MACROMOLECULAR RAPID COMMUNICATIONS
·
2015
·Vol. 36
·期 6
·533-537
·
IF 4.941
Hao Meng,Jing Zheng,Xiufang Wen,Zhiqi Cai,Jiawei Zhang,Tao Chen
A simple strategy is provided to construct a novel pH- and sugar-induced shape memory hydrogel based on dynamic phenylboronic acid (PBA)–diol interactions formed by PBA-modified sodium alginate (Alg-PBA) and poly(vinyl alcohol) (PVA). The dynamic PBA–diol ester bonds serve as temporary cross-links and stabilize the deformed shape of the hydrogel. The disassociation of the PBA–diol ester bonds is explored in acidic conditions and aqueous solutions of glucose and fructose, which endow the hydrogel with shape memory performances.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2020
·
IF 6.289
Qin Mao,Oskar Hoffmann,Kun Yu,Fei Lu,Guangqian Lan,Fangyin Dai,Songmin Shang,Ruiqi Xie
Major challenges in traditional wound closure methods ( e.g. using sutures and skin staplers) remain inadequately unaddressed; these invasive treatments induce extra puncture wounds, anesthetic side effects, and severe scarring. Herein, an oxidized starch/gelatin-based shape memory hydrogel (OSG) was fabricated as a self-contracting wound dressing to facilitate noninvasive wound closure. The self-contracting properties were attributed by introducing crosslink net-points in the hydrogel polymer structure through Schiff base reaction between oxidized starch (OS) and gelatin. We systematically investigated the self-contracting properties to determine the feasibility of the hydrogel to treat wounds and promote wound closure noninvasively. Following elongation, OSGs could be entirely fixed in a temporary shape at 4 °C, and then contracted under infrared irradiation (IR) for shape memory activation near human physiological temperature (38 °C), providing sufficient recovery force (4 kPa) for successful noninvasive wound closure. Additionally, H&E staining revealed that thicker epidermis and dermis layers were achieved upon OSG treatment, confirming that the OSG facilitated tissue reconstruction in an in vivo rabbit model. Moreover, the OSG-treated wounds displayed smoother skin and no visible scarring compared to sutured wounds. Such excellent performance suggests that OSG hydrogel exhibits high potential as an alternative to medical sutures to facilitate noninvasive would closure.
研究领域:
生物材料学
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医学工程
·
组织修复
✓ 已验证
DOI
高影响因子
Soft Matter
·
2012
·Vol. 9
·期 1
·132-137
·
IF 4.39
Wenjing Nan,Wei Wang,Han Gao,Wenguang Liu
A dipole–dipole reinforced copolymer hydrogel was synthesized by the one-step photopolymerization of vinylimidazole (VI) and acrylonitrile (AN) comonomer in the presence of a polyethylene glycol-based crosslinker. The mechanical properties of PVI–AN gels were tremendously increased by only chelating several mmol L−1 zinc ions, which was shown to firmly lock the temporary shape of the gel. Extraction of zinc ions by a complexing agent could facilitate the recovery of a permanent shape, and the memory behavior was reversible. The PVI–AN hydrogels supported the growth of L929 cells. The cell-seeded flat hydrogel sheet was folded into a temporary tubular scaffold and fixed in a culture medium containing 5 mmol L−1 zinc ions. After unfolding the tube, the exposed L929 cells were shown to adhere well on the surface of the gel. It is anticipated that this cell-loaded SM hydrogel could be fixed to a desired shape in vitro by small numbers of zinc ions for a potential implantable tissue engineering scaffold.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Mingzi Li,Rong Chen,Qin Yang,Wenjing Yang,Chuanjian Qin,Hongzhao Song,Liang Zhang,Wei Chen
Industrial development has led to contamination of the environment with heavy metal ions, which accumulate in soil or water and pose a serious threat to human health. Simple and rapid detection methods are effective in controlling or preventing the further increase of pollution. However, existing detection methods are relatively complex or require expensive instruments and special sample handling, often resulting in secondary contamination. Therefore, there is a real need for a simple and economical on-site detection method. Herein, we describe a new method for the detection of Fe3+ ions in industrial wastewater using shape change in a hydrogel. Metal ions coordinate with the carboxyl groups in a polyacrylic acid/poly(vinyl alcohol) shape memory hydrogel, and this fixes temporary shapes that depend on the metal ions and their concentrations. This shape change is reversible by the dissociation of ethylenediaminetetraacetic acid. In particular, this change can be well reproduced and observed with the naked eyes. The shape memory performance experiments and density functional theory (DFT) simulation calculations showed that Fe3+ ions coordinated most strongly with the carboxyl groups in the hydrogel under experimental conditions. A quantitative relationship between the shape fixation ratio and Fe3+ ion concentrations was established. According to this, an economic on-site testing device was designed to achieve analogue effluent detection. The method has potential applications for rapid detection of Fe3+ ion concentration in highly acidic industrial wastewater, which offers the possibility of practical application of shape memory hydrogels in environmental management.
