JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Can Hong,Yiming Liu,Dingwen Shi,Chao Liu,Shidong Zou,Mengqin Guo,Xingyu Chen,Chuansheng Zheng,Yanbing Zhao,Xiangliang Yang
Radiofrequency-responsive nanoparticles (RFNPs) have drawn increasingly attentions as RF energy absorbing antenna to enhance antitumor efficacy of radiofrequency ablation (RFA). However, it remains a huge challenge for inorganic RFNPs to precisely synergize RFA with other antitumor modes in a clinically acceptable way on bio-safety and bio-compatibility. In this work, RF-responsive black phosphorus (BP) nanogel (BP-Pt@PNA) was successfully fabricated by crosslinking coordination of cisplatin with BP and temperature sensitive polymer PNA. BP-Pt@PNA exhibited strong RF-heating effect and RF-induced pulsatile release of cisplatin. Under RF irradiation, BP-Pt@PNA exhibited cytotoxic enhancement on 4T1 cells. By the synergistic effect of BP and cisplatin, BP-Pt@PNA achieved RF-stimulated systemic immune effect, thus induced enhance suppression on tumor growth and metastasis. Moreover, BP-Pt@PNA realized long-term drug retention in tumor and favorable embolization to tumor-feeding arteries. With high drug loading capacity and favorable bio-safety and bio-degradability, BP-Pt@PNA is expected as an ideal RFNP for precisely synergizing RFA with other antitumor modes in clinical application.
研究领域:
纳米技术
·
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2024
·
IF 5.6
Lihui Zhang,Jialing Zhu,Shaojin Wang,Long Chen,Zihan Song,Lei Zhang,Haile Ma
Effectively controlling molds in dried shiitake mushrooms is important for food industry to maintain the product quality. To improve the edible safety of shiitake mushrooms, this study applied radio frequency (RF) energy combined with natamycin to inactivate Aspergillus niger spores, and evaluate the quality changes after the treatment. The results showed that the population of A. niger spores in shiitake mushrooms with different moisture contents (MCs) could achieve a 5-log (CFU/g) reduction after the combined treatment at different temperatures. Weibull distribution ( R 2 = 0.978 to 1.000) provided a better fit for the inactivation kinetics of A. niger spores than Linear model ( R 2 = 0.954 to 0.990) and Logistic one ( R 2 = 0.953 to 0.988). Meanwhile, the three-dimensional inactivation curves were constructed based on the sample MCs, RF heating time, and holding time. In addition, the MCs of treated shiitake mushrooms decreased by 4.12%–7.66% (w.b.) after natural cooling, achieving synchronous drying. There was no significant difference in textural properties of shiitake mushrooms after the combined treatment. The changes in color, structure, rehydration ratio, and total sugar content were affected by the treatment time and temperatures. As one of the main aroma substances, the content of sulfur-containing compounds in shiitake mushrooms after treatment increased compared to that of the control samples. This study indicates that the combination of RF energy and natamycin is feasible for inactivating pathogens in shiitake mushroom and ensuring the safety of their consumption.
