MOLECULES
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2019
·Vol. 24
·期 10
·1881
·
IF 3.06
Geng Zhao,Ming Liu,Xinkui Xia,Li Li,Bayin Xu
In this study, a carbon-based solid acid was created through the sulfonation of carbon obtained from the hydrothermal pretreatment of glucose. Additionally, ethyl levulinate, a viable liquid biofuel, was produced from furfuryl alcohol using the environmentally benign and low-cost catalyst in ethanol. Studies for optimizing the reaction conditions, such as reaction time, temperature, and catalyst loading, were performed. Under the optimal conditions, a maximum ethyl levulinate yield of 67.1% was obtained. The recovered catalyst activity (Ethyl levulinate yield 57.3%) remained high after being used four times, and it was easily regenerated with a simple sulfonation process. Moreover, the catalyst was characterized using FT-IR, XRD, SEM, elemental analysis, and acid-base titration techniques.Keywords:furfuryl alcohol;ethanol;ethyl levulinate;carbon-based solid acid
研究领域:
化学工程
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可再生资源与环境科学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Yong Xu,Shi Chen,Mingfu Ye,Mingyue Wang,Wenhai Wang,Konglin Wu
Levodopa (LDA) is a principal medication for the treatment of Parkinson’s disease, with its therapeutic efficacy and potential side effects being closely associated with administered dosages. Consequently, the development of sophisticated LDA detection methods is of significant importance. Herein, we present the successful fabrication of an innovative electrochemical sensor utilizing Fe/Fe 3 C nanoparticles supported on activated N-doped carbon spheres (Fe/Fe 3 C-ANC), which makes full use of the large specific area of ANC to accommodate more dispersive Fe/Fe 3 C NPs that exhibits outstanding electrocatalytic activity for LDA oxidation. The experimental findings demonstrate that Fe/Fe 3 C-ANC sensor can deliver wide linear response ranges (1–40 µM) with an impressively low limit of detection of 0.22 µM, surpassing the performance of most previously reported electrochemical sensors. Additionally, the good selectivity of Fe/Fe 3 C-ANC sensor was also proved through measuring a series of LDA structural analogues and potential interfering substances. Furthermore, its excellent selectivity was confirmed through the analysis of LDA structural analogs and potential interferents. The practical utility of the sensor was evaluated by detecting LDA in commercial tablets, spiked human serum and spiked artificial cerebrospinal fluid samples.
研究领域:
医学
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材料科学
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分析化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Songlin Chen,Zhengyong Song,Zhihao Shen,Guang Han,Qicheng Feng
Conventional flotation separation methods for Cu–Fe sulfide minerals, such as highly alkaline processes and cyanidation processes, often lead to environmental pollution. As a result, the development of low-alkalinity processes and environmentally friendly reagents has become both critical and challenging. In this study, levodopa (L-dopa) was evaluated as a potential depressant for the flotation separation of Cu–Fe sulfide minerals, with a focus on its selective depressive effect under low-alkalinity conditions. Micro-flotation test showed that, under low-alkalinity conditions, L-dopa at a concentration of 4 × 10 –4 mol/L demonstrated a notable selective depression effect on pyrite. Specifically, the pyrite recovery was only 11.81 %, while chalcopyrite recovery reached 94.53 %. Zeta potential, total organic carbon (TOC), adsorption quantity, and atomic force microscopy (AFM) studies confirmed that L-dopa adsorbed differently on the surfaces of the two minerals. The adsorption of L-dopa on pyrite was substantially stronger than on chalcopyrite. Furthermore, pretreatment with L-dopa effectively hindered KBX adsorption on the pyrite surface, further diminishing its floatability. In contrast, L-dopa had a relatively minor effect on the adsorption of KBX on chalcopyrite. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR) analyses indicated that L-dopa was likely chemisorbed onto the pyrite surface, with Fe sites acting as active binding sites. In contrast, the adsorption of L-dopa on chalcopyrite was relatively weak. Thus, L-dopa demonstrated a potent selective depressive effect on pyrite, showing promise for the effective separation of chalcopyrite from pyrite under low-alkalinity conditions.
