ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Guanyi Lin,Shan Jiang,Chunying Zhu,Taotao Fu,Youguang Ma
The mass-transfer process of CO2 absorption into aqueous solution of N-methyldiethanolamine (MDEA) + diethanolamine (DEA) in a T-shaped microchannel was studied using a high-speed camera. The effects of two-phase flow rates and diethanolamine concentration on CO2 absorption efficiency, liquid mass-transfer coefficient kL, specific surface area a, and volumetric mass-transfer coefficient kLa were investigated under slug flow. Results showed that the CO2 absorption efficiency increased with the increase of DEA concentration and liquid flow rate, and decreased with increasing gas flow rate. The kL increased with the increase of liquid flow rate and DEA concentration, while it was insensitive to gas flow rate. For a given liquid flow rate, both kLa and a increased rapidly with gas flow rate and then the trend was slowing down. The increase of liquid flow rate and DEA concentration led to the decrease of the a, whereas the kLa was improved. The enhancement of the liquid flow rate on kL and kLa was more obvious under low DEA concentration. An empirical correlation for predicting the volumetric mass-transfer coefficients kLa was proposed by taking the Hatta number Ha into account for characterizing the effect of chemical reaction.
研究领域:
化学工程
·
传质过程
·
碳捕集与封存（CCS）
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微流控技术
·
反应工程
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Jia-Ji Cao,Zhi-Shan Hou,Zhen-Nan Tian,Jian-Guan Hua,Yong-Lai Zhang,Qi-Dai Chen
Natural compound eyes provide the inspiration for developing artificial optical devices that feature a large field of view (FOV). However, the imaging ability of artificial compound eyes is generally based on the large number of ommatidia. The lack of a tunable imaging mechanism significantly limits the practical applications of artificial compound eyes, for instance, distinguishing targets at different distances. Herein, we reported zoom compound eyes that enable variable-focus imaging by integrating a deformable poly(dimethylsiloxane) (PDMS) microlens array (MLA) with a microfluidic chamber. The thin and soft PDMS MLA was fabricated by soft lithography using a hard template prepared by a combined technology of femtosecond laser processing and wet etching. As compared with other mechanical machining strategies, our combined technology features high flexibility, efficiency, and uniformity, as well as designable processing capability, since the size, distribution, and arrangement of the ommatidia can be well controlled during femtosecond laser processing. By tuning the volume of water injected into the chamber, the PDMS MLA can deform from a planar structure to a hemispherical shape, evolving into a tunable compound eye of variable FOV up to 180°. More importantly, the tunable chamber can functionalize as the main zoom lens for tunable imaging, which endows the compound eye with the additional capability of distinguishing targets at different distances. Its focal length can be turned from 3.03 mm to infinity with an angular resolution of 3.86 × 10–4 rad. This zoom compound eye combines the advantages of monocular eyes and compound eyes together, holding great promise for developing advanced micro-optical devices that enable large FOV and variable-focus imaging.
研究领域:
光学工程
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仿生机器人
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微光学器件
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成像系统
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微流控技术
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2022
·
IF 4.855
Zhichang Du,Gangnan Zhao,Anyang Wang,Wei Sun,Shengli Mi
Microfluidic technology has been used for precise drug delivery for many years, but microfluidic wearable devices have mostly been used for skin drug delivery. The application of eye drops is currently one of the most common ways to treat eye diseases. However, due to their low corneal bioavailability and short residence time in tears, topical eye drops must be applied multiple times a day. Contact lenses, as a wearable device for the eye, are a good platform for drug delivery. In this paper, we propose a type of microfluidic contact lens that integrates a microchannel and a micropump and uses a pressure source to trigger the release of a drug. Here, a flat microfluidic chip component is first fabricated by photolithography and then cast into a curved surface by secondary thermosetting. Through experiments, the outlet check valve opening pressure and liquid flow test were studied to prove that the liquid release is controllