iScience
·
2024
·
IF 4.6
Haochuan Yang,Khalid Javed,Xi Li,Yuqi Zou,Xingliang Dai,Haiping He,Xvsheng Qiao,Guangming Tao
Multifunctional micro- and nanoparticles have found their applications in fields like medicine, display materials, cosmetics, and so on. Advances in these fields have been demonstrated to need scalable uniformly sized, mass-produced, and structured spherical particles. In this work, we proposed structure-tailored and multifunctional composite polymeric microspheres with tunable diameter size, by using a versatile and scalable in-fiber particle fabrication through the Plateau-Rayleigh capillary instability method. The results show that the characteristic shapes of the luminescence spectra of CsPbBr 3 remained similar before and after embedding in the microspheres. The luminescence intensity was stabilized at 85–90% of their original photoluminescence intensities over an extended period. Moreover, the photoluminescence lifetime of the fluorescent microspheres was increased by 9.03% compared to CsPbBr 3 . The X-ray diffraction results revealed that there was no change in the crystal structure of the dopants before and after the encapsulation. Also, precise magnetic manipulation of Janus microspheres was successfully demonstrated.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Current Drug Delivery
·
2023
·Vol. 20
·期 6
·818-829
·
IF 2.4
Yi Shaoling,Xie Jingwen,Chen Lingli,Xu Feng
Background: The orally disintegrating tablets (ODTs) are especially suitable for elders and children with dysphagia, who need to be given customized dosages. Objectives: This study aimed to prepare orally disintegrating tablets (ODTs) which can be customized as drug content by using
semi-solid 3D printing pressure extrusion technology, with water insoluble and thermally unstable drug loratadine. Methods: The influence of binder concentration, disintegrating agent dosage and ratio mannitol: cellulose on formability and disintegration time was investigated. The properties
of orally disintegrating tablets were investigated by ATR-FTIR, XRPD, DSC and SEM. The correlation formula between tablet bottom area and drug content was established. Results: The formulation was optimized, and contained loratadine 3 g, cellulose 4 g, mannitol 2 g, carboxy methyl starch
sodium 1g, 6% PVP K30 16 ml. The disintegration time was less than 60 s with infilling percentage of 60%, and the disintegration time was less than 30 s with infilling percentage of 40%. There was no detectable interaction between loratadine and the selected excipients by the analysis of ATR-FTIR,
DSC and XRPD. The structure of the tablets was porous, and the drug was dissolved completely within 10 min. The drug content (x) of the tablet and the bottom area (y) of the tablet showed a linear fitting relationship, y = 3.8603x - 0.7176, r2 = 0.9993. Conclusion:
Semi-solid extrusion of 3D printing technology was applied to prepare loratadine orally disintegrating tablets with customized drug content, which provides an alternative method for the research of customized preparation.
研究领域:
药剂学
·
制药工程
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DOI
PubMed
高影响因子
Advanced Materials Interfaces
·
2022
·Vol. 9
·期 11
·2102426
·
IF 6.389
Peng Wang,Guoxian Li,Wei Yu,Chuizhou Meng,Shijie Guo
Recently, flexible sensors have attracted great interest for their promising application in wearable electronics. However, previous mechanical sensors are typically limited to detecting one type of stimulus and monotonous in color, which are not able to meet the sensing nor fashion requirements by customers who will wear them in daily life. Herein, a flexible and stretchable sensor based on highly conductive ionic gel is developed. Different phosphor nanoparticles are uniformly embedded into gel to enable color-customization and even self-illumination depending on preference. The gel is also self-healable after complete severance and degradable in hot water. The sensors can detect multiple mechanical deformation modes to allow for detections of strain, pressure, and torsion on a single device. Wearable sensing prototypes are demonstrated with attachment to different parts of human body to detect various human motions, including strain sensing for frowning and elbow/knee bending, pressure sensing for vocal cord vibrations and pulse at wrist, and torsion sensing for shoulder and forearm rotations, through an in-house, wireless, real-time signal transmission and process system. Considering its sensing capability toward different stimuli as well as superior physical properties, the developed color-customizable and self-illuminating ionic gel sensor would find its promising applications toward wearable sensing.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Small
·
2024
·
IF 13
Luyao Zhan,Wanxuan Xu,Zixi Hu,Jiayin Fan,Luping Sun,Xingchi Wang,Yingying Zhang,Xiaodi Shi,Bin Ding,Jianyong Yu,Ying Ma
Responsive thermochromic fiber materials capable of miniaturization and integrating comfortably and compliantly onto the soft and dynamically deforming human body are promising materials for visualized personal health monitoring. However, their development is hindered by monotonous colors, low-contrast color changes, and poor reversibility. Herein, full-color “off–on” thermochromic fluorescent fibers are prepared based on self-crystallinity phase change and Förster resonance energy transfer for long-term and passive body-temperature monitoring, especially for various personalized customization purposes. The off–on switching luminescence characteristic is derived from the reversible conversion of the dispersion state and fluorescent emission by fluorophores and quencher molecules, which are embedded in the matrix of a phase-change material, during the crystallizing/melting processes. The achievement of full-color fluorescence is attributed to the large modulation range of fluorescence colors according to primary color additive theory. These thermochromic fluorescent fibers exhibit good mechanical properties, fluorescent emission contrast, and reversibility, showing their great potential in flexible smart display devices. Moreover, the response temperature of the thermochromic fibers is controllable by adjusting the phase-change material, enabling body-temperature-triggered luminescence; this property highlights their potential for human body-temperature monitoring and personalized customization. This work presents a new strategy for designing and exploring flexible sensors with higher comprehensive performances.