研究领域:
矿物加工工程
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环境科学
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化学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Shang-Jin Yang,Ling-Yun Zou,Chang Liu,Qi Zhong,Zhao-Yu Ma,Jing Yang,Jian Ji,Peter Müller-Buschbaum,Zhi-Kang Xu
Mussel-inspired poly(catecholamine) coatings from polydopamine (PDA) have been widely studied to design functional coatings for various materials. The chemical precursor of dopamine (DA), levodopa (l-DOPA, 3,4-dihydroxyphenyl-l-alanine), is known as the main element of mussel adhesive foot protein, but it is relatively hard to be constructed into a desirable coating on a given material surface under the same conditions as those for DA. Herein, we report a codeposition strategy to achieve the rapid fabrication of mussel-inspired coatings by l-DOPAwith polyethyleneimine (PEI) and to deeply understand the formation mechanism of those aggregates and coatings from l-DOPA/PEI. DFT calculations, fluorescence spectra, nuclear magnetic resonance analysis, and liquid chromatography–tandem mass spectrometry identification demonstrate that the formation of l-DOPA/PEI aggregates is effectively accelerated by PEI crosslinking with those intermediates of oxidized l-DOPA, including l-DOPAquinone and 5,6-dihydroxyindole-2-carboxylic acid as well as 5,6-dihydroxyindole, through Michael-addition and Schiff-base reactions. Therefore, we can facilely control the growth rate and the particle size of the l-DOPA/PEI aggregates in the deposition solution by adjusting the concentration of PEI. The coating formation rate of l-DOPA/PEI is four times faster than that of PDA and DA/PEI within 12 h. These l-DOPA/PEI coatings are demonstrated to display potential as structure colors, superhydrophilic surfaces, and antibacterial materials.
研究领域:
材料科学
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生物化学
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DOI
PubMed
高影响因子
International Journal of Electrochemical Science
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2023
·
IF 1.5
Feng Yang,Jiayu Wei,Shihui Qiu,Chengbao Liu,Li Cheng,Haichao Zhao
The corrosion inhibition effect of polylevodopa (poly-(L-DOPA)) on Q235 carbon steel in 1 M HCl was studied owing to its low cytotoxicity and special structure. Electrochemical measurements show that the corrosion inhibition efficiency increases with the increase of poly-(L-DOPA) concentration and the immersion time. When the concentration of poly-(L-DOPA) is 300 mg/L, the corrosion inhibition efficiency can reach 97%. Confocal laser scanning microscopy (CLSM) and field emission scanning electron microscope (FESEM) proved that poly-(L-DOPA) has a good corrosion inhibition effect on Q235 carbon steel immersed in 1 M HCl. Poly-(L-DOPA) adsorbs on the surface of Q235 carbon steel to form a protective film, and followed the Langmuir adsorption isotherm.
研究领域:
材料科学
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电化学
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表面工程
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2018
·
IF 3.849
Qian Guan,Tingzhou Lei,Zhiwei Wang,Haiyan Xu,Lu Lin,Gaofeng Chen,Xueqin Li,Zijie Li
Wheat straw, a typical lignocellulosic biomass, is difficult to be liquefied because of its complex structure, which limits its further conversion to valuable products. Ionic liquid can dissolve the cellulose, which can destroy the connection of biomass components. Ionic liquids, [BMIM][HSO 4 ], [BMIM][Cl], and [HSO 3 -BMIM][HSO 4 ], were used in the liquefaction of wheat straw to produce ethyl levulinate (EL) in a one-pot reaction under mild conditions in ethanol, which served as both solvent and reactant. The highest conversion rate, 85.50%, was obtained following reaction at 200 °C for 60 min using the acidic ionic liquid 1-methyl-3-(4-sulfobutyl) imidazole bisulphate as the catalyst. Under optimal conditions, ethyl levulinate was obtained with a yield of 16.23% and its content in the liquid products was 28.11%. Without the acidic ionic liquid catalyst, the conversion rate of wheat straw and the yield of ethyl levulinate were only 22.33% and 6.23%, respectively. Of the catalysts evaluated, [HSO 3 -BMIM][HSO 4 ] was the most effective, and its recovery rate was 64.71%. This study provides a theoretical basis for the development and utilisation of low-corrosion and environment-friendly catalysts for liquefaction processes for the preparation of high-grade chemicals.
