Chinese Physics B
·
2017
·Vol. 26
·期 6
·067804
·
IF 1.223
Qi Ding,Xiao-Song Zhang,Lan Li,Jian-Ping Xu,Ping Zhou,Xiao-Fei Dong,Ming Yan
Colloidal ZnAgInSe (ZAISe) quantum dots (QDs) with different particle sizes were obtained by accommodating the reaction time. In the previous research, photoluminescence (PL) of ZAISe QDs only could be tuned by changing the composition. In this work the size-tunable photoluminescence was observed successfully. The red shift in the photoluminescence spectra was caused by the quantum confinement effect. The time-resolved photoluminescence indicated that the luminescence mechanisms of the ZAISe QDs were contributed by three recombination processes. Furthermore, the temperature-dependent PL spectra were investigated. We verified the regular change of temperature-dependent PL intensity, peak energy, and the emission linewidth of broadening for ZAISe QDs. According to these fitting data, the activation energy (ΔE) of ZAISe QDs with different nanocrystal sizes was obtained and the stability of luminescence was discussed.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2013
·
IF 2.144
Beibei Wang,Huan Shang,Cuiping Nie,Qi Wang,Meihu Ma,Zhaoxia Cai
A novel two-step controlled basic water phase method has been developed for synthesizing size-tunable and water-soluble CdTe/Cd(OH) 2 core/shell quantum dots with high quantum yield and good stability. The size of the prepared CdTe/Cd(OH) 2 core/shell quantum dots can be easily manipulated by varying the concentrations of NaOH solution step by step. The maximal emission wavelengths of the series CdTe/Cd(OH) 2 core/shell QDs were from 513 nm to 610 nm (emission colors tuned from green to red). The CdTe/Cd(OH) 2 core/shell quantum dots not only possess high quantum yield (up to 83%) but also exhibit excellent photostability (being stable after being stored for more than 2 months). The CdTe/Cd(OH) 2 core/shell quantum dots were characterized by transmission electron microscopy , high-resolution transmission electron microscopy, X-ray powder diffraction spectrometry , ultraviolet–visible spectrometry and fluorescence spectrometry. The water-soluble nature of the CdTe/Cd(OH) 2 core/shell quantum dots offers great potentiality for their chemical and biological applications. This method is easily controlled, low-cost and reproducible. So it is possible to extend this approach to the preparation of other size-tunable inorganic metal hydroxide capped core/shell quantum dots.
研究领域:
材料科学
·
纳米技术
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 32
·7469-7477
·
IF 3.858
Chenghui Xia,Lixin Cao,Wei Liu,Ge Su,Rongjie Gao,Hua Qu,Liang Shi,Guanghui He
This paper aims to systematically optimize the preparation process of CuInS2 (CIS) QDs by intensively manipulating kinetic variables including reaction temperature, reaction time, In/Cu ratio and surface ligand. CIS QDs were synthesized using copper iodide and indium acetate in the presence of 1-octadecene (ODE) that was used as reaction solvent, while 1-dodecanethiol (DDT) was chosen as the sulfur source and surface ligand. UV-Vis spectroscopy and fluorescence spectroscopy were applied to reveal the growth kinetics and fluorescence properties of CIS QDs. Transmission electron microscopy and X-ray diffraction were utilized to characterize the size, morphology and crystal structure of the final products. Our results reveal that the emission wavelength of CIS QDs could be found at visible light and near-infrared regions ranging from 630 to 825 nm. By scrupulous regulation of the reaction temperature, reaction time and the amount of DDT, highly dispersed and stable hydrophobic CIS QDs could be prepared directly without any further modification by one-step method. The fluorescence intensity could be enhanced by introducing Cu defects with the fluorescence quantum yield (QY%) reaching around 7%, while the particle size could be tuned from ultra-small sizes approaching 1.5 nm to 4 nm, by controlling the In/Cu ratio.
