GENE
·
2025
·
IF 2.4
Yirui Hong,Xinyu Zhang,Wenni Rong,Chenwei Hu,Yujie Jiang,Jiayi Xu,Huimin Wen,Fangjian Feng,C. Benjamin Naman,Haowei Shen,Shan He,Lijian Ding,Wei Cui
The discovery of novel drugs from the ocean is a relatively recent development. However, for most studies of marine drugs, the priority is the discovery of compounds with new structures. Normally, only small amounts (< 1 mg) of new compounds could be extracted from marine microbes, and it is difficult to evaluate the therapeutic potentials of these newly-identified marine-derived natural compounds by traditional cell- or animal-based phenotypic screenings. Genes play a crucial role in determining the phenotype of diseases and the action of drugs. By comparing genomic expression associated with disease conditions and compound treatments, it is possible to predict the potential of a certain compound to counteract a specific type of disease. In this study, marine-derived natural compounds-induced genomic changes in cells were collected either from public databases or by using RNA-seq analysis. The therapeutic potentials of representative marine-derived natural compounds, namely phycocyanobilin, cycloheximide and NBU-1, a newly-identified natural compound extracted from a marine sponge-associated Streptomyces, on bipolar disorder (BD), Parkinson’s disease (PD) and Alzheimer’s disease (AD), were predicted by gene set enrichment analysis (GSEA), respectively. The anti-neurological disorder activity of these marine-derived natural compounds were further validated in methamphetamine-induced rats mimicking manic phase of BD, 6-OHDA-treated PC12 cells mimicking PD neurotoxicity and β-amyloid oligomer-incubated SH-SY5Y cells mimicking AD neuronal loss. Our study provides not only new insights for pharmacological applications of the marine-derived natural compounds here studied, but also a method for predicting and evaluating therapeutic potentials of newly-identified marine-derived natural compounds with small quantities.
研究领域:
药理学
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神经科学
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海洋生物学
·
基因组学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jiangyun Zhe,Huan He,Zhanwei Yi,Ziwei Guo,Haisheng Xu,Bin Huang,Xuejun Pan
Landfill leachate usually contains a substantial content of refractory dissolved organic matter (RDOM), which mainly consists of humic acid and fulvic acid. RDOM easily blocks the membrane pores resulting in membrane fouling when treated using membrane technologies, and it costs abundant chemical regents using advanced oxidation processes. To achieve the economically efficient treatment of RDOM in landfill leachate, this study established the electroflocculation coupled with ozone (EFCO) system. EFCO achieved a higher removal for organic matter than single electroflocculation and ozonation, where RDOM was the main component of organic matter in landfill leachate. The remaining RDOM was decomposed into lots of micromolecule weight and biodegradable proteins and lipids. Ozone improved the removal of dissolved organic matter (DOM) mainly by changing the functional groups on its surface and improving the mechanical strength of flocs to enhance the complexation between flocs and DOM. Cl 2 − and ClO produced in the EFCO system were the main active chlorine species, which enhanced the mineralization of RDOM. The study provides an efficient method for the pretreatment of RDOM in landfill leachate.
研究领域:
环境工程
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水处理
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废物管理
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产品关联
DOI
高影响因子
Science Advances
·
2024
·Vol. 10
·期 32
·
IF 11.7
Ayan Yao,Junjun Hou,Pengjia Dou,Jingcheng Du,Qian Sun,Ziye Song,Linghao Liu,Jian Guan,Jiangtao Liu
Thin-film composite (TFC) membranes have gradually replaced some traditional technologies in the extraction, separation, and concentration of high value-added pharmaceutical ingredients due to their controllable microstructure. Nevertheless, devising solvent-stable, scalable TFC membranes with high permeance and efficient molecule selectivity is urgently needed to improve the separation efficiency in the separation process. Here, we propose phenolphthalein, a commercial acid-base indicator, as an economical monomer for optimizing the micropore structure of selective layers with thickness down to 30 nanometers formed by in situ interfacial reactions. Molecular dynamics simulations indicate that the polyarylate membranes prepared using three-dimensional phenolphthalein monomers exhibit tunable microporosity and higher pore interconnectivity. Moreover, the TFC membranes show a high methanol permeance (9.9 ± 0.1 liters per square meter per hour per bar) and small molecular weight cutoff (≈289 daltons) for organic micropollutants in organic solvent systems. The polyarylate membranes exhibit higher mechanical strength (2.4 versus 0.8 gigapascals) compared to the traditional polyamide membrane.
研究领域:
材料科学
·
化学工程
·
膜技术
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Guiju Xu,Shengju Liu,Jiaxi Peng,Wenping Lv,Ren’an Wu
In this work, a novel core–shell structured gold@graphitized mesoporous silica nanocomposite (Au@GMSN) was synthesized by in situ graphitization of template within the mesochannels of mesoporous silica shell on gold core and demonstrated to be promising nanomaterials for surface-assisted laser desorption/ionization time-of-flight mass spectroscopy (SALDI-TOF MS). The integration of the graphitized mesoporous silica with the gold nanoparticles endowed Au@GMSN with large surface areas of graphitic structure, good dispersibility, and strong ultraviolet (UV) absorption. Au@GMSN exerted the synergistic effect on the efficient detection of small-molecular-weight analytes including amino acids, neutral saccharides, peptides, and traditional Chinese medicine. The Au@GMSN-assisted laser desorption/ionization exhibited the following superiorities: high ionization efficiency, low fragmentation interference, favorable salt tolerance, and good reproducibility. Moreover, because of the large hydrophobic inner surface area of the graphitized mesoporous silica shell, the Au@GMSN demonstrated its promising capacity in the pre-enrichment of aromatic analytes prior to SALDI-TOF MS, which favored rapid and sensitive detection.
研究领域:
纳米技术
·
分析化学
·
质谱学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）