研究领域:
食品科学
·
微生物学
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产品关联
DOI
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2022
·Vol. 46
·期 10
·e16921
·
IF 2.609
Jianghong Wu,Min Zhang,Liqing Qiu,Yaping Liu
In the condiment industry, people usually use enzymatic hydrolyzate to improve the umami of the product, and there are few reports on the umami intensity of the enzymatic hydrolysate. To explore the differences in taste and flavor of the samples pretreated with different physical fields, the chicken was pretreated by ultrasound (US, 600 W, 30 min), infrared radiation (IR, 90°C, 30 min), and radio frequency (RF, 120 mm, 30 min), respectively, and followed by a two-step enzymatic hydrolysis. Results revealed that the chicken enzymatic hydrolyzate after RF pretreatment (120 mm, 30 min) had the best overall taste and stronger umami. The sample treated with 90°C IR has a richer flavor, while there were no significant changes in taste of the 600 W ultrasound treatment group compared with the “control.” Therefore, RF pretreatment (120 mm, 30 min) is more suitable for industrial to produce low cost and high umami chicken enzymatic hydrolyzates. Practical applications In the condiment food industry, people usually use umami-rich enzymatic hydrolysates to improve the umami taste of products. The 120 mm plate spacing radio frequency pretreatment proposed in this study for 30 min before enzymolysis can significantly improve the taste characteristics of the chicken enzymolysate, significantly enhance its saltness and umami, and make the overall taste more harmonious. It provides a certain theoretical basis for the industrial production of low-cost umami-enhancing enzymatic hydrolysis products.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2017
·
IF 4.529
Zhenna Zhang,Juan Wang,Xueying Zhang,Qingli Shi,Le Xin,Hongfei Fu,Yunyang Wang
This paper is focused on the effects of radio frequency (RF) heating on the relative activity of polyphenol oxidase (PPO), weight loss, texture, color, and microstructure of potatoes. The results showed that pure mushroom PPO was almost completely inactivated at 80 °C by RF heating. The relative activity of potato PPO reduced to less than 10% with increasing temperature (25–85 °C). Enzyme extract showed the lowest PPO relative activity at 85 °C after RF treatment, followed by the potato cuboids and mashed potato, about 0.19 ± 0.017%, 3.24 ± 0.19%, and 3.54 ± 0.04%, respectively. Circular dichroism analysis indicated that RF heating changed the secondary structure of PPO, as α-helix content decreased. Both electrode gap and temperature had significant effect ( P < .05) on weight loss, color, and texture of the potato cuboids. Microstructure analysis showed the changes of potato cell and starch during RF heating.
研究领域:
食品科学
·
食品工程
·
生物物理学
·
酶学
·
农产品加工
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Ling Li,Hongsen Zhang,Hao Zhao,Dingwen Shi,Chuansheng Zheng,Yanbing Zhao,Xiangliang Yang
Improving the synergistic effect of radiofrequency ablation (RFA) and trans -artery chemo-embolization (TACE) remains the main challenge in interventional cancer therapy. The present study reports cisplatin-crosslinking poly( N -isoprylacrylamide- b -methyl acrylic acid) nanogels (Pt-PNA) based on the RF-thermal effect of cisplatin as the RF-responsive embolic nano-platform that acts via coordination bonding between Pt(II) ions and carboxyl, thereby triggering cell apoptosis, necrosis, and metastasis inhibition. Moreover, Pt-PNA might diffuse rapidly into tumor peripheral arteries and block the tumor blood supply facilitated by temperature-sensitive sol–gel transition, thereby achieving efficient TACE cancer therapy. The antitumor efficacy exhibited in vivo by Pt-PNA indicated that the radiofrequency-responsive Pt-PNA greatly improved the hypoxic tumor microenvironment after the TAE procedure, thereby inducing a favorable immune response and enhancing the synergistic antitumor effect of RFA and TACE.
研究领域:
医学
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生物材料学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Lu Ju,Buyun Yu,Hao Chen,Zhida Xiao,Wei Xiang,Junlin Zhan,Chao Zhang,Zhenguo Liu,Li Tao,Weibing Lu
As a noncontact target recognition technique, radio-frequency identification (RFID) technology demonstrates attractive potential in constructing human–machine interaction (HMI) systems. However, the current development of RFID technologies in HMI systems is hampered by critical challenges in manufacturing high-performance RFID readers with superior flexibility and wearing comfort. Hence, we propose a multilevel printing strategy to overcome the difficulties in manufacturing high-performance large-scale microwave systems. Compared to traditional processes, the RFID system fabricated by the hybrid additive manufacturing technique exhibits equivalent electromagnetic performance and has obvious advantages in terms of manufacturing cost and environmental friendliness. A printed reconfigurable antenna with intelligent radiation mode is seamlessly integrated with the reader circuit via a “one-step” printing technology. Additionally, through chemical doping and artificial intelligence (AI) prediction, we have developed a modified polydimethylsiloxane (PDMS) encapsulation to miniaturize the system volume and enhance reliability. Electromagnetic and mechanical measurements demonstrated that our flexible RFID platform offers superior reliability and stability during long-term daily use. The RFID platform possesses exceptional capabilities in target positioning and accurate identification, demonstrating unique potential in noncontact sensing and recognition, which are highly demanded by flexible and wearable HMI systems.
