ACS Biomaterials Science & Engineering
·
2020
·
IF 4.152
Jiachen Yu,Lan Jiang,Jianfeng Yan,Wenqi Li
Proteins with different micropatterns have various applications in biosensing, structural analysis, and other biomedical fields. However, processing of micropatterns on single protein crystals remains a challenge due to the fragility of protein molecules. In this work, we studied femtosecond laser processing on single hen egg white lysozyme protein crystals. Optimized laser parameters were found to achieve micropatterning without cracking of protein crystals. The ablation morphology dependence on the laser fluence and the pulse number was discussed to control the processing results. Under a laser fluence higher than 1 J/cm2, the ablation hole was formed. While multipulses with fluence lower than the ablation threshold were applied, the foaming area was observed due to the denaturation of protein. The numerical simulation shows that the ablation results were influenced by the ionization and energy deposition process. Micropatterns including lines, areas, and microarrays can be processed with a minimum size of 2 μm. Processed patterns on the crystal surface can be used for biosensing microarrays and the enhancement of crystal growth. The microprocessing method proposed in this study has potential applications in different fields including biodevices and biomedicine.
研究领域:
生物物理学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Micromachines
·
2024
·Vol. 15
·期 4
·460
·
IF 3
Yu Wu,Xianshan Dong,Xuefang Wang,Junfeng Xiao,Quanquan Sun,Lifeng Shen,Jie Lan,Zhenfeng Shen,Jianfeng Xu,Yuqingyun Du
In this paper, we proposed an efficient and high-precision process for fabricating large-area microlens arrays using thermal reflow combined with ICP etching. When the temperature rises above the glass transition temperature, the polymer cylinder will reflow into a smooth hemisphere due to the surface tension effect. The dimensional differences generated after reflow can be corrected using etching selectivity in the following ICP etching process, which transfers the microstructure on the photoresist to the substrate. The volume variation before and after reflow, as well as the effect of etching selectivity using process parameters, such as RF power and gas flow, were explored. Due to the surface tension effect and the simultaneous molding of all microlens units, machining a 3.84 × 3.84 mm2silicon microlens array required only 3 min of reflow and 15 min of ICP etching with an extremely low average surface roughness Sa of 1.2 nm.
研究领域:
微纳米技术
·
光学工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Chenglin Zheng,Feng Jin,Yuanyuan Zhao,Meiling Zheng,Jie Liu,Xianzi Dong,Zhong Xiong,Yanzhi Xia,Xuanming Duan
Light-driven micro/nano-actuators are one of the most important topics in the biomedical micro-electromechanical systems (MEMS) field. Currently, their development is hampered due to the difficulties in designing and fabricating biocompatible light-driven microactuators with the dimensions less than one hundred micrometres and a response time in the order of seconds. In this work, gel photoresists were prepared by embedding photothermal surface-modified Fe 3 O 4 nanoparticles (NPs) into a mixture that included a photoinitiator, photosensitizer, monomers, crosslinkers and solvents. Macroscopic poly( N -isopropylacrylamide) (PNIPAM)/nano-Fe 3 O 4 hydrogels were prepared by ultraviolet photopolymerization of gel photoresists, which showed good temperature-responsive volume changes and light-triggered bending deformation. Then the two-photon polymerization (TPP) microfabrication properties of gel photoresists with 0, 0.48 and 0.95 wt% Fe 3 O 4 NPs were investigated in detail. Importantly, after the TPP microfabrication and subsequent solvent-exchange procedure, a double-armed near-infrared (NIR)-light-driven three-dimensional (3D) hydrogel microcantilever with a size of ∼26 μm was successfully fabricated. The hydrogel microactuator had a fast response time of ∼0.033 s in water under NIR radiation and showed good reversibility. Furthermore, the distance between the two arms of the hydrogel microcantilever could be manipulated by controlling the laser focus and incident laser power.
研究领域:
生物医学工程
·
材料科学
·
微机电系统(MEMS)
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产品关联
DOI
高影响因子
Microsystems & Nanoengineering
·
2022
·Vol. 8
·期 1
·1-12
·
IF 8.006
Yin Jiawen,Gao Wanlei,Yu Weijian,Guan Yihua,Wang Zhenyu,Jin Qinghui
Free chlorine is one of the key water quality parameters in tap water. However, a free chlorine sensor with the characteristics of batch processing, durability, antibiofouling/antiorganic passivation and in situ monitoring of free chlorine in tap water continues to be a challenging issue. In this paper, a novel silicon-based electrochemical sensor for free chlorine that can self-clean and be mass produced via microfabrication technique/MEMS (Micro-Electro-Mechanical System) is proposed. A liquid-conjugated Ag/AgCl reference electrode is fabricated, and electrochemically stable BDD/Pt is employed as the working/counter electrode to verify the effectiveness of the as-fabricated sensor for free chlorine detection. The sensor demonstrates an acceptable limit of detection (0.056 mg/L) and desirable linearity ( R 2 = 0.998). Particularly, at a potential of +2.5 V, hydroxyl radicals are generated on the BBD electrode by electrolyzing water, which then remove the organic matter attached to the surface of the sensor though an electrochemical digestion process. The performance of the fouled sensor recovers from 50.2 to 94.1% compared with the initial state after self-cleaning for 30 min. In addition, by employing the MEMS technique, favorable response consistency and high reproducibility (RSD < 4.05%) are observed, offering the opportunity to mass produce the proposed sensor in the future. A desirable linear dependency between the pH, temperature, and flow rate and the detection of free chlorine is observed, ensuring the accuracy of the sensor with any hydrologic parameter. The interesting sensing and self-cleaning behavior of the as-proposed sensor indicate that this study of the mass production of free chlorine sensors by MEMS is successful in developing a competitive device for the online monitoring of free chlorine in tap water.
