Biosensors-Basel
·
2024
·Vol. 14
·期 4
·186
·
IF 4.9
Yanpeng Wang,Zhaoyang Wang,Haotian Sun,Tong Lyu,Xing Ma,Jinhong Guo,Ye Tian
Nano-doped hollow fiber is currently receiving extensive attention due to its multifunctionality and booming development. However, the microfluidic fabrication of nano-doped hollow fiber in a simple, smooth, stable, continuous, well-controlled manner without system blockage remains challenging. In this study, we employ a microfluidic method to fabricate nano-doped hollow fiber, which not only makes the preparation process continuous, controllable, and efficient, but also improves the dispersion uniformity of nanoparticles. Hydrogel hollow fiber doped with carbon nanotubes is fabricated and exhibits superior electrical conductivity (15.8 S m−1), strong flexibility (342.9%), and versatility as wearable sensors for monitoring human motions and collecting physiological electrical signals. Furthermore, we incorporate iron tetroxide nanoparticles into fibers to create magnetic-driven micromotors, which provide trajectory-controlled motion and the ability to move through narrow channels due to their small size. In addition, manganese dioxide nanoparticles are embedded into the fiber walls to create self-propelled micromotors. When placed in a hydrogen peroxide environment, the micromotors can reach a top speed of 615 μm s−1and navigate hard-to-reach areas. Our nano-doped hollow fiber offers a broad range of applications in wearable electronics and self-propelled machines and creates promising opportunities for sensors and actuators.
研究领域:
材料科学
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生物医学工程
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2025
·
IF 4.9
Xiaowen Wang,Yingnan Gao,Changyou Liu,Yaping Wang,Anqin Liu,Wenguang Yang
Robots have a profound impact on human production and life, which have been developed by leaps and bounds in recent decades. As the higher and higher requirements for operations in complex environments, researchers continue to develop wireless driven miniature robots. In this paper, the ratio and deformation properties of PNIPAM and PEGDA hydrogels were researched, and the microcrawls and microgrippers with 3D structure were prepared through secondary curing technology. They have light stimulus response and magnetic response characteristics, and can be reversibly transformed from 3D to 2D structure to complete crawling and transportation functions. This research offers a reference for the fabrication and programmable actuation of intelligent materials. It holds certain promise in the domains of transportation and bionics.
研究领域:
材料科学
·
仿生学
·
机器人技术
✓ 已验证
产品关联
DOI
高影响因子
IEEE SENSORS JOURNAL
·
2024
·Vol. 24
·期 11
·17560-17569
·
IF 4.3
Weicen Chen,Boquan Wang,Jianzhong Chen,Chenzhi You,Jing Yao,Dawei Wu
Intraluminal ultrasonic (ILUS) technology, an advanced interventional imaging technique, employs a miniaturized high-frequency ultrasound transducer mounted at the tip of a thin catheter to visualize anatomical structures within the human body. This allows for the acquisition of high-quality images of lesions in close proximity. However, existing ILUS probes predominantly offer specialized visualization in a single direction of the ultrasound catheter due to space constraints within the catheter, posing challenges to the fabrication process. In this study, an ILUS high-frequency mini-convex array probe was developed which featured 64 array elements arranged in a curvilinear configuration, providing a 90° imaging field of view. The mini-convex array was housed within a stainless-steel tube with an outer diameter of 4 mm, positioned such that its central imaging axis was oriented at a 45° angle relative to the axial direction of the tube. This configuration enabled observation of objects ahead of the catheter, even though not entirely covered, and offered detailed features of the interior configuration on its side. This probe exhibited an average center frequency, −6 dB bandwidth, and sensitivity of approximately 17.85 MHz, 61.95%, and 32.64 mV, respectively. Imaging of a wire phantom yielded axial and lateral resolutions at 5 mm depth of approximately 0.11 and 0.25 mm, respectively. Subsequently, the actual imaging capability was assessed through ex vivo imaging of the artery and esophagus of a swine, demonstrating the suitability of the high-frequency mini-convex array probe for ILUS imaging applications.
