MACROMOLECULAR MATERIALS AND ENGINEERING
·
2020
·Vol. 305
·期 12
·2000457
·
IF 3.853
Chenkai Sun,Liming Zou,Yongjing Xu,Yanli Wang
To solve the problems of limited drug solubility and poor biodistribution with polymers in drug delivery system, ibuprofen (IBU) is chosen to prepare IBU-loaded poly(lactic acid) (PLA) micro-fibrous mats via electrospinning. Distinguished from the previous studies, a lower toxic binary solvent dichloromethane/ethanol (DCM/EtOH, v / v = 8/2) is used to successfully fabricate PLA/IBU electrospun mats with outstanding properties. In order to further evaluate the effects of IBU content on PLA, there are characterization methods employed as follows: scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and UV–vis spectrophotometer. The results show that IBU can be physically and uniformly distributed both on the surface and inside of PLA fibers. Compared with pure PLA mats, the crystallinity and mechanical properties of PLA/IBU electrospun mats has significantly improved. Meanwhile, in vitro drug release behavior demonstrates that with the increasing content of IBU, the rate of IBU release has increasingly improved. Particularly, the release behavior of PLA/IBU mats exhibited best with 20% IBU content, and the release amount reached 74.3% at the end of 240 h. Considering all these features, PLA/IBU electrospun mats have the potential to be used in the fields of wound dressing and drug delivery.
研究领域:
材料科学
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药学
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产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2023
·Vol. 224
·期 21
·2300195
·
IF 2.5
Xiuling Lin,Jiali Shi,Ge Meng,Chen Yu
Sodium alginate (SA) hydrogels crosslinked by calcium carbonate (CaCO 3 ) and gluconolactone (GDL) are prepared and characterized by X-ray diffraction (XRD) analysis and Fourier transform infrared (FTIR) spectrometry. The morphologies of the gel are observed with scanning electron microscopy (SEM). The SA hydrogels are used as carriers of the anti-inflammatory drug ibuprofen (IBU). The effects of GDL content, pH value, and temperature on IBU release behavior are investigated and associated kinetic analysis is performed. The results show that the cumulative release of IBU shows a trend of increasing and then decreasing with increased GDL content. The maximum cumulative release is observed when the molar ratio of calcium ions (Ca 2+ ) in CaCO 3 to GDL is 0.6. The release behavior of IBU is observed to be influenced by pH levels, and it exhibits an optimal release trend at a pH value of 7.4. The impact of temperature on the release behavior of IBU is relatively insignificant compared to other factors. The Korsmeyer–Peppas release kinetic model is well fitted and suitable to explain the release behavior of IBU from the sodium alginate hydrogel.
研究领域:
药剂学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2023
·
IF 3.6
Meng-qiu Xia,Jingbao Chen,Liu Liu,Chun-ling Tian,Wang-kai Cheng,Zhiyun Zheng,Xiao-qin Chu
Primary dysmenorrhea is a common disease in women, and oral administration of Ibuprofen (IBU) is associated with first-pass effects and gastrointestinal irritation. Here, we developed ibuprofen-loaded hexagonal liquid crystal (IBU HLC) gel for transdermal administration. In this study, the structure of prepared IBU HLC was characterized using polarizing microscopey (PLM) and small angle X ray diffraction (SAXS). In vitro drug release behavior and percutaneous penetration were investigated, and drug transdermal behavior was observed by confocal laser scanning microscope (CLSM). Finally, the pharmacokinetic profile and tissue distribution were investigated after transdermal administration. The PLM and SAXS results showed that the inner structure of IBU HLC was hexagonal phase. Moreover, in vitro release, skin permeation and CLSM demonstrated that IBU HLC had an excellent sustained-release effect, and a good transdermal penetration effect accompanied by the combination of multiple percutaneous routes. Pharmacokinetic studies indicated that IBU entered the blood circulation through abdominal transdermal administration in small amounts, mainly entering the uterus, and had a certain targeting ability. In conclusion, the IBU HLC gel would be a promising sustained-release preparation for transdermal administration to relieve dysmenorrhea with a significant drug concentration in the uterus.