研究领域:
环境科学
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材料科学
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传感器技术
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DOI
PubMed
高影响因子
Optical Materials Express
·
2016
·Vol. 7
·期 1
·32-42
·
IF 2.657
Bin Sun,Yan Wang,Guifu Ding
We report on the fabrication, characterization, and field emission behavior of cold electron cathodes that are specifically designed to be used for X-ray sources. The emitter was designed as a two-tier system, with the patterned CNT field emission array and the Pt comb electrode beneath. The micromachining patterning process, which enhanced the edge effect, significantly improved the field emission performance. By using an inorganic binder, the cathode could resist high temperature annealing up to 800°C. Our novel emitter showed relatively good field emission properties such as low turn on field, high current density, and good stability. We ascribed the improved emission properties after the annealing process to the oxygen desorption induced decrease of work function, and defect annealing which could stabilize the emitter. To check the application of the emitter, the fabricated emitter was sealed in a conventional X-ray tube. The blackened shade on the sensitive film confirmed the X-ray generation, which demonstrated that our emitter successfully survived the high temperature processing steps of the X-ray source fabrication.
研究领域:
材料科学
·
电子工程
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产品关联
DOI
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Jianping Tang,Yachao Zhang,Yansheng Yao,Nianwei Dai,Zhangsen Ge,Dong Wu
Aeration is a mass transfer process, in which gas is dispersed into a liquid by utilizing air inflation or agitation. Typically, a microporous device is often used for aeration. Increasing the gas flow rate and decreasing the pore size reduce the bubble size, but the surface wettability of the gas/solid interface also has a significant impact on the bubble size, which is rarely studied. In this study, a superhydrophilic/superhydrophobic Janus aluminum foil (JAF) is fabricated by laser microstructuring and low surface energy modification. The gas-repelling superhydrophilic surface not only facilitates ultrafine bubble generation but also allows the bubbles to detach from the aerator surface quickly, while the superhydrophobic surface prevents water from infiltrating into the aeration chamber and reduces the mass transfer resistance. The micropores with different diameters are obtained by adjusting the laser processing parameters. The pore prepared by the laser is uniform, consequently leading to the uniform bubble size. When the pore diameter is set to 30 μm, the diameter of bubbles released from the superhydrophilic surface of the JAF is only 0.326 mm, and the gas dissolution rate is about six times that of the double-sided superhydrophobic aluminum foil. This simple, low-cost, and controllable method of the laser processing JAF has broad applications in wastewater treatment, energy production, and aquaculture.
研究领域:
环境科学
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材料科学
·
生物工程
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Ziqing Ouyang,Yongkang Yan,Yiqiang Long,Bingjun Luo,Zhengliang Su,Jiangyou Long
Multiscale copper-based surface microstructures are required in miniaturized two-phase heat exchange devices. In this study, we propose a method that combines picosecond laser micromachining and electrodeposition to prepare copper-based two-tiered surface microstructures. The surface structures consist of periodic mini-grooves covered by dense microcones. The mini-grooves, prepared using ultrafast laser micromachining, offer a superior capillary transport performance. On the other hand, the microcone structures, prepared by electrodeposition, provide more effective nucleation sites for liquid–vapor phase changes. Compared to single-tiered mini-groove structures, the minigroove-microcone composite structures demonstrate an 8.2% increase in critical heat flux (CHF) and a 21–58% increase in heat transfer coefficient (HTC) during capillary-fed boiling tests. The method presented in this study introduces a new approach for fabricating high-performance wick structures suitable for ultrathin two-phase heat exchange devices.
研究领域:
材料科学
·
热能工程
·
微制造技术
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Feiyao He,Jinwei Yin,Tianzhi Wang,Juan Pu,Jianxiong Dai,Zhongjun Zhao,Yixiang Duan
A new ambient ionization technique named laser ablation micro-fabricated glow discharge plasma (LA-MFGDP) was developed for mass spectrometry in this study. This technique used low energy laser for sample ablation and ionized sample aerosol with MFGDP in sequence. The combination of laser ablation and MFGDP exhibited a synergetic effect that significantly improved the performance of MFGDP. Experimental results showed that MFGDP dominated the ionization process while laser played the role of desorption in LA-MFGDP. [M+H] + and M + proved that proton transfer reactions and charge transfer reactions were involved in the ionization process, respectively, indicating that the ionization character was the same as MFGDP. LA-MFGDP could analyze less volatile samples that were unable to be detected by MFGDP because laser significantly improved the ionization capability of MFGDP. Strong ion signals were obtained by LA-MFGDP with low sample consumption. The limits of detection (LODs) of LA-MFGDP was as low as three orders of magnitude than that of MFGDP, which demonstrated that LA-MFGDP possessed an outstanding advantage in detecting trace substances. LA-MFGDP was successfully applied to detect pharmaceutical tablets without any pretreatment. Benefited from the excellent performance, LA-MFGDP offers great potential in broadening the application of ambient mass spectrometry.