研究领域:
医学影像
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超声技术
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生物医学工程
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DOI
高影响因子
Materials
·
2025
·Vol. 18
·期 10
·2277
·
IF 3.2
Anyi Zhang,Yiming Wang,Haidong Yu,Yabin Zhang
The advent of the Internet of Things has boosted portable and wearable miniature electronics, especially micro-supercapacitors (MSCs) with excellent integrated performance as well as high-power density and a long lifetime. However, the rational design of electrode material formulations and the construction of three-dimensional (3D) structured electrodes with scalable and cost-effective fabrication remains an arduous task for improving the energy density of MSCs to meet all industrial sector requirements, such as the mass-production of microscale structures, a lasting power supply, and safety. To address these challenges, combining the respective capacitance merits of MXenes and polyaniline (PANI), we propose a constructing strategy for the preparation of a 3D MXene@PANI hierarchical architecture consisting of one-dimensional (1D) PANI nanofibers grown on two-dimensional (2D) Ti3C2MXene nanosheets via extrusion-based 3D printing. Such a 3D architecture not only achieves a high loading mass of MSC electrodes prior to conventional planar MSCs for abundant active site exposure, but it also overcomes the restacking of MXene nanosheets accounting for sluggish ionic kinetics. These features enable the resulting MSCs to deliver excellent electrochemical properties, including a high volumetric capacitance of 1638.3 mF/cm3and volumetric energy density of 328.2 mWh/cm3. This power supply ability is further demonstrated by lighting up a blue bulb or powering an electronic thermometer. This study provides a promising design strategy of the architecture of MXene@PANI composites for high-performance MSCs with 3D printing technology.
研究领域:
材料科学
·
能源存储
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2013
·Vol. 13
·期 6
·3832-3840
·
IF 1.149
Cui Qinmin,Dai Lijun,Yang Liu,Ziener Ulrich,Cao Zhihai
Cross-linked chitosan (CS) nanohydrogels were successfully prepared via cross-linking CS nanodroplets in inverse miniemulsions. The cross-linker was transferred to the CS nanodroplets via the evaporation from its aqueous solution and diffusion through the continuous phase. The formation
of cross-linked CS nanohydrogels was confirmed by the morphological investigation during the reaction and the successful preparation of acidic aqueous dispersion of CS nanohydrogels. The size and size distribution of the CS nanodroplets and nanohydrogels were characterized by dynamic light
scattering (DLS). The particle morphology of CS nanohydrogels was observed by transmission electron microscopy (TEM). The influence of the synthetic parameters on the particle properties and colloidal stability was investigated with respect to sonication time, surfactant type and amount, type
of low polarity solvent, and concentration of CS solution. The cross-linked CS nanohydrogels could be easily re-dispersed in water, and showed a pH sensitivity.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Matter
·
2022
·
IF 19.967
Rong Tan,Xiong Yang,Haojian Lu,Liu Yang,Tieshan Zhang,Jiaqi Miao,Yu Feng,Yajing Shen
A millirobot that can work in the alimentary tract is of great interest for future biomedical treatments, but challenges remain for the robot in the integration of multiple drugs, effective locomotion under the harsh in-body environment, controllable anchoring on the desired area, and adaptive stepwise release. Here, we report a nanofiber-based biodegradable millirobot, named Fibot, fabricated by integrating magnetic-assisted molding and electrospin-assisted assembling. By adjusting the material components of Fibot during fabrication, we can program the adaptive release of different drugs responding to variations in acidic physiological concentrations. Moreover, the multi-legged design gives it an effective locomotive ability even in the harsh in-body environment. We demonstrate locomotion abilities in the GI tract, desired-region anchoring, and multiple-drug stepwise release in a rabbit model. This research will shed new light on millirobot development and promote the realization of untethered, biodegradable, functional, and environmental adaptive devices to be implemented in various biomedical applications.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Talanta Open
·
2024
·
IF 4.1
Mingtao Sun,Yiyu Jiang,Wenshan Liang,Hui Zeng,Huiwen Chen,Min Zhang
An affordable droplet-based flow analyzer incorporating peristaltic micro-pumps has been developed for fluorescent ammonium sensing. The cost-effective peristaltic micro-pumps, modified using 3D-printing techniques, feature a 3D-printed pump base integrated with a Hall sensor to monitor the rotation of the pump motor. This setup generates a pulse flow instead of a continuous flow, delivering specific volumes (typically between 3 to 4 μL) of solution with each rotation. By using separate pumps to deliver the aqueous and oil phases, these phases merge to form a droplet flowing stream. The relative standard deviation (RSD) values for droplet volumes range from 3.97 % to 5.99 % ( n =50) across different pumps. The analyzer utilizes a reaction between ammonium, ortho-phthalaldehyde, and sulfite to produce a fluorescent derivative, allowing for sensitive detection of low ammonium concentrations. A custom light-emitting diode (LED)-based fluorescence detector has been fabricated using 3D printing, ensuring cost-effective production. The analyzer provides a limit of detection of 0.02 μM (3 σ ) and an RSD of 0.15 % ( n =10, 1 μM ammonium). This analyzer offers several practical advantages, including reduced reagent consumption and the potential for further development in distributed on-site analysis. The use of 3D printing facilitates rapid prototyping and customization, making the system adaptable to various analytical applications.
