MATERIALS LETTERS
·
2019
·
IF 3.019
Fei-Fei Wang,Zan Liu,Zhi-Lin Cheng
In this study, the zeolitic imidazolate frameworks-8 (ZIF-8) with nano- and micro-sized morphologies was successfully fabricated by solvothermal method. The dispersibility of as-obtained ZIF-8 in oil was studied. As an application, the tribological behavior of the as-obtained ZIF-8 in the based oil was investigated. The nano- and micro-sized morphologies of as-obtained ZIF-8 were conductive to reduce the friction coefficient and wear, and raise the carrying capacity in the base oil. In addition, the friction reducing mechanism was proposed.
研究领域:
材料科学
·
摩擦学
·
化学工程
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Hongyu Wang,Ruili Liu,Yue Yu,Hongrui Xue,Runjia Shen,Yanshuang Zhang,Jiandong Ding
Epithelial-mesenchymal transition (EMT) is a key phenotypic switch in cancer metastasis, leading to fatal consequences for patients. Under geometric constraints, the morphology of cancer cells changes in both cellular and subcellular levels, whose effects on EMT are, however, not fully understood. Herein, we designed and fabricated chimeric micropatterns of polystyrene (PS) with adhesion contrast to reveal the impacts of cell shapes and nuclear shapes on EMT in a decoupled way. Cell elongation was modulated via microwell aspect ratios (ARs), and nuclear deformation was generated through a micropillar array in the microwell. Human non-small cell lung cancer cells (A549) were cultured on the quasi-three dimensional micropatterned surfaces, and transforming growth factor-β1 (TGF-β1) was added to induce EMT. We found that chimeric micropatterns upregulated EMT with an increase of cellular AR and nuclear indentation under given TGF-β1. The subsequent assessment of the contractility and oriented assembly of microfilaments elucidated the key role of mechanotransduction in cell elongation and EMT, as proved by myosin inhibition, while it was obstructed by micropillars in the chimeric micropattern. Hence, the micropillar array possessed a nonmonotonic influence, enhancing the EMT of cells with AR of 1, but hindering the EMT with an impact more significant on microwells with large ARs due to the impeded cytoskeleton assembly. This fundamental research has illustrated the complex of cellular and subcellular geometries on cell behaviors including phenotype transition in cancer metastasis.
研究领域:
生物医学工程
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细胞生物学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2022
·Vol. 10
·期 17
·2200687
·
IF 10.05
Shuhua Chen,Xinnan Mao,Qixuan Zhong,Qi Pan,Jun Liu,Jie Fu,Di Yang,Jinxing Chen,Lu Wang,Qiao Zhang,Muhan Cao
Heterostructures integrated by diverse material featuring nanocrystals (NCs) tunable properties and functions are of great interest. However, to rationally design and precisely control the heterostructures in multiple shapes still remains a tremendous challenge. In this work, the nucleation of SiO 2 nanoparticles is manipulated via a kinetics-controlled water–hexane interfacial reaction system to construct Cs 3 Cu 2 I 5 /SiO 2 heterostructures, which can be well controlled in Janus and patchy morphology. In this interfacial reaction, the evolution of Cs 3 Cu 2 I 5 NCs and the intrinsic formation mechanism of the heterostructures are investigated. It is observed that the Cs 3 Cu 2 I 5 NCs on the interface undergo a morphology transformation driven by ligand loss and exposed facets evolution. Increased wettability between Cs 3 Cu 2 I 5 and SiO 2 favors the formation of Cs 3 Cu 2 I 5 /SiO 2 heterostructures. The key to this strategy is to break the rule of thermodynamic domination in reaction by kinetics manipulation when constructing the patchy heterostructure. To be noted, an increased stability is conferred on the resultant heterostructure product compared to naked perovskite NCs. This work enables to better control the complicated heterostructure configurations and understand their formation mechanism.