研究领域:
药剂学
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药物递送系统
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Junwei Huang,Zilin Zhu,Ruomu Chen,Dandan Pan,Qing X. Li,Xiangwei Wu
Ibuprofen, a widely used nonsteroidal anti-inflammatory drug, contaminates agricultural products and potentially threatens human health due to its frequent detection and poor biodegradability. Microbial metabolism dominates the elimination of residual ibuprofen in the environment. In mineral salt medium at pH 6 with 5 mM glucose, Streptomyces sp. D218 transformed ibuprofen concentrations ranging from 0.05 to 0.40 mM in 24 h. The optimal temperature, pH, and initial OD600 nm for ibuprofen transformation by strain D218 were 25–37 °C, 5.0–6.0, and 1.0–1.5, respectively. Strain D218 could simultaneously transform ibuprofen into the intermediates 2-hydroxyibuprofen and ibuprofen amide (IBUA). The two intermediates were further metabolized to 2-hydroxyibuprofen amide (2HIBUA), thus relieving the growth inhibition of ibuprofen in Scenedesmus obliquus. This is the first complete pathway reported for the detoxification of ibuprofen transformation by a Gram-positive strain. These findings further our understanding of the microbial catabolism of the IBU.
研究领域:
环境微生物学
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药物代谢
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生态毒理学
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产品关联
DOI
PubMed
高影响因子
BIOREMEDIATION JOURNAL
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2022
·
IF 2.14
Zhuo-yi Zhou,Yi-cheng Wu,Yi Kuang,Guan-zhu Lin,Hai-yan Fu,Ze-jie Wang
Ibuprofen, a most widely used anti-inflammatory drug, is frequently detectable in surface water, which might negatively affect the ecosystem. The present research investigated acute toxicity of ibuprofen to Chlorella vulgaris, and ibuprofen removal by C. vulgaris was also evaluated via a first order kinetic model. The results showed that ibuprofen in water has certain freshwater ecological risks, and ibuprofen-contaminated water can be effectively treated by C. vulgaris. The growth and the photosynthetic activity of C. vulgaris were decreased with the increase in ibuprofen exposure concentration, while superoxide dismutase and catalase activities were markedly promoted. The dry weight of C. vulgaris exposed to 100 mg/L ibuprofen was determined as 0.238 ± 0.008 g/L, which was 60.82% of the control group (without added ibuprofen in medium). The capacity of C. vulgaris to ibuprofen removal was decreased with the increase in ibuprofen concentration. The removal efficiency reached to 67.25% after 10-day treatment at ibuprofen concentration of 25 mg/L, while that was just 32.77% when the ibuprofen concentration increased to 100 mg/L. The ibuprofen removal by C. vulgaris accorded with the first-order kinetic model, and the removal rate constants of C. vulgaris to different ibuprofen concentrations (25, 50, 75 and 100 mg/L) were determined as 0.115, 0.097, 0.093 and 0.043 d−1, respectively.
研究领域:
环境科学
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水生毒理学
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生物修复
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
·
IF 5.3
Yu Chen,Xirong Huang
CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propane sulfonate), a biocompatible zwitterionic surfactant derived from bile salt, has attracted great attention due to its distinct molecular structure and aggregation behavior. Addition of a low level of CHAPS to AOT (sodium bis(2-ethylhexyl) sulfosuccinate) reverse micelles has been found to be able to enhance the catalytic activity of the solubilized lipase. In this study, the effect of CHAPS on the lipase-catalyzed selective synthesis of (S)-n-octyl ibuprofen ester was investigated in AOT reverse micelles at 37 °C. The results demonstrate that the presence of CHAPS in AOT reverse micelle enhances both the yield and the enantiomeric excess (ee) value of (S)-n-octyl ibuprofen ester, especially at low water content. With 8 mM CHAPS in AOT reverse micelle ([AOT] = 100 mM, [H 2 O]/[AOT] = 12, pH = 7.0), a 48-hour yield of 34.2 % could be obtained, which is approximately twice that without CHAPS. In addition, the ee value of the product is increased from 89.1 % to 98.2 %. To understand the mechanism of the CHAPS effect, dynamic light scattering, fluorescence emission spectroscopy and Fourier transform infrared spectroscopy techniques were used to characterize the size of the reverse micelle, the conformation of the solubilized lipase and the activity of the bulk water in the reverse micelle. It reveals that at low water content, the addition of CHAPS enlarges the size of AOT reverse micelle, stabilizes the lipase conformation and reduces the nucleophilicity of bulk water in AOT reverse micelle. The synergistic effect of the aforementioned factors results in the improvement of the enzymatic synthesis of the ester. The above research provides scientific support for the lipase-based preparation of chiral acids/alcohols in the reverse micellar system.
