JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Wenfeng Huang,Yufeng Wei,Xiaocong Liu,Ruonan Li,Qiuxiang Yin,Lihong Jia
The equilibrium solubility of quetiapine fumarate was determined in twelve individual solvents and one binary solvent mixture by the gravimetric method at atmospheric pressure over a temperature range of 283.15–323.15 K. The results showed that the solubility increases with increasing temperature in all selected solvents. The solubility order is tetrahydrofuran–water (mole fraction of tetrahydrofuran 0.8083) > tetrahydrofuran > n-propanol > dichloromethane > butanone > methyl isobutyl ketone > xylenes > ethyl formate > tert-butyl methyl ether > isopropyl acetate > toluene > hexane ≈ heptane. The modified Apelblat model, λh model, nonrandom two-liquid model, and van’t Hoff–Jouyban–Acree model were employed to correlate the experimental solubility. The four models provided satisfactory fits, as confirmed by the average relative deviation and the root-mean-square deviation. The modified Apelblat model showed the best performance among them. The accurate solubility data are essential for the design and optimization of the crystallization process of QF.
研究领域:
药学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Chemistry-An Asian Journal
·
2025
·
IF 3.3
Tao Zhao,Xue Wang,Jiacheng Li,Chunqi Wang,Aziz Bakhtiyarovich Ibragimov,Junkuo Gao,Xiaogang Yang
Efficient extraction of uranyl ions from seawater is crucial for the commercialization of nuclear technology. Metal-organic frameworks (MOFs), with their superior uranium extraction properties, face challenges in large-scale applications due to their powdery nature and the difficulty of assembling them into mechanically stable macroscopic composites. To address this, successfully synthesized 90 wt% nanoMOF (aluminum fumarate) loaded directional aerogels (AlFA-3-10) using polyvinyl alcohol (PVA) as an adhesive, which demonstrates robust strength longitudinally and transversely. Our uranium adsorption experiments reveal that at a pH of 8 (akin to that of seawater), the AlFA-3-10 achieves a maximum adsorption capacity of 1146.25 mg g-1, maintaining this exceptional performance over five cycles. Notably, in simulated seawater, AlFA-3-10 exhibits high selectivity for uranyl ions with minimal interference from other ions. The directional pores within AlFA-3-10 facilitate fluid transmission and exchange, ensuring optimal contact between the MOF and uranyl ions, thereby enhancing electrostatic attraction and electron transport for improved capture efficiency. This streamlined approach maximizes the intrinsic potential of nano-MOFs and heralds a new era for their integration into macroscopic composite materials.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Ziyang Cheng,Hao Sun,Yinghui Xu,Naixin Wang,Quan-Fu An
Pervaporation has emerged as a promising technology for the separation of methanol azeotropes. However, developing membrane material to enhance the separation performance remains crucial. In this study, aluminum fumarate (Al-fu) particles were successfully incorporated into polyvinyl alcohol (PVA) via in-situ growth method, creating mixed matrix membranes (MMMs) on a porous polyacrylonitrile substrate. These Al-fu MMMs were then used for the separation of the methanol azeotropes. Compared to pure PVA membranes, the Al-fu MMMs exhibited a significant increase in both the separation factor and flux when separating a 20/80 wt% methanol/dimethyl carbonate mixture at 40 °C. The separation factor increased from 9.2 to 13.2, while the flux increased from 376.8 g·m −2 ·h −1 to 928.2 g·m −2 ·h −1 . This enhancement can be attributed to the synergetic effects of size sieving through the pore windows and preferential adsorption of polar solvent molecules by the Al-fu MMMs. Furthermore, the low cost of both Al-fu and PVA, coupled with the facile membrane preparation process, renders this strategy economically viable and practical. Consequently, this approach offers a promising avenue for the development of efficient pervaporation membranes for the separation of azeotropic mixtures.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENERGY
·
2022
·
IF 8.857
Yudong Ding,Lijiao Ma,Fengqi Zeng,Xingxing Zhao,Hong Wang,Xun Zhu,Qiang Liao