研究领域:
材料科学
·
纳米技术
·
光学
✓ 已验证
DOI
高影响因子
Applied Materials Today
·
2020
·
IF 8.352
Chen Zhang,Chenxi Liu,Wenxin He,Dian Jiao,Zhe Liu
The ever-growing development of advanced biomaterials has substantially influenced the diagnosis and treatment against various diseases. In this study, a novel type of bio-inspired cross-linked polymer has been constructed with prominent size-tunability from micro- to nano-dimension and versatile enhanced drug loading mechanisms. In the meanwhile, this functional polymer has been applied to sustained and ultrasound (US)-triggered/promoted stimuli-responsive drug release upon an external US irradiation. Proof-of-principle in vivo animal studies proved their utility as a useful tool for a precision assessment of drug deposition and targeting delivery as well as a state-of-the-art visualized therapeutic strategy by this means. These valuable merits validated the as-reported functional polymer a useful tool for the precision assessment of drug deposition and targeted delivery, and also opened up an era to the state-of-the-art visualized therapeutic translations.
研究领域:
生物材料学
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药物递送系统
·
医学影像
·
精准医疗
✓ 已验证
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2021
·Vol. 47
·期 5
·1775-1787
·
IF 2.914
Chen Rong,Wu Songshuai,Meng Chuangang
A facile green synthesis of platinum nanoparticles (PtNPs) using chlorogenic acid (CGA) as a reducing agent and stabilizing agent has been reported here for the first time to the knowledge of the authors. Well-dispersed PtNPs are synthesized in spherical shapes and are tuned in size by simply changing the molar ratio of H 2 PtCl 6 to CGA, with the same salt, temperature and solvent. The average sizes of the particles were 16.9 ± 4.7, 13.3 ± 4.0, 10.8 ± 3.4, and 7.5 ± 2.3 nm, respectively, corresponding to molar ratios of the initial H 2 PtCl 6 /CGA of 1:1, 1:2, 1:3 and 1:4 and decreased with an increase in CGA concentration. Transmission electron microscope; energy-dispersive spectrometer; UV–visible absorption spectra (UV–Vis); and Fourier transmission infrared spectra were used to characterize the PtNPs. Additionally, the advantage of CGA for possible synergistic biological activity was studied through the in vitro antioxidant activity of PtNPs by CGA for capture of free radicals. Our results indicate that CGA is an excellent reducing and stabilizing agent in green synthesis of PtNPs, and these size-tunable PtNPs can provide potential applications in the field of biomedicines. Graphic abstract
研究领域:
纳米医学
·
材料科学
·
生物化学
✓ 已验证
DOI
高影响因子
OPTICAL MATERIALS
·
2020
·
IF 2.779
Hua Li,Xiaobo Shi,Xia Li,Lingbo Zong
Size-tunable β-NaYF 4 : Yb/Er (50–400 nm) up-converting nanoparticles (UCNPs) with a strong green emission were successfully prepared by a facile thermal decomposition method in a short period of time. The effects of the reaction time, the oleic acid (OA) content, and the doped Gd 3+ concentration on the crystal structure, the size evolution mechanism and the luminescence mechanism of the β-NaYF 4 : Yb/Er nanoparticles were discussed in detail. Characterization was completed using X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution (HR-TEM), scanning electron microscopy (SEM), and photoluminescence (PL). The results reveal that the phase transition was completed at 15 min and the morphology of the NaYF 4 : Yb/Er UCNPs changed from spherical to large hexagonal disks (200–400 nm) in non-doped Gd 3+ . An appropriate decrease in the volume ratio of oleic acid (OA) to 1-octadecene (ODE) promoted NaF production, resulting in the formation of the hexagonal phase crystals and the subsequent increase of luminous intensity by 30–40 times. More importantly, the size of the β-NaYF 4 : Yb/Er decreased with Gd 3+ doping, and the UCNPs ultimately transformed into small hexagonal prisms (50 nm) with high monodispersity when the doping concentration of Gd 3+ was 60 mmoL. The PL spectra confirmed that the luminous intensity of the UCNPs with doped Gd 3+ was much higher than that of the undoped UCNPs. The results show that this route for UCNP fabrication with high luminous efficiency and a small size could be extended to other UCNP systems for multifunctional biomedical applications.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Donghua Dong,Tong Zhu,Guoxing Liao,Fangrong Tan,Lei Chen,Qianqian Yu,Linge Wang
Polymer vesicles hold immense potential in biomedicine and nanotechnology, yet conventional rehydration methods face critical limitations in controlling vesicle architecture due to stochastic block copolymer (BCP) self-assembly. Here, we present a first-reported microsphere-templated strategy that synergizes microfluidic precision with BCP assembly to overcome these constraints. By engineering emulsion templates via flow rate, BCP concentration and collection distance optimization, we establish a method based on radius-square law governing the evolution of uniform vesicles (size range diameter 70 - 170 nm, PDI 0.16), enabling on-demand size tuning, a capability unattainable with traditional approaches. Multi-scale characterization (DLS, OM, SEM, TEM) elucidates the non-equilibrium templating-to-vesicle transition, revealing critical dynamics of BCP film reorganization. The resultant nano-scale vesicles exhibit rapid cellular uptake (> 95% in 3 h) by HUVEC and 4T1 cells with exceptional biocompatibility (> 85% viability, 36 h), outperforming many cytotoxic counterparts. This work not only provides a scalable platform for precision vesicle fabrication but also establishes foundational principles for templated self-assembly, bridging microfluidics and soft matter science. Our methodology opens avenues for tailored vesicles in drug delivery, nanoreactors and synthetic biology, addressing a persistent demand for functionally adaptive polymeric nanostructures.
