Pressure injury (PI) is a hard-to-heal wound to patients with the limited mobility, especially paralyzed or elderly persons. These patients also commonly suffer from sensation loss or dementia that is unable to indicate symptoms in time, resulting in missing the “golden period” for treatment. Therefore, it is highly required to domestic continously real-time monitoring as well as promoting wound healing of PI. However, no existing device has realized these functions for PI. Herein, we prepare a zwitterionic skin sensor that enables pro-healing as well as domestic real-time monitoring the multi-indicators of PI. To apply for a PI dressing that requires to tolerate patient body weight, organosilicon nanoparticles (OSNPs) are designed as crosslinks in the zwitterionic conductive hydrogel (CH-OSNP), which exhibits pressure-resistant properties (99.81% compression to recovery) as well as anti-bacterial adhesion. Moreover, the CH-OSNP-based skin sensor is developed, and the resultant sensor can be sensitive to stress stimuli even under a long-term constant heavy load, which stimulates the pressure of a PI person lying down. In vivo results show that this sensor can not only promote PI healing, but also continuously monitor and distinguish multiple information, such as exudate, swelling, and infection, to prevent PI from being worsen. This work provides a domestic feasible device to cure and monitor the PI of patients.
Mechanoluminescence (ML) behavior has been extensively studied in recent years in fields such as sensing and lighting. The primary obstacle hindering the large-scale commercial application of ML materials is that they only exhibit significant luminescence when subjected to relatively strong stress stimuli. We in this work employed the aliovalent doping strategy in the ML matrix CaZnOS for the first time to modify the crystal and electronic structure of the material, thereby optimizing its ML property. The impact of Ca 2+ substitution by (K + , Gd 3+ ) ionic pair on phase purity, composition and morphology was systematically analyzed by the combined techniques of XRD, ICP, TEM, and XPS. The band structure of the representative samples was further investigated using UV-Vis measurements and density functional theory (DFT) calculations. After aliovalent doping, not only the concentration of oxygen vacancy increased but also the band gap narrowed. These two changes respectively enhanced the number of hole-electron pairs and facilitated their combination during the ML process, ultimately leading to an enhancement of the ML intensity.
危险品化学品经营许可证（带存储）