INDUSTRIAL CROPS AND PRODUCTS
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2024
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IF 5.6
Jiayu Xie,Xuran Jin,Hong Cheng,Wei Chen,Wancheng Yu,Linlin Wang
Glycerol has been proved to be an effective plasticizer for polyvinyl alcohol (PVA), which can significantly increase PVA’s processability and ductility, whose molecular origin remains unclear. In current study, the physical structure and chain dynamics of polyol plasticized PVA were studied in detail, including ethylene glycol , glycerol, erythritol , xylitol , and sorbitol under the same addition level. The glycerol plasticized PVA exhibits the most significant reduction in Young’s modulus, enhanced superior toughness, and the lowest melting temperature (195 °C) as compared with other polyols. The molecular mechanism was elucidated through comprehensive analysis, with a particular focus on solid state NMR (SS NMR) results. The physical structure was first elucidated by the Small Angle X-ray Scattering (SAXS) and Wide Angle X-ray Scattering (WAXS). The crystallinity of the glycerol plasticized PVA was the lowest 29 % by WAXS and the thickness of the amorphous layer was the largest 7.76 nm by SAXS among different plasticized PVA films. This suggests the significant influence of glycerol on structure change of PVA. The molecular dynamics information was further accessed by Low Field Nuclear Magnetic Resonance (LF NMR), where two key features are obtained: i) Different dynamics dimensionality. The 1 H spin diffusion NMR was used to check the dimensionality from the aspect of chain dynamics. Compared with other plasticizers, LF NMR result shows that glycerol plasticized PVA has a two-dimensional (2D) structure; ii) Chain dynamics heterogeneity in the interphase . With respect to the chain dynamics heterogeneity in the interphase, the glycerol plasticized PVA shows the most heterogeneous dynamics, with the lowest ratio of the rigid amorphous fraction (RAF) of 0.507 in the interphase. Current study provides a versatile analytical strategy to quantify the plasticizing effect.
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FOOD CHEMISTRY
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2024
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IF 8.5
Rui Hu,Da-Wen Sun,You Tian,Liang Xu,Libin Sun
Natural deep eutectic solvents (NADESs) showing higher cryoprotective effects are attracting concerns, because during the storage, system browning always occurs in aldose/amino acid-based NADESs, which generated brown substances remarkably weaken the cryoprotective effects. In this study, proline/glucose-based (PG) and proline/sorbitol-based (PS) NADESs were prepared, of which storage stability, browning profile, brown substance, and cryoprotective effects were investigated. Results showed that PG at molar ratios of 1:1, 2:1, and 3:1, as well as PS at 1:1, and 2:1 can form NADESs, among which only the PG-based ones could get browning after storage. The predominant brown substance was identified as 1-deoxy-1-L-proline- d -fructose (C 11 H 19 O 7 N, 278 m / z ), which was subsequently verified to show cytotoxicity and decrease Saccharomyces cerevisiae cells viability after cryopreservation, suggesting that the brown substance could take a negative effect on cryopreservation. This study may help to attract more concerns to the storage and cryopreservation stabilities of the NADESs in food-related applications.
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PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2026
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IF 6
Tan Guohongfang,Chen Jialuo,Xing Teiling,Kundu Subhas C.,Lu Shenzhou
Minimally invasive microneedle devices have emerged as highly promising platforms for localized interstitial fluid (ISF) sensing and biomarker detection. In this study, we present a bilayer silk fibroin microneedle system that leverages material structure regulation to achieve optimal mechanical strength, controlled swelling, and limited dissolution. Our dual-layer architecture spatially separates skin penetration and local interstitial-fluid access from the sensing region, improving reagent retention and enabling clear, localized colorimetric readouts. Furthermore, the incorporation of 2-hydroxypropyl-β-cyclodextrin stabilizes chromogenic substrates within the hydrophilic silk matrix, delivering robust responses both in vitro and in vivo. The optimized microneedles exhibit uniform morphology and sufficient compressive strength for reliable transdermal insertion, successfully producing visually distinguishable outputs in animal models. Ultimately, this material-guided, device-integrated platform highlights the tremendous potential of combining biomaterial engineering with microscale design for next-generation minimally invasive biosensors.
