Current Drug Delivery
·
2023
·Vol. 20
·期 6
·818-829
·
IF 2.4
Yi Shaoling,Xie Jingwen,Chen Lingli,Xu Feng
Background: The orally disintegrating tablets (ODTs) are especially suitable for elders and children with dysphagia, who need to be given customized dosages. Objectives: This study aimed to prepare orally disintegrating tablets (ODTs) which can be customized as drug content by using
semi-solid 3D printing pressure extrusion technology, with water insoluble and thermally unstable drug loratadine. Methods: The influence of binder concentration, disintegrating agent dosage and ratio mannitol: cellulose on formability and disintegration time was investigated. The properties
of orally disintegrating tablets were investigated by ATR-FTIR, XRPD, DSC and SEM. The correlation formula between tablet bottom area and drug content was established. Results: The formulation was optimized, and contained loratadine 3 g, cellulose 4 g, mannitol 2 g, carboxy methyl starch
sodium 1g, 6% PVP K30 16 ml. The disintegration time was less than 60 s with infilling percentage of 60%, and the disintegration time was less than 30 s with infilling percentage of 40%. There was no detectable interaction between loratadine and the selected excipients by the analysis of ATR-FTIR,
DSC and XRPD. The structure of the tablets was porous, and the drug was dissolved completely within 10 min. The drug content (x) of the tablet and the bottom area (y) of the tablet showed a linear fitting relationship, y = 3.8603x - 0.7176, r2 = 0.9993. Conclusion:
Semi-solid extrusion of 3D printing technology was applied to prepare loratadine orally disintegrating tablets with customized drug content, which provides an alternative method for the research of customized preparation.
研究领域:
药剂学
·
制药工程
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Luyao Zhan,Wanxuan Xu,Zixi Hu,Jiayin Fan,Luping Sun,Xingchi Wang,Yingying Zhang,Xiaodi Shi,Bin Ding,Jianyong Yu,Ying Ma
Responsive thermochromic fiber materials capable of miniaturization and integrating comfortably and compliantly onto the soft and dynamically deforming human body are promising materials for visualized personal health monitoring. However, their development is hindered by monotonous colors, low-contrast color changes, and poor reversibility. Herein, full-color “off–on” thermochromic fluorescent fibers are prepared based on self-crystallinity phase change and Förster resonance energy transfer for long-term and passive body-temperature monitoring, especially for various personalized customization purposes. The off–on switching luminescence characteristic is derived from the reversible conversion of the dispersion state and fluorescent emission by fluorophores and quencher molecules, which are embedded in the matrix of a phase-change material, during the crystallizing/melting processes. The achievement of full-color fluorescence is attributed to the large modulation range of fluorescence colors according to primary color additive theory. These thermochromic fluorescent fibers exhibit good mechanical properties, fluorescent emission contrast, and reversibility, showing their great potential in flexible smart display devices. Moreover, the response temperature of the thermochromic fibers is controllable by adjusting the phase-change material, enabling body-temperature-triggered luminescence; this property highlights their potential for human body-temperature monitoring and personalized customization. This work presents a new strategy for designing and exploring flexible sensors with higher comprehensive performances.