研究领域:
生物化学
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酶工程
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有机合成
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产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Ping-fu Huang,Miaomiao Ma,Hao Wu,Wen-min Niu,Lu-lu Liu,Jia-bing Tong
Purpose Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory. Ibuprofen (IBF) and curcumin (CUR) were the commonly therapeutic ingredients for RA treatment and the combination administration possessed the ideal efficacy, however, the low solubility and lack of targeting produced the significant obstacles for the treatment. Methods In this study, the IBF prodrug decorated with the CD44 receptors and ROS-sensitive was prepared and encapsulated with the CUR named CUR@HA-TK-IBF were designed, the characterization of CUR@HA-TK-IBF were performed in vitro and the efficacity effect were evaluated using collagen induced arthritis (CIA) model. Results The obtained product CUR@HA-TK-IBF exhibited the diameter of 137.3 ± 4.5 nm, and the morphology of the nanoparticles showed the sphericity via the TEM. In vitro release results indicated that the IBF and CUR could slowly release in the normal environment and quickly release at the H 2 O 2 environment. Furthermore, the combination of CUR and IBF could significantly decrease the expression of the proinflammatory factors and the concentration of ROS and COX-2 in vitro . The animal experiment indicated that the CUR@HA-TK-IBF could alleviate the foot tumefaction and decrease the expression of proinflammatory factors in the RA model mice. Conclusion The CUR@HA-TK-IBF developed the new approach for co-deliver the IBF and CUR, which provided a new therapeutic strategy for the treatment of RA.
研究领域:
药学
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免疫学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2024
·
IF 12.2
Ruobing Pi,Zhe Yang,Jin Chai,Yuan Qi,Xuhui Sun,Yunlong Zhou
Many studies have shown that Peroxymonosulfate (PMS) works synergistically with ferrate (Fe(VI)) to remove refractory organic compounds in a few minutes. However, little has been reported on the combined effects of peroxydisulfate (PDS) and Fe(VI). Since PDS is stable and cost effective, it is of practical significance to study the reaction mechanism and conditions of the PDS/Fe(VI) system. The results of the study indicate that the intermediate Fe(II) is formed during the decomposition of Fe(VI), which is then rapidly oxidized. Due to the asymmetry of the PMS molecular structure, PMS can rapidly trap Fe(II) (k PMS/Fe(II) = 3 × 10 4 M −1 ∙s −1 ), whereas PDS cannot (k PDS/Fe(II) = 26 M −1 ∙s −1 ). Hydroxylamine hydrochloride (HA) can reduce Fe(VI) and Fe(III) to Fe(II) to excite PDS to produce SO 4 •− . Acetate helps to detect Fe(II), but does not help PDS to trap Fe(II). Active species such as SO 4 •− , •OH, 1 O 2 , and Fe(IV), Fe(V) are present in both systems, but in different amounts. In the PMS/Fe(Ⅵ) system, all these active species react with ibuprofen (IBP) and degrade IBP within several minutes. The effects of the initial pH, PMS or Fe(VI) dosage, and different amounts of IBP on the removal rate of IBP were investigated. According to the intermediates detected by the GC-MS, the degradation process of IBP includes hydroxylation , demethylation and single bond breakage. The degradation pathways of IBP were proposed. The degradation of IBP in tap water and Songhua River was also investigated. In actual water treatment, the dosage needs to be increased to achieve the same results. This study provides a basis and theoretical support for the application of PMS/Fe(Ⅵ) and PDS/Fe(VI) system in water treatment.
研究领域:
环境科学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Kaiqiang Shi,Yi Wang,Anlin Xu,Xiezhen Zhou,Hongwei Zhu,Kajia Wei,Xiaodong Liu,Jinyou Shen,Weiqing Han
Gas-diffusion electrodes (GDEs) are the efficient generator for the hydrogen peroxide, which plays an important role in the degradation of refractory organic contaminants by electro-Fenton processes. In this work, the microtubular gas-diffusion electrodes (MGDEs) were fabricated with the carbon nanotubes (CNTs) hollow fiber base by wet-spinning technology and then employed as gas-diffusion electrodes (GDEs). Characterized by FESEM, TEM, BET, XPS, the MGDEs were proved to be relatively compact and intact without fracture on the hollow fiber surface. Cyclic voltammetry test in three electrodes system was carried out to prove the catalysis effect of the surface functional groups in the electrochemical reactions. The time-course of H 2 O 2 production rate in the range of the different current density (10 ~ 25 mA cm −2 ), pH value (3.0 ~ 9.0) and electrolyte concentration (0.01 ~ 0.1 M Na 2 SO 4 ) were conducted to evaluated the electrochemical performance of MGDEs and explorer the optimal condition. The stability of electrocatalytic was also tested by repeated runs. Furthermore, several parallel-degradation process of the simulated wastewater with the 1.0 ~ 10.0 mg L -1 IBP were carried out in electro-Fenton system. Under the optimal conditions, the removal rate of IBP could reach 90.2% in 120 min with the pseudo first-order degradation rate constant of 0.01415 min −1 . It shows the potential of this system to degrade NSAIDs.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Guangyu Wu,Qi Liu,Jingyi Wang,Siye Xia,Hualong Wu,Jiaxiang Zong,Jiangang Han,Weinan Xing
