Materials Science and Engineering B-Advanced Functional Solid-State Materials
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2021
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IF 4.051
Rongzheng Liu,Xin Wang,Na Fan,Hang Song,Pingping Ma,Chang Li,Jing Li,Jin Sun
The main objective of this study was to investigate the improved effect of chiral-handed mesoporous silica nanoparticles (Ch-MSNs) on drug delivery. The Ch-MSNs (Ch-D-MSN and Ch-L-MSN) were successfully prepared by grafting molecular functional groups and verified by infrared spectrometer (IR). TEM and nitrogen adsorption/desorption analysis results show that Ch-D-MSN and Ch-L-MSN were regular spheres with hidden pore channels. Nimesulide (NMS) was chosen as a model drug to study the drug loading properties of the carrier. In vitro drug release studies showed that both Ch-D-MSN and Ch-L-MSN significantly improved NMS dissolution compared to NMS. Besides, NMS loaded carriers exerted different chiral recognition functions in the chiral environment in vitro. The results of anti-inflammation pharmacodynamics further demonstrated that Ch-L-MSN can trigger chiral biological environment and improve the efficacy.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2020
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IF 7.1
Ying Zhang,Xie-an Yu,Yiting Hu,Xuefei Bai,Ran Zhang,Mi Lu,Jianhui Sun,Jiangwei Tian,Bo-Yang Yu
Cell surface charge serves a significant role in maintaining cell membrane stability and integrity, affecting cell structure/functions and the expression of signaling molecules. With the aggravation of the cell injury, cell surface charge would have a difference, which could be treated as a vital indicator for the discernment of cell pathological states. Herein, we developed a novel and instantaneous response method for the determination of cell viability based on cell surface charge. This study introduced a fluorescence resonance energy transfer-based polydopamine-polyethyleneimine/quantum dot (PDA-PEI/QD) sensor constructed by PDA-PEI with positive charge and QD with negative charge via electrostatic interaction, which can be used to instantaneously read out the cell injured states through fluorescent signal change induced by the comprehensive charged materials on the cell surface. The resulting fluorescence signals induced by different hepatotoxic drugs showed the difference. Furthermore, it was worth noting that the fluorescence change induced by 12 hepatotoxic drugs had a close relationship with cellular states, presenting the consistent tendency with cell viability. Accordingly, this method may have applications in the fields of cell viability detection, drug toxicity evaluation, and even elucidating the mechanism of drug-induced liver injury in the future.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Wei Liu,Jiabin Zhou,Ying Zhou,Dan Liu
Non-steroidal anti-inflammatory drugs (NSAIDs) are a kind of emerging pollutants that have caused people's concerns. In this work, the catalytic system with perovskite-like material Bi 2 MoO 6 modified graphitic carbon nitride (g-C 3 N 4 ) combined with peroxymonosulfate (PMS) was constructed to efficiently degrade nimesulide (NIM) in water. After the characterization by various technologies, it was found that the g-C 3 N 4 @ Bi 2 MoO 6 composite possessed an increased specific surface area, enhanced light absorption range, and lower recombination rate of the photogenerated carriers. Thereby the composites displayed stronger photocatalytic activity than pure g-C 3 N 4 and Bi 2 MoO 6 . The introduction of PMS not only provided more reactive oxygen species (ROSs) for the photocatalytic system, such as SO 4 − and 1 O 2 but also further promoted the transfer of photogenerated electrons. The multiple active species that existed in the system were involved in the photocatalytic process so that 97.4% NIM was degraded with 12 min. The degradation path of NIM was analyzed by LC-MS detection, which revealed that the structure of NIM was decomposed by the cleavage of the phenyl ether bond. The detection results of the total organic carbon (TOC) indicated that the proposed method could enhance the mineralization efficiency of NIM. This work could propose a solution for the rapid removal and degradation of NSAIDs in water.
