ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Xianjing Zhou,Jingjing Nie,Binyang Du
A functional ionic microgel sensor array was developed by using 1-(2-pyridinylazo)-2-naphthaleno (PAN)- and bromothymol blue (BTB)-functionalized ionic microgels, which were designed and synthesized by quaternization reaction and anion-exchange reaction, respectively. The PAN microgels (PAN-MG) and BTB microgels (BTB-MG) were spherical in shape with a narrow size distribution and exhibited characteristic colors in aqueous solution in the presence of various trace-metal ions, which could be visually distinguished by the naked eye. Such microgels could be used for the colorimetric detection of various metal ions in aqueous solution at submicromolar levels, which were lower than the U.S. Environmental Protection Agency standard for the safety limit of metal ions in drinking water. A total of 10 species of metal ions in aqueous solution, Ba2+, Cr3+, Mn2+, Pb2+, Fe3+, Co2+, Zn2+, Ni2+, Cu2+, and Al3+, were successfully discriminated by the as-constructed microgel sensor array combined with discriminant analysis, agglomerative hierarchical clustering, and leave-one-out cross-validation analysis.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Shuangli Zhang,Jingmei Li,Lihao Lei,Lan Li,Rongyu Li,Xianhui Yin,Zhuo Chen,Yue Ma,Fengpei Du
Nonuniform deposition of pesticide droplets on crops and their runoff create excessive pesticide waste, posing a major threat to public health and the environment. Microgels are a class of soft colloids that combine the properties of solid particles and polymers to regulate the resistance of pesticides to rainwater runoff and mitigate the coffee-ring effect (CRE). In this study, we developed amphiphilic calcium alginate microgels (UAMs) capable of enhancing the pesticide evaporation uniformity and the deposition of berberine sulfate (BS) on a target crop, as well as its surface adhesion. A BS-loaded UAM (UAM–BS) solution was sprayed onto the surface of pepper leaves. The gel coating contained flexible and complex networks, which are easily entangled with the microstructures on the leaf surface. This ultimately resulted in the removal of the interface void and the improvement of the BS deposition uniformity at multiple scales. In addition, the surfactivity of the microgels was regulated through grafting, which affected the uniformity of the liquid film deposition. Furthermore, the effect of UAM–BS on pepper anthracnose was investigated, and its control efficacy was found to be over 80%. Additionally, it could improve the BS deposition uniformity and adhesion while mitigating the CRE. This study establishes the use of alginate-based gel coatings as a promising strategy for improving pesticide utilization while addressing the issues of easy runoff and nonuniform deposition. The findings will prove valuable in the fields of bionic materials science, bio-macromolecular chemistry, and agricultural science.
研究领域:
农业科学
·
仿生材料科学
·
生物大分子化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Yang Yang,Wu Peng,Hao Zhang,Hao Wang,Xiaoxuan He
Microscale crosslinked polymeric hydrogels, termed microgels, have attracted considerable attention as enhancing oil recovery (EOR) agents due to their favorable in-depth fluid diversion effect. However, the oil/water interfacial behavior of microgels remains unclear, limiting the comprehensive understanding of the EOR mechanism. In this study, the oil/water interfacial behavior of microgel powder (MP) and microgel emulsion (ME) was studied through emulsification tests and interfacial tension (IFT) measurements. Despite the similar properties of the microgel particles, such as morphology, size distribution and zeta potential , ME exhibited better emulsification performance than MP in deionized (DI) water due to the presence of additional surfactants in ME. However, since the competitive adsorption between the microgel particles and surfactants on the oil/water interface changed with salinity, ME exhibited a higher emulsion volume but lower emulsion stability than MP in brine. Moreover, W/O and O/W emulsions were formed in DI water, but only an O/W emulsion was formed in brine for ME. Furthermore, MP exhibited better IFT reduction performance in brine due to the weaker steric hindrance and tighter adsorption layer on the oil/water interface. In contrast, ME showed better IFT reduction performance in DI water owing to the interaction between the microgel particles and the surfactants. Considering that MP is usually used in the laboratory while commercial microgels are provided in the form of ME, the different oil/water interfacial behaviors of MP and ME may result in an inconsistent understanding of the EOR mechanism in laboratory study and field application.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 13
