JOURNAL OF PHARMACEUTICAL SCIENCES
·
2019
·
IF 3.197
Xiangjun Shi,Shengjie Song,Zejie Ding,Baibai Fan,Wan Huang,Tiantian Xu
At present, coamorphous systems have attracted increasing interest in the pharmaceutical field owing to their enhanced stabilities, increased solubilities, and improved bioavailabilities compared with those of their pure amorphous and crystalline counterparts. In this study, a novel coamorphous solid form of ibrutinib (IBT) and saccharin (SAC) (1:1 molar ratio) was prepared through rotary vacuum evaporation and then characterized. Differential scanning calorimetry and X-ray powder diffraction indicated the formation of the coamorphous IBT-SAC after rotary vacuum evaporation. Compared with amorphous IBT, coamorphous IBT-SAC exhibited enhanced stability owing to the intermolecular interaction between IBT and SAC. Moreover, the solubility and dissolution of the coamorphous IBT-SAC were increased up to 4.0-7.7 times and 4.3 times, respectively, compared with those of its crystalline Form A. In addition to the superior behaviors of coamorphous IBT-SAC in vitro , the in vivo bioavailability study revealed notable increases in the C max and area under the curve 0-t of the coamorphous form compared with those of its crystalline Form A. The current study demonstrates that the coamorphization of IBT and SAC presents a promising technology to overcome the limitations of solubility and stability that arise from IBT and can therefore contribute to a major improvement in the bioavailability of IBT.
研究领域:
药剂学
·
药物化学
✓ 已验证
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2014
·
IF 4.558
Huachao Ding,Haihua Pan,Xurong Xu,Ruikang Tang
Magnesium ions (Mg2+) are widely present in biological fluids, and they are suggested as the vital factors that inhibit spontaneous hydroxyapatite (HAP) precipitation in nature. However, the regulation mechanisms of Mg2+ on HAP crystallization are still under intensive debates. We find that a typical precipitation of HAP from supersaturated solutions should include five stages: s1, formation of ion clusters and amorphous calcium phosphate (ACP); s2, stabilization of ACP; s3, transformation from ACP to HAP via dissolution and crystallization; s4, classical crystal growth of HAP; s5, HAP aging under a near equilibrium state. Actually, Mg2+ ions exhibit different inhibitory effects on these stages. The ions have a negligible influence on the kinetics of initial ACP formation in solutions (s1) and final aging of crystals (s5). Rather, the ions can either adsorb onto or incorporate into the ACP precursor particles during s1. In s2, the lifetime of ACP in solution is extended significantly by both two types of Mg2+ ions. However, the absorbed ones are more effective than the incorporated ones on the inhibition of the phase transformation from ACP to HAP in this s2. In stages of s3 and s4, it is only surface Mg2+ ions that retard crystal growth of HAP and the incorporated Mg2+ become inert. These detailed findings reveal how Mg2+ ions affect the crystallization process of HAP mineralization from supersaturation. Such a detailed understanding can provide a chemical strategy for precise regulation of HAP formation kinetics in intermediate phase mediated crystallization.
研究领域:
生物材料学
·
矿物学
·
生物化学
✓ 已验证
DOI
高影响因子
Carbon Letters
·
2022
·Vol. 32
·期 3
·893-905
·
IF 3.117
Yang Shuyi,Xing Zhenqiang,E Tao,Liu Lin,Qian Jianhua
Organic reagent is considered as one of the most promising reductants for deeply removing vanadium (V) trichloride oxide (VOCl 3 ) from crude titanium tetrachloride (TiCl 4 ). Nevertheless, indeterminate active component and unclearly removal mechanisms appear to be the obstacles to separate VOCl 3 from TiCl 4 using organic reagent. Herein we conduct the experiment to explore it. Firstly, the organic reagents are obtained from enterprise (noted as EOR 1 –EOR 7 ), and then it is determined that carbon aromatic (C A ) is the active component for removing VOCl 3 . Furthermore, modified organic reagents (noted as MOR 1 –MOR 4 ) are prepared via adding aromatic hydrocarbon oil and stearic acid to EOR 7 , then indicating that MOR 3 is endowed with the best capacity to remove VOCl 3 . In addition, the residues obtained from distillation experiment are comprehensively analyzed (using X-ray diffraction (XRD), transmission electron microscope (TEM) and scanning electron microscope (SEM) etc.), revealing that porous amorphous carbon that deriving from MOR, plays an excellent role in removing VOCl 3 from TiCl 4 system. Therefore, the removal mechanisms can be explained like that porous amorphous carbon reduces VOCl 3 into insoluble vanadium (III) chloride (VCl 3 ) and vanadium (IV) oxide dichloride (VOCl 2 ), and then they are separated via adsorption process, with the help of porous amorphous carbon.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CRYSTAL GROWTH
