Yang Sun,Mengling Zhong,Jingjie Wang,Mingmei Feng,Caihong Shen,Zhipeng Han,Xiaonian Cao,Qi Zhang
Aging can cause age-related diseases such as cancer, cardiovascular and neurodegenerative diseases. Cordycepin exerts anti-oxidation, anti-inflammatory and neuroprotective effects. However, the anti-aging effect of cordycepin is still unclear. This study aimed to investigate the anti-aging effect of cordycepin and unravel the underlying mechanism. Cordycepin prolonged the lifespan of C. elegans under normal and heat stress conditions, without effects on the normal growth and reproduction of C. elegans . Cordycepin also improved the locomotion ability, inhibited the deposition of aging pigment lipofuscin and alleviated the oxidative stress damage by decreasing the excessive accumulation of ROS and raising the antioxidant enzyme activities in C. elegans . The metabolomics study showed that cordycepin changed 19 metabolites including citric acid, linoleic acid, oleic acid, glutamic acid, pyruvic acid and so on. Transcriptomics study revealed that cordycepin up-regulated the gene expression of acox-1.2, acox-1.3, acox-1.4, acs-1, acs-15, acdh-1, acdh-4 and acdh-8 in C. elegans , suggesting that cordycepin prolonged its lifespan via regulating fatty acid degradation, fatty acid metabolism and so on. In summary, the current study demonstrated that cordycepin exerted the anti-aging effect on C. elegans by improving the antioxidant system and regulating the genes involved in fatty acid metabolism to inhibit the accumulation of linoleic acid and oleic acid. Therefore, cordycepin might be a promising agent for aging and age-related diseases.
Gu Zhuo,Fu Xiong,Wang Ping-Ping,Tan Chin-Ping,Chen Chun
Sugarcane, as one important and heavily planted industrial crop, is meaningful to develop its byproducts. In this paper, the ultrasonic collaborative pulse was beneficial for the yield improvement and good bioactivity protection. The sugarcane polyphenol extract (SPE) yield reached 2.42 ± 0.08 mg/g DW at the optimized conditions: pulse time of 60 s, pulse intensity of 2 kV/cm, ultrasonic time of 90 min, and ultrasonic power of 120 W. The SPE contained the total phenolic content of 6.01 ± 0.12 mg GAE/g extract and total flavonoids content of 7.15 ± 0.24 mg RE/g extract. The SPE was mainly composed of chlorogenic acid, schaftoside, hyperoside, quercitrin, and trans-3-hydroxycinnamic acid with 10.24 %, 14.92 %, 4.22 %, 12.05 %, 25.54 %, respectively. The SPE showed good radical scavenging activity with ORAC value of 134.57 μmol/g. The SPE could reduce the oxidative stress and extend the mean lifespan of nematodes by 7.19 % in vivo through increasing the activity of SOD and CAT to decrease the ROS level and MDA content. In addition, the SPE showed strong α-glucosidase inhibitory activity with IC50 of 0.53 mg/mL in a mixed inhibition type, which suggested that the SPE had good hypoglycemic potential.
危险品化学品经营许可证（带存储）