OPTIK
·
2022
·
IF 2.84
Xiang-Lin Fang,Rui-Tong Zhao,Na Chen,Xin Wang,Peng Wang,Zhi-Wei He,Shao-Xin Li,Yang Xu,Yong-Hong He
As one of important optical properties of chiral molecules, the real-time monitoring of the optical rotation is of great significance to study the reaction characteristics of chiral molecules. In this study, we have built an optical frequency domain weak measurement system with linear common-path method for chiral sensing, in which the response between optical rotation and central wavelength shift can reach more than 1200 nm/rad. The high-precision measurement of the optical rotation of chiral molecules and the high-sensitivity real-time monitoring of the decomposition rate in the acidic hydrolysis of sucrose under different concentrations of catalysts are realized using this system. The experimental results are basically consistent with the theoretical prediction. This study shows that optical weak measurement chiral sensing can monitor the hydrolysis degree of chiral molecules in real time without separating and labeling molecules. It has great application potential in the production and research of chiral compounds, especially chiral medicine.
研究领域:
化学
·
光学
·
药物研究
✓ 已验证
产品关联
DOI
高影响因子
FOOD AND AGRICULTURAL IMMUNOLOGY
·
2020
·
IF 0
Meiguo Xin,Lin Zeng,Di Ran,Xiangmei Chen,Yang Xu,Daoxuan Shi,Yonghong He,Suyi Zhong
A label-free and rapid detection of cooked rat meat-based molecular-imprinted polymer (MIP) conjugated with quantum weak measurement system (QWM) has been developed. Cooked rat protein-specific MIP was prepared by a modified reverse-phase microemulsion method and coated on the internal surface of measuring channels assembled into Mach-Zrhnder interferometer of an optical weak measurement system. The measurement is based on the optical phase shift due to the refractive index change, which is induced by the specific capture of rat protein at its MIP sites. The results can be characterized and calculated by the central wavelength shift of output spectra through weak value amplification. This MIP-WQM system was demonstrated with cooked rat protein showing linear dynamic range from 0 to 20 µg/L. The limit of detection is calculated as 0.1 µg/L for cooked rat meat protein. The system also showed high specificity to cooked rat meat protein, compared to cooked pork meat proteins.
研究领域:
食品科学
·
光学检测
·
生物技术
✓ 已验证
产品关联
DOI
LASER PHYSICS
·
2022
·Vol. 32
·期 12
·125201
·
IF 1.38
Ruitong Zhao,Xin Wang,Peng Wang,Xingda Wu,Xianglin Fang,Yanjiao Zhang,Shaoxin Li
The real-time measurement of optical activity is of great significance for studying the chemical reactions of chiral molecules. In this study, we have built a set of linear common path optical weak measurement chiral sensor system in frequency domain, and the optical sensitivity of the system feasibly reaches 1524 for activity. Using this system, we have realized the state measurement of the ultrafast alkaline hydrolysis reaction of gluconolactone under different concentrations of catalyst. This study shows that the optical weak measurement chiral sensor can well monitor and compare the degree of hydrolysis reaction, and partly reflect the approximate change of the optical rotation in the real-time process of hydrolysis. Optical weak measurement chiral sensing does not require separation and labeling molecules, and has great application potential for the production and development of chiral compounds, especially chiral drugs.
研究领域:
分析化学
·
生物化学
·
药物开发
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Yang Xu,Cuixia Guo,Yuxuan Yang,Chongqi Zhou,Lizhong Zhang,Han Li,Zishuo Song,Bei Wang,Yonghong He,Ke Cao
Protein-polyphenol interactions are crucial in food chemistry, yet current detection methods have limitations. This study innovatively uses optical weak measurement. Key variables like central wavelength shifts were measured in systems with chlorogenic acid, tea polyphenols, and various proteins. A linear relationship between polyphenol concentration and wavelength shift was found, and a new calculation strategy for binding constants and sites was developed, showing consistent trends with fluorescence quenching. The method is label-free and applicable to non-immobilized biomolecules, offering cost-effective and accurate detection. However, it's sensitive to solution fluctuations and complex samples. Future research should optimize the device and detection techniques to improve stability and capture interaction dynamics. This study provides a valuable tool for food chemistry research.
研究领域:
食品化学
·
生物物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IEEE SENSORS JOURNAL
·
2024
·Vol. 24
·期 24
·40710-40716
·
IF 4.3
Jiao Ren,Xiaoxue Xu,Pengpeng Xie,Guiqiang Wang
An improved weak measurement scheme, a weak measurement sensor with a mesoporous silica film (MSF) structure, was first proposed. A simple Stöber solution growth method was used to prepare MSF with a large surface area and high stability, which can be utilized to their mesoporous advantage during adsorption detection. The MSF-based weak measurement sensor achieved a sensitivity of 1418.8 nm/RIU and a refractive index resolution of
$2.56\times 10^{-6}$
RIU. A detection limit of 53 mg/L was recorded for nonadsorbed glucose detection. In the detection of hexadecyl trimethyl ammonium bromide (CTAB), which could be physically adsorbed within the mesoporous thin-film layer, the limit of detection was significantly reduced to 12.6 nM. Heavy metal copper ions could be captured by the carboxyl complex of the MSF mesoporous layer, and a detection limit of 24.4 nM was obtained. The detection of small molecules and heavy metal ions demonstrates the high performance and great potential of MSF-based weak measurement sensors and it might be used as a versatile platform for high-sensitivity label-free optical biosensing.