·
2021
·
IF 1.797
Ming Ma,Bing Zhang,Weipeng Lu,Yihu Wang,Xiaofeng Cao,Yanchuan Guo
Calcium carbonate (CaCO 3 , CC) distributes diversely among the abiotic and biogenic minerals/biominerals. It has six phases (three anhydrous crystalline, two hydrates and one amorphous). Phase selectivity of the synthetic CC is of considerable interest and determines its physicochemical properties and destinated applications. In the present study the reactive crystallization process of CC has been subjected to the treatment of different disturbances, i.e., mechanical stirring (ms), ultrasonication (us), and composed ms + us at lower temperature (0 ± 1℃) and higher supersaturation condition (initial concentration of Ca 2+ is 0.1 M), in comparison with the quiescent condition. In order to gain insight on the role of these disturbances in controlling the crystallization process, nature, crystal habits of precipitated CC and their consecutive phase transformation, samples were collected at different time intervals (30 s, 1 min, 5 min, 10 min, 20 min, 45 min and 60 min) for investigation. Results reveals that these disturbing ways play a significant role on the CC crystallization process and can stabilize the amorphous calcium carbonate (ACC) phase for prolonged periods of time (1–60 min) in aqueous solution, which will be a powerful way for large-scale fabrication of pure ACC nanoparticles (about 100 nm) without addition of any chemicals. Longer disturbing time tends to transform the pure and spherical ACC nanoparticles competitively into spherical vaterite particles and rhombohedral calcite particles through the self-assembly of nanoparticles aggregation or Ostwald ripening mechanism, respectively. The investigation also suggested that the reactive crystallization of CC with the three disturbances undergoes a non-classical crystallization pathway to crystallize CC particles, in comparison with the quiescent reference condition. To the best of our knowledge, the report on reactive crystallization of CC crystallites as a function of different disturbances is first of its kind in the literature.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2019
·
IF 3.073
Kai Yang,Yifan Li,Zejun Zhao,Zhongliang Tian,Yanqing Lai
The amorphous porous layered-Al 2 O 3 derived from aluminium fumarate metal-organic frameworks (AlFu MOFs) by roasting at 773 K under air has been applied to remove fluorine ions from industrial ZnSO 4 solution. The amorphous porous layered-Al 2 O 3 was characterized by XRD, SEM and BET. The adsorption experiments were conducted under different conditions, including adsorbent dosage, initial pH, adsorption temperature and adsorption time. And the process of removing fluorine ions is well fitted with the pseudo-second-order kinetic model and Langmuir isotherm model, which is studied by the adsorption kinetics and isotherms. The theoretical maximum adsorption capacity was 12.05 mg g −1 . Moreover, the adsorption mechanism of the amorphous porous layered-Al 2 O 3 was analyzed by SEM-EDS and FTIR. The results indicate that the adsorption process is affected by complexation and ion exchange between fluorine ions and amorphous porous layered-Al 2 O 3 . The regeneration of the amorphous porous layered-Al 2 O 3 shows that the adsorbent could be reused to reduce the production cost.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Yuan Xia,Xiaohang Zhu,PengPeng Qiu,Mengjie Li,Bo Wang,Guojuan Hai
Titania is considered to be an attractive candidate as anode for sodium ion batteries due to excellent cycle stability, advanced safety features, and small volume deformation in the charge-discharge process. However, limited by sodium storage mechanism, the fast charge and discharge performance of multi-crystals titania is failed to satisfy the requirements of commercial application. Here, we develop a Matryoshka-like carbon nanotubes@anatase nanocrystalline@amorphous carbon (CNTs@aTiO 2 @C) nanofibers for ultrafast sodium ion storage. A nano-confinement coating strategy is demonstrated for constructing an intermediate layer assembled by ultrafine nanocrystalline (2-3 nm) of anatase. The synthesized Matryoshka-like nanofibers with diameters of ∼95 nm consists of amorphous carbon outer layer (10-13 nm), anatase nanocrystalline assembled intermediate layer (13-15 nm), and carbon nanotube core. Benefit from the ultra-refinement of anatase nanocrystalline and Matryoshka-like micro-morphology, the proportion of the capacitive-controlled contribution are up to 90.1 %, 90.6%, 91.9 %, 92.3%, and 93.6% with sweep rate increased from 0.2 to 0.4, 0.6, 0.8, and 1.0 mV s −1 , thus result in an outstanding reversible specific capacities of ∼120 mA h g −1 with Coulombic efficiency of ∼99.5% after long-life of 10000 cycles at ultrafast rate of 10 A g −1 .