研究领域:
分析化学
·
环境科学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Integrative Neuroscience
·
2024
·Vol. 23
·期 1
·6
·
IF 2.5
Dongxia Duan,Xiaojin Wu,Usman Ali,Di Wang,Xue Li,Ruimei Liu,Le Ma,Yemeng Mao,Yan Ma
Background: Metformin has been shown to have potent analgesic effects; however, the underlying mechanism of synaptic plasticity mediating analgesia remained ambiguous. Methods: In this study, animal behavioral tests, whole-cell patch‑clamp recording, immunofluorescence staining, and network pharmacology techniques were applied to elucidate the mechanisms and potential targets of metformin-induced analgesia. Results: Single or consecutive injections of metformin significantly inhibited spinal nerve ligation (SNL)-induced neuropathic pain, and formalin-induced acute inflammatory pain. Network pharmacology analysis of metformin action targets in pain database-related targets revealed 25 targets, including five hub targets (nitric oxide synthase 1 (NOS1), NOS2, NOS3, epidermal growth factor receptor (EGFR), and plasminogen (PLG)). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that metformin-induced analgesia was markedly correlated with calcium signaling and synaptic transmission. Intrathecal injection of metformin significantly reversed nerve injury-induced c-Fos (neural activity biomarker) mRNA and protein expression in neuropathic rats by regulating NOS2 expression. In addition, whole-cell recordings of isolated spinal neurons demonstrated that metformin dose-dependently inhibited the enhanced frequency and amplitude of miniature excitatory synaptic currents (mEPSCs) but did not affect those of miniature inhibitory synaptic currents (mIPSCs) in neuropathic pain. Conclusions: This study further demonstrated that metformin might inhibit spinal glutamatergic transmission and abnormal nociceptive circuit transduction by monitoring synaptic transmission in pain. Results of this work provide an in-depth understanding of metformin analgesia via synaptic plasticity.
研究领域:
药理学
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神经科学
·
疼痛研究
·
突触生理学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2021
·Vol. 33
·期 10
·2005449
·
IF 30.849
Shuanghao Zheng,Hui Wang,Pratteek Das,Ying Zhang,Yuexian Cao,Jiaxin Ma,Shengzhong (Frank) Liu,Zhong-Shuai Wu
The future of mankind holds great promise for things like the Internet of Things, personal health monitoring systems, and smart cities. To achieve this ambitious goal, it is imperative for electronics to be wearable, environmentally sustainable, and safe. However, large-scale manufacture of self-sufficient electronic systems by exploiting multifunctional materials still faces significant hurdles. Herein, multitasking aqueous printable MXene inks are reported as an additive-free high-capacitance electrode, sensitive pressure-sensing material, highly conducting current collector, metal-free interconnector, and conductive binder. By directly screen printing MXene inks, MXene-based micro-supercapacitors (MSCs) and lithium-ion microbatteries (LIMBs) are delicately fabricated on various substrates. The as-prepared MSCs exhibit ultrahigh areal capacitance of 1.1 F cm −2 and the serially connected MSCs offer a record voltage of 60 V. The quasi-solid-state LIMBs deliver a robust areal energy density of 154 μWh cm −2 . Furthermore, an all-flexible self-powered integrated system on a single substrate based on the multitasking MXene inks is demonstrated through seamless integration of a tandem solar cell, the LIMB, and an MXene hydrogel pressure sensor. Notably, this integrated system is exceptionally sensitive to body movements with a fast response time of 35 ms. Therefore, this multipurpose MXene ink opens a new avenue for powering future smart appliances.