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高影响因子
ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 11
·1379-1385
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IF 2.049
Zhongxia WANG,Yuanfei GAO,Wenjuan WANG,Fenying KONG,Hengye LI,Dahe FAN,Wei WANG
Here, we present an excellent strategy of unmodified near-ultraviolet fluorescence nitrogen doping carbon nanobelts (NFNCBs) for detecting nimesulide (Nim). After a simple hydrothermal process of uric acid and hydroquinone in DMF solvent, NFNCBs shows the shape of corroded stalactite-like composed of nanobelts aggregates, near-ultraviolet luminescence and a narrowed full width at half maximum. This could improve/change the electronic properties and surface chemical active site, as the result of a sensitive response to Nim. By employing this sensor, the quantitative measurement displays a linear range of 2.0 nM – 100.0 μM with a lower detection limit of 0.21 nM (3σ/k) for Nim. Our work has provided a high selectivity for Nim, which may be capable for pharmaceutical sample analysis in real tablets. Furthermore, the results concerning the recoveries (96.3 – 106.2%) for real sample analysis indicate that this nanoprobe might expand a good avenue to design an effective luminescence nanoprobe for other biologically related drugs.
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PubMed
高影响因子
ANALYST
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2020
·Vol. 146
·期 3
·874-881
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IF 3.978
Zhong-Xia Wang,Xing Jin,Wen-Juan Wang,Fen-Ying Kong,Jing Zhu,Heng-Ye Li,Yu-Jie Ding,Wei Wang
Recently, the development of a novel fluorescent (FL) nanoprobe for ratiometric detection of antibiotics in real-world samples has received more and more attention. In this article, the distinctive optical properties of deep-ultraviolet emission, a narrowed full width at half maximum (∼20 nm) and excitation-independent emission of a carbonized nanoprobe (CNP) were easily prepared by an environmentally friendly approach of solvothermal treatment using melamine as the precursor and H2O as the solvent. The obtained CNP can be further utilized as an efficient ratiometric FL nanoprobe for enrofloxacin (EFC) and feroxacin (FXC) detection based on the fact that the FL quenching of the CNP was accompanied by an FL increase with EFC/FXC based on the inner filter effect (IFE). Under the optimal conditions, excellent linear relationships existed between the relative FL intensity (FL290 nm/FL412 nm, CNP for FL290 nm and antibiotics for FL412 nm) and the concentrations of FXC and EFC in the range of 0.05–500.0 μM and 0.05–200.0 μM, with limits of detection of 21.74 and 22.43 nM (3σ/k), respectively. With the proposed ratiometric FL sensor, FXC and EFC in milk and serum samples can be rapidly and selectively analyzed without tedious pretreatment processes for real-world samples.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2019
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IF 8.355
Zhongjuan Wang,Li-chao Nengzi,Xinyi Zhang,Zhuanjun Zhao,Xiuwen Cheng
In recent years, sulfate radicals-based advanced oxidation process becomes an effective and common technique for elimination of emerging organic contaminants. In this study, novel NiCo 2 S 4 /CS composite was synthesized through hydrothermal method, with the physicochemical properties being characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microcopy (TEM), Brunauer-Emmett-Teller (BET) and Fourier Transform infrared spectroscopy (FT-IR). Then, NiCo 2 S 4 /CS composite acted as catalyst to activate PS for nimesulide degradation. The results showed that NiCo 2 S 4 /CS composite owned the highest activity compared with pure NiCo 2 S 4 and carbon sphere (CS), achieving 92% nimesulide degradation in 10 min with 0.1 g/L catalyst and 0.4 g/L persulfate. Furthermore, the NiCo 2 S 4 /CS membrane was fabricated by vacuum filtration, and 94% and 80% above nimesulide degradation were realized for the first time and after six times repeated experiment, which demonstrated that the catalyst was convenient to achieve recovery and reusability. In addition, the radical quenching experiment, XPS and the electrochemical methods (LSV and EIS) were measured to investigate the possible mechanism pathway, the results of which showed that both the non-radical pathway and radical pathway might attribute to nimesulide degradation, while the SO4 − remained the dominant species. This research provided a novel sulfide NiCo 2 S 4 /CS membrane for the oxidative technique for emerging organic contaminants in water treatment.
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高影响因子
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