研究领域:
材料科学
·
生物医学工程
·
柔性电子
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2021
·Vol. 15
·期 3
·2599-2607
·
IF 8.897
Yuan Zhanhong,Meng Dingding,Wu Yingzhu,Tang Guangqing,Liang Ping,Xin John H.,Ye Dongdong
Because of a weak interface-bonding force between metal-organic frameworks (MOFs) and substrates and the loss of customization in structural designs owing to the lack of the regulation of ion sites, MOFs tend to escape from the constructed composite template. In this study, the as-prepared 2,2,6,6-tetramethylpiperidyl-1-oxyl (TEMPO)-oxidized algae cellulose nanofibers (TACFs) were used to chelate metal ions at controllable sites and subsequently firmly entangle the assembled MOF crystals. The distribution of ions and synthesized MOFs inside the gel was monitored using Raman imaging technology, which provided an intuitive approach for visually observing the ions and MOF distribution. Using this technology, the synthesized customizable TACFs@ZIF-67 aerogels exhibited a high specific surface area (734.7 m 2 /g), low density (6.18 mg/cm 3 ), controlled particle distribution, good underwater structural stability, and excellent adsorption of dyes. This study provides a way for solving the dispersion problem of MOFs in nanofibrous aerogels using Raman imaging technology-assisted microcosmic fixed-point design.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Shengchen Lv,Donghui Liu,Xueke Liu,Zhiqiang Zhou,Peng Wang
A novel fluorescent sensor utilizing customized carbon dots (CDs) has been developed for the rapid and efficient detection of the herbicide paraquat. The 4,4′-diamino-2,2′-stilbenedisulfonic acid (DSD acid) functionalized CDs (DSD-CDs) were synthesized by a hydrothermal method using citric acid and L-cysteine as precursors, followed by amidation with DSD acid. The resultant DSD-CDs exhibited bright blue fluorescence upon UV excitation. The fluorescence of the functionalized carbon dots was effectively quenched by paraquat, following a static quenching mechanism as confirmed by fluorescence lifetime measurements. Interestingly, the mechanism study revealed that the excited-state of the DSD-CDs could interact effectively with paraquat, resulting in stronger fluorescence quenching compared to the ground-state. The sensor showed high sensitivity, selectivity, and stability, with a wide linear range of 0.01 ∼ 2 mg/L (R 2 = 0.997) and a low detection limit of 0.003 mg/L. The developed fluorescent sensor demonstrated exceptional potential for paraquat detection in actual samples, encompassing blood, urine, soybean, and river water, with recovery rates exceeding 83 % and relative standard deviations (RSD) below 10 %. This underscores its practical utility in environmental protection and clinical testing applications.
研究领域:
分析化学
·
环境科学
·
生物医学
✓ 已验证
DOI
高影响因子
Journal of Manufacturing Processes
·
2023
·
IF 6.2
Peikai Duan,Xiaoyang Zhu,Houchao Zhang,Hongke Li,Zhenghao Li,Rui Wang,Junyi Zhou,Daoseng Song,Youchao Zhang,Guangming Zhang,Hongbo Lan
Low-temperature co-fired ceramic (LTCC) devices have been widely used in the defense, automotive, medical, and aerospace industries. However, the traditional manufacturing process of LTCC devices is hardly suitable for cost-effective, fast design and customization requirements. In this work, we propose a multi-material integrated 3D printing technology for LTCC. LTCC slurry was configured using homemade borosilicate glass powder and Al 2 O 3 powder, and the influence of printing parameters on the printed effect was investigated. The shrinkage of the ceramics sintered at 850 °C for 15 min was 14.82 ± 0.47 % in the XY direction and 13.7 ± 0.26 % in the Z direction, comparable to that of commercial LTCC. Wireless sensing multilayer LED circuit and passive humidity sensor were fabricated, where the sensor with a sensitivity of 0.132 MHz/%RH. These cases demonstrate that the proposed technology can rapidly produce LTCC devices and meet the demand for custom LTCC devices in high-end manufacturing.
研究领域:
制造工程
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Wenjing Wang,Zixiong Wang,Xiaomin Sun,Zhuan Yi,Congjie Gao
Isoporous block copolymer membranes with high porosity and narrow pore size distribution have been viewed as ideal membrane platforms for precise separation of similarly sized particles or solutes. However, tailored made fabrication of solvent-resistant isoporous membranes with switchable pores and rigid pores for customizable sieving have been rarely reported. Herein, we show that site-selective hyper-crosslinking is effective and robust to prepare such membranes from polystyrene- block -poly(4-vinylpyridine) (PS- b -P4VP). The selective crosslinking in PS domains endows the membrane with excellent solvent resistance and structural stability. Since not participated in the crosslinking reaction, the P4VP brushes located in pore walls endow the crosslinked membranes with adaptive pore size, switchable permeance and tunable rejections that vary with Hansen solubility parameter of solvents. Moreover, by a facile while complete etching the P4VP from pores, the switchable performance is removed and resultant membranes show rigid pore characteristics and constant rejections. Crosslinked membranes with either switchable pores or rigid-likes pores exhibit superior long-term stability (30 days) in harsh solvents. This work presents a top-down method to construct highly stable isoporous membranes with both switchable and rigid pore characteristics from the same block copolymer , which will shed the light on precisely tailoring the pore size and pore rigidity for crosslinked isoporous membranes that will not only enable the tailored sieving but also the modelling of solvent flowing behaviours in nanopores .