研究领域:
电子工程
·
材料科学
·
人工智能
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
·
2012
·
IF 1.207
Changjuan Guo,Zhongyao Jiang,Chunguang Xie,Hui Zhu,Wei Gao,Zhengxu Huang,Ping Cheng,Zhong Fu,Zhen Zhou
According to the demand of home-made spectrometer, a radio frequency (RF) signal driver was developed. This RF signal driver is composed of signal generating circuit, signal amplification circuit and power output circuit, to drive the radio frequency quadrupole (RFQ). The designed RFQ is used to transfer ions generated in atmospheric pressure ion source to a home-made desktop orthogonal-injection time-of-flight mass analyzer. This signal driver is divided into low-frequency part and high-frequency part to support RFQ transferring ions of larger values (i.e., m / z =100–600) and smaller values (i.e., m / z =20–100) respectively. The low-frequency part of the RF signal driver can provide RF signals with resonance frequency of 1.43 MHz, peak to peak voltage V p–p of 0–1080 V, and the high-frequency part can provide RF signals with resonance frequency of 2.05 MHz, peak to peak voltage V p–p of 0–520 V. With the radio frequency signal driver described in this paper, ions in the range m/z 20–600 can be transmitted efficiently by RFQ.
研究领域:
分析化学
·
质谱技术
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产品关联
DOI
高影响因子
Plasma Processes and Polymers
·
2017
·Vol. 15
·期 4
·1700176
·
IF 2.846
Lei Wang,Jinxiu Wang,Junxin Lin,Songlin Zhang,Yongjun Liu
Degradation of metronidazole (MNZ) by radio frequency discharge in water was examined. Results showed that • OH, H • , and • O were produced. Decay of MNZ followed pseudo-first order kinetics, where the apparent rate constant was independent of its initial concentration in the range 0–0.5 mM, decreased in the range 0.5–1.0 mM, and leveled off in the range higher than 1.0 mM. pH had no effects on MNZ degradation. • OH scavengers enhanced the MNZ removal. Formic acid, nitrite ion, oxalic acid, nitrate ion, and acetic acid were determined as the primary intermediate byproducts. The eventual products were ammonia and inorganic carbon. Both • OH and H • participated in the MNZ degradation. H • played more efficient role than • OH in the early stage.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Duo Wang,Tianqi Nie,Yifei Fang,Linzhu Zhang,Chao Yu,Ming Yang,Ruijie Du,Junjie Liu,Lei Zhang,Liangzhu Feng,Haidong Zhu
Radiofrequency ablation (RFA), a thermoablative treatment for small hepatocellular carcinoma (HCC), has limited therapeutic benefit for advanced HCC patients with large, multiple, and/or irregular tumors owing to incomplete RFA (iRFA) of the tumor mass. It is first identified that iRFA-treated tumors exhibited increased pyruvate kinase M2 (PKM2) expression, exacerbated tumor immunosuppression featured with increased tumor infiltration of suppressive immune cells and increased proliferation, and programmed cell death ligand 1 expression of cancer cell and ultimately a poor prognosis. Herein, a multifunctional nanomedicine is fabricated by encapsulating nanoassemblies of anti-PD-L1 and spermidine-grafted oxidized dextran with shikonin-containing lipid bilayers to reverse iRFA-induced treatment failure. Shikonin, a PKM2 inhibitor, is used to suppress glycolysis in cancer cells, while anti-PD-L1 and spermidine are introduced to collectively reprogram the proliferation and functions of infiltrated CD8+ T lymphocytes. Combined with iRFA, which promoted the exposure of tumor antigens, the intravenous injection of liposomal SPS-NPs effectively stimulated dendritic cell maturation and reversed tumor immunosuppression, thus eliciting potent antitumor immunity to synergistically suppress the growth of residual tumor masses and lung metastasis. The as-prepared liposomal nanomedicine is promising for potentiating the therapeutic benefits of RFA toward advanced HCC patients through reprogramming iRFA-induced tumor immunosuppression.