研究领域:
生物化学
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可再生能源
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Fan Wang,Junhua Li,Xiangxiong Chen,Hao Feng,Huiyang Liao,Jinlong Liu,Dong Qian,Geoffrey I.N. Waterhouse
Metal single-atom catalysts offer the dual advantages of high electrochemical activity and near 100 % metal atom utilization, leading to their potential use in low-cost electrochemical sensor development. Herein, a novel electrocatalyst comprising atomically-dispersed Mn on B,N co-doped bamboo-derived carbon (MnSAs-BN-BC) was synthesized via a facile pyrolysis procedure. A high dispersion of Mn single atoms in MnSAs-BN-BC was confirmed by aberration-corrected transmission electron microscopy and elemental mapping. The Mn loading in the MnSAs-BN-BC determined by inductively coupled plasma mass spectrometry was 255 mg kg −1 . MnSAs-BN-BC displayed outstanding electrocatalytic performance for levodopa (LD) oxidation, allowing a robust electrochemical sensing platform for LD detection to be established. The MnSAs-BN-BC/GCE sensing platform offered a wide LD detection range (concentrations from 2 to 683 µM) and a very low limit of detection (LOD) of 0.45 µM, outperforming almost all electrochemical sensors reported to date for LD sensing. The MnSAs-BN-BC/GCE platform also featured outstanding repeatability, reproducibility, selectivity, and stability. The as-developed sensing platform was successfully applied to LD quantification in commercial tablets with satisfactory recoveries (85.2–102.4 %), with the analytical precision of method validated against a traditional UV–vis spectrophotometry method. Density functional theory (DFT) calculations showed that Mn single atom sites lowered the reaction energy barrier for LD oxidation, with the favorable d-band center position of Mn single atom sites in MnSAs-BN-BC contributing to the enhanced LD sensing performance. This work encourages the use of single-atom metal catalysts in design of high-performance electrochemical sensors for the rapid detection of LD.
研究领域:
材料科学
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电化学
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医学检测
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
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2024
·
IF 4.9
Lu Fang,Yi Zhang,Ye Liu,Jialong Shou,Hongying Liu,Lihua Li
Levodopa (L-Dopa) is a widely prescribed drug for treating Parkinson's disease (PD), however, due to its motor complications, dosage management is required during clinical treatment. Uric acid (UA) is an important antioxidant in the body and is believed to have a defensive effect on the development and progression of PD. Therefore, accurate measurement of L-Dopa and UA in PD patients is of great significance. In this study, a flexible electrochemical sensor based on carbon nanotube (CNT) fibers was developed for individual and simultaneous determination of L-Dopa and UA. The electrochemical behavior and detection performance of the sensor were studied by cyclic voltammetry and differential pulse voltammetry. The CNT fibers (CNTF) electrode exhibited a wide detection range of 0.16–2.08 mM and 0.08–0.96 mM for L-Dopa and UA, as well as a high sensitivity of 0.7142 μA μM −1 cm −2 and 1.33 μA μM −1 cm −2 , respectively. In addition, the sensor also exhibited good anti-interference, repeatability and bending stability, and has been successfully applied to the detection of L-Dopa and UA in bovine serum samples.
研究领域:
生物医学工程
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分析化学
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神经科学
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DOI
高影响因子
ANTI-CORROSION METHODS AND MATERIALS
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2023
·Vol. 70
·期 3
·129-138
·
IF 1.2
Jiao Li,Tianshu Li,Jodie A. Yuwono,Guozhe Meng,Zhiyuan Feng
Purpose This study aims to develop a sol-gel-based coating to provide a long-lasting corrosion protection on AZ31 Mg alloy. Silane-based sol-gel coatings have been successfully applied to Mg alloys for corrosion protection. However, the micro or nano defects formed during condensation and solidification will cause the coating failure during a long-lasting immersion in a saline solution. More durable corrosion-protective sol-gel coatings are needed. Design/methodology/approach A sol-gel-based coating was modified on AZ31 Mg alloy by levodopa (DOPA). The long-lasting corrosion protection mechanism was studied by multiple electrochemical testing methods and surface characterization techniques. Findings Long-term testing by electrochemical impedance spectroscopy in aqueous 0.1 M NaCl indicated that the modified DOPA@sol-gel coating exhibited significant corrosion protection performance (>14 days). In comparison, the DOPA-free sol-gel coating failed only after three days of testing. The improved corrosion protection is attributed to the self-polymerized DOPA filling to the micro or nano defects in the glassy cross-linked networks of the sol-gel coating, which greatly improves the compactness of the coating. Originality/value The method of this study is simple and easy to process, the raw materials are green and the protective effect is excellent, which is of significance for the study of magnesium alloy corrosion protection.
研究领域:
材料科学
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腐蚀与防护
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生物医学工程
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2020
·
IF 3.594
Saipeng Huang,Wenshuai Li,Xin Zhou,Mengyao Xie,Qing Luo,Huiyun Wen,Yane Luo,Weiming Xue
Tyrosinase (TYR), a key enzyme for melanin biosynthesis, is an important biomarker for melanoma, thus a biosensor that can specifically detect and image tyrosinase would be in urgent demand to diagnose tyrosinase related disease. Therefore, a novel levodopa (L-Dopa) functionalized carbon quantum dots (Dopa-CQDs) was firstly constructed and synthesized by a convenient “one-step synthesis” strategy without any modified steps, utilizing L-Dopa and urea as precursors. The Dopa-CQDs also illustrated excellent linear relationship with a wide range (0–1200 U·L −1 ) and a low detection limit of 7.3 U·L −1 . Importantly, the nanosensor exhibited high selectivity for tyrosinase over other biological substances including various amino acids and intercellular proteases. Moreover, the Dopa-CQDs demonstrated practicability for TYR detection in human serum samples and inhibitor screening with satisfactory results. Particularly, the designed biosensor was successfully applied for intracellular TYR detection with excellent biocompatibility and cellular imaging capability, which provided a novel platform for selective detection of tyrosinase in biosystems. The novel methodology can be extended for fabricating novel biosensor for other analytes in various field, which will illustrate great importance for both fundamental research in biological systems and potential practical applications in clinical diagnosis.