研究领域:
材料科学
·
分离技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Weidong Liu,Zhiyun Li,Jiayi Wang,Yizihan Yu,Taowen Dong,Qiushi Zhang,Nan Lin,Zhenhai Gao,Weitao Zheng
Structural supercapacitors (SSCs), a key technology for lightweighting and extending the range of electric automotive vehicles and drones, can achieve energy storage and load-bearing simultaneously. However, the development of SSCs is hindered by the lack of solutions for customized design and manufacturing. In this work, we demonstrate the technical feasibility of customized design and manufacturing of SSCs by using finite element simulations. First, COMSOL, Digimat and Abaqus were used to create simulation models and evaluate their electrochemical performance and mechanical performance, respectively. Second, SSCs are fabricated on the basis of simulation models, and their electrochemical and mechanical performance is evaluated, with errors of 12.0 % for capacitance and 8.0 % for modulus between simulation and experiment values, confirming model’s reliability. Third, a customized structural supercapacitor is designed and fabricated. This device exhibited excellent electrochemical performance (areal specific capacitance of 46.50 mF cm −2 ) and mechanical performance (bending modulus of 7.25 GPa). This work not only demonstrates a high-performance structural supercapacitor but also provides a novel approach for the customized design and manufacturing of SSCs on the basis of specific customer requirements.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small Methods
·
2024
·Vol. 8
·期 10
·2301557
·
IF 10.7
Binbin Wang,Huicheng Hu,Mohan Yuan,Ji Yang,Jing Liu,Liang Gao,Jianbing Zhang,Jiang Tang,Xinzheng Lan
HgTe nanocrystals (NCs) possess advantages including tunable infrared absorption spectra, solution processability, and low fabrication costs, offering new avenues for the advancement of next-generation infrared detectors. In spite of great synthetic advances, it remains essential to achieve customized synthesis of HgTe NCs in terms of industrial applications. Herein, by taking advantage of a high critical nucleation concentration of HgTe NCs, a continuous-dropwise (CD) synthetic approach that features the addition of the anion precursors in a feasible drop-by-drop fashion is demonstrated. The slow reaction dynamics enable size-customized synthesis of HgTe NCs with sharp band tails and wide absorption range fully covering the short- and mid-infrared regions. More importantly, the intrinsic advantages of CD process ensure high-uniformity and scale-up synthesis from batch to batch without compromising the excitonic features. The resultant HgTe nanocrystal photodetectors show a high room-temperature detectivity of 8.1 × 10 11 Jones at 1.7 µm cutoff absorption edge. This CD approach verifies a robust method for controlled synthesis of HgTe NCs and might have important implications for scale-up synthesis of other nanocrystal materials.
研究领域:
材料科学
·
纳米技术
·
光电探测器
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Hao Zheng,Guoliang Guo,Xiaoqiang Pei,Pengke Huang,Xiaoling Liu,Wenge Zheng
Elastomer foams with customized multimodal cellular structures have great application requirements in advanced fields, but a simple and practical way to realize it needs to be further studied. Herein, a strategy of presetting cells into elastomers before supercritical CO2 foaming was introduced to customize the cellular structures. Typically, taking olefin block copolymers (OBC, a thermoplastic elastomer with crystalline hard segments and rubbery soft segments) foams as an example, bimodal, sandwich, and gradient multimodal cellular structures were successfully prepared. The interaction between preset cells and newly nucleated cells during foaming had been systematically studied by controlling the morphology of preset cells and foaming conditions. It was found that the configuration of preset cells and the nucleation rate of small cells in OBC foams had a significant impact on their cellular structures. Specifically, the bimodal cellular structures can improve the expansion ratio and elasticity of OBC foams, and their rebounding ability could be improved by 14%, while their energy loss coefficient would be decreased by 17% (compared to homogeneous ones in this study). Furthermore, the feasibilities of this strategy in other elastomer foams (like POE, EPDM, and EVA foams) with bimodal cellular structures were also verified, which was expected to promote the development of high-performance elastomer foams.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITE STRUCTURES
·
2025
·
IF 7.1
Jiasen Gu,Syed Mesum Raza Naqvi,Long Chao,Chen Jiao,Youwen Yang,Muhammad Ali Nasir,Zongjun Tian,Lida Shen,Dongsheng Wang,Huixin Liang
The human mandible exhibits significant variation among individuals, necessitating customised restoration. This study proposes a stress distribution-driven modelling algorithm for gradient triply periodic minimal surface (TPMS) structures, specifically Gyroid-type double TPMS (GTDT) structures. The design process determines stress distribution in the macroscopic repair region through finite element method (FEM) mechanical analysis. In addition, designed structures were fabricated using laser powder bed fusion (LPBF). FEM analysis, mechanical testing, permeability experiments, and in vitro experiments were performed and identified an optimal Iso Value of 1.25 for bone regeneration. The results showed that the structures produced by the stress-driven design method had higher yield strength and more uniform stress distribution and double the strength in three-point bending tests, all at comparable relative density. Compared to the solid structure, the customized prostheses designed for maxillofacial repairs using this method exhibit stress distribution and displacement behaviour more closely aligned with native bone during mastication, thereby enhancing post-operative comfort.