·2259
·
IF 5.719
Peiyan He,Minghao Shen,Wanli Xie,Yue Ma,Jianming Pan
Uranium is an indispensable part of the nuclear industry that benefits us, but its consequent pollution of water bodies also makes a far-reaching impact on human society. The rapid, efficient and convenient extraction of uranium from water is to be a top priority. Thanks to the super hydrophilic and fast adsorption rate of microgel, it has been the ideal adsorbent in water; however, it was too difficult to recover the microgel after adsorption, which limited its practical applications. Here, we developed a uranyl-ion affine and recyclable microgel container that has not only the rapid swelling rate of microgel particles but also allows the detection of the adsorption saturation process by the naked eye.Keywords:microgel;self-assembly;adsorption
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 2
·期 17
·2575-2582
·
IF 0
Fang Wang,Yuting Zhang,Peng Yang,Sha Jin,Meng Yu,Jia Guo,Changchun Wang
Functional polymeric microgels have great potential for biomedical applications owing to the outstanding advantages of their well-defined structures and tunable surface properties. However, traditional polymerization methods lack the efficient techniques needed for the fabrication of polymeric microgels. Herein, we have developed a novel technique, reflux-precipitation polymerization, for the preparation of a new type of monodisperse poly(ethylene glycol methacrylate phosphate) (PEGMP) microgel with a well-defined spherical structure and abundant phosphate groups. Furthermore, we have extended this technique to fabricate various monodisperse microgels baring different functional groups, including crosslinked PVIM, PHEMA and PVPBA microgels, as well as non-crosslinked poly(AAm-co-MAA) nanohydrogels, which could serve as promising candidates for specific protein enrichment and drug delivery systems. The morphologies and particle size distributions of the microgels were characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS), whereas the surface properties were measured via a zeta potential test. In addition, the use of the PEGMP microgels for the identification of phosphoproteins in both a protein mixture and drinking milk was investigated, and demonstrated high selectivity towards phosphoproteins.
研究领域:
生物医学工程
·
材料科学
·
蛋白质组学
✓ 已验证
DOI
PubMed
ACS Applied Bio Materials
·
2025
·
IF 4.7
Xueyu Wang,Zhuojun Yan,Mengmeng Yao,Xiuqiang Li,Zhongming Zhao,Cheng Cao,Zhijie Zhao,Fanglian Yao,Yuping Wei,Hong Zhang,Junjie Li
Blood-contacting devices serve as a mainstay in clinical treatment, yet thrombosis remains a major cause of device failure and poses risks to patient health. In this study, we developed a diselenide cross-linker, N,N′-bis(methacryloyl)selenocystamine (BMASC), incorporated into poly(sulfobetaine methacrylate) (PSBMA) microgels (defined as BSM) to create an enzyme-mimetic zwitterionic microgel coating (BSMC). The superhydrophilicity of PSBMA provides outstanding antifouling performance, while the diselenide bonds mimic the catalytic action of glutathione peroxidase (GPx) in generating nitric oxide (NO). The microgels are covalently anchored to substrates pretreated with polydopamine (PDA) and polyethylenimine (PEI) through an epoxy-amine ring-opening reaction. During the drying process, the interpenetrating PSBMA chains of the microgels diffuse, forming a dense and smooth hydrogel coating. The BSMC exhibits exceptional resistance to nonspecific adhesion of proteins, cells, and bacteria, with the synergistic effects of antifouling properties and NO effectively inhibiting platelet adhesion. Furthermore, rabbit blood circulation experiments demonstrate the superior antithrombotic efficacy of the BSMC. This coating holds promise as an effective solution to address the thrombus formation challenges of blood-contacting devices.