研究领域:
材料科学
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纳米技术
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化学工程
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DOI
高影响因子
Advanced Materials Interfaces
·
2025
·
IF 4.4
Jiawang Li,Guang Wang,Hongzhao Fan,Zhigang Li,Chi Yan Tso,Yanguang Zhou
Metal–organic frameworks (MOFs) have been widely applied for adsorption applications owing to their high surface area and porosity. In this paper, the atmospheric water adsorption kinetics in a prototypical MOF with two forms, that is, powder and monolithic MOF-801, are systematically investigated. It is shown that the total pore volume (average pore diameter) of the monolithic MOF-801 is 0.831 cm 3 g −1 (5.20 nm) which is much larger than that of powder MOF-801, that is, 0.488 cm 3 g −1 (1.95 nm). Monolithic MOF-801 absorbs more water than powder MOF-801 at a relative humidity (RH) above 90%. However, between the RH ranges from 10% to 90%, its water uptake is significantly lower than that of the powder form. Molecular dynamics simulations demonstrate that the unexpected water uptake capacity of monolithic MOF-801 at RH of 10%∼90% is caused by the water film formed by the capillary condensation in these mesopores of monolithic MOF-801. The capillary force of the formed film can be overcome by water vapor pressure when RH is over 90%. These findings reveal the underlying mechanisms for water adsorption kinetics in both powder and monolithic MOFs, which can motivate and benefit the new passive cooling or water harvesting system design based on MOFs.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2025
·
IF 7
Jianlei Lu,Chujun Ni,Xin Wen,Xin Guan,Baoyi Wu,Nan Hai,Yang Li,Jiawei Zhang
Inspired by sign language, responsive materials construct an efficient encryption channel via programmable shape morphing, offering a potential solution to the decryption vulnerabilities of existing optical anticounterfeit. However, these pioneering approaches often fail to conceal morphological information due to predictable shape-shifting, let alone achieve higher-level encryption such as multiple and transient information storage. Herein, we report a schizophrenic shape memory hydrogel that can be applied for transient information encryption. In particular, two opposite shape fixation mechanisms, heating-induced aggregation of poly(acrylic acid)-Ca2+ (PAAc-Ca2+) coordination and cooling-induced clustering of alkyl chain-modified poly(vinyl alcohol) (PVA-C6), are coupled in one system. Through a two-step shape programming process involving alternating heating and cooling, complex morphological information can be hidden within an initially simple shape. During its temperature-triggered shape morphing process, the hydrogel rapidly undergoes shape-shifting to reveal the hidden morphological information, followed by an onset recovery to erase it, thereby achieving a transient information display. This single-triggered multiple shape-shifting system opens an unprecedented pattern-independent channel for existing encryption strategies and can motivate the development of advanced anticounterfeiting materials with integrated multifunctionality.
研究领域:
材料科学
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生物医学工程
·
加密技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jiaoe Dang,Sining Yun,Yongwei Zhang,Jingjing Yang,Zhuolei Liu,Changwei Dang,Yinhao Wang,Yingying Deng
With the increasing energy demands and impending climate change, significant concerns have been raised over the metal–organic frameworks (MOFs)-derived porous carbons and their utilization for hydrogen evolution reaction (HER) and triiodide reduction reaction (IRR). However, the provision of high intrinsic activity, active-site accessibility, and structural stability of MOF-derived Co-embedded N-doped carbon (Co/N-C) for HER and IRR is challenging. In this work, core-shell MOF-in-MOF precursors are designed to construct novel double-shell N-C-in-Co/N-C electrocatalysts with nanorod- and rhombic dodecahedron-shaped hollow morphologies (NR-H-C and RD-H-C). The double-shell structured NR-H-C and RD-H-C significantly enhance the HER and IRR activity of Co-MOF-derived Co/N-C. Specifically, NR-H-C achieves a high N-content (10.35 at.%), large specific surface area (590.87 m 2 g −1 ), and hierarchical porous configuration (micropores and mesopores). When NR-H-C is applied as the HER catalyst in alkaline electrolyte, it exhibits an admired overpotential of 123 mV at 10 mA cm −2 and a Tafel slope of 51 mV dec −1 . The solar cell adopting NR-H-C as counter electrode for IRR achieves a high short circuit current density of 16.77 mA cm −2 , an open-circuit voltage of 0.745 V, a fill factor of 0.682, and a power conversion efficiency of 8.51%, higher than that of Pt-based solar cell (16.26 mA cm −2 , 0.744 V, 0.602, and 7.28%). The elucidatory Volmer-Heyrovsky HER mechanism and reversed Volmer-Heyrovsky IRR mechanism give a better understanding of the enhanced dual-functional activity of NR-H-C. This work provides an essential information for the rational design of high-performance dual-functional HER and IRR catalysts and further open up a new avenue for the construction of multicomponent MOFs in the energy conversion field.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiacheng Wang,Yuhang Zhang,Yingbin Xu,Hongyu Jin,Can Yang,Hongxing Liu,Yongbo Bao
The blood clam ( Anadara granosa ) exhibits innovative red blood compared to other molluscs, with erythrocytes constituting 79 % to 89 % of the total hemocyte count. Previously, we identified that GATA-binding protein 1 (designated as Ag GATA1) was significantly up-regulated in the transcriptomes of blood clam populations with high hemocyte counts. However, the function of Ag GATA1 in erythropoiesis remains unknown. In this study, we conducted GATA1 knockdown experiments in A. granosa , which resulted in a significant reduction of both erythrocytes and other cells during the S phase, as well as significantly decreased proliferative activity in the gill tissue. The cell proliferation assay demonstrated that overexpression of Ag GATA1 increased the DNA replication activity of K562 cells. Additionally, o-dianisidine staining revealed defects in erythropoiesis within the gill tissue following Ag GATA1 knockdown, while protein analyses confirmed a significant reduction in Ag GATA1 expression. Furthermore, decreased cytoskeletal fluorescence and morphological changes in erythrocytes suggest that Ag GATA1 influenced cytoskeletal protein expression, leading to changes in erythrocyte morphology. This study provides new insights into the role of Ag GATA1 in hemocyte formation and highlights its significance in understanding erythropoiesis within invertebrate developmental tissues.