As a promising CO 2 adsorbent, Aluminum Fumarate (AlFu) metal organic frameworks (MOFs) were explored for pelletizing technology and CO 2 adsorption characteristics. The effects of binder type (sodium carboxymethylcellulose (CMC), aluminum sol (AS)) and content (2.5 wt%-20 wt%), CO 2 partial pressure (0.3 bar–1 bar) and temperature (35 °C–65 °C) on the mechanical performance and adsorption process were investigated. The results revealed that with the increase of binder mass, the pellet mechanical strength rose while the CO 2 adsorption amount decreased. The AlFu pellet with 2.5 wt% CMC could retain the powder porosity and adsorption capacity . The mechanical strength of AlFu@CMC-2.5 wt% achieved 1.486 MPa, and the maximum adsorption capacity was 1.26 mmol/g at 35 °C and 1.0 bar. The CO 2 adsorption capacity was increased with lower adsorption temperature and higher CO 2 partial pressure. Compared with pseudo second order model and pseudo first order kinetic model , Avrami kinetic model could better describe the CO 2 adsorption behavior of AlFu pellet. It indicated that the adsorption process was not a single physical or chemical adsorption . The rate-limiting kinetic analysis showed that the CO 2 adsorption rate was determined by film diffusion and intraparticle diffusion rather than inter-particle diffusion.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2023
·
IF 3.6
XiaoNan Zhang,WenQin Xu,Xing Li,GuangHua Pan,NanChun Chen,QingLin Xie,XiuLi Wang
This experiment was done to study the zeolite molecular sieve as a drug-binding effector, the non-antibiotic drug potassium diformate uniformly disperse in the internal aqueous phase of the 'egg box' structure formed by pectin-calcium ions. With oil phase as the intermediate phase and Xanthan gum Chitosan as the external water phase, the W/O/W type sustained release bacteriostatic microcapsules with pH response were prepared and characterized by Fourier transform infrared, thermogravimetric, SEM, and TEM. It can be obtained through characterization experiments that the inner water phase, oil phase, and outer water phase were formed by observation, and W/O/W emulsion microcapsules were obtained and the bacteriostasis effect of microcapsules was verified by bacteriostasis experiment. The permeance experiment showed that the molecular sieve was successfully coated in the microsphere. Studying on drug release mechanism and sustaining release performance of composite emulsion microcapsules. In vitro drug release study showed that the encapsulation efficiency and drug loading rate of microcapsules were improved by adding molecular sieve, reaching 12.31% and 61.55%, respectively. At the same time, we observed that the drug release rate slowed down during the simulated intestinal release process, and the drug release kinetics were in line with the first-order kinetic model and Ritger-Peppas model equation. Experiments had proven that the drug-loaded microcapsules exerted a significant bacteriostatic effect on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis, with the highest antibacterial rates of 97.25%, 94.05%, and 95.93%, respectively. Therefore, the composite emulsion microcapsules can be used as a new controlled-release drug delivery system in vivo.
研究领域:
药物递送系统
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2015
·
IF 3.391
Tian Gan,Zhaoxia Shi,Danyang Hu,Zhen Lv,Junyong Sun,Yanming Liu
In this paper, we report a facile route to synthesize yolk–shell structured copper oxide@silica oxide (CuO@SiO 2 ) spheres and their application to construct an electrochemical Formoterol fumarate (FF) sensor. The CuO@SiO 2 was characterized by means of Fourier transform infrared spectroscopy, X-ray powder diffraction, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy. Further, FF was electrocatalytically oxidized at the CuO@SiO 2 film modified glassy carbon electrode (GCE), which led to a sensitive determination of FF. The oxidation current of FF was linear with concentration in the range of 0.030–10 μM and the detection limit was found to be 5.0 nM (S/N = 3). The observed analytical parameters such as wide linear range, low detection limit and short response time were superior to previously reported FF sensors. Finally, it was demonstrated that the proposed sensor could be used for the selective determination of FF present in swine feed and tissues.
