Advanced Science
·
2024
·
IF 14.3
Liang Li,Yongzhu Yan,Jufu Liang,Jinchuan Zhao,Chaoyi Lyu,Haoxiang Zhai,Xilong Wu,Guizhen Wang
Biomaterial-based flexible electromagnetic interference (EMI) shielding composite films are desirable in many applications of wearable electronic devices. However, much research focuses on improving the EMI shielding performance of materials, while optimizing the comprehensive safety of wearable EMI shielding materials has been neglected. Herein, wearable cellulose nanofiber@boron nitride nanosheet/silver nanowire/bacterial cellulose (CNF@BNNS/AgNW/BC) EMI shielding composite films with sandwich structure are fabricated via a simple sequential vacuum filtration method. For the first time, the electrical safety, biosafety, and thermal safety of EMI shielding materials are optimized integratedly. Since both sides of the sandwich structure contain CNF and BC electrical insulation layers, the CNF@BNNS/AgNW/BC composite films exhibit excellent electrical safety. Furthermore, benefiting from the AgNW conductive networks in the middle layer, the CNF@BNNS/AgNW/BC exhibit excellent EMI shielding effectiveness of 49.95 dB and ultra-fast response Joule heating performance. More importantly, the antibacterial property of AgNW ensures the biosafety of the composite films. Meanwhile, the AgNW and the CNF@BNNS layers synergistically enhance the thermal conductivity of the CNF@BNNS/AgNW/BC composite film, reaching a high value of 8.85 W m ‒1 K ‒1 , which significantly enhances its thermal safety when used in miniaturized electronic device. This work offers new ideas for fabricating biomaterial-based EMI shielding composite films with high comprehensive safety.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Hezhen Xu,Shiyi Zuo,Danping Wang,Yu Zhang,Wenxiao Li,Lingxiao Li,Tian Liu,Yuanhao Yu,Qingzhi Lv,Zhonggui He,Jin Sun,Bingjun Sun
The clinical application of cabazitaxel (CTX) is restricted by severe dose-related toxicity, failing to considering therapeutic efficacy and safety together. Self-assembled prodrugs promote new drug delivery paradigms as they can self-deliver and self-formulate. However, the current studies mainly focused on the use of straight chains to construct self-assembled prodrugs, and the role of branched chains in prodrug nanoassemblies remains to be clarified. In this study, we systematically explored the structure–function relationship of prodrug nanoassemblies using four CTX prodrugs that contained branched chain aliphatic alcohols (BAs) with different alkyl lengths. Overall, CTX-SS-BA 20 NPs with the proper alkyl length exhibited significant improvements in both antitumor efficacy and biosafety. Furthermore, compared with straight chain (SC) modified prodrug nanoassemblies (CTX-SS-SC 20 NPs), CTX-SS-BA 20 NPs still hold great therapeutic promise due to its good biosafety. These findings illustrated the significance of BAs as modified chains in designing prodrug nanoassemblies for narrowing the efficacy-to-safety gap of cancer therapy.
研究领域:
药学
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纳米技术
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癌症研究
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产品关联
DOI
PubMed
高影响因子
Defence Technology
·
2023
·
IF 5.1
Binghui Duan,Hongchang Mo,Bojun Tan,Xianming Lu,Bozhou Wang,Ning Liu
The weak interface interaction and solid-solid phase transition have long been a conundrum for 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX)-based polymer-bonded explosives (PBX). A two-step strategy that involves the pretreatment of HMX to endow – OH groups on the surface via polyalcohol bonding agent modification and in situ coating with nitrate ester-containing polymer, was proposed to address the problem. Two types of energetic polyether — glycidyl azide polymer (GAP) and nitrate modified GAP (GNP) were grafted onto HMX crystal based on isocyanate addition reaction bridged through neutral polymeric bonding agent (NPBA) layer. The morphology and structure of the HMX-based composites were characterized in detail and the core-shell structure was validated. The grafted polymers obviously enhanced the adhesion force between HMX crystals and fluoropolymer (F 2314 ) binder. Due to the interfacial reinforcement among the components, the two HMX-based composites exhibited a remarkable increment of phase transition peak temperature by 10.2°C and 19.6°C with no more than 1.5% shell content, respectively. Furthermore, the impact and friction sensitivity of the composites decreased significantly as a result of the barrier produced by the grafted polymers. These findings will enhance the future prospects for the interface design of energetic composites aiming to solve the weak interface and safety concerns.