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MACROMOLECULES
·
2026
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IF 5.2
Qiao Fan,Kai Zhang,Yufei Liu,Lanlan Wei,Yucheng Yin,Tingting Luo,Min He,Chong Chen,Shigui Peng,Jie Yu
High-fidelity bioelectric signal acquisition is crucial for wearable precision medicine, but traditional poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) electrodes struggle to balance conductivity, stretchability, and skin compatibility, particularly under perspiration or physical activity. To address this challenge, we developed a PEDOT-based functional system doped with PSS-co-poly(acrylic acid)/poly(acrylamide) binary copolymers (PSA/PSM). Through multiscale characterization, molecular simulations, and in vitro testing, we systematically investigated the unique roles of carboxyl (−COOH) and amide (−CONH2) groups in regulating microstructure, electrical and interfacial properties, and hydrogen bond network dynamics. Key findings reveal that −COOH groups enhance π-π stacking interactions and charge doping effects in PEDOT. The PSA 3:1 sample exhibits the highest conductivity, surpassing pure PEDOT:PSS, but displays severe swelling and poor adhesion owing to strong electrostatic interactions. In contrast, −CONH2 groups in PSM form a hydrogen bond network with distinct static structural features characterized by uniform bond length and angle distributions and a homogeneous network structure. This optimizes interfacial performance with only a minor conductivity loss (≤10%). The PSM 3:1 electrode demonstrates strong adhesion, low contact impedance (62.8 kΩ at 10 Hz), swelling resistance, and high electromechanical stability. Molecular dynamics simulations confirm that the static structural advantages of the PSM hydrogen bond network, including stable distribution of bonding sites and moderate fluctuations in bond length and angle, are critical to enhancing electromechanical stability and wet performance. In practical electrocardiogram (ECG)/electromyogram (EMG) monitoring, the PSM 3:1 electrode achieves low noise (ECG RMS: 10.3 μV) and high signal fidelity during both resting and exercise states. Under a 25 kg grip force, it reaches an EMG peak-to-peak voltage of 0.32 mV, outperforming commercial Ag/AgCl electrodes. This study provides a molecular-level synergistic multiperformance optimization strategy for conductive polymers, advancing the development of high-fidelity wearable bioelectronics.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
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2026
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IF 4
Cong Liu,Xiaolong Miao,Dihang Zhou,Hongxing Wang
Isosorbide, a bio-based diol derived from sorbitol, is a promising alternative to bisphenol A (BPA) in polymer manufacturing, yet its large-scale production remains limited by diffusion constraints, secondary dehydration, and energy-intensive separation. In this work, we develop a continuous, high-selectivity process for isosorbide synthesis using a heterogeneous azeotropic catalytic distillation strategy. A direct-pump feeding system enables the continuous introduction of high-viscosity sorbitol without dilution, while an ion-exchange resin catalyst provides efficient dehydration under intensified reaction–separation conditions. Nearly complete sorbitol conversion (∼100 %) and 91.2 % isosorbide selectivity were achieved. Temperature-dependent LHHW kinetic modeling reveals that equilibrium shifting through continuous water removal, rather than mass-transfer limitations, governs selectivity enhancement. Process simulation further establishes a scalable three-column azeotropic catalytic distillation design capable of producing 10,000 tons per year, supported by favorable thermal and economic performance. This study demonstrates a practical and energy-efficient route for industrial isosorbide production and provides mechanistic and design guidance for future process scale-up.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Yin Hao-Ting,Ye Dong-Yuan,Zhao Wei,Wei Xue-Wei,Meng Xiao-Yu,Ye Hai-Mu
Poly(ethylene succinate) (PES), a promising biodegradable polyester with cost advantages, suffers from inherently slow crystallization kinetics, which severely limits its processability and practical applications. To address this challenge, this study explored the use of commercially available, low-cost, and food-safe sugar alcohols, including Xylitol (Xy), D-sorbitol (DS), and D-mannitol (DM), as effective nucleating agents for PES. Remarkably, all three polyols significantly enhanced the nucleation and crystallization ability of PES, with DM exhibiting the most pronounced effect. DM increased the crystallization temperature by up to 23.9 °C and accelerated the overall crystallization rate by more than 13-fold at only 0.5 wt% loading level. Through a combination of differential scanning calorimetry (DSC), polarized optical microscopy (POM), and wide-angle X-ray diffraction (WAXD) analyses, we revealed that DM promotes PES crystallization via a dual mechanism: epitaxial templating facilitated by excellent lattice matching, and enhanced chain adjustment through intermolecular hydrogen-bonding interactions. In contrast, Xy and DS primarily function through hydrogen-bonding interactions. This work not only identifies DM as a highly efficient, economical, and industrially viable nucleating agent for PES, but also provides fundamental insights into the role of the molecular structure and crystallization ability of nucleating agents in regulating polymer crystallization.
