as an economical, efficient strategy for enhancing the quality and safety of perishable foods, representing an advancement in the field of sustainable food packaging.
研究领域:
食品科学
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生物材料学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Jiemei Zhou,Yifei Huang,Can Chen,Yong Wang
The remarkable permselectivity of homoporous membranes (HOMEs) confers them with unparalleled advantages in high-precision separation. However, the upscalable fabrication of HOMEs remains a challenging yet crucial task to meet practical demands. Herein, we present a facile and controllable strategy for producing HOMEs through spray coating of block copolymers (BCPs) on macroporous substrates, followed by annealing and selective swelling. By controlling the BCP concentrations and ambient humidity during spray coating, dense BCP layers with adjustable thickness can be formed. The use of suitable pore-filling agents for filling the pores of substrates during spray coating and annealing prevents BCP from penetrating into the substrates. Also, it ensures robust adhesion between the BCP layers and macroporous substrates. Direct spray-coating circumvents the intricate and uncontrollable BCP layer transformation process, thereby enabling the successful fabrication of HOMEs over a large area of 100 cm 2 . The separation performances of thus-prepared homoporous membranes can be easily regulated by changing the swelling durations. Furthermore, the selective swelling process leads to the enrichment of BCP polarity chains on the surface and pore walls, allowing for further quaternization modification. Consequently, a synchronous promotion in permeability and selectivity of HOMEs is achieved.
研究领域:
材料科学
·
分离技术
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DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 8
·1921
·
IF 3.098
Huanlu Song,Hao Wu,ShuJing Li,Huafeng Tian,YanRu Li,JianGuo Wang
Using a solvent formed of alkali and urea, chitosan was successfully dissolved in a new solvent via the freezing–thawing process. Subsequently, quaternized chitosan (QC) was synthesized using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTAC) as the cationic reagent under different incubation times and temperatures in a homogeneous system. QCs cannot be synthesized at temperatures above 60 °C, as gel formation will occur. The structure and properties of the prepared QC were characterized and quaternary groups were comfirmed to be successfully incorporated onto chitosan backbones. The degree of substitution (DS) ranged from 16.5% to 46.8% and the yields ranged from 32.6% to 89.7%, which can be adjusted by changing the molar ratio of the chitosan unit to CHPTAC and the reaction time. QCs inhibits the growth ofAlicyclobacillus acidoterrestriseffectively. Thus, this work offers a simple and green method of functionalizing chitosan and producing quaternized chitosan with an antibacterial effect for potential applications in the food industry.Keywords:chitosan;homogeneous system;quaternization;characterization;Alicyclobacillus acidoterrestris
研究领域:
生物化学
·
食品科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）