研究领域:
材料科学
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生物医学工程
·
柔性电子
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Ziyue Gao,Minghao Li,Haoxu Yu,Shuai Huang,Faze Chen
Spontaneous liquid transport is increasingly being applied in various fields such as microfluidics, fuel cells, phase change heat transfer, water harvesting, etc. However, long-distance spontaneous liquid transport with path-customizable motion trajectories is still challenging. Drawing multi-inspirations from the wedge-shaped structures of iris petals, the continuous structures of bamboo joints, and the microgroove structures of Nepenthes mouth edge, we fabricate a modular, pump-free biomimetic liquid transport platform by 3D printing and surface modification. The platform is composed of sequential wedge notches, and a crescent-shaped groove is designed at the joint of every two connected wedge structures. The platform is characterized by path-customizable liquid transport trajectories and can be used to achieve long-distance liquid transport without the need of external energy fields, and the multi-level nested structures along the depth significantly facilitates the liquid transport. Experimental study and theoretical force analysis show that the crescent-shaped grooves enable the liquid to overcome joint barriers by converting potential energy accumulated at joints into kinetic energy, achieving a maximum velocity of 18 mm/s. Taking advantage of the flexibility of 3D printing and long-distance transport capability, the modular structure of the platform enables customization of the transport distance and trajectory. By assembling 14 bamboo-like wedge-shaped units in series, we realized a transport distance up to 350 mm, which could be further increased by connecting more units. Furthermore, we develop various modular and multifunctional liquid transport platforms for anti-gravity transport, liquid diversion, and customized transport trajectories, which demonstrate that our design strategy could be an available solution for path-customizable liquids transport in fields like bio-sensing, fuel cells, etc.
研究领域:
微流控技术
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材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Nano Research
·
2021
·Vol. 15
·期 3
·2599-2607
·
IF 8.897
Yuan Zhanhong,Meng Dingding,Wu Yingzhu,Tang Guangqing,Liang Ping,Xin John H.,Ye Dongdong
Because of a weak interface-bonding force between metal-organic frameworks (MOFs) and substrates and the loss of customization in structural designs owing to the lack of the regulation of ion sites, MOFs tend to escape from the constructed composite template. In this study, the as-prepared 2,2,6,6-tetramethylpiperidyl-1-oxyl (TEMPO)-oxidized algae cellulose nanofibers (TACFs) were used to chelate metal ions at controllable sites and subsequently firmly entangle the assembled MOF crystals. The distribution of ions and synthesized MOFs inside the gel was monitored using Raman imaging technology, which provided an intuitive approach for visually observing the ions and MOF distribution. Using this technology, the synthesized customizable TACFs@ZIF-67 aerogels exhibited a high specific surface area (734.7 m 2 /g), low density (6.18 mg/cm 3 ), controlled particle distribution, good underwater structural stability, and excellent adsorption of dyes. This study provides a way for solving the dispersion problem of MOFs in nanofibrous aerogels using Raman imaging technology-assisted microcosmic fixed-point design.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ChemElectroChem
·
2017
·Vol. 5
·期 4
·637-642
·
IF 4.136
Zhaohan Hao,Feng Tao,Zhikui Wang,Ximing Cui,Qinmin Pan
Graphical Self-help : An omni-healable aqueous lithium-ion battery, fabricated by integrating all of the electroactive components into polymer networks cross-linked through dynamic borate ester bonding, can self-repair its electrodes and electrolyte simultaneously after mechanical breakage. It can also be tailored into complicated patterns without significant deterioration in lithium-storage properties. Reliability and safety are critical issues for portable power sources aiming for next-generation electronics. However, most lithium-ion batteries (LIBs) will fail to work or will cause safety problems after physical damage or violent deformation. Here, an omni-healable aqueous LIB, which can self-repair its electrodes and electrolyte simultaneously after mechanical breakage, is fabricated by integrating all of the electroactive components into polymer networks cross-linked by dynamic borate ester bonding. Once suffering from repeated cutoffs, the battery quickly recovers its configuration integrity as well as mechanical and electrochemical properties autonomously without external stimuli. Furthermore, the battery can also be tailored into complicated patterns while maintaining its lithium-storage properties. The present investigation offers a strategy to design a smart and sustainable energy-storage device that has potential applications in wearable/flexible electronics, flexible robot or intelligent apparel, and so on.
