COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Zewei Zhao,Zhiguang Wu,Sven Rutkowski,Sergei I. Tverdokhlebov,Johannes Frueh
Micropumps are in animal and human bodies and on cellular levels vital for the life functions. In case of critical problems like diseases, artificial micropumps are candidates to take over important functions. These functions are ranging from release of substances over removing toxics to stirring stomach fluids, helping to disperse medicine. We hereby present a Janus micropump, powered by hydrogen bubbles, which is able to operate in a gastric pH environment. This Janus micropump consumes hydrochloric acid as an external fuel and releases magnesium ions , which act as micronutrients . The presented Janus micropumps do display significant pumping power by moving external tracer particles and stop after exhausting their magnesium or alternatively acid fuel. The pumping properties depend significantly on the surrounding pH environment and the amount of external surfactant added. Analysis of tracer particle motion shows, that the cause of this movement are the bubbles generated that drag the liquid along after bubble release.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Nano Research
·
2018
·Vol. 11
·期 4
·1810-1821
·
IF 7.994
Li Mingtong,Su Yajun,Zhang Hui,Dong Bin
A micropump induces the flow of its surrounding fluids and is extremely promising in a variety of applications such as chemical sensing or mass transportation. However, it is still challenging to manipulate its pumping direction. In this study, we examine a binary micropump based on perovskite and poly[(2-methoxy-5-ethylhexyloxy)-1,4-phenylenevinylene] (MEHPPV). The micropump is operational under the influence of light. Light exhibits significant versatility in controlling the pumping phenomenon of the micropump. It governs the start and stop and also regulates the velocity and directions. The direction control signifies immense opportunities for the development of micropumps with unprecedented pumping behaviors and functions (such as heartbeat-like pumping, rectification, and amplification). This makes them potentially useful in various fields. Hence, it is expected that the micropump reported in the current study could act as a key step towards the further development of more sophisticated micropumps for diverse applications.
研究领域:
材料科学
·
光学工程
·
微流控技术
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 6
·517
·
IF 4.4
Yunyu Sun,Hao Wang,Jiwei Jiang,Hui Zhang,Limei Liu,Keying Zhang,Bo Song,Bin Dong
Inspired by the collective behaviors of active systems in nature, the collective behavior of micromotors has attracted more and more attention in recent years. However, little attention has been paid to the collective behavior of the immobilized micromotor, i.e., the micropump. In this paper, a unique pentacene-based micropump is reported, which demonstrates dynamic collective behavior activated by white light irradiation. The light irradiation may generate the photochemical reactions between pentacene and water, leading to the electroosmotic flow. As a result, this micropump is capable of pumping the surrounding solution inward along the substrate surface based on the electroosmosis mechanism. Intriguingly, the inward pumping causes the agglomeration of the tracer particles on the surface of the micropump. In addition, the aggregation can migrate following the change in the light irradiation position between two adjacent micropumps. Based on the aggregating and migrating behaviors of this pentacene-based micropump, we have achieved the conductivity restoration of the cracked circuit.