研究领域:
材料科学
·
光学传感
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Dongmei Li,Qinghua He,Yonghong He,Meiguo Xin,Yilong Zhang,Zhiyuan Shen
A new type of sensing protocol, based on a high precision metrology of quantum weak measurement, was first proposed for molecularly imprinted polymers (MIP) sensor. The feasibility, sensitivity and selectivity of weak measurement based MIP (WMMIP) sensor were experimentally demonstrated with bovine serum albumin (BSA). Weak measurement system exhibits high sensitivity to the optical phase shift corresponding to the refractive index change, which is induced by the specific capture of target protein molecules with its recognition sites. The recognition process can be finally characterized by the central wavelength shift of output spectra through weak value amplification. In our experiment, we prepared BSA@MIP with modified reversed-phase microemulsion method, and coated it on the internal surface of measuring channels assembled into the Mach-Zehnder (MZ) interferometer based optical weak measurement system. The design of this home-built optical system makes it possible to detect analyte in real time. The dynamic process of the specific adsorption and concentration response to BSA from 5×10 −4 to 5×10 −1 μg/L was achieved with a limit of detection (LOD) of 8.01×10 −12 g/L. This WMMIP shows superiority in accuracy, fast response and low cost. Furthermore, real-time monitoring system can creatively promote the performance of MIP in molecular analysis.
研究领域:
生物传感技术
·
分子识别
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2022
·
IF 6.556
Lizhong Zhang,Qiang Huang,Xiaonan Zhang,Zhen Zeng,Hailong Zhang,Tian Guan,Yang Xu,Chongqi Zhou,Lingqin Meng,Gengyu Liang,Zhangyan Li,Bei Wang,Le Liu,Cuixia Guo,Yonghong He
In this study, an interfacial biosensing scheme with ultra-precision is proposed. The scheme uses weak measurement techniques to ensure ultra-high sensitivity of the sensing system while improving the stability of the system through self-referencing and pixel point averaging, thus achieving ultra-high detection accuracy of biological samples. In specific experiments, we have used the biosensor in this study to perform specific binding reaction experiments for protein A and Mouse IgG with a detection line of 2.71 ng/mL for IgG. In addition, the sensor is non-coated, simple in structure, easy to operate, and low in cost of use.
研究领域:
生物传感器
·
生物技术
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS
·
2021
·Vol. 21
·期 3
·1003
·
IF 3.576
Dongmei Li,Chaofan Weng,Yi Ruan,Kan Li,Guoan Cai,Chenyao Song,Qiang Lin
A chiral sensor with optical rotation detection based on weak measurement for the kinetic study of sucrose hydrolysis is presented. Based on the polarization modulation to the pre-selection state, the optical rotation of chiral sample was accurately determined through the central wavelength shift of the output spectrum. With this approach, the concentration response curves of sucrose and its hydrolysis products, i.e., fructose and glucose, were experimentally obtained for the hydrolysis analysis. By collecting the output spectrum with a frequency of 100 Hz and fitting the central wavelength shift synchronously during the measurement, the sucrose hydrolysis process was monitored in real time. Different hydrolysis conditions with varied concentration of invertase enzyme and citrate were implemented in this work. As a consequence, the real-time hydrolysis curves of the hydrolysis process with distinct velocities was achieved and analyzed. Such a kinetic monitoring about sucrose hydrolysis with optical rotation detection technology played a critical role in the researches involving sucrose, and also revealed the great potential of weak measurement in intersections, such as food safety inspection and chemical analysis.Keywords:chiral sensor;optical sensors;weak measurement;sensor systems and applications;sucrose hydrolysis
研究领域:
光学传感器
·
化学分析
·
食品安全检测
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Chongqi Zhou,Yang Xu,Xiaonan Zhang,Zhangyan Li,Tian Guan,Yonghong He,Yanhong Ji
A modified weak measurement scheme, rotatory biased weak measurement, is proposed to significantly improve the sensitivity and resolution of the total internal reflection sensor. This method introduces an additional phase in the post-selected procedure and generates an extinction point in the spectrum distribution. The biased post-selection makes smaller coupling strength available, which leads to an enhancement of phase sensitivity and refractive index sensitivity. In rotatory biased weak measurement, an enhanced refractive index sensitivity of 13605 nm/RIU is achieved compared to 1644 nm/RIU in standard weak measurement. The performance of total internal reflection sensors with different sensitivity is analyzed, and it is shown the optimal refractive index resolution of sensors increases with sensitivity. An optimal refractive index resolution of 4 × 1 0 − 7 RIU on a total reflection structure is demonstrated, which is far beyond the state-of-the-art resolution of 3 × 1 0 − 6 RIU of total internal reflection sensors. The rabbit anti-mouse IgG and mouse IgG binding reaction experiments demonstrate that our system has a high response to the concentration of IgG in a wide range and the limit of detection is 15 ng/mL. This work provides a total internal reflection sensor with the advantages of simple structure, low cost, and high resolution at the same time.