研究领域:
生物传感
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医学诊断
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纳米材料
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DOI
高影响因子
PHARMACEUTICAL BIOLOGY
·
2023
·
IF 3.8
Jiayuan Li,Jiahe Yu,Jianyou Guo,Jinfeng Liu,Guohui Wan,Xiaojia Wei,Xue Yang,Jinli Shi
Context Levodopa combined with traditional Chinese medicine has a synergistic effect on Parkinson’s disease (PD). Recently, we demonstrated that Nardostachys jatamansi (D. Don) DC. [syn. Patrinia jatamansi D.Don, N. grandiflora DC.] (Valerianaceae) (NJ) can alleviate PD.Objective To explore the synergistic effect of NJ combined with levodopa against PD.Materials and methods The PD model was established by injecting rotenone. Eighty-four Sprague-Dawley rats were randomly divided into seven groups: sham, model, different doses of NJ (0.31, 0.62, or 1.24 g/kg) combined with levodopa (25 mg/kg), and levodopa alone (25 and 50 mg/kg) groups. The synergistic effect of the combination was investigated by pharmacodynamic investigation and detection of expression of nuclear factor erythro2-related factor 2 (Nrf2) and NLR family proteins containing Pyrin-related domain 3 (NLRP3) pathways.Results Compared with the model group, NJ + levodopa (1.24 g/kg + 25 mg/kg) increased the moving distance of PD rats in the open field (2395.34 ± 668.73 vs. 1501.41 ± 870.23, p < 0.01), enhanced the stay time on the rotating rod (84.86 ± 18.15 vs. 71.36 ± 17.53, p < 0.01) and the combination was superior to other treatments. The synergistic effects were related to NJ + levodopa (1.24 g/kg + 25 mg/kg) increasing the neurotransmitter levels by 38.80%-88.67% in PD rats, and inhibiting oxidative stress and NLRP3 pathway by activating Nrf2 pathway.Discussion and conclusions NJ combined with levodopa is a promising therapeutic candidate for PD, which provides a scientific basis for the subsequent clinical combination therapy of levodopa to enhance the anti-PD effect.
研究领域:
神经学
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药理学
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中医
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动物模型
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
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2018
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IF 4.427
Peng Liu,Xiangyu Wang,Jun Ma,Huiling Liu,Ping Ning
To provide superior substrates and determine the specific species of immobilized nano zero-valent iron (NZVI) system, polyacrylonitrile (PAN) membrane was functionalized by bio-inspired polydopamine (PDA) and poly( l -DOPA) (PDOPA) for efficient immobilization of NZVI. The synthesized composites were denoted as PAN/PDA-NZVI (PPN) and PAN/PDOPA-NZVI (PON), respectively. Analyses of XRD, SEM/EDS and XPS show that the aggregation and release of iron nanoparticles had been successfully controlled by improving membrane hydrophilcity and iron-chelating capacity via the graft of functionalized groups (i.e. OH and COOH) of PDA and PDOPA on PAN membrane. Both PPN and PON composites exhibited superior reactivity for Cr(VI) removal (Cr(VI) removal efficiency and reaction rate were 2.21–2.22 and 9.90–10.14 times higher than that of bare NZVI, respectively). The stability and recyclability of PPN and PON composites could be maintained over repeated cycles. Further analyses indicate that PON is more capable for Cr(VI) elimination than PPN due to the proprietary carboxyl of l -DOPA. With the addition of 1,10-phenanthroline, membrane-chelated Fe(II) was determined to be the major species in Cr(VI) removal system, accounting for 56.9% and 53.8% with regard to PPN and PON composites, and Fe 0 was responsible for the reduction of residual Cr(VI). Analyse of reacted composites revealed that Cr(VI) was completely converted into Cr(III), followed by formation of dominant Cr(III)/Fe(III) (oxy)hydroxides and partial desorption from NZVI reactive sites. This study suggested that both synthesized PPN and PON composites have potentials for Cr(VI)-contaminated wastewater treatment .
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）