International Journal of Electrochemical Science
·
2023
·Vol. 11
·期 12
·10135-10149
·
IF 1.5
Lijuan Gong,Kangquan Qiao
The corrosion inhibition performances of Diantipyrylmethane (DAM) for mild steel in 0.5 M H 2 SO 4 were investigated using weight loss, electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, scanning electron microscope (SEM) and quantum chemical calculation. The obtained results reveal that DAM acts as a mixed-type inhibitor with a predominantly anodic reaction, and the inhibition efficiency increases with increasing inhibitor concentration whereas decreases with increasing temperature. The adsorption of DAM on steel surface is found to obey Langmuir isotherm, and the adsorption mechanism is mixed physical and chemical adsorption. The results of quantum chemical calculation demonstrate that pyrazolone rings within molecular structure of DAM play a dominant role in corrosion inhibition of mild steel.
研究领域:
材料腐蚀与防护
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物理化学
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电化学
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表面科学
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量子化学
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Analytical Methods
·
2012
·Vol. 4
·期 6
·1736-1741
·
IF 1.547
Xiaomeng Meng,Zhenning Xu,Mo Wang,Huanshun Yin,Shiyun Ai
A simple electrochemical method based on a Bi2S3 modified glassy carbon electrode (GCE) was developed to determine antipyrine using cyclic voltammetry and differential pulse voltammetry. Antipyrine shows a well-defined oxidation peak at the fabricated electrode in phosphate buffer solution and the oxidation peak current is much higher than that at the bare GCE, indicating that Bi2S3 can effectively improve the oxidation of antipyrine. Several effect factors on antipyrine determination were optimized, such as Bi2S3 amount, solution pH, scan rate and accumulation time. Under the optimal conditions, the oxidation peak current of antipyrine was proportional to its concentration in the range of 2.0 to 100 μM and 100 to 800 μM with a correlation coefficient of 0.9974 and 0.9956, respectively. The limit of detection was estimated to be 0.7 μM (S/N = 3). The developed method showed good reproducibility and excellent anti-interference performance. The fabricated electrode was successfully used to determine antipyrine in pharmaceutical formulations with recovery from 96% to 103.5%.
研究领域:
分析化学
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电化学
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药物分析
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药剂学
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药物代谢
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ACS Nano
·
2022
·
IF 18.027
Wanbao Wu,Yihong Liang,Deping Li,Yiyang Bo,Dong Wu,Lijie Ci,Mingyu Li,Jiaheng Zhang
The development of electrolytes with high safety, high ionic conductivity, and the ability to inhibit lithium dendrites growth is crucial for the fabrication of high-energy-density lithium metal batteries. In this study, a ternary eutectic electrolyte is designed with LiTFSI (TFSI = bis(trifluoromethanesulfonyl)imide), butyrolactam (BL), and succinonitrile (SN). This electrolyte exhibits a high ion conductivity, nonflammability, and a wide electrochemical window. The competitive solvation effect among SN, BL, and Li+ reduces the viscosity and improves the stability of the eutectic electrolyte. The preferential coordination of BL toward Li+ facilitates the formation of stable solid electrolyte interphase films, leading to homogeneous and dendrite-free Li plating. As expected, the LiFePO4/Li cell with this ternary eutectic electrolyte delivers a high capacity retention of 90% after 500 cycles at 2 C and an average Coulombic efficiency of 99.8%. Moreover, Ni-rich LiNi0.8Co0.1Al0.1O2/Li and LiNi0.8Co0.1Mn0.1O2/Li cells based on the modified ternary eutectic electrolyte achieve an outstanding cycling performance. This study provides insights for understanding and designing better electrolytes for lithium metal batteries and analogous sodium/potassium metal batteries.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shilong Jiang,Song Cheng,Jiashun Cao,Cailiang Yue,Jianglei Xiong,Cong Jiang,Hongzhan Cai,Jianhua Wu
The removal of trace urea presents a significant challenge in the production of electronic-grade ultra-pure water (UPW). This study proposed a simple strategy to regulate the low-coordination of a single-atom cobalt catalyst (R y Co-CN 0.20 ) for the efficient removal of trace urea via peroxymonosulfate (PMS) activation. The optimal R 0.50 Co-CN 0.20 with low-coordination Co-N 3 sites was constructed by in-situ reduction of NaBH 4 and significantly enhanced the PMS activation. The removal efficiency of trace urea achieved 94 % within 5 mins. The k obs of trace urea degradation in R 0.50 Co-CN 0.20 /PMS system reached 0.4576 min −1 , which was much higher than previous reported systems. Experiments of free radical quenching and electron paramagnetic resonance demonstrated that singlet oxygen species were the dominant free radical. The corresponding steady concentration of singlet oxygen species in the R 0.50 Co-CN 0.20 /PMS system was enhanced to be 16.361 × 10 –6 μM, which was twice of Co-CN 0.20 /PMS. Density functional theory calculations revealed that the optimized electron distribution of the Co center in the Co-N 3 sites processed a higher d band center (−1.08 eV) and richer electron transfer number (0.75 e − ) compared with Co-N 4 sites, hence realizing the stronger PMS activation. Continuous operation verified that R 0.50 Co-CN 0.20 /PMS could maintain the removal rate of trace urea above 80 % after 150 h operation. Moreover, R 0.50 Co-CN 0.20 /PMS in the pilot UPW production process effectively reduced the pollution caused by trace urea and ensured the quality of the terminal UPW (Total organic carbon <1 μg/L). This study provides a new approach for the removal of trace urea through PMS activation by low-coordination single-atom catalysts.