Wastewater containing pharmaceuticals can be bioaccumulated, posing a potential risk to drinking water, human health, and ecosystems. In order to make the adsorption process more suitable for actual application, rape straw biomass fiber (treated by an acidified sodium chlorite solution, 5%) and Fe 3 O 4 embedded β-CD to prepare a novel adsorbent (RSBCDF), which was used for the removal of ibuprofen (IBP) from aqueous solution. The RSBCDF was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) measurements, scanning electron microscopy (SEM), and zeta potential measurements. The synthesized adsorbent was studied with regard to IBP removal percent under different adsorption conditions such as varying initial pH levels (4–10), initial ibuprofen concentrations (20−160 mg/L), contact time (5−150 min), and the dosage of adsorbent (10−100 mg) via batch adsorption experiments. The adsorption kinetics, thermodynamics, and isotherms were also investigated. The IBP adsorption behaviour followed a pseudo-second-order kinetic model and the Freundlich isotherm model. The maximum adsorption capacity obtained for ibuprofen was 48.29 mg/g. The values of Gibbs free energy change were negative (-2.58∼-3.56KJ/mol), suggesting that the process of ibuprofen adsorption onto adsorbent was spontaneous. The positive value of standard enthalpy change (12.09 kJ/mol) indicated that the adsorption process was endothermic. The obtained results prove that RSBCDF is a proficient and economically suitable material for removing IBP from water environments.
研究领域:
环境科学
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材料科学
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药学
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产品关联
DOI
高影响因子
Soft Matter
·
2022
·Vol. 18
·期 40
·7859-7865
·
IF 4.046
Lei Fan,Chao Song,Ximing Lu,Tong Wang,Jie Han,Rong Guo
Arthritis is a disease that seriously affects the quality of human life, which is partly caused by the reduction of joint lubrication performance. Thus, for the treatment of arthritis, how to improve the lubrication performance of joints is important. The lamellar liquid crystals (LLCs) systems have the potential to be used as joint lubrication due to their double-layer structure and good biocompatibility, however, the LLCs system alone could not provide a satisfactory lubrication effect. Herein, this work synthesized hydroxyapatite (HAP) in situ inside Tween 85/Tween 80/H2O LLCs to construct a biocompatible HAP/Tween 85/Tween 80/H2O LLCs (HAP/LLCs) lubrication system with both sustained drug release properties and anti-wear properties. HAP is the main component of bone with good stability and bioactivity. The LLCs have good lubricating and drug-carrying properties. The impact of HAP on the structure and lubrication properties of LLCs, the mechanism of friction, and the anti-wear reduction of HAP/LLCs were investigated. Moreover, the drug release behavior of the ibuprofen-loaded HAP/LLCs during the friction process was also studied. The results indicated that the addition of HAP could improve the lubricity performance of LLCs. The cumulative drug releasing increased with the friction frequency and was less affected by the load. The related studies provided the theoretical basis for HAP/LLCs for joint lubrication and synergistic therapy.
研究领域:
材料科学
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生物医学工程
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骨科
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Yang Liu,Zhuofeng Hu,Jimmy C. Yu
Doping heterogeneous atoms into BiOX is recognized as an effective method to improve its photocatalytic activity. Here, S-doped BiOBr (S–BiOBr) was synthesized via a solvothermal method in the absence of water, which is supposed to substitute O as S 2− in the lattice. This material is firstly used for the visible-light-driven degradation of ibuprofen, a model anti-inflammatory drug. The degradation efficiency of S–BiOBr is much higher than that of pure BiOBr. The degradation kinetic constant for S–BiOBr (2.48 × 10 −2 min −1 ) is about 3 times as high as that of pure BiOBr (0.83 × 10 −2 min −1 ). It is found that S-doping tunes the band structure of BiOBr, leading to a narrower band gap and thus higher utilization efficiency of visible light. The degradation of ibuprofen on S–BiOBr can be attributed to the generation of H 2 O 2 and OH radicals. OH radical plays a synergistic role along with holes in the photocatalytic degradation process, which is supposed to be better than the reported single hole- or superoxide-dominant reaction. This work reveals a previously unrecognized and more efficient method for the degradation of organic contaminants on BiOBr.
研究领域:
环境科学
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材料科学
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化学工程
✓ 已验证
DOI
PubMed
高影响因子
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