研究领域:
纳米医学
·
软物质科学
·
材料科学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 36
·22079-22085
·
IF 3.108
Hongtao Xie,Wensheng Lu,Jide Wang,Wei Wang
The structure–activity relationship of surfactants is a topic that has been pursued for a long time in colloid science. We report a study on the self-assembling of a new type of surfactant with a dendritic headgroup in dilute aqueous solutions. Three surfactants, N-alkyldipropionic acids (ADPA) with different chain lengths (n = 14, 16, and 18), were synthesized. As a result of the carboxylic acids and one tertiary amine in the headgroup, the protonation state of the surfactants changes with pH. The morphology of the surfactant aggregates in aqueous solutions was studied at various pH values by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Vesicles were formed spontaneously at pH > 5. Potentiometric titration, turbidity and surface tension were used to determine the effect of protonation state on aggregation behavior. The results show that the vesicle size depends directly on the pH of the solution. The size distribution of vesicles was analyzed by the model of spontaneous curvature. The thermodynamic stability of the vesicles can be attributed to long-range repulsive interactions caused by the low bending modulus of the bilayers.
研究领域:
胶体科学
·
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2014
·
IF 4.384
Yanzhen Cao,Rongfeng Zheng,Xiaohui Ji,Hong Liu,Renguo Xie,Wensheng Yang
Nearly monodispersed spherical silver nanoparticles (Ag NPs) were synthesized by using tannic acid (TA) as both reductant and stabilizer in a 30 °C water bath. The size of the as-prepared Ag NPs could be tuned in a range of 7–66 nm by changing the molar ratio of TA to silver nitrate and pH of the reaction solutions. UV–vis spectra, TEM observations, and temporal evolution of the monomer concentrations for the reactions carried out at different experimental conditions showed that the improved size distribution and size tunability of the Ag NPs were mainly attributed to the use of TA, which could promote the balance of nucleation and growth processes of the NPs effectively. The size of the Ag NPs was extendable up to 200 nm in one-pot fashion by the multi-injection approach. The size-dependent surface-enhanced Raman scattering (SERS) activity of the as-prepared Ag NPs was evaluated, and the NPs with size around 100 nm were identified to show a maximum enhanced factor of 3.6 × 105. Moreover, the as-prepared TA-coated Ag NPs presented excellent colloidal stability compared to the conventional citrate-coated ones.