研究领域:
材料科学
·
电化学
·
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF DAIRY SCIENCE
·
2025
·
IF 4.4
Huixin Dong,Xintong Zhang,Shuaishuai Li,Jingbo Ma,Jun Zhang,Hongyang Chen,Yudith lamothe Crespo,Junhu Yao,Zongjun Li
The objective of the current study was to evaluate the short-term effects of fumarate and active dry yeast (ADY) on ruminal fermentation, methane (CH 4 ) emissions, microbiota (composition and function), apparent total-tract digestibility, production performance, and blood metabolites in dairy goats using a 2 × 2 factorial design. Twenty-eight primiparous dairy goats were blocked and randomly assigned to 1 of 4 treatments: (1) control; (2) fumarate supplied at 34 g/d; (3) ADY supplied at 1.5 g/d; and (4) fumarate and ADY supplied in combination. The treatments lasted for 38 d. The results showed that fumarate supplementation reduced CH 4 production (L/d), yield (L/kg DMI), and intensity (L/kg milk yield) by 11.3%, 15.5%, and 21.9%, respectively, without affecting DMI, milk yield, or apparent nutrient digestibility. However, the CH 4 -depressing effect of fumarate began to decline 3 h postprandially and gradually diminished thereafter. Additionally, fumarate supplementation increased FCM with a higher NE L while reducing the ADG of goats with a lower NE G , resulting in no overall change in the net energy available for production. Fumarate supplementation also increased ruminal pH but reduced total VFA concentrations and microbial α diversity. Although fumarate did not alter the ruminal microbial structure at the genome or gene level, it stimulated the growth of fumarate- and lactate-utilizing bacteria, which may contribute to CH 4 mitigation and raise rumen pH. Supplementation with ADY increased the NE L and the molar proportion of ruminal butyrate and tended to increase CH 4 production and FCM without affecting CH 4 yield or intensity. Most of the blood metabolites and enzymes influenced by fumarate were involved in the tricarboxylic acid (TCA) and the urea cycles. Fumarate reduced the substrate concentrations of the TCA cycle (e.g., glucose, malondialdehyde) and the urea cycle (e.g., ammonia) in blood, but it increased the end products of the urea cycle (BUN, MUN) and enhanced the activity of malate dehydrogenase, a key enzyme in the TCA cycle. These findings indicate that fumarate can reduce enteric CH 4 emissions and enhance the TCA and the urea cycles in host animals.
研究领域:
畜牧学
·
反刍动物营养
·
甲烷减排
·
微生物学
·
代谢组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHROMATOGRAPHIA
·
2023
·Vol. 86
·期 3
·213-222
·
IF 1.7
Lin Li,Huang Lingyi,Ke Yanbing,Xu Xiaowen,Huang Liying
This study aims at developing a high-performance liquid chromatography–mass spectrometry (LC–MS) method to analyze tenofovir disoproxil fumarate (TDF) and its pharmaceutical preparations. Several cyclodextrin mobile-phase additives were applied to reversed-phase and normal-phase chromatography, and the effects of three chiral stationary phases on the TDF separation were investigated in this study. The R-type and S-type of TDF tablets were quantitatively analyzed in the single ion monitoring (SIM) scanning mode with a Unichiral CMD column. This method has been successfully applied to the separation and quantification of TDF and its isomers. The linear ranges of (R)-TDF and (S)-enantiomer were 1–20 and 0.2–16 μg/mL, respectively. The limit of detection for (R)-TDF and (S)-enantiomer was 0.0015 and 0.0012 μg/mL, respectively. (S)-enantiomer was not detected in the formulas from all the seven manufacturers, and the drug content of each took more than 98.5% of the labeled amount, which complies with the regulations. The method shows its advantages on high sensitivity, low detection limit, good practicability, and repeatability. The proposed method may provide a novel platform for separation of TDF enantiomers and quality control of TDF raw materials and preparations.
研究领域:
分析化学
·
药学
·
色谱学
·
质谱学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Yanbo Liu,Xiaolei Wang,Chenyang Zhao,Shuo Wang,Xiaogang Lian,Weiqi Chen,Lei He,Mingyang Chen,Songgu Wu,Junbo Gong
Tenofovir amibufenamide fumarate (TMF) is the first oral drug developed in Asia for the treatment of adult patients with chronic viral hepatitis B, however, further applications are limited by poor tableting performance and high sticking propensity. In this work, the spherulitic growth process of TMF has been designed and explored with the help of molecular dynamics simulation and process analysis technologies (ATR-FTIR, FBRM and EasyViewer). The spherical particles with high bulk density, good flowability and uniform particle size distribution are prepared by a simple quenching process. More importantly, experimental results show that spherical particles have higher average tensile strength (100.8% increase), higher plastic deformability and lower amount of punch sticking (87.4% decrease in 30 tablets) compared to the commercial powder products. These contributions not only shed light on the design principle of drug spherulitic growth processes, but also provide guidance for the manufacture of high-quality tablet products.
研究领域:
药学
·
结晶工程
·
材料科学
·
药物开发
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）