研究领域:
材料科学
·
能源存储
·
智能设备
✓ 已验证
DOI
高影响因子
Polymers
·
2017
·Vol. 9
·期 12
·717
·
IF 3.364
Yang Li,Pingxiong Cai,Zhang-fa Tong,Huining Xiao,Yuanfeng Pan
Polyacrylate and guanidine-based nanoparticles which involve acrylate monomers and glycidyl methacrylate modified oligo-guanidine were prepared by a seeded semi-continuous emulsion polymerization. The results from transmission electron microscope and dynamic light scattering measurements showed that the nanoparticles were spherical in shape and the particle size was in the range of 80–130 nm. Antimicrobial experiments were performed with two types of bacteria, Gram-negative (Escherichia coli, ATCC 8739) and Gram-positive (Staphylococcus aureus, ATCC 6538). The as-synthesized cationic nanoparticles exhibited effective antimicrobial activities onEscherichia coliandStaphylococcus aureuswith the minimal inhibitory concentrations at 8 μg/mL and 4 μg/mL, respectively. The mechanism of action of the resulted nanoparticles against these bacteria was revealed by the scanning electron microscopic observation. In addition, the films consisting of latex nanoparticles are non-leaching antimicrobial materials with excellent antimicrobial activity, which indicates the polymers could preserve their antimicrobial activity for long-term effectiveness.Keywords:antimicrobial activity;nanoparticles;tailor-modified;guanidine-based;scanning electron microscope
研究领域:
生物学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Shengchen Lv,Donghui Liu,Xueke Liu,Zhiqiang Zhou,Peng Wang
A novel fluorescent sensor utilizing customized carbon dots (CDs) has been developed for the rapid and efficient detection of the herbicide paraquat. The 4,4′-diamino-2,2′-stilbenedisulfonic acid (DSD acid) functionalized CDs (DSD-CDs) were synthesized by a hydrothermal method using citric acid and L-cysteine as precursors, followed by amidation with DSD acid. The resultant DSD-CDs exhibited bright blue fluorescence upon UV excitation. The fluorescence of the functionalized carbon dots was effectively quenched by paraquat, following a static quenching mechanism as confirmed by fluorescence lifetime measurements. Interestingly, the mechanism study revealed that the excited-state of the DSD-CDs could interact effectively with paraquat, resulting in stronger fluorescence quenching compared to the ground-state. The sensor showed high sensitivity, selectivity, and stability, with a wide linear range of 0.01 ∼ 2 mg/L (R 2 = 0.997) and a low detection limit of 0.003 mg/L. The developed fluorescent sensor demonstrated exceptional potential for paraquat detection in actual samples, encompassing blood, urine, soybean, and river water, with recovery rates exceeding 83 % and relative standard deviations (RSD) below 10 %. This underscores its practical utility in environmental protection and clinical testing applications.