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Advanced Optical Materials
·
2026
·
IF 7.2
Xuetao Yan,Lifei Chen,Yuze Ren,Kaixuan Cui,Tianliang Li,Lixing Lin,Zeyu Li,Haicheng Song,Yingying Chen,Zhenzhen Li,Lingyan Feng
Circularly polarized luminescence (CPL) materials are highly sought after for their unique chiroptical properties, but their rational design remains challenging. To address this, a machine learning (ML) platform that intelligently screens deep eutectic solvents (DES) for crafting G-quartet-based gels with tailored CPL is established. An ML classifier trained on experimental data predicts CPL activity with 0.916 accuracy. SHapley Additive exPlanations (SHAP) analysis identifies key DES molecular descriptors, guiding the discovery of novel materials that exhibit a record-high luminescence dissymmetry factor (g lum ) of 0.222 for nucleotide-based systems and achieve chirality inversion via DES modulation. The Sure Independence Screening and Sparsifying Operator (SISSO) algorithm further yields interpretable design formulas. Leveraging the distinct polarization of these gels, we demonstrate a fourth-level anti-counterfeiting strategy, decrypting concealed information via Morse and ASCII codes to enhance information security. This ML-driven methodology accelerates the discovery of high-performance CPL materials and opens new design avenues.
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高影响因子
Aggregate
·
2026
·Vol. 7
·期 3
·e70307
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IF 14.5
Lifei Chen,Xuetao Yan,Tianliang Li,Kaixuan Cui,Lixing Lin,Zeyu Li,Yingying Chen,Zhenzhen Li,Lingyan Feng
Circularly polarized luminescence (CPL) materials, which exhibit their unique chiroptical properties, display great potential for applications in optoelectronics and bioimaging. However, it remains a significant challenge to synthesize CPL materials with high dissymmetry factors (g lum ) and photoluminescence quantum yields (PLQY) simultaneously. Herein, we report a deep-eutectic-solvent (DES)-assisted self-assembly protocol integrated with an active-learning (AL) framework that enables the targeted fabrication of G-quadruplex (G4) supramolecular gels with high g lum and PLQY. AL pinpointed the optimal synthesis parameters in just four iterations, dramatically accelerating material development. The top-performing gel achieved a g lum of 0.29, setting a new benchmark for nucleoside/nucleotide-based CPL materials. The maximum PLQY reached 10.64%, which represents a substantial level of performance. Furthermore, by integrating SHapley Additive exPlanations (SHAP), we elucidated the relationship between reaction parameters and target properties. Building on this result, we also demonstrated multicolor fluorescence resonance energy transfer (FRET) by incorporating dyes, successfully developing a series of multicolor CPL-active materials. This work not only provides new insights into the design of bio-based chiral CPL materials but also highlights the promising role of artificial intelligence in advancing material development.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Chong Li,Yi Zhang,Guixiang Yang,Qian Jin,Wang Chen,Ruihua Zhang,Tong Shi,Jingchen Wei,Xuejun Chen,Liqin Li