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2021
·
IF 3.534
Yiru Wang,Yudan Fang,Feng Zhou,Qi Liang,Yueyi Deng
HPMCAS-HF, HPMCAS-MF and HPMCAS-LF were used as carriers to prepare the amorphous solid dispersions (ASDs) of quercetin (Que) by co-precipitation. The Que ASD based on PVP K30 was prepared by solvent evaporation method. The ability of polymer to inhibit Que crystallization was evaluated. The study found the order of the ability of polymer to inhibit Que nucleation to be: HF > MF > LF > K30, and that to maintain Que supersaturation to be: HF > K30 > MF > LF. The prepared solid dispersions were characterized by IR, DSC and PXRD. Although HF was the most effective crystallization inhibitor, the release of the Que/HF ASD was poor and assigned to the carrier-controlled dissolution for the strong interactions between Que and HF. The Que/MF ASD exhibited better dissolution behavior compared to the Que/K30 ASD. The dissolution behavior of the Que ASD depended on the polymer-Que interactions and the ability of crystallization inhibition of the polymer.
研究领域:
药剂学
·
药物传递系统
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shuo-Hang Zheng,Xiao-Tong Wang,Zhen-Yi Gu,Hong-Yan Lü,Shuying Li,Xin-Yi Zhang,Jun-Ming Cao,Jin-Zhi Guo,Xing-Long Wu
Due to the rapid increase in the number of spent lithium-ion batteries, there has been a growing interest in the recovery of degraded graphite. In this work, a rapid thermal shock (RTS) strategy is proposed to regenerate spent graphite for use in lithium-ion batteries. The results of structural and morphological characterization demonstrate that the graphite is well regenerated by the RTS process. Additionally, an amorphous carbon layer forms and coats onto the surface of the graphite, contributing to excellent rate performance. The regenerated graphite (RG-1000) displays excellent rate performance, with capacities of 413 mAh g −1 at 50 mA g −1 and 102.1 mAh g −1 at 1000 mA g −1 , respectively. Furthermore, it demonstrates long-term cycle stability, maintaining a capacity of 80 mAh g −1 at 1000 mA g −1 with a capacity retention of 78.4 % after 600 cycles. This RTS method enables rapid and efficient regeneration of spent graphite anodes for lithium-ion batteries, providing a facile and environmentally friendly strategy for their direct regeneration.
研究领域:
材料科学
·
环境科学
·
能源技术
✓ 已验证
DOI
高影响因子
TRIBOLOGY INTERNATIONAL
·
2020
·
IF 4.271
Jiasheng Hu,Yujuan Zhang,Guangbin Yang,Chuanping Gao,Ningning Song,Shengmao Zhang,Pingyu Zhang
Forming carbon based tribo-film in situ is an environmentally friendly and efficient way to solve the boundary lubrication problem. In this paper, the cubic nickel nanoparticles (average particle size 21.3 nm) modified by oleylamine were used as additives of poly-alpha-olefin (PAO6) for extreme pressure (EP) lubrication between bearing steel and stainless steel. It was found that in the range of 1.4–2.2 GPa contact pressure, nickel nanoparticles can catalyze the carbonization of PAO6 on the friction surface, which reduced the wear rate by 94%, the friction coefficient (COF) by 79%, and can withstand the extreme pressure friction of 4.2 GPa. XPS , EDS, TEM and FIB were used to analyze the microstructure, composition and chemical state of tribo-film. The tribo-film is composed of oxide layer, concrete structure layer and amorphous carbon layer. The oxide layer formed by oxidation of steel surface produced better binding force with the steel substrate. Nickel nanoparticles catalyze the carbonization of PAO6 to form a concrete structure with nickel nanocrystals embedded in the amorphous carbon phase, which provides high bearing capacity. The carbon layer graphitizes under the friction induction to form a lubricating layer with low friction characteristics. Oleylamine modified nickel nanoparticles is expected to be widely used as an environmentally friendly EP additive .