研究领域:
生物材料
·
医学工程
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2014
·Vol. 29
·期 10
·1153-1161
·
IF 1.815
Lin Chen,Longfei Li,Weifeng Liu,Yongzhen Yang,Xuguang Liu
A novel thermosensitive core/shell microgel with carbon microspheres (CMSs) cores was prepared by three steps. First, oxidized-carbon microspheres were obtained by mixed-acid oxidization. Second, the silane agent of 3-(trimethoxysilyl)-propyl methacrylate was used to functionalize the oxidized-carbon microspheres so as to generate the vinyl groups on the microspheres. Thereafter, the as-synthesized particles were used as seeds in the precipitation polymerization of N-isopropylacrylamide to introduce a thermosensitive polymer microgel shell onto the surfaces of the silanized-CMSs in the presence of an initiator and a crosslinker. The morphology and thermosensitive properties of the composite microspheres were characterized by field emission scanning electron microscopy, transmission electron microscopy, Fourier transformation infrared spectroscopy, thermogravimetry, and dynamic light scattering. Results indicate that the thickness of polymer layer could be adjusted by the crosslinking agent's concentration. The composite microgels had a low critical solution temperature at about 30 °C and exhibited strong thermosensitivity. The controlled release of a drug molecule (a model drug, acetosalicylic acid) was also investigated.
研究领域:
材料科学
·
生物医药
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2020
·
IF 4.499
Ying Ji
The combination of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidization and annealing was applied to modify structural properties of corn starch in order to obtain starch polymer microgels. Microgels were characterized by X-ray diffraction, ATR-FTIR and thermogravimetry analysis (TGA). The effects of microgels on the uptake and release of lysozyme were also analyzed. The formation of oxidized microgels through the crosslinking between starch molecules and sodium trimetaphosphate was confirmed by X-ray diffraction. The ATR-FTIR analysis suggested that TEMPO-oxidation results in the formation of carboxyl groups. TGA data indicated that oxidized-annealed microgels had less thermal stability than oxidized microgels. Furthermore, the oxidized-annealed microgels had an improved capacity for uptake and release of lysozyme. At this stage of the exploration, microgels prepared from corn starches by annealing and oxidation is simple and efficient.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Xing Li,Jipeng Zhang,Xiangyu Liu,Zijian Wu,Zhipeng Yu,Wen Zhang,Yuanzhi Wang,Zekun Li,Martien A. Cohen Stuart,Leonard M.C. Sagis,Minchun Lv,Jie Xiao,Yuan Li
Helicobacter pylori ( H. pylori ) is a prevalent global pathogen responsible for gastritis and the potential development of gastric cancer. Sulforaphane (SFN), a foodborne compound, exhibits notable antibiotic properties against H. pylori . However, its utility is limited by poor stability and susceptibility to environmental degradation. Here, we developed a gastric-responsive-release microgel for delivering anti- H. pylori SFN. The microgels were prepared by cross-linking α-lactalbumin nanotubes then coated with chitosan (CTS-MGs). SFN was loaded into microgels with a loading rate of 10.73 ± 0.25 %. The CTS-MG showed a strong adhesion to the gastric mucosa, prolonging gastric retention for up to 24 h and responsively releasing SFN in the stomach. Furthermore, CTS-MG/SFN dissociated and released nanotubes/SFN, which could penetrate into the gastric mucus layer and arrive at the deepest mucus sites where most H. pylori were colonized. Our results revealed that CTS-MG/SFN displayed an obvious inhibitory effect against H. pylori . The oral administration of CTS-MG/SFN in H. pylori -infected mice effectively alleviated H. pylori -induced gastritis and modulated gastric microbiota homeostasis. This work demonstrated high potential of CTS-MG microgels for gastric-targeted and oral delivery of antibiotic natural compounds against H. pylori infection.