The rapid aging kinetics of soman (< 2 min) necessitate the development of effective prophylactic countermeasures, as conventional post-exposure therapies are often inadequate. To address this challenge, we engineered a novel separable microneedle (MN) system based on silk fibroin (SF) for sustained transdermal delivery of huperzine A (Hup A)—a reversible acetylcholinesterase inhibitor with demonstrated blood - brain barrier penetration capabilities. The optimized SFMNs design featured a distinctive tip-separation mechanism that facilitated reliable detachment of drug-loaded needle tips within 2 min after dermal application. The characterization results showed that the MN patch exhibited robust mechanical strength (155.49±11.18 N/patch), uniform morphology, effective skin penetration and homogeneous distribution of Hup A within the needle tips. Notably, the SFMNs platform provided controlled release kinetics, achieving sustained in vitro release of Hup A over 12 h, with an initial burst phase conducive to rapid drug onset. Pharmacokinetic evaluations in mice revealed that transdermal delivery via SFMNs (4 mg/kg Hup A) maintained therapeutic plasma concentrations for up to 12 h, significantly prolonging the mean residence time (11.87 ± 0.88 h) compared to oral administration (2.39 ± 0.31 h). This sustained-release profile markedly reduced systemic toxicity; whereas oral Hup A elicited severe cholinergic adverse effects (e.g., sweating, tremors), SFMNs-mediated delivery circumvented these toxic responses. In a prophylactic efficacy study, Hup A-loaded SFMNs (4 mg/kg) conferred complete protection (100% survival) for 12 h against a 95% lethal dose soman challenge, substantially extending the protective window compared to both oral Hup A (2 h) and intramuscular pyridostigmine bromide (45 min). These findings demonstrate that the SFMNs platform represents a promising, convenient, and well-tolerated strategy for long-acting prophylaxis against soman intoxication.
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JOURNAL OF RARE EARTHS
·
2026
·
IF 9.6
Dan Wu,Yanni Lang,Junhao Li,Qiu Fu,Yugeng Wen,Dacheng Zhou,Yong Yang,Yongjin Li,Zhiguo Song,Jin Han,Jianbei Qiu
Upconversion luminescent materials can convert near-infrared excitation into higher-energy emissions, showing great potential in applications such as temperature sensing and optical anti-counterfeiting. However, it remains challenging to simultaneously achieve high thermal stability, sensitive temperature response, and circularly polarized luminescence within a single system. In this work, chiral Bi 4 O 5 Br 2 : Yb 3+ /Er 3+ nanosheets were synthesized via a hydrothermal method combined with chiral modification and pH regulation, and their structural and luminescent properties were systematically investigated. The results indicate that pH regulation during precursor synthesis facilitates the optimization of the Bi 4 O 5 Br 2 morphology and improves its crystallinity, thereby promoting a more ordered crystal growth process. Subsequently, chiral induction introduces local lattice distortion while suppressing defect formation. The synergistic effect of both helps to significantly enhance upconversion luminescence performance. Under variable-temperature conditions, the 849 nm near-infrared emission ( 4 I 9/2 - 4 I 15/2 ) exhibits negligible thermal quenching over the temperature range of 293−533 K, in sharp contrast to the thermally quenched behavior of visible emissions. Based on this feature, a fluorescence intensity ratio (FIR) thermometry strategy was established, achieving high sensitivity with an absolute sensitivity ( S a ) of 20.73%/K and a relative sensitivity ( S r ) of 3.45%/K. Furthermore, the material exhibits pronounced emission intensity differences under circularly polarized excitation and detection. This enables the construction of a polarization-color synergistically tunable luminescent anti-counterfeiting system. This work provides a new strategy for designing multifunctional upconversion materials that integrate optical thermometry and polarization-based anti-counterfeiting capabilities.
