Wang Ying,Ye Qiufeng,Hang Pengjie,Yao Yuxin,Li Biao,Kan Chenxia,Zhang Daoyong,Yu Xuegong,Yang Deren
Full-inorganic CsPb(I x Br 1- x ) 3 (0 < x < 1) optoelectronic devices have given rise to widespread interest of researchers owing to their excellent photovoltaic properties and promising thermal stability. However, defects at the interface between the electron transport layer (ETL) and the perovskite layer cause the open-circuit voltage ( V OC ) deficiency for inorganic perovskite solar cells (PSC). In this work, Baclofen (BCF), with carboxy group, amidogen group, and Cl in its molecule, is used as an interlayer between SnO 2 and CsPb(I x Br 1- x ) 3 inorganic perovskite. It is proved that the BCF can not only be beneficial for the growth of perovskite film but also act as a passivation layer for the SnO 2 /perovskite (PSK) interface, which significantly improves the open-circuit voltage of PSCs. Finally, a high V OC of 1.31 V and a power conversion efficiency (PCE) of 15.36% are realized for our BCF-treated PSCs.
Suhui Ni,Yun Liu,Yue Tang,Jing Chen,Shuhan Li,Ji Pu,Lidong Han
The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis of lung tumor has been attracted more interest. GABA B receptor ligand-directed nanoparticles consisting of baclofen functionalized trimethyl chitosan (Bac-TMC) as polymeric carriers, tripolyphosphate (TPP) as ionic crosslinker, and siSurvivin as therapeutic genes, were designed to enhance the survivin gene silencing. GABA B receptor agonist baclofen (Bac) was initially introduced into TMC as a novel ligand. This Bac-TMC/TPP nanoparticles increased the uptake of survivin siRNA through the interaction with GABA B receptor, further resulted in efficient cell apoptosis and gene silencing. For siRNA-loaded nanoparticles pulmonary delivery, mannitol was utilized for it delivery into pressurized metered dose inhalers (pMDI). The fine particle fractions of this formulation was (45.39 ± 2.99)% indicating the appropriate deep lung deposition. These results revealed that this pMDI formulation containing Bac-TMC/TPP nanoparticles would be a promising siRNA delivery system for lung cancer treatment.
Lixia Chen,Xiangjun Li,Tingting Tian,Sen Yang,Huiqun Wang
Enantioselective analysis of chiral drugs plays a significant role in chemistry , biology and pharmacology. Baclofen , an antispasmodic chiral drug, has been widely studied due to the obvious differences in toxicity and medical activity between enantiomers . Herein, a simple and efficient method for separation of baclofen enantiomers by capillary electrophoresis was established without complicated sample derivatization and expensive instruments. Then, the molecular modeling and density functional theory were used to simulate and investigate the chiral resolution mechanism of electrophoresis , the calculated intermolecular forces were directly presented by visualization softwares. Moreover, the theoretical and experimental electronic circular dichroism (ECD) spectra of ionized baclofen were compared, and the configuration of dominant enantiomer in the nonracemic mixture can be determined by ECD signal intensity, which was proportional to the electrophoresis peak area difference of the corresponding enantiomer excess experiments. In this way, the peak order identification and configuration quantification of baclofen enantiomers in electrophoretic separation were successfully achieved without relying on a single standard.
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