研究领域:
材料科学
·
纳米技术
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2021
·Vol. 47
·期 10
·4051-4066
·
IF 2.914
Chen Rong,Yi Guohui,Wu Songshuai,Meng Chuangang
Well-dispersed Au–Pt alloyed bimetallic nanoparticles are synthesized using chlorogenic acid as the only reducing agent and stabilizer to reduce Au/Pt precursors successively has been presented here. The shapes of Au–Pt bimetallic nanoparticles are controlled by changing the sequence of successive reduction: the spherical shape in the sequence of Pt precursor reduced prior to Au precursor, and the flower shape by reversing the sequence. The sizes of Au–Pt bimetallic nanoparticles can be tuned by changing the molar ratios of the precursors to chlorogenic acid, and the average size of Au–Pt bimetallic nanoparticles decreased or increased with an increase in chlorogenic acid concentration in different sequence of successive reduction. Additionally, the high antioxidant activity of Au–Pt bimetallic nanoparticles was verified by in vitro radical scavenging assays. Our results show that chlorogenic acid is an excellent reducing and capping agent for the controlled synthesis and stabilization of Au–Pt bimetallic nanoparticles, which could be extended to reduce other metal precursors for synthesizing bimetallic and trimetallic nanoparticles. These shape-controlled and size-tunable Au–Pt bimetallic nanoparticles by chlorogenic acid will expand their biomedical applications in future. Graphic abstract
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2017
·
IF 6.337
Jing Chong,Xiaojing Zhu,Wenquan Huang,Xiufang Wang,Yong Tian
The synthesis of nitrogen-doped dual-mesoporous carbon nanospheres (N-DMCNs) with tunable sizes remains a great challenge due to the high cross-linking rate of carbon precursors and the weak interactions among the carbon precursors, inorganic components and templates. Herein, we demonstrated a colloidal silica nanoparticles (SN) driving co-assembly strategy for the first time to fabricate such N-DMCNs with hydrochloric acid (HCl) as a catalyst. Interestingly, SN not only acted as a pore-forming agent but also as a driving agent to induce the co-assembly of F127, carbon precursors and SN. The affinity between carbon precursor and template was enhanced by the Coulombic interaction originating from the I + X − S + mechanism driven by the protonation under highly acidic conditions. Furthermore, the mesoporous structure and particle sizes could be facilely tuned by varying the HCl concentration, which was elucidated by both reversible reaction and nuclei growth mechanism. The as-prepared N-DMCNs could be potentially used as drug carrier for poorly water-soluble drug carbamazepine by improving its aqueous release rate. Compared with previously reported method, the present strategy has striking features such as convenient, inexpensive and environmentally friendly, especially affording a paradigm for the preparation of spherical mesoporous carbon nanoparticles through driving-induced assembly engineering.
研究领域:
材料科学
·
药物递送
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Ya Jin,Zimei Wu,Chenchen Wu,Yixuan Zi,Xinyu Chu,Jianping Liu,Wenli Zhang
The conventional active-targeting nano-chemotherapy suffers from poor tumor tissue penetration and non-negligible toxicity due to the size/ligand dilemmas and insufficient target selectivity. In this report, a stimuli-responsive size-adaptable and ligand (biotin)-sheddable drug delivery system (DDS) combined with two-step strategy of biotin-avidin system was designed to seek a balance between tumor targeting and penetration as well as to self-scavenge the nonresponsive nanocarriers in normal tissues. This DDS was composed of ‘multi-seed’ polymeric liposomes (ASL-BIO-MPL) with asulacrine-loaded micelles as seeds in their aqueous cavities. The shell of such liposomes was modified with MMP-9 cleavable polymer-polypeptide functionalized with the tumor targeting ligand biotin . ASL-BIO-MPL could disintegrate into mixture of irregularly-shaped liposomes (~200 nm) and scattered tiny micelles (~40 nm) after incubation with MMP-9. The fluorescence-labeled BIO-MPL could travel to the center of the 4T1 breast tumor spheroids under the action of MMP-9, possibly benefited from the relay of released tiny micelles. Conversely, neither the biotin-modified micelles nor non-MMP-9-responsive multi-seed liposomes could penetrate into the spheroids possibly due to the potent binding-site barrier of biotin and large size, respectively. In tumor-bearing mice, ASL-BIO-MPL exhibited the strongest drug penetrability and thus the optimal inhibition of tumor growth compared to other formulations. Following administration of avidin with a rational dosage regimen, the number of apoptotic cells in normal tissues induced by ASL-BIO-MPL reduced without affecting their targeting effect, suggesting the followed administration of adivin could scavenge the DDS in non-target site. Overall, the size/ligand adapting MPL system combined with two-step strategy of biotin-avidin may provide potential avenues for nanocarriers to enhance deep tumor tissue targeting and protect normal tissues.
研究领域:
纳米医学
·
癌症治疗
·
药物递送
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）