研究领域:
生物医学工程
·
材料科学
·
口腔医学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaolan Chen,Naiding Zhang,Chujun Ni,Ruijue Cao,Lanting Hu,Jinyi Chen,Qian Zhao,Tao Xie,Zhenjie Liu
Porous shape memory polymers (SMPs) can execute large volume expansion from their compressed temporary shapes to porous permanent shapes, which present promising practical potentials in biomedical and aerospace fields. While constructing sophisticated geometries are essential for achieving the corresponding functions of the foams, the original shapes which are typically determined by molds cannot be post-tuned in a customized fashion. Here we propose an easy but effective emulsion lyophilization method to fabricate porous SMPs, the original shapes of which can be post-regulated via a two-stage curing mechanism. A thermo-curable acrylate emulsion and a photo-curable polyurethane emulsion were prepared individually and then mixed in proportion. After lyophilization of the mixed emulsion, porous SMPs were prepared due to the first thermo-curing stage between epoxy and amine groups from the acrylate emulsion. The foams can be temporarily programmed into alternative shapes with relatively complex geometries which can afterwards be permanently fixed through the secondary photo-curing stage. In this way, simple permanent shapes of the porous SMPs determined by planar molds were converted into customized three-dimensional ones taking advantage of various deformation such as bending, imprinting, and twisting. Accordingly, customized biomedical devices were fabricated via the two-stage curing process, inspiring further application opportunities for porous SMPs.
研究领域:
材料科学
·
生物医学工程
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Tong Yu,Yeqing Wang,Yi Kong,Jianwei Wang,Hong Yun,Yunchao Wang,Fuqiang Hu,Zhongxin Zhu,Hong Yuan
Drug delivery system (DDS) is an important branch of pharmaceutics. Rational modification of the physicochemical properties of DDSs can further improve their targeting efficiency. Herein, a bionic DDS is reported for AKI that is scRNA-seq-guided, custom-designed, and prepared, targeting the Key Cell Subtype for Pathological Progression (KCS-PP) of acute kidney injury (AKI). Specifically, scRNA-seq is utilized to identify a specific renal tubular epithelial cell subtype (PTIs) as the KCS-PP for AKI from numerous cellular subtypes. Additionally, specific cell adhesion molecules (VCAM1 and ICAM1) are identified as the Targeting Drug Delivery Mediators (TDDMs) for PTIs from a list of 1000 marker genes of PTIs. Based on this progress, PTI-targeting bionic DDS, named BRNCs@AMMOs is custom-designed and prepared, and used them for AKI treatment in vitro and in vivo. In vitro, BRNCs@AMMOs shows that its adhesion ability in PTI model cells is 3.2 times that in normal cells. In vivo, 6 h after renal pelvis injection, the MFI of BRNCs@AMMOs-DiI in AKI kidneys is 3.7 times that of sham kidneys. The findings demonstrate that BRNCs@AMMOs exhibits prolonged retention in PTI model cells and AKI kidneys. Overall, the custom-designed and prepared PTI-targeting bionic DDS, may promote the customized design and preparation of DDSs for different diseases and targets, is reported.
研究领域:
药剂学
·
药物递送
·
分子医学
·
纳米技术
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）