研究领域:
肿瘤学
·
免疫学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Liumin Fan,Gaoji Yang,Mengge Li,Juanjuan Xu,Dingting Zhou,Rui Li,Shaojin Wang
Whey protein (WP) is a highly nutritious animal protein, but its functional properties are sensitive to environmental factors, such as temperature, pH, and ionic strength, which prevent its applications in various food systems. The conjugation of proteins with polysaccharides via the Maillard reaction is an efficient method to improve their functionalities. The purpose of this study was to use radio frequency (RF) heating technology to assist the covalent coupling of WP and gum Arabic (GA) for improving their grafting efficiency and functional properties. Results showed that under the optimal condition of RF heating, the degree of glycosylation (DG) of the conjugate could reach 19.19 %, while the maximum DG value of the conjugate obtained by water bath (WB) heating was only 10.60 %. There was a good correlation between the DG and dielectric properties of WP-GA conjugates. Structural analysis revealed that compared with their mixtures, the network structure of WP-GA conjugates was clear, the content of β-turn and random coil increased, and the fluorescence intensity and surface hydrophobicity decreased. In addition, glycosylation enhanced the emulsifying, foaming, and antioxidant properties of WP-GA conjugates. This study indicates that the RF heating technology has potential application values in the glycosylation modification of proteins.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Yishun Yao,Xunjiao Wei,Huiyun Pang,Ke Wang,Qiang Liu,Hongfei Fu,Xiangwei Chen,Yunyang Wang
This paper investigated the effects of radio-frequency (RF) energy and conventional hot-water blanching (95 °C for 2 min) on the peroxidase (POD) activity, physiochemical properties, and changes in the cellular morphology of stem lettuce. The relative residual POD activity significantly decreased ( P < 0.05) from 66.03% to 6.46% with increased RF heating temperature (65 °C–85 °C). The weight loss (3.06%–7.64%), color, texture, relative electrolyte leakage (23.45%–67.90%), and residual vitamin C content (72.22%–16.67%) significantly changed ( P < 0.05) with increased RF heating temperature (65 °C–85 °C). Micrographs indicated that the changes in physiochemical property can be attributed to the destruction of cell membranes, loss of cell turgor, reduced rigidity of cell walls, and loose adhesion between adjacent cells. Samples treated by RF heating at 75 °C showed lesser cell damage and better nutrient retention than those treated by hot-water blanching at a similar level of POD inactivation.
研究领域:
食品科学
·
植物生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2019
·
IF 3.714
Meiji Liao,Yanyun Zhao,Yuanrong Xu,Chuting Gong,Shunshan Jiao
Hot air-assisted radio frequency (HA-RF) heating has great potential in roasting of cashew nut kernels with high roasting efficacy. This study further investigated HA-RF roasting effects on nutritional quality , malondialdehyde (MDA) and aroma compounds of cashew nut kernels. After HA-RF roasting, crude fiber content of kernels increased from 2.49 g/100 g to 3.18 g/100 g while ash and protein content did not change significantly ( p > 0.05). In raw and roasted kernels, 14 fatty acids were detected including 7 saturated fatty acids and 7 unsaturated fatty acids . Fatty acid composition and individual amino acid content were not affected by HA-RF or conventional hot air (HA) roasting. MDA content increased from 0.36 mg/kg to 0.48 mg/kg and 0.64 mg/kg after HA-RF roasting and HA roasting. The types of aroma compounds of cashew nut kernels roasted by HA-RF and HA were similar, but HA-RFK had lower furan content and higher ketone and terpene contents. This study indicated HA-RF roasting was comparable or even better than HA roasting in improving nutritional quality and flavor.
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）