研究领域:
药学
·
微生物学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 4.1
Wang Ya-Jie,Zhang Ping,Serpe Michael J.,Chen Hong,Hu Liang
Photonic materials, which react to light, have garnered interest due to their capability to exhibit adjustable structural colors. Typically, light targets the UV, visible, or near-IR spectrums. In this study, microgel-based photonic materials that are capable of reversibly responding to X-rays have been engineered. To accomplish this, azobenzene (Azo)-containing poly( N -isopropylacrylamide) (pNIPAm)-based microgels are synthesized. Subsequently, ZnS scintillator and Cr/Au are applied on each side of the poly(methyl methacrylate (PMMA) substrate. Subsequently, the Azo MG monolayer is deposited onto the Au surface, followed by the deposition of an additional layer of Cr/Au. This process generates ZnS/PMMA/Cr/Au/Azo MG/Cr/Au or ZnS/Au-Azo MG-Au structure. Functioning as a typical interferometer, ZnS/Au-Azo MG-Au demonstrates tunable colors based on the separation distance between the two Au layers. The ZnS scintillator can absorb and convert X-rays into UV light, initiating the transition of the Azo groups from a trans to a cis state. Consequently, this transition causes the Azo MG to swell. As Azo MG swells, the distance between the two Au layers increases, resulting in a red-shift of approximately 350 nm in the optical signal of the ZnS/Au-Azo MG-Au interferometer. Remarkably, this X-ray responsivity of the interferometer is reversible, as it returns to its initial state after being stored in the dark for 24 h. To demonstrate its capabilities, the ZnS/Au-Azo MG-Au interferometer successfully releases a drug when triggered by X-ray stimulation, thus validating its potential. The microgel-based interferometers hold significant promise for applications in chemoradiotherapy, radiobiology, and actuators in space.
研究领域:
生物医学工程
·
材料科学
·
放射生物学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yawen Li,Xuefan Qiu,Chencan Li,Zhihan Sun,Wei Qiu,Ling Wang
The dynamic control of fluorescence intensity in a time-dependent manner is crucial for enhancing the complexity of dynamic information encryption. In this study, we introduce a new system that combines a pH-responsive microgel with a non-equilibrium Eu-containing polyoxometalate. This system is created through dissipative self-assembly based on urease, enabling precise regulation of fluorescence intensity on a time scale. This intelligent fluorescent system exhibits potential applications in fluorescent ink, enzymatic logic gate and information encryption. Moreover, by simply manipulating the concentration of urease, the lifetime of encoded information can be accurately regulated. These time-encoding characteristics endow Eu-containing polyoxometalate with significant potential for advanced information encryption and data storage.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 10
·3214
·
IF 4.927
Yi Gao,Xuesong Yao,Qinggeng Jiang,Jianhe Liao,Yongping Chen,Rentong Yu
Microgels have unique and versatile properties allowing their use in forward osmosis areas as a draw agent. In this contribution, poly(4-vinylpyridine) (P4VP) was synthesized via RAFT polymerization and then grafted to a poly(N-Isopropylacrylamide) (PNIPAAm) crosslinking network by reverse suspension polymerization. P4VP was successfully obtained by the quasiliving polymerization with the result of nuclear magnetic resonance and gel permeation chromatography characterization. The particle size and particle size distribution of the PNIPAAm-g-P4VP microgels containing 0, 5, 10, 15 and 20 wt% P4VP were measured by means of a laser particle size analyzer. It was found that all the microgels were of micrometer scale and the particle size was increased with the P4VP load. Inter/intra-molecular-specific interactions, i.e., hydrogen bond interactions were then investigated by Fourier infrared spectroscopy. In addition, the water flux measurements showed that all the PNIPAAm-g-P4VP microgels can draw water more effectively than a blank PNIPAAm microgel. For the copolymer microgel incorporating 20 wt% P4VP, the water flux was measured to be 7.48 L∙m−2∙h−1.Keywords:microgel;forward osmosis;draw agent;P4VP
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）