研究领域:
材料科学
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爆炸物工程
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产品关联
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Ying Zhao,Xinyi Zhang,Haotian Xue,Bin Gong,Qingxu Li,Wenshan Guo,Xiaoguang Meng
Antimony (Sb) contamination in certain areas caused by activities such as antimony mining and smelting poses significant risks to human health and ecosystems. In this study, a stable composite material consisting of natural zeolite-supported nanoscale zero-valent iron (Z-ZVI) was successfully prepared. The immobilization effect of Z-ZVI on Sb in contaminated soil was investigated. Experimental results showed that Z-ZVI exhibited superior performance compared to pure nano zero-valent iron (nZVI) in terms of stability, with a lower zeta potential (−25.16 mV) at a pH of 7 and a higher specific surface area (54.54 m 2 /g). It can be easily applied and dispersed in contaminated soils. Additionally, Z-ZVI demonstrated a more abundant porous structure. After 60 days of treatment with 3% Z-ZVI, the leaching concentration of Sb in the contaminated soil decreased from 1.32 mg/L to 0.31 mg/L (a reduction of 76%), and the concentration of available Sb species decreased from 19.84 mg/kg to 0.71 mg/kg, achieving a fixation efficiency of up to 90%. X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) analysis confirmed the effective immobilization of Sb in the soil through reduction of antimonate to antimonite , precipitation, and adsorption processes facilitated by Z-ZVI. Moreover, the addition of Z-ZVI effectively reduced the bioavailability of Sb in the contaminated soil, thereby mitigating its toxicity to earthworms. In conclusion, Z-ZVI can be utilized as a promising material for the safe remediation and antimony and other heavy metal-contaminated soils.
研究领域:
环境科学
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材料科学
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生态毒理学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
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2025
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IF 5.2
Xianhao Zhang,Bingrui Guo,Bing Dai,Shimiao Wang,Siqi Zhang,Sufang Zhang,Chaofan Ji,Beiwei Zhu,Xinping Lin
In this study, the effect of fermentation on the safety, flavor, and texture of largemouth bass (Micropterus salmoides ) was investigated. Compared to fresh fish, the proteins formed a network structure that enhanced bound water proportion, texture hardness, and water holding capacity, while it reduced cooking losses. TVB-N and TBARS levels increased gradually but stayed within safe limits. However, histamine accumulation surpassed the recommended limit at 56.84 ± 0.17 mg/100 g in late stages. A total of 67 volatile compounds were detected, with 13 identified as key flavor compounds (OAV > 1). 3rd-generation full-length 16S rRNA gene sequencing revealed a microbial community shift from high diversity to dominance by strains like Vibrio anguillarum , Vagococcus fessus , and Vagococcus coleopterorum . Among these, 10 species were highly correlated with flavor formation. This study reveals quality patterns in fermented largemouth bass, providing insights into achieving a balance among safety, flavor, and texture in fermented fish.
研究领域:
食品科学
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微生物学
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生物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
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2024
·
IF 3.6
Chenyang Pu,Zhi Wang,Boren Zheng,Bin Zhang
1,2,4-Triazole is a common intermediate used in the synthesis of pesticides and medicine, and has a very wide range of applications. As a kind of polynitrogen heterocycles, 1,2,4-triazole will release a lot of heat during thermal decomposition. If there is no comprehensive understanding of its pyrolysis behavior, there will be a very large thermal safety risk in the process involving 1,2,4-triazole in industrial production. At the same time, the instability of the substance may be affected by the presence of impurities, and the existing research on this aspect is quite scarce. Therefore, it is very necessary to study the effect of adding other substances on the thermal decomposition of 1,2, 4-triazole. The thermal decomposition characteristics and thermal runaway behavior of 1,2, 4-triazoles were revealed by thermodynamic experiments and various kinetic theoretical methods. According to the risk matrix, the thermal runaway danger level of 1,2, 4-triazole was determined to be level Ⅲ, which was an unacceptable risk. The results show that 1,2, 4-triazole has a huge heat release and the effect of thermal runaway is serious. In this study, three substances involved in the industrial production of fluconazole and flutriafol mixed with 1,2, 4-triazole were selected to explore their influence on the thermal decomposition of 1,2, 4-triazole under non-working conditions. DSC and ARC experiments consistently showed that these three impurities could reduce the reaction heat release of 1,2, 4-triazole to varying degrees, and confirmed that these three impurities could reduce the risk of thermal runaway of 1,2, 4-triazole to varying degrees. Among them, sodium hydride has the most outstanding performance, both in terms of reducing reaction heat release and reducing adiabatic temperature rise. The results can provide reference for loss control of 1,2,4-triazole in industrial applications.