研究领域:
分子生物学
·
发育生物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 2
·1663
·
IF 5.6
Huan Jiang,Jiabao Hu,Huihui Xie,Man Zhang,Chunyang Guo,Youyi Zhang,Yaya Li,Cheng Zhang,Shanliang Xu,Danli Wang,Xiaojun Yan,Yajun Wang,Xubo Wang
The pharyngeal sac is a comparatively rare organ in the digestive tract among teleost fishes. However, our understanding of this remarkable organ in the silver pomfret (Pampus argenteus) is limited. In the present study, we examined the various morphological and histological characteristics of the pharyngeal sac using histochemical techniques and electron microscopy. The pharyngeal sac showed unique characteristics such as well-developed muscular walls, weakly keratinized epithelium, numerous goblet cells, and needle-like processes on the papillae. The porous cavity of the papillae contained numerous adipocytes and was tightly enveloped by type I collagen fibers. These structures might provide mechanical protection and excellent biomechanical properties for grinding and shredding prey. A comparison of gene expression levels between the pharyngeal sac and esophagus using RNA-seq showed that phenotype-associated genes (epithelial genes and muscle genes) were upregulated, whereas genes related to nutrient digestion and absorption were downregulated in the pharyngeal sac. These results support the role of the pharyngeal sac in shredding and predigesting food. Overall, these findings provide a clearer understanding of the pharyngeal sac morphology and explain the morphological adaptations of the digestive tract for feeding on gelatinous prey. To our knowledge, this is the first report on pharyngeal sac gene expression inP. argenteus.Keywords:Pampus argenteus;pharyngeal sac;morphology;papilla;transcriptome
研究领域:
生物学
·
分子生物学
·
动物学
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产品关联
DOI
PubMed
高影响因子
FUEL
·
2023
·
IF 7.4
Yang Liu,Chengxuan Wu,Xiaofang Lv,Hui Du,Qianli Ma,Chuanshuo Wang,Shidong Zhou,Bohui Shi,Shangfei Song,Jing Gong,Jimiao Duan
During deep-sea and ultra-deep-sea oil and gas exploitation, multiphase transmission lines are prone to be clogged by sediments produced by the various components in crude oils under extreme subsea conditions, such as hydrates, wax, resins, and asphaltenes. The pipelines face higher plugging risks when these deposits exist simultaneously. In order to elucidate the effects of wax and anti-agglomerants (AA) on hydrate growth and aggregation, microscopic morphology observation and cohesive force measurement of cyclopentane hydrate particles were conducted through a piece of equipment similar to the micromechanical force (MMF) apparatus. Results showed that in the low concentration of AA (0.05 wt%), hydrate particles experienced an approximately 10 % reduction in the profile area after converting water droplets to hydrate particles. Furthermore, the cohesive force between hydrate particles decreased from 8.57 ± 0.90 mN/m to 3.51 ± 0.43 mN/m as the AA concentration increased from 0.05 to 0.2 wt%. On the other hand, the presence of wax significantly altered the morphologies of hydrate particles. When wax coexisted with AA, the hydrate cohesive force was reduced by wax under low AA concentration (0.05 wt%) but increased under higher AA concentration. For a given concentration of AA, the hydrate cohesive force increased with the increasing wax content (from 0.1 to 0.3 wt%), indicating that wax crystals weakened the efficiency of AA, such as Span 80. Additionally, the effect of surface wetness of waxy hydrate particles on their cohesion was also investigated. The liquid bridge appeared between wet waxy hydrate particles, while the solid–solid contact existed between dry waxy hydrate particles. The cohesive force between dry waxy hydrate particles was smaller. Either liquid bridge or solid–solid contact that dominated hydrate cohesive force was affected by wax.