研究领域:
材料科学
·
生物仿生学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 8
·2299-2304
·
IF 6.641
Yutong Guo,Danchen Wang,Jieai Li,Yunyu Sun,Mingtong Li,Hui Zhang,Ruomeng Duan,Dafeng Zhang,Bo Song,Bin Dong
Micropumps, especially those based on polymers, have shown great potential in sensing and mass transportation applications. However, polymer-based micropumps only exhibit a certain pumping direction, which is not adjustable, thus limiting their further applications. In this paper, a light-driven micropump with tunable pumping directions is reported. The direction control of this micropump relies on the photothermal effect of the polymeric component and the light-induced release of the encapsulated surfactant. Both on–off, inward and outward, or even the unique heartbeat-like pumping behaviors could be realized. The direction-controlled micropump has great potential for a variety of applications. Among others, it has the ability to rectify the fluid flow or accelerate the solution stirring.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Micromachines
·
2022
·Vol. 13
·期 10
·1620
·
IF 3.523
Gang Guo,Xuanye Wu,Demeng Liu,Lingni Liao,Di Zhang,Yi Zhang,Tianjiao Mao,Yuhan He,Peng Huang,Wei Wang,Lin Su,Shuhua Wang,Qi Liu,Xingfeng Ma,Nan Shi,Yimin Guan
Currently, many microchips must rely on an external force (such as syringe pump, electro-hydrodynamic pump, and peristaltic pump, etc.) to control the solution in the microchannels, which probably adds manual operating errors, affects the accuracy of fluid manipulation, and enlarges the noise of signal. In addition, the reasonable integration of micropump and microchip remain the stumbling block for the commercialization of microfluidic technique. To solve those two problems, we designed and fabricated a thermal bubble micropump based on MEMS (micro-electro-mechanical systems) technique. Many parameters (voltage, pulse time, cycle delay time, etc.) affecting the performance of this micropump were explored in this work. The experimental results showed the flow rate of solution with the assistance of a micropump reached more than 15 μL/min in the optimal condition. Finally, a method about measuring total aflatoxin in Chinese herbs was successfully developed based on the integrated platform contained competitive immunoassay and our micropump-based microfluidics. Additionally, the limit of detection in quantifying total aflatoxin (AF) was 0.0615 pg/mL in this platform. The data indicate this combined technique of biochemical assays and micropump based microchip have huge potential in automatically, rapidly, and sensitively measuring other low concentration of biochemical samples with small volume.Keywords:thermal bubble micropump;microfluidics;competitive immunoassay;aflatoxin
研究领域:
微机电系统(MEMS)
·
分析化学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Research
·
2022
·
IF 11.036
Yiqun Liu,Qi Yu,Xiaojin Luo,Le Ye,Li Yang,Yue Cui
Diabetes is a chronic metabolic disease with a high blood glucose level, leading to both seriously acute and chronic complications. The closed-loop system is an ideal system for diabetes management. However, the large size and high cost of the commercial systems restrict their widespread uses. Here, we present for the first time a microtube-based wearable closed-loop minisystem for diabetes management. The closed-loop minisystem includes a biosensing device, an electroosmotic micropump, and a printed circuit board (PCB) with an algorithm. The microtube-based sensing device coated on the outer surface of the microtube is inserted into subcutaneous tissue for detecting interstitial glucose; the current signal for sensing glucose is processed by the PCB to power the electroosmotic micropump intelligently for the delivery of insulin into the subcutaneous tissue via the microtube channel. The closed-loop minisystem worn on a diabetic SD rat can successfully maintain its blood glucose level within a safe level. It is expected that this new closed-loop paradigm could open up new prospects for clinical diabetes management.
研究领域:
医学工程
·
生物技术
·
糖尿病研究
✓ 已验证
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Li Qian,Ye Zi,Liu Mingyang,Liu Wei,Zhang Pan,Sun Xiao,Zhang Huimin,Li Zhenming,Gui Lin
This work proposes an “N2-1” sacrificial strategy to help to improve the accuracy of the bonding technique from the existing level. The target micropattern is copied N2 times, and (N2-1) of them are sacrificed to obtain the most accurate alignment. Meanwhile, a method for manufacturing auxiliary solid alignment lines on transparent materials is proposed to visualize auxiliary marks and facilitate the alignment. Though the principle and procedure of alignment are straightforward, the alignment accuracy substantially improved compared to the original method. With this technique, we have successfully fabricated a high-precision 3D electroosmotic micropump just using a conventional desktop aligner. Because of the high precision during the alignment, the flow velocity is up to 435.62 μm/s at a driven voltage of 40 V, which far exceeds the previous similar reports. Thus, we believe that it has great potential for high precision microfluidic device fabrications.