研究领域:
环境科学
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材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 45
·2206912
·
IF 19.924
Huanhuan Lu,Baoyi Wu,Xiaoxia Le,Wei Lu,Qiu Yang,Qingquan Liu,Jiawei Zhang,Tao Chen
Morphological information encryption such as gesture and sign language is a traditional but efficient way of information storage and communication. However, due to the limited deformability, almost all of the existing information encryption materials store and deliver information via the pattern or color changes on the 2D plane. Herein, a thermo and ion dual-responsive shape memory hydrogel containing short alkyl chains modified polyvinyl alcohol (PVA-C6) and polyacrylamide-co-polyacrylic acid [P(AAm-co-AAc)], is prepared. In this system, the ion-responsive shape memory process of P(AAm-co-AAc) provides the preprogrammed morphological information and actuating force while the thermo-responsive hydrophobic clusters of PVA-C6 are utilized as a molecular switch to control the deformed posture within the deformation process. Incorporated with a photothermal particle, Fe 3 O 4 , the photothermal PVA-C6 hydrogel is capable of generating diverse configurations that can be encoded as the corresponding information. With the assistance of the programmable NIR, the hydrogel can transfer to the encoded configuration and decrypt the information. Besides, the obtained morphological information can also be erased by immersing the hydrogel in hot water, in order to avoid the leakage of information. This study motivates the design and fabrication of deformable materials and provides a new insight into the information encrypt materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SOFT MATERIALS
·
2019
·
IF 0.973
Minying Wang,Ling Wang,Yuande Xu,Lihua Fu,Hua Yang
In order to achieve the application of shape memory hydrogel (SMH), the hydrogel must be simple in design, adjustable in mechanical properties, and easy to achieve in shape memory properties. In the article, triple SMHs were fabricated by simple method with adjustable mechanical properties. The triple SMH including coordination bond between sodium alginate and Fe3+, the dynamic borate ester bonds, and hydrogen bond of poly (vinyl alcohol) (PVA) were designed to memorize temporary shapes.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2019
·Vol. 10
·期 25
·3488-3496
·
IF 4.76
Tian Tian,Jiao Wang,Shanshan Wu,Zijian Shao,Tao Xiang,Shaobing Zhou
Shape memory hydrogels with capacity of shape deformation after being triggered by physiological stimuli have potential to be used in biomedical fields. In this study, a body temperature and water-responsive shape memory hydrogel with excellent mechanical properties was prepared by crosslinking dopamine-terminated tetra-poly(ethylene glycol) (4-arm PEG) with an oxidation reaction. By adjusting the water content of hydrogels, the temperature/water responsivity and the mechanical properties could be well controlled. Under the synergistic effect of body temperature and water stimulation, the hydrogels can achieve fast shape recovery with a recovery time of 1 min 14 s, and a recovery ratio of 98.9%. Tensile tests reveal that the gel has good mechanical properties. The tensile fracture strength can reach the megapascal level ranging from 2.68 to 13.02 MPa, and the elongation at break can reach 2501%. The integration of body temperature and water-induced shape memory properties and mechanical properties will broaden the application of the 4-arm PEG hydrogel in the biomedical field.
研究领域:
生物材料学
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医学工程
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2021
·Vol. 17
·期 38
·2101356
·
IF 13.281
Yongping Liang,Meng Li,Ying Huang,Baolin Guo
The inevitable bleeding during tumor resection greatly increases the risk of tumor recurrence caused by metastasis of cancer cells with blood, and hemostasis and prevention of post-operation tumor recurrence is still a challenge. However, a biomaterials approach for rapid hemostasis during tumor resection and simultaneous prevention of tumor recurrence is rarely reported. Here, zeolitic imidazolate framework (ZIF-8) nanoparticle-enhanced multinetwork cryogels are proposed which provide an integrated treatment regimen for rapid hemostasis through intraoperative blood trigger shape recovery and enhanced coagulation, and prevention of postoperative cancer recurrence via sonodynamic anticancer in a hepatocellular carcinoma model. A series of antibacterial shape memory multifunctional cryogels are synthesized based on glycidyl methacrylate-functionalized quaternized chitosan (QCSG), dopamine-modified hyaluronic acid (HA-DA), and hematoporphyrin monomethyl ether (HMME)-loaded dopamine-modified ZIF-8 (ZDH). Blood loss in different bleeding models confirms good hemostasis of ZIF-8 loading cryogels. Besides, in vitro tests confirm that QCSG/HA-DA/ZDH (QH/ZDH) cryogels significantly killed cancer cells by generating reactive oxygen species under ultrasound. Finally, significantly reduced tumor recurrence after the resection of ectopic hepatocellular carcinoma further confirms the good effect of QH/ZDH cryogels in preventing recurrence by a coordinated strategy of intraoperative hemostasis and postoperative sonodynamic therapy by pH-responsive HMME release, showing great potential in clinical application.