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CHEMOSPHERE
·
2023
·
IF 8.8
Yuqiong Gao,Han Ning,Yanyan Rao,Kexuan Li,Chaole Zeng,Naiyun Gao
The feasibility of the degradation of phenazone (PNZ), a common anti-inflammatory drug used for reducing pain and fever, in water at neutral pH by an electrochemically assisted Fe 3+ -ethylenediamine disuccinate-activated persulfate process (EC/Fe 3+ -EDDS/PS) was investigated. The efficient removal of PNZ at neutral pH condition was mainly attributed to the continuous activation of PS via electrochemically driven regenerated Fe 2+ from a Fe 3+ -EDDS complex at the cathode. The influence of several critical parameters, including current density, Fe 3+ concentration, EDDS to Fe 3+ molar ratio, and PS dosage, on PNZ degradation was evaluated and optimized. Both hydroxyl radicals (•OH) and sulfate radicals (SO 4 ●– ) were considered major reactive species responsible for PNZ degradation. To understand the mechanistic model of action at the molecular level, the thermodynamic and kinetic behaviors of the reactions between PNZ with •OH and SO 4 ●– were theoretically calculated using a density functional theory (DFT) method. The results revealed that radical adduct formation (RAF) is the most favorable pathway for the •OH-driven oxidation of PNZ, while single electron transfer (SET) appears to be the dominant pathway for the reaction of SO 4 ●– with PNZ. In total, thirteen oxidation intermediates were identified, and hydroxylation, pyrazole ring opening, dephenylization, and demethylation were speculated to be the major degradation pathways. Furthermore, predicted toxicity to aquatic organisms indicated that PNZ degradation resulted in products that were less harmful. However, the developmental toxicity of PNZ and its intermediate products should be further investigated in the environment. The findings of this work demonstrate the viability of effectively removing organic contaminants in water at near-neutral pH by using EDDS chelation combined with electrochemistry in a Fe 3+ /persulfate system.
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高影响因子
Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·1-12
·
IF 52.7
Chen Junyang,Xiang Pan,Duro-Castano Aroa,Cai Huawei,Guo Bin,Liu Xiqin,Yu Yifan,Lui Su,Luo Kui,Ke Bowen,Ruiz-Pérez Lorena,Gong Qiyong,Tian Xiaohe,Battaglia Giuseppe
The blood‒brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous system (CNS) from potentially harmful substances while regulating the transport of essential molecules. Its dysfunction is increasingly recognized as a pivotal factor in the pathogenesis of Alzheimer’s disease (AD), contributing to the accumulation of amyloid-β (Aβ) plaques. We present a novel therapeutic strategy that targets low-density lipoprotein receptor-related protein 1 (LRP1) on the BBB. Our design leverages the multivalent nature and precise size of LRP1-targeted polymersomes to modulate receptor-mediated transport, biasing LRP1 trafficking toward transcytosis and thereby upregulating its expression to promote efficient Aβ removal. In AD model mice, this intervention significantly reduced brain Aβ levels by nearly 45% and increased plasma Aβ levels by 8-fold within 2 h, as measured by ELISA. Multiple imaging techniques confirmed the reduction in brain Aβ signals after treatment. Cognitive assessments revealed that treated AD mice exhibited significant improvements in spatial learning and memory, with performance levels comparable to those of wild-type mice. These cognitive benefits persisted for up to 6 months post-treatment. This work pioneers a new paradigm in drug design, where function arises from the supramolecular nature of the nanomedicine, harnessing multivalency to elicit biological action at the membrane trafficking level. Our findings also reaffirm the critical role of the BBB in AD pathogenesis and demonstrate that targeting the BBB can make therapeutic interventions significantly more effective. We establish a compelling case for BBB modulation and LRP1-mediated Aβ clearance as a transformative foundation for future AD therapies.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 8
·3569
·
IF 4.9
Fu Zeng,Lian Huang,Ding Han,Renjie Liu,Kongjia Zhang,Yuwen Su,Tong Su,Yarong Lin,Jianbo Xiu
Recent advances in tissue clearing chemistry have revolutionized three-dimensional imaging by enabling whole-organ antibody labeling, even in thick human tissue samples. However, these techniques face limitations, including reduced clearance efficiency in thick tissue blocks, prolonged processing times, and other challenges specific to formalin-fixed human brain tissue, such as autofluorescence due to the presence of lipofuscin, neuromelanin pigments, and residual blood. To address these challenges, we have developed an improved SHANEL procedure, iSHANEL, which is compatible with brain tissue from multiple species, including nonrodents. iSHANEL significantly enhances the tissue transparency. It effectively removes lipids, particularly sphingolipids, from brain tissue across different species. For brain vasculature imaging, it offers the better visualization of vascular structures at high magnification, reducing light scattering and background noise. Moreover, iSHANEL can be effectively applied to large tissue from pigs and cynomolgus monkeys, and it preserves protein immunogenicity well, as evidenced by immunostaining with the microglia-specific marker IBA-1. We also investigated methods to reduce blood vessel autofluorescence. Overall, iSHANEL provides an improved procedure for the high-resolution 3D imaging of brain tissue across multiple species.
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高影响因子
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