研究领域:
材料科学
·
摩擦学
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Meng Ning,Guojian Qiu,Xinying Wang,Bingbing Li,Zhenghui Li,Haiyan Zhang
Although great progress has been made in carbon anodes for potassium-ion batteries, the development of advanced carbon anodes with fast reaction kinetics and high cycle stability is still a great challenge due to the large radius of K + (0.138 nm). In this work, novel ultrathin carbon nanosheets (UCNs) fabricated by vapor-induced bubbling strategy are reported to address current challenge. The results show that the UCNs are composed of 3D interconnected 30 nm-thick sheet units with well-developed hierarchical micro-/meso-/macro-pores, which can not only increase the contact area between electrode/electrolyte, but also effectively buffer the volume expansion caused by the (de)potassiation. In addition, UCNs have a carbon composite structure of intertwined pseudo-graphite domains and amorphous carbon domains, providing abundant storage active sites and fast transport channels for K + . Specifically, the UCN-1300 delivers a K + storage capacity of ≈350 mAh g −1 at a current density of 0.05 A g −1 . Moreover, it presents excellent cycle stability, maintaining a capacity of 120 mAh g −1 after 5000 cycles at a current density of 5 A g −1 , with a capacity retention rate of more than 99%. In prior reports, carbon anodes demonstrating such a high K + storage capacity and outstanding cycle stability are rarely obtained.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Junjie Liu,Ning Qi,Bo Zhou,Zhiquan Chen
A series of amorphous melamine-based polymer networks synthesized by Schiff base chemistry (SNW) were successfully prepared by varying the strut length. The pore structure was analyzed by gas adsorption and positron annihilation methods. Positron lifetime measurements indicate the existence of ultramicropores and also larger mesopores in the SNW materials. The sizes of micropores and mesopores are almost the same in these samples, which are about 0.7 and 16.5 nm, respectively. The relative number of micropores increases in the order of SNW-1 < SNW-2 < SNW-3, while the number of mesopores increases in the reverse order. N2 adsorption/desorption measurements also reveal micropores and mesopores in these materials. However, it gives an underestimation of the micropore volume. Benefiting from the abundant nitrogen content and high microporosity, the SNW materials exhibit exceptionally high CO2 capture ability, which reaches a maximum value of 18.3 wt % in SNW-3 at 273 K and 1 bar, followed by SNW-2 and SNW-1. This order is exactly the same as the order of micropore volume revealed by positron annihilation measurement, suggesting that micropores play a crucial role in the CO2 uptake. Our results show that positron can provide more precise information about the structure of micropores and thus can offer an accurate prediction for the adsorption capacity of complex porous materials.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
Small
·
2019
·Vol. 16
·期 5
·1905736
·
IF 10.856
Donglin He,Ping Li,Wei (Alex) Wang,Qi Wan,Jian Zhang,Kai Xi,Xiumei Ma,Zhiwei Liu,Lin Zhang,Xuanhui Qu
Although silicon-based materials are ideal candidate anodes for high energy density lithium-ion batteries, the large volumetric expansion seriously damages the integrity of the electrodes and impedes commercial processes. Reasonable electrode design based on adjustable structures of silicon and strong binders prepared by a facile method is still a great challenge. Herein, a three-pronged collaborative strategy via hollow nanocubes, amorphous Void@SiO x @C, and in situ cross-linked polyacrylic acid and d -sorbitol 3D network binder (c-PAA-DS) is adopted to maintain structural/electrode integrality and stability. The all-integrated c-PAA-DS/Void@SiO x @C electrode delivers excellent mechanical property, which is attributed to ductility of the c-PAA-DS binder and high adhesion energy between Void@SiO x @C and c-PAA-DS calculated by density functional theory. Benefiting from the synergistic effect of accommodation of the hollow structure, protection of outer carbon shell, amorphous Void@SiO x @C, and strong adhesive c-PAA-DS binder, c-PAA-DS/Void@SiO x @C shows excellent electrochemical performance. Long cycling stability with a reversible capacity of 696 mAh g −1 is obtained, as well as tiny capacity decay after 500 cycles at 0.5 A g −1 and high-rate performance. The prelithiated Void@SiO x @C||LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM523) full cell is also assembled and shows a reversible capacity of 157 mAh g −1 at 0.5 C, delivering an excellent capacity retention of 94% after 160 cycles.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）