研究领域:
分析化学
·
质谱技术
·
环境科学
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产品关联
DOI
PubMed
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2022
·
IF 4.939
Zhaoxu Zhang,Huaping Gong,Changgui Yu,Kai Ni,Chunliu Zhao
An optical fiber relative humidity(RH) sensor based on femtosecond laser micromachining Fabry-Perot cavity with composite film is proposed. The effect of the hole perforated on the Fabry-Perot cavity by femtosecond laser on the humidity performance of the sensors is studied for the first time. And the humidity characteristics of the sensors with different mixture ratios of HA/PVA composite are investigated. The influence of film thickness on the humidity sensitivity of the sensor is also discussed. The sensor perforated the hole of 40 μm with the mixture ratios of 1:2 HA/PVA and the film thickness of 20 μm has the best performance. The sensor has a linear response to humidity with the linearity of 99.5% and the sensitivity is up to −525 pm/%RH, within the relative humidity range of 35–85%, under the room temperature of 25 °C. The response time is as short as 2 s. The sensor has the advantages of simple fabrication, high sensitivity and high stability.
研究领域:
光学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2021
·Vol. 146
·期 22
·6944-6954
·
IF 4.616
Yuhan Yang,Yuting Li,Zhijun Huang,Yonghui Tian,Cheng Qian,Yixiang Duan
In this study, an innovative rapid detection technology for quickly screening and quantifying organophosphorus pesticides (OPPs) in vegetables was developed based on ambient micro-fabricated glow discharge plasma desorption/ionization mass spectrometry (MFGDP-MS), where Fe3O4/ZrO2 synthesized by a one-step coprecipitation was used for enrichment. It can not only effectively enrich OPPs, but can be separated by an external magnetic field, thereby simplifying the traditional steps of centrifugation and cleanup in sample preparation. The introduction of a temperature control system (TCS) can tackle the problem of the low ionization efficiency in MFGDP and expand its application range. Under optimized experimental conditions, the limits of detection (LODs) of the standard solution as low as 0.0068–0.7500 μg L−1 mm−2 were achieved, with relative standard deviations (RSDs) being less than 17.8%. Moreover, vegetable extracts were spiked to evaluate the accuracy of the method, and good recoveries (76.9–123.5%) were obtained. Remarkably, it took no more than 7 minutes from sample preparation to testing, resulting in significantly improved ability of the quantitative detection of plentiful samples.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Zhou Chenchen,Liang Shuaishuai,Qi Bin,Liu Chenxu,Cho Nam-Joon
In the quest for miniaturization across technical disciplines, microscale ceramic blocks emerge as pivotal components, with performance critically dependent on precise scales and intricate shapes. Sharp-edged ceramic microparticles, applied from micromachining to microelectronics, require innovative fabrication techniques for high-throughput production while maintaining structural complexity and mechanical integrity. This study introduces a “one-pot microfluidic fabrication” system incorporating two device fabrication strategies, “groove & tongue” and sliding assembling, achieving an unprecedented array of microparticles with diverse, complex shapes and refined precision, outperforming traditional methods in production rate and quality. Optimally designed sintering profiles based on derivative thermogravimetry enhance microparticles’ shape retention and structural strength. Compression and scratch tests validate the superiority of microparticles, suggesting their practicability for diverse applications, such as precise micromachining, sophisticated microrobotics and delicate microsurgical tools. This advancement marks a shift in microscale manufacturing, offering a scalable solution to meet the demanding specifications of miniaturized technology components.
研究领域:
材料科学
·
微工程
·
制造技术
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Device
·
2023
·
IF 0
Jian Chen,Keju Ji,Chi Xu,Jiahui Zhao,Tingwei Huo,Yi Song,Stanislav N. Gorb,Yi Long,Zhendong Dai
Adhesive materials have many potential applications for daily life, such as soft robotics, grippers, and wearable devices. However, robust and reversible adhesion under extreme thermal conditions—like ultralow temperature surfaces and conditions with large temperature variations—is a significant challenge and has rarely been studied. Here, we report a new design of a mushroom-shaped adhesive based on materials design and structural microfabrication. The fabricated adhesive possesses one to two orders of higher adhesive strength at −100°C than those recently reported in the literature, with promising reversible adhesion under temperature variations from −100°C to 100°C and on −98.5°C dry-state ice surfaces. We believe this new strategy will have broad potential applications including but not limited to glacier rescue and polar exploration.
研究领域:
材料科学
·
机械工程
·
应用物理
·
机器人学
✓ 已验证
DOI
危险品化学品经营许可证（带存储）