研究领域:
化学工程
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热力学
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安全科学
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DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 39
·22198-22204
·
IF 3.049
Fang Yang,Ya Chen,Chuande Zhao,Long Zhang
Thermal decomposition of a highly thermostable explosive dihydroxylammonium 2,4,8,10-tetranitro-benzopyrido-1,3a,6,6a-tetraazapentalene (BPTAP) was studied using conventional thermal analysis techniques (Thermal Gravimetric Analysis and Differential Scanning Calorimetry). To obtain more comprehensive insight into the kinetics mechanism of BPTAP decomposition, thermoanalytical experiments were performed under non-hermetic and hermetic conditions. Several widely used thermoanalytical data processing techniques based on model-free kinetics (Flynn–Wall–Ozawa, Kissinger, Freidman, numerical optimization) were studied and compared. Furthermore, to fully understand the thermal safety property of BPTAP, the kinetic model and the kinetic parameters were evaluated based on the non-isothermal DSC data by using a non-linear optimization method. The kinetic models of thermal decomposition of BPTAP under non-hermetic and hermetic conditions were different, which were identified as the generalized autocatalysis reaction and two parallel generalized autocatalysis reactions, respectively. On the basis of the aforementioned study, two important safety parameters including the time to maximum rate under adiabatic conditions and self-accelerating decomposition temperature for BPTAP in DEWAR were calculated and discussed.
研究领域:
化学
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材料科学
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爆炸物研究
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2016
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IF 3.055
Hui-hui Xie,Jian-ya Xu,Tong Xie,Xin Meng,Li-li Lin,Li-li He,Hao Wu,Jin-jun Shan,Shou-chuan Wang
Ethnopharmacological relevance Banxia (BX) is the root of Pinellia ternata (Thunb.) Berit. Its processed products, such as Jiang Banxia (JBX), have been clinically used in traditional Chinese medicine to treat vomiting, coughing , and inflammation. However, data for their safety for pregnant women are contradictory and confusing. Aim of the study To further explore the safety of BX, an ultra-performance liquid chromatography coupled with liquid chromatography–mass spectrometry (LC–MS) and gas chromatography-mass spectrometry (GC–MS) metabolomics approach was used to evaluate the metabolic perturbation in pregnant rats caused by BX and JBX. Materials and methods Placenta and amniotic fluid samples were collected from control Sprague-Dawley pregnant rats and exposed to BX suspension and JBX decoction (1.434 g/kg/day). Samples were analyzed using LC–MS and GC–MS. The acquired MS data of above samples were further subjected to multivariate data analysis, and the significantly altered metabolites were identified. The associated pathways were constructed using MetaboAnalyst 3.0. Results The weight and histopathology of the placenta from each group of rats had no definite difference. However, we found 20 differential endogenous metabolites that changed significantly in the placenta and amniotic fluid samples. The alterations of identified metabolites indicated a perturbation in glycerophospholipid metabolism, amino acid metabolism, and carbohydrate metabolism in pregnant rats exposed to BX and JBX. Conclusion In summary, this work suggested that oral administration of BX and JBX may induce disturbances in the intermediary metabolism in pregnant rats. This work contributes to further understanding the safety of BX and its processed products.
研究领域:
药理学
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传统医学
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代谢组学
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2018
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IF 5.116
Yaoming Deng,Tianxing Kang,Zhen Ma,Xinxin Tan,Xiaona Song,Zheng Wang,Peipei Pang,Dong Shu,Xiaoxi Zuo,Junmin Nan
Under the abusive conditions, it is demonstrated that the thermal stability of LiCoO 2 and the safety of LiCoO 2 /graphite batteries are improved by doping and coating Al and Ti elements into the bulk structure and surface of LiCoO 2 . The trickle charge and the differential scanning calorimeter (DSC) results show that after coating Al and Ti oxides on the doped LiCoO 2 with 2000 ppm Al, the exothermic peak shifts to a higher temperature and the exotherm decreases, resulting in the increase of the thermal stability of LiCoO 2 . In addition, compared to the LiCoO 2 without Al doping, it is also indicated that the thermal stability of LiCoO 2 can be enhanced by doping Al, the exothermic peak of the LiCoO 2 with Al doping amount of 10000 ppm is up to 250 °C. Under the abusive testing conditions including thermal shock and overcharge, the safety evaluation results of pouch polymer LiCoO 2 /graphite batteries are in good agreement with the trickle charge and DSC results. These results reveal that the thermal stability of LiCoO 2 can be used as an indicator to evaluate the safety characteristics of LiCoO 2 /graphite batteries, and especially the introduction of Al and Ti into LiCoO 2 can effectively improve the safety of LiCoO 2 /graphite batteries under the abusive conditions.