研究领域:
石油工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Chu-Xin Li,Yongdan Qi,Yingge Chen,Yu Zhang,Bin Li,Jun Feng,Xian-Zheng Zhang
Morphology tuning is a potent strategy to modulate physiological effects of synthetic biomaterials, but it is rarely explored in microbe-based biochemicals due to the lack of artificial adjustability. Inspired by the interesting phenomenon of microbial transformation, Escherichia coli is rationally adjusted into filamentous morphology-adjusted bacteria (MABac) via chemical stimulation to prepare a bacteria-based vaccine adjuvant/carrier. Inactivated MABac display stronger immunogenicity and special delivery patterns (phagosome escape and cytoplasmic retention) that are sharply distinct from the short rod-shaped bacteria parent (Bac). Transcriptomic study further offers solid evidence for deeply understanding the in vivo activity of MABac-based vaccine, which more effectively motivates multiple cytosolic immune pathways (such as NOD-like receptors and STING) and induces pleiotropic immune responses in comparison with Bac. Harnessing the special functions caused by morphology tuning, the MABac-based adjuvant/carrier significantly improves the immunogenicity and delivery profile of cancer antigens in vivo, thus boosting cancer-specific immunity against the melanoma challenge. This study validates the feasibility of tuning bacterial morphology to improve their biological effects, establishing a facile engineering strategy that upgrades bacterial properties and functions without complex procedures like gene editing.
研究领域:
生物技术
·
免疫学
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癌症研究
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Huachun Liu,Yanfang Cheng,Hongwei Zhou,Xinhong Pan,Rongfei Peng,Zhijun Bai,Juntao Li,Lei Tan
Arsenic is a widely studied toxic element that exists in various species with different oxidation states and forms in the environment and biological systems. The different physicochemical properties, environmental behaviors, and toxicities of these arsenic species make speciation analysis essential for environmental monitoring and human health risk assessment. In this study, we demonstrated the determination and monitoring of six arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenocholine (AsC), and arsenobetaine (AsB) in seafood using high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). We optimized the chromatographic condition and sample preparation for the separation and extraction of arsenic species, and the method was validated with accuracy and reproducibility using certified reference materials and actual samples. Baseline separation of the arsenic species was achieved within 12 min, and oven heat extraction was selected for sample preparation. The method showed excellent linearity for arsenic species from 0.1 to 100 μg L−1, with recoveries ranging from 92% to 123%, intra-day precision of 0.9–5.0%, and inter-day precision of 1.1–19.4%. The method was further used to determine the arsenic species in 109 mollusks, 195 crustaceans, and 195 marine fish samples from Guangdong, China. Distinctive patterns of arsenic species distribution were observed among different seafood categories. AsB was consistently the predominant species across all samples, with a detection frequency higher than 97.9% and contributed to more than 90% of total arsenic, other arsenic species showed marked variations in their occurrence and concentrations.
研究领域:
分析化学
·
环境科学
·
食品安全
·
毒理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Haiyang Tian,Yunfeng Shi,Hongping Quan,Zhiyu Huang
The effect of CaCl 2 on the micromorphology of a self-thickening agent (TZXJ) was investigated. This study involved analyzing the compositional changes in acid solutions during acid–rock reactions. It combined dynamic light scattering and viscosity testing to confirm that the presence of CaCl 2 enhances the aggregation strength of the TZXJ network structure in acid solutions. This enhancement is macroscopically evident as an increase in viscosity. Incorporating 10 % CaCl 2 as a promoter into a fresh acid solution, the hydrodynamic radius (Rh) distribution of TZXJ in varying reaction stages was analyzed using dynamic light scattering experiments. The results indicated that the promoter CaCl 2 further strengthens the network association of the TZXJ acid solution, thereby improving its thickening capability. Investigating the viscosity of TZXJ aqueous solutions with varying concentrations of CaCl 2 revealed that TZXJ exhibits notable salt-thickening effects and can withstand saturated CaCl 2 solutions. The microstructural aggregation state and morphology of TZXJ in aqueous solutions were characterized at different CaCl 2 concentrations. Dynamic light scattering results demonstrated an increase in the Rh of TZXJ solutions with CaCl 2 concentrations. In particular, the mean Rh of a 0.8 % TZXJ solution increased from 150.8 nm to 3078.93 nm. Ultraviolet spectral analysis confirmed that the absorption intensity of the TZXJ solutions increased with CaCl 2 concentration, indicating a strengthened network aggregate structure in the TZXJ solutions. Microscopic observations using environmental scanning electron microscopy and transmission electron microscopy revealed that under the influence of calcium chloride, the microstructure of TZXJ transitions from a non-associated, linear carbon chain skeleton to a dense, aggregated network structure. The findings of this study offer theoretical insights for researching polymers resistant to extreme concentrations of CaCl 2 .
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）