JOURNAL OF CHROMATOGRAPHY A
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2020
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IF 4.049
Siqi Zhuo,Yan Liu,Wei Li,Zhi Ding,Mingda Li,Qianjin Li,Xin Wang,Jie Liu,Rui Shao,Qianqian Ling,Tiesong Zheng,Jianlin Li
Ordered porous materials are attracting enormous attention due to their uniform pore structures, particularly the magnetic photonic crystal microspheres (PCMs) which not only possess unique photonic crystal structure but also can achieve separation easily based on magnet. Here, a two-phase microfluidic self-assembly synthetic system was established simply and employed for the preparation of three dimensional PCMs (3DPCMs) by using the emulsion droplet approach. One phase (dispersed phase) was an aqueous emulsion containing Fe 3 O 4 , silica (SiO 2 ) and polystyrene (PS) nanoparticles; another phase (continuous phase) was pure silicone oil. The droplets were formed by introducing the dispersed phase into the continuous phase through a tee valve. By heating the droplets, the water would evaporate and the nanoparticles would finally assemble into solid microspheres, which could be changed into macroporous 3DPCMs after removal of the PS nanoparticles by calcination. The contents and particle sizes of Fe 3 O 4 , SiO 2 and PS nanoparticles in the dispersed phase were investigated in detail and optimized to prepare macroporous magnetic 3DPCMs with high quality. The morphologies, surface crystal structure, magnetic property, particle size distribution, specific surface area and pore size of the macroporous magnetic 3DPCMs were characterized. The expected 3DPCM displayed regular and uniform photonic crystal structure, narrow particle size distribution and strong magnetic property. The macroporous magnetic 3DPCMs grafted with vomitoxin (DON)-antibodies could be applied for selective enrichment of DON in real samples.
研究领域:
材料科学
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分析化学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Science Bulletin
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2024
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IF 18.8
Zhenghao Zhang,Zekai Zhang,Junyu Hou,Yiyue Zhao,Jia Jia,Jiwei Wang,Jie Zhao,Cheng Lian,Angang Dong,Dongyuan Zhao,Wei Li
Hierarchical organization is prevalent in nature, yet the artificial construction of hierarchical materials featuring asymmetric structures remains a big challenge. Herein, we report a stress-induced self-assembly strategy for the synthesis of hierarchically twisted stripe arrays (HTSAs) with mesoporous structures. A soft and thin mesostructured film assembled by micelles and TiO 2 oligomers is the prerequisite. Then, the external stress coming from the exfoliation process triggers the deformation of this mesostructured film into hierarchically twisted structures. The stripe width and twist degree can be well manipulated by adjusting the cross-linking degree and thickness of the mesostructured films. Furthermore, this strategy is facile and versatile to synthesize HTSAs with diverse components, including carbon, Al 2 O 3 and ZrO 2 . We find that mesoporous TiO 2 HTSAs can serve as an ideal integrator for adsorption-enrichment-detection process, exhibiting a rapid and high adsorption capacity towards molecules at low concentrations and enabling the subsequent surface-enhanced Raman scattering (SERS) detection. Such twisted stripe arrays achieve 2.3-fold and 5.6-fold enhancements in SERS compared with flat surfaces and solution conditions, respectively, due to the increased Raman scattering among the hierarchical, twisted, and mesoporous structures.
研究领域:
材料科学
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纳米技术
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化学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
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2025
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IF 6.7
Shengmao Chao,Xueqing Wang,Fan Li,Hong Shao,Changyu Tang,Meikun Fan
Phthalate esters (PAEs), prevalent plasticizers used extensively in packaging materials, pose significant environmental and health risks. Addressing the challenge of their trace detection, we introduce a dual-functional superhydrophobic sponge (Ag NPs@rGO/PU) that seamlessly integrates sample enrichment and ultrasensitive surface-enhanced Raman scattering (SERS) analysis. This platform (Ag NPs@rGO/PU) combines superhydrophobicity, strong adsorption capacity, and high SERS sensitivity for rapid quantification of trace PAEs in plastic bottled water. The composite was fabricated by photochemical reduction of Ag NPs@GO anchored on polyurethane (PU) foam, enabling efficient reduction of GO and formation of densely distributed plasmonic hotspots. The resulting material exhibited excellent superhydrophobicity (>150°), rapid adsorption kinetics (<80 s), and robust cyclic adsorption capability (>100 cycles). Furthermore, combining SERS with principal component analysis (PCA) enables accurate classification and quantitative analysis of six structurally similar PAEs even in complex mixtures with ultralow detection limits down to 1 × 10–10 M and linear response (R2 ≥ 0.98). Practical applicability was demonstrated by successfully identifying and quantifying trace PAEs in commercial bottled water, uncovering significant migration under high-temperature storage conditions. This platform not only advances the analytical performance for trace contaminant detection but also offers a versatile tool with substantial implications for environmental safety monitoring and protection of public health.
研究领域:
环境分析化学
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食品安全
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纳米材料
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表面科学
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光谱学
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污染物监测
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产品关联
DOI
PubMed
高影响因子
LAB ON A CHIP
·
2023
·Vol. 23
·期 10
·2469-2476
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IF 6.1
Xinyu He,Junyan Xu,Xiaoli Wang,Chuang Ge,Shunbo Li,Li Wang,Yi Xu
In this paper, a multifunctional microfluidic chip integrated with a centrifugal separation zone, aqueous two-phase system (ATPS) mixing zone and enrichment detection zone was proposed and fabricated. An automatic and efficient separation and quantitative analysis method for vascular endothelial growth factor 165 (VEGF165) in whole blood samples was established with the designed microfluidic chip. A blood sample was divided into blood cells and plasma in the centrifugation zone. In the ATPS mixing zone, plasma was mixed with PEG/KH2PO4 aqueous two-phase solution containing Apt–Au NP nanoprobes. In the enrichment detection zone, the mixture was separated on CN140 modified with a ZnO NP–anti VEGF165 nanostructure. The VEGF165 captured by Apt–Au NPs was distributed in the PEG phase, concentrated at the front of CN140 and combined with anti-VEGF165 to form a sandwich structure. The sensitive detection of VEGF165 was achieved through fluorescence resonance energy transfer between rhodamine B and Au NPs on the nanoprobe. Under the optimized rotation program, capillary and centrifugal forces propelled the fluid in the whole process of pretreatment and detection. The detection linear range was between 1 pg mL−1 and 50 ng mL−1, the detection limit of VEGF165 in blood was 0.22 pg mL−1 and the enrichment efficiency was 983. It was illustrated that a convenient and reliable way for detection of tumor markers based on the multifunctional microfluidic chip was provided and it has a potential value for early screening and prognosis of clinical cancer.
研究领域:
生物医学工程
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分析化学
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癌症研究
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分子生物学
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产品关联
DOI
PubMed
高影响因子
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