研究领域:
材料科学
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电池安全
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 4
·946
·
IF 3.267
Mengling Zhang,Rui Zhang,Jian Liu,Hongliang Wang,Zhen Wang,Juan Liu,Yang Shan,Huanling Yu
5,6,7,8,3,4′-Hexamethoxyflavone, also called nobiletin (NOB), widely found in the citrus peel, is one of the main byproducts in citrus processing. NOB is considered safe, but its safety for women during pregnancy is unknown. Therefore, the effect of NOB on apoptosis in human choriocarcinoma trophoblast cells (BeWo cells) was evaluated. Cells were divided into four groups and cultured with different concentrations of NOB (0, 10, 33, and 100 μM) for 12, 24, 36, and 48 h respectively. Cell viability was detected by CCK-8 assay, cell morphology was detected by a Cell Imaging Multi-Mode Reader, and cell cycle and apoptosis were detected by flow cytometry. Cleaved PARP level, the expressions of B cell lymphoma 2 (BCL2) family proteins, and p53 pathway proteins were detected by Western blot. The results showed that after 48 h of cell culture, the cell viability was decreased significantly, but apoptosis was significantly increased. Compared to the cells without NOB treatment, the cells treated with NOB at 10 or 33 μΜ showed no significant differences in the number of suspended cells or late apoptosis rate, except the increase of cell viability. Treatment of NOB at the concentration of 100 μM improved cell viability, attenuated apoptosis, decreased suspended cells, and did not alter the G1 phase arrest, compared with the non-NOB-treated group after 48 h of culturing. The 100 μΜ NOB treatment increased the levels of BCL2 and BCLXL, and decreased p53 accumulation in BeWo cells at 48 h, but had no effect on the expression of BAX, BAK, BAD, p21, and G1 phase arrest. These findings provide evidence that NOB (10, 33, and 100 μΜ) was safe for BeWo cells. NOB at the concentration of 100 μΜ could attenuate apoptosis in BeWo cells, which might be helpful to prevent pregnancy-related diseases caused by apoptosis.Keywords:nobiletin;safety;trophoblast;BeWo cells;apoptosis
研究领域:
药理学
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细胞生物学
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妇产科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2022
·Vol. 45
·期 18
·3404-3411
·
IF 3.614
Yudan Wang,Cheng Zhang,Lei Zhang,Zhen OuYang,Ming Zhao,Jiaoyang Luo,Meihua Yang
In this study, a sensitive and accurate immunoaffinity columns coupled with high-performance liquid chromatography method was established to monitor the presence of aflatoxins—aflatoxin B 1 , aflatoxin B 2 , aflatoxin G 1 , and aflatoxin G 2 —in different medicinal herbs. The proposed method was found to be suitable for the detection of aflatoxins in eight kinds of herbs and their corresponding granules. Two batches of Arecae semen were positive for aflatoxins, with high residue levels of different aflatoxins. To better understand the presence and transfer of aflatoxins during the formulation of dispensing granules from the herbs, the aflatoxins-free herbs were artificially inoculated with Aspergillus flavus to explore aflatoxins production. Both aflatoxin B 1 and aflatoxin B 2 were detected in all inoculated samples, while aflatoxin G 2 was only detected in Astragali radix samples. Additionally, the presence of aflatoxin B 1 was extremely high compared to other aflatoxins. More specifically, the transfer rate of the aflatoxin B 1 and the total aflatoxins from original herbs to granules were both approximately 40%. These findings indicated that the preparation of herbs into dispensing granules reduced the content of aflatoxins. The high-level presence of aflatoxins in inoculated herbs indicated that attention is needed to the safety of A. flavus -contaminated herbs.
研究领域:
药学
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食品安全
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植物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Tian Duan,Wang Zhe,Zhang Jiaqian,Luo Ying,Zhang Zhenlong,Li Chao,Ye Kai,Peng Chaoliang,Chen Yiming,Lin Wenxue,Zhang Jingyan
This study examines attapulgite-bentonite-pyrite (AB 7 Fe) and zeolite-bentonite-pyrite (ZB 7 Fe) mixtures as buffer and backfill materials for nuclide migration using soil column experiments and COMSOL modeling. The results indicated that ZB 7 Fe possessed higher adsorption capacities for cesium (Cs) and strontium (Sr) compared to AB 7 Fe. Conversely, AB 7 Fe demonstrated superior retardation performance, more effectively slowing nuclide migration. After 1000 years, Cs and Sr concentrations in AB 7 Fe surpassed those in ZB 7 Fe. Additionally, nuclide migration increased with higher initiation pressure, dispersion, and diffusion coefficients. This research is crucial for improving the long-term safety of nuclear waste repositories.
研究领域:
环境科学
·
核废物管理
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）