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高影响因子
ANALYTICAL SCIENCES
·
2026
·
IF 2
Lu Chang,Ma Wei-bo,Wang Jun,Duan Ding-ding,Chen Zhi-zhou,Ma Yan-li
Accurate quantification of pesticide residues is critical to ensure the quality and safety of Rhizoma Polygonati , a well-recognized medicine-food homologous herb widely applied in functional food development. Strong matrix interference in gas chromatography-tandem mass spectrometry (GC-MS) detection and notable quantitative bias are frequently induced by the abundant pigments, polysaccharides, saponins and endogenous components in the herbal matrix. Conventional PSA and C 18 adsorbents in standard QuEChERS protocols exhibit restricted purification capacity for this complex matrix, while most documented magnetic carbon-based adsorbents demand tedious pre-synthesis procedures that may block the active adsorption sites of nanomaterials. A modified QuEChERS-GC-MS method coupled with dynamic in-situ assembly strategy was established for 12 pesticide residues in Rhizoma Polygonati . Without pre-synthesis of any composites, in-situ functional synergy between NH 2 -SWCNTs and magnetic Fe 3 O 4 nanoparticles was achieved during the dispersive solid-phase extraction (d-SPE) step. Superior purification performance to conventional adsorbents was obtained by this system, with the matrix effect range of target pesticides narrowed from -31.4%−64.3% to -25.3%−36.7%. Favorable linearity ( R ≥ 0.9990), acceptable spiked recoveries (86.2%–106.5%) and stable precision (RSD ≤ 15.20%) were validated through systematic method validation, providing a feasible and robust analytical protocol for pesticide residue monitoring in Rhizoma Polygonati and other complex herbal matrices. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Dan Wu,Yanni Lang,Liang Xu,Qiyuexin Wang,Qiu Fu,Bingli Li,Xinye Zhao,Zhaoyi Yin,Yongjin Li,Dacheng Zhou,Yangke Cun,Zhiguo Song,Yugeng Wen,Yong Yang,Jin Han,Jianbei Qiu
The circular dichroism (CD) signal of D-BiOBr/Bi 0.3 g flipped and intensified. • The nanosheets of D-BiOBr/Bi 0.3 g were arranged in a spiral (counterclockwise) manner, forming petal-shaped nanospheres. • 0.3 g D-BiOBr/Bi exhibits a CO production rate of 84.27 μmol・g −1 h −1 , 3.34 times the value of D-BiOBr and 4.00 times that of 0.3 g pristine BiOBr/Bi sample. • LSPR boosts the migration of spin−down polarized electrons and improves the separation efficiency of photogenerated electron−hole pairs. Chiral inorganic nanomaterials have shown considerable promise in photocatalysis, owing to their distinctive optical activity and asymmetric interfacial effects. Metallic bismuth (Bi) exhibits a localized surface plasmon resonance (LSPR) effect, which markedly enhances both the generation and separation efficiencies of photogenerated electron-hole pairs. By employing D-sorbitol as a chiral inducer, we successfully synthesized chiral D-BiOBr/Bi nanocomposites. We propose that the synergistic integration of metallic Bi and chiral BiOBr enables effective modulation of chirality-induced spin selectivity (CISS), thereby enhancing spin polarization and promoting CO production from CO 2 reduction. Among the prepared samples, D-BiOBr/Bi 0.3 g exhibited the highest photocatalytic CO 2 reduction activity, selectively converting CO 2 to CO. The CO production rate of D-BiOBr/Bi 0.3 g was 84.27 μmol g −1 h −1 , which was 4.00 times and 3.34 times that of BiOBr/Bi 0.3 g and D-BiOBr respectively. Furthermore, magnetic conductive atomic force microscopy (Mc-AFM) measurements revealed that D-BiOBr/Bi 0.3 g generated the strongest tunneling current with an opposite polarity compared to its controls, providing indirect evidence for CISS-associated spin-selective charge transport. Collectively, our findings demonstrate a strong coupling between the LSPR of metallic Bi and structural chirality, which cooperatively boosts spin-polarized electron generation, accelerates electron-hole pair separation, and significantly improves photocatalytic CO 2 reduction performance.
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危险品化学品经营许可证（带存储）