研究领域:
分析化学
·
环境科学
·
生物医学
✓ 已验证
DOI
高影响因子
Advanced Materials Technologies
·
2023
·Vol. 8
·期 18
·2300548
·
IF 6.8
Zongwen Zhang,Chunhui Wang,Yuanping Luo,Changxin Yuan,Wanbiao Hu
It is important but challenging to develop high-performance electromagnetic interference (EMI) shielding materials with customizable structures, tailorable properties, light weight, and high-efficiency EMI shielding effectiveness (SE). Herein, a facile approach is proposed to customize aramid nanofiber (ANF) based EMI shielding aerogels with pre-designed architectures through ultra-malleable ANF jellies. By precisely regulating the interfiber interactions between ANF and constructing a robust 3D skeleton, ANF jelly can be ‘kneaded-frozen-heated’ like dough to produce ultralight, elastic and porous ANF aerogels with special structures, such as aerogel sandwich, spring, fabric, etc. Benefiting from the interconnected porous structure, conductive fillers such as silver nanowires (AgNW) can easily cover the aerogel skeleton by dip-coating to form highly conductive paths. With an ultra-low loading (7.5 wt.%) of AgNW, a 5.2 mm-thick AgNW/ANF aerogel exhibit an average EMI SE of 75.4 dB in the X-band. Aerogels with additional functions can be customized according to the actual application environment. A customized sandwich aerogel with fire-retardant outerlayer and EMI shielding interlayer can be used in high-temperature environments. A flexible aerogel fabric as an EMI shielding gasket can effectively block wireless power transmission. This work provides a forward-looking strategy for constructing high-performance EMI shielding materials with tailored properties.
研究领域:
材料科学
·
电磁学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ChemSusChem
·
2020
·Vol. 13
·期 7
·1906-1914
·
IF 7.962
Yuqi Ke,Jingzhu Zhang,Yuanbang Xie,Qiwei Yang,Qilong Ren,Huabin Xing
Graphical Flex those ABSs : Aqueous biphasic systems (ABSs) based on poly(ionic liquid)s (PILs) were designed and used for the extraction of bioactive compounds. Extraordinary partition coefficients were achieved by customizing the structure of the PILs. The performance of the PIL-based ABSs was tuned by changing the molecular weight and anionic character of the PIL. Ionic liquid (IL)-based aqueous biphasic systems (ABSs) provide a sustainable and efficient alternative to conventional liquid–liquid extraction techniques and can be used for the extraction, recovery, and purification of diverse solutes. However, the construction of a high-performance ABS that has both excellent phase separation ability and extraction performance remains challenging. This study concerns the preparation of a family of novel ABSs based on poly(ionic liquid)s (PILs) with customized structure and controllable molecular weight for the extraction of bioactive compounds. Several tailor-made PILs consisting of a hydrophobic backbone, hydrophilic imidazolium pendant groups and strong hydrogen bonding basic counteranions are prepared by reversible addition fragmentation chain-transfer polymerization. The PILs have a perfect balance of hydrophobicity/hydrophilicity and functionality, affording outstanding phase separation, which was better than with either the IL monomer poly(1-butyl-3-vinylimidazolium bromide ([BVIm]Br) or the normal free-radical polymer P[BVIm]Br*. More importantly, PIL-based ABSs exhibited unprecedented high partition coefficients for six bioactive compounds including tryptophan, phenylalanine, and caffeine, as well as high extraction yields. The performance of the PIL-based ABSs could also be tuned by changing the molecular weight and anionic character of the PILs. This work shows that tailor-made PIL-based ABSs are a promising platform for bioactive compound extraction and provides significant clues for the design of new ABSs for various applications.
研究领域:
化学工程
·
材料科学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2020
·
IF 16.602
Jun-Hong Pu,Xing Zhao,Xiang-Jun Zha,Wu-Di Li,Kai Ke,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang
Wearable flexible electronics are experiencing rapid development for smart life assistance, rehabilitation, and even human enhancement. Owing to the complexity and diversity of wearable and implantable applications, strain sensors with customizable sensing ranges and sensitivities have aroused great interest, while it is still challenging to simultaneously achieve high sensitivity and stretchability. In this work, we report a novel crack design strategy to fabricate sensors for targeted detections via formation of nanocrystal titanium oxide (TiO 2 ) by means of Ti 3 C 2 T x MXene surface oxidation and typical micro- and through-crack pattern sensors for stable large and accurate subtle motion detections are fabricated, respectively. An efficient crack pattern control strategy based on strain localization induced fracture mechanism is proposed. Two typical sensors with a stable sensitivity in a wide sensing range (GF = 1.3 for 0–100% strain) and high sensitivities in small sensing ranges (GF = 530, 3380, 4650, and 75000 in the strain ranges of 0–0.175%, 0.175%–0.45%, 0.45%–3.6%, and 3.6%–5%, respectively) are obtained for large and subtle human motion detection, respectively. This work introduces a new way to fabricate and combinedly use customizable strain sensors for full-range human motion monitoring, addressing the sensitivity-stretchability contradiction issues for conventionally fabricated and solely used strain sensors via strain localization dominated crack control strategy.
研究领域:
材料科学
·
柔性电子
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）