研究领域:
光学
·
传感器
·
生物物理学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED OPTICS
·
2019
·Vol. 58
·期 31
·8583-8588
·
IF 1.973
Suyi Zhong,Tian Guan,Yang Xu,Chongqi Zhou,Lixuan Shi,Cuixia Guo,Xuesi Zhou,Zhangyan Li,Yonghong He,Yanhong Ji
The ability to identify L(+)-ascorbic acid from D(-)-isoascorbic acid in medicinal products is of practical interest. Based on the method of frequency domain weak measurement, a set of common optical path sensors for identification of L(+)-ascorbic acid and D(-)-isoascorbic acid is established. By quantificationally analyzing the magnitude and offset direction of the spectral central wavelength, a good identification of the concentration and the optically active forms of ascorbic acid has been achieved. The sensitivity and resolution of the sensor for optical rotation can reach 34.35 nm/° and ${5.53} \times {{10}^{ - 5}}^\circ $, respectively. The detection resolution for L(+)-ascorbic acid is ${2.00} \times {{10}^{ - 4}}\;{\rm mol}/{\rm mL}$, and that for D(-)-isoascorbic acid is ${2.73} \times {{10}^{ - 4}}\;{\rm mol}/{\rm mL}$. The potential of the sensor in the detection of transparent but optically inactive impurities has been verified by comparative experiments of sodium chloride solution. The sensor also has been applied to identify medicinal vitamin C tablets, which verified the feasibility of the method in optically active pharmaceutical solutions with water-insoluble, optically inactive impurities. Since the sensor has the advantages of high precision, real-time, high robustness, and being non-destructive, it has a great prospect in the field of drug detection containing chiral molecules.
研究领域:
分析化学
·
药学
·
光学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED OPTICS
·
2022
·Vol. 61
·期 34
·10065-10071
·
IF 1.905
Jing-Ru Zhao,Jing-Ru Zhao,Zhen-Jie Wu,Gui-Qiang Wang,Chun-Nan Wang,Bo-Fu Deng,Shu-Qing Sun
A total internal reflection system based on the weak value amplification principle is set up for the precise measurement of the thickness of an ultra-thin film. In this system, the film thickness is derived from the change of the double-peak pointer caused by the effective refractive index of the film, which is correlated to its thickness. The sensitivity and resolution of this system reached 2727.21 nm/RIU and ${7.2} \times {{10}^{- 6}}\;{\rm RIU}$, respectively, determined by using a sodium chloride solution with a refractive index of 1.331911. The growth process of TA/Fe(III) assembled films with thicknesses in the few nanometers range is monitored using the as-set-up system, and the experimental results are consistent with a theoretical calculation based on the Maxwell Garnett effective medium. Additionally, we theoretically calculated the detection limit for the thickness measurement of the film as 22 pm. We clearly provide a potential method for the precise measurement of the thickness of an ultra-thin film.
研究领域:
光学
·
材料科学
·
物理学
✓ 已验证
DOI
PubMed
高影响因子
Small Methods
·
2023
·
IF 12.4
Hao Lin,Yang Xu,Xiao Chen,Zengxian Fang,Tian Yan,Kaijie Ma,Le Liu,Jingyu Xi
Vanadium flow batteries (VFBs) face a challenge with the low reaction rates of the V(II)/V(III) redox couple, which limits the performance of VFBs. Additionally, the negative electrode in VFBs is often accompanied by the persistent hydrogen evolution reaction (HER), which is difficult to eliminate. Therefore, understanding the spatial distribution of activity on the negative electrode and the HER side reaction on the electrode surface is of critical importance. This study proposes a weak measurement imaging method to characterize the spatial distribution of surface activity and HER onset potential on the negative electrode in VFBs). This method enables the visualization and in situ detection of key parameters such as the absolute values of |i pa |, |i pc |, |∆E|, |i pc /i pa |, and the HER onset potential. By comparing three different types of graphite felts with varying activity levels, it validates the feasibility of this method. Furthermore, electrochemical stability tests are conducted to study the electrodes repeatability, uniformity, and durability. This method holds promise in guiding the design of electrodes with enhanced activity, good reversibility, minimized HER side reactions, and uniform distribution.
研究领域:
能源存储
·
电化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）