研究领域:
材料科学
·
储能技术
·
柔性电子学
·
印刷电子学
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可穿戴技术
·
微型电池
·
可持续能源
✓ 已验证
DOI
高影响因子
Chinese Optics Letters
·
2020
·Vol. 18
·期 10
·101202
·
IF 2.045
Hai Zhang,Jianyu Shang,Xiujuan Liu,Weimin Sun,Feiru Wang,Yongjun Liu,Yongjun Liu
This Letter presents a new type of optical fiber probe used to detect temperature, whose structure is very simple. The optical fiber probe is filled with cholesteric liquid crystals (CLCs) whose reflected light varies with temperature. The experimental results show that the proposed sensor can achieve a temperature sensitivity of 5.64 nm/°C in the temperature range of 18–40°C. The sensor has the advantages of simple structure, low cost, and easy mass manufacture. Its size is very tiny (the tapered structure, 125 μm in maximum diameter and <300 μm in length) and it is easy to integrate and measure. Meantime, the tapered structure of the probe is also ideal for measuring small samples such as cells and microfluidic channels, which will be a promising candidate for monitoring temperature fluctuations in small spaces.
研究领域:
光学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Yuanyuan Ren,Limin Liu,Zhen Wang,De Li,Yong Chen
Compared with traditional centimeter-level electrodes, microelectrodes exhibit a small reaction area, high sensitivity, fast mass transfer rate, and low polarization current. However, current microelectrode preparation processes are very complicated and costly. Herein, we proposed a facile and universal method for fabricating single-particle microelectrodes. In the precursor solution, polyvinyl alcohol and ammonia were introduced as the polymeric binder and pore-forming agent, respectively. Through spaying-drying-sintering processes, the single-particle microelectrodes were successfully prepared for Li4Ti5O12 (LTO), LiCrTiO4 (LCTO), and LiFePO4/C (LFP/C), which showed excellent electrochemical properties. Furthermore, the single-particle microelectrode can be adopted to study the electrochemical oscillations of Li-ion batteries and assemble a full-cell microbattery as a potential next-generation microscale power source.
研究领域:
电化学
·
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Jiahui Yang,Yao Lin,Xi Wang,Yuanyuan Li,Yurong Deng,Chengbin Zheng
Background Arsenic contamination of drinking water has become a public health challenge over the world, particularly in Bangladesh, India, and China. Compared to the most used field test kits of waterborne arsenic, miniature microplasma atomic spectrometry retains advantages of accuracy, elemental specificity, and less matrix interference. Despite increased interest in arsenic detection by using miniature microplasma spectrometry, the improvements of its analytical performance, manufacturing cost and consistency still remain significant challenges. Results Herein, a miniature, battery-operated, and integrated hydride generation point discharge optical emission spectrometer (HG-μPD-OES, 116 mm length × 92 mm width × 104 mm height) was printed with a simple 3D printer and used for the highly sensitive and element-specific determination of arsenic by coupling to a dispersive solid-phase extraction (d-SPE) using zeolitic imidazolate framework-8 as adsorbent. The d-SPE simplifies sample treatment, significantly alleviates the interference arising from transition metal ions and improves sensitivity. A LOD of 0.07 μg L −1 for arsenic was obtained with relative standard deviations (RSDs, n = 11) better than 3.8 %. Significance The 3D printing technique significantly improves the manufacturing cost and fabricating consistency of HG-μPD-OES. LOD were remarkably improved 27-fold compared to those obtained by conventional HG-μPD-OES, providing a promising method for the reliable, sensitive, and convenient field analysis of waterborne arsenic even its concentration as low as 0.2 μg L −1 . The practicability and accuracy of the proposed method have been successfully verified via the field analysis of waterborne arsenic in a Certified Reference Material (GBW(E)080390) and a series of river and lake water samples.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）