研究领域:
生物材料学
·
肿瘤学
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医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Zhen Han,Yang Li,Xinjun Wu,Jiawei Zhang
Remotely controllable soft actuators have promising potential applications in many fields including soft robotics, exploration, and invasion medical treatment. Shape memory polymers could store and release energy, resulting in shape deformation, and have been regarded as promising candidates to fabricate untethered soft robots. Herein, an untethered and battery-free soft navigator and gripper based on a shape memory hydrogel is presented. The shape memory hydrogel is obtained through hydrogen bonding between gelatin and tannic acid, and the hydrogel displays excellent shape memory properties on the basis of hydrogen bonding and the coil–triple helix transition of gelatin. Moreover, Fe3O4 nanoparticles are introduced to endow the hydrogel magnetic responsiveness and photothermal conversion capacity. Finally, the shape memory hydrogel in a stretched state is assembled with an inert hydrogel to achieve a bilayer hydrogel actuator, which could produce complex shape transformation due to the shape recovery of the shape memory layer induced by heat or light. Taking advantage of the magnetically control and light-responsive shape deformation, remotely controllable soft grippers that could navigate through tortuous paths and grasp objects from a hard-to-reach place have been accomplished. This approach will inspire the design and fabrication of novel shape memory hydrogels as remotely controllable soft robots.
研究领域:
材料科学
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软体机器人学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2020
·Vol. 60
·期 11
·2724-2734
·
IF 1.917
Yan-Yu Yin,Xin Li,Zai-Yin Hu,Ru Wang
Shape memory hydrogels (SMHs) have been the subject of great interest in recent years. However, there were few reports on the simultaneous multiple shape memory and high mechanical performance. Therefore, a novel nanocomposite (NC) hydrogel poly (acrylic acid)/Chitosan/ Laponite (PAA/CS/Laponite) was developed by using Laponite as physical cross-linker. In order to achieve three temporary shapes, the PAA/CS/Laponite was soaked in iron chloride hexahydrate (FeCl 3 ), sodium hydroxide (NaCl) and sodium hydroxide (NaOH) respectively to (a) form metal coordination; (b) gain the chains entanglement of chitosan; (c) get the microcrystalline structure of chitosan. The maximum shape fixity ratio of PAA/CS/Laponite can reach 100% in 1 minute and it can be restored its original shape within 5 minutes. Moreover, PAA/CS/Laponite showed excellent mechanical performance. The maximum tensile and compressive strengths were 0.73 MPa and 13.1 MPa. By comparison with PAA/CS obtained from our previous work, the tensile strength, elongation at break and compressive strength increased by 2.21 times, 1.46 times, and 3.26 times respectively. Scanning electron microscopy (SEM) showed that the obtained sample has uniform honeycomb network structures which can effectively explain why the gel has strong mechanical performance. These characteristics make PAA/CS/Laponite have huge application potential in reality.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yongzhou Wang,Ying Miao,Jieling Zhang,Jian Ping Wu,Thomas Brett Kirk,Jiake Xu,Dong Ma,Wei Xue
Hydrogels with shape memory behavior and internal structure have wide applications in fields ranging from tissue engineering and medical instruments to drug delivery; however, creating the hydrogels has proven to be extremely challenging. This study presents a three-dimensional (3D) printing technology to fabricate the shape memory hydrogels with internal structure (SMHs) by combining sodium alginate (alginate) and pluronic F127 diacrylate macromer (F127DA). SMHs were constituted by a dual network structure. One is a stable network which is formed by F127DA photo-crosslinking; the other one is a reversible network which is formed by Ca 2 + cross-linked alginate. SMHs recovery ratio was 98.15% in 10 min after Ca 2 + was removed in the Na 2 CO 3 solution, and the elastic modulus remains essentially stable after the shape memory cycle. It showed that the drug releasing rate is more rapid compared with traditional drug-loaded hydrogels in in vitro experiments. The viability of 3T3 fibroblasts remained intact which revealed its excellent biocompatibility. Therefore, SMHs have a huge prospect for application in drug carriers and tissue engineering scaffold.
研究领域:
生物材料
·
组织工程
·
药物递送
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Chen Fei Dai,Cong Du,Yao Xue,Xin Ning Zhang,Si Yu Zheng,Kun Liu,Zi Liang Wu,Qiang Zheng
Shape memory hydrogels have drawn increasing attention in recent years. Practical applications require these hydrogels to have good mechanical properties as well as contactless stimulations to trigger the shape deformations. Here we report a stiff and tough shape memory hydrogel that can transform to various configurations sequentially by phototriggered site-specific deformations. Response of the shape memory hydrogel to near-infrared (NIR) light irradiation was achieved by incorporating gold nanorods (AuNRs) into the glassy gel matrix of poly(methacrylic acid-co-methacrylamide) without compromising the excellent mechanical properties. Owing to the photothermal effect of the AuNRs, the localized temperature rise led to a dramatic decrease in Young’s modulus (from 200 to 2 MPa) of the prestretched hydrogel and bending deformation with a programmable direction and amplitude. More complex three-dimensional configurations can be obtained by multidirectional prestretching and shape memorizing the individual parts of the nanocomposite hydrogel. Furthermore, the AuNRs embedded in the gel were aligned along the prestretching direction, leading to anisotropic plasmon resonance. These photomediated programmable deformations of tough shape memory hydrogels should find applications in the biomedical and engineering fields.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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