研究领域:
微纳米制造
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Jin Zhang,Hui Zeng,Wenshan Liang,Honghua Hu,Michael C. Breadmore,Min Zhang
Capillary electrophoresis (CE) is increasingly used in distributed field environmental monitoring, teaching, and citizen science. Consequently, the development of low-cost CE instruments using inexpensive components and do-it-yourself approaches has gained significant attention. Peristaltic micro-pumps (PMPs), with dimensions as small as 15 × 17 × 34 mm 3 , offer advantages such as low cost, compact size, and energy efficiency, making them highly suitable for miniaturized CE instruments with automated flow-through injection. This study presents the development and application of a closed-loop PMP integrated into a CE system to enhance flow-through injection precision and analytical performance. The closed-loop control design incorporates a Hall sensor to monitor pump rotor positions, ensuring stable operation. The modified PMP achieved a pressure relative standard deviation (RSD) of 0.7% ( n = 10), representing a threefold improvement over time-based and back electromotive force feedback controls. The system was applied to detect common cations and anions in drinking water. Experimental validation confirmed the reliability and precision of the CE system, with injection RSDs below 4.0% ( n = 42 for anions and 58 for cations). The calibration ranges were 0–500 μM with R 2 values ≥ 0.994. Detection limits ranged from 0.9 to 3.6 μM. The RSDs ( n = 10) of peak heights for ions in tap water were between 1.1% and 7.7%. Additionally, the CE system was employed to analyze total nitrogen and total phosphorus in water following persulfate oxidation. The total cost of the system was estimated to be approximately 6000 USD, including a ∼4000 USD TraceDec contactless conductivity detector. These findings demonstrate that the modified CE system with a closed-loop PMP significantly enhances injection precision, analytical performance, and versatility for environmental ion and nutrient detection. This system provides a reliable and cost-effective tool for on-site water quality monitoring.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Wuzhen Qi,Lingyan Zheng,Yu Hou,Hong Duan,Lei Wang,Siyuan Wang,Yuanjie Liu,Yanbin Li,Ming Liao,Jianhan Lin
A microfluidic biosensor was developed for rapid detection of Salmonella using a finger-actuated micropump, a finger-actuated micromixer, [email protected] nanocatalysts ( [email protected] ) and a smartphone App. First, immune magnetic nanobeads (MNBs), bacterial sample and immune [email protected] were successively finger-actuated pumped into microfluidic chip. Then, they were fully mixed using finger-actuated micromixer to form MNB- Salmonella [email protected] complexes. After hydrogen peroxide-tetramethylbenzidine was pumped into chip and catalyzed by nanocatalysts on complexes, resulting in color change from colorless to blue, the image of catalysate was collected and finally analyzed by self-developed smartphone App or directly compared with Pantone color card in chip to determine bacterial concentration. Experimental results showed this biosensor could quantitatively detect Salmonella from 3.5 × 10 2 to 3.5 × 10 5 CFU/mL in 1 h with lower detection limit of 350 CFU/mL. This biosensor has successfully integrated loading, mixing, incubation, washing, separation and detection onto a chip and might pave a promising way for bacterial detection.
研究领域:
微流控技术
·
生物传感器
·
食品安全
·
病原体检测
·
纳米技术
·
即时诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROPHORESIS
·
2022
·
IF 3.595
Yulan Liu,Ling Xia,Xiaohua Xiao,Gongke Li
Microfluidic CE (MCE) is an effective solution for rapid and sensitive determination of multiple analytes. Herein, a dynamic coated cyclic olefin copolymer microchip was developed having an on-chip micropump for fluid velocity adjusting in electrophoretic separations. This micropump was fabricated by constructing a polyacrylamide gel membrane at one channel terminal. Once applying electric field across the membrane, a pressure-driven flow generated automatically to balance the electroosmotic flow (EOF) mismatch at the channel-membrane interface. The influence of gel precursor concentration and operating voltages on the fluid velocity was carefully evaluated. Moreover, the highly integration of injection, separation, and pumping units of the MCE system minimized the dead volume and provides satisfied column efficiency. Experiments showed that by adjusting of pumping voltage reduced the fluid velocity by a factor of 6, resulting six- and threefold resolving power enhancements of rhodamine dye mixture and amino acid mixture, respectively. Furthermore, the developed MCE method was applied for rhodamines and amino acids quantitation in food and cosmetics, with standard addition recoveries of 87.3–106.9% and 89.9–117.4%, respectively. These results were also confirmed by standard HPLC method, revealing the application potential in fast and onsite analysis of complex samples.
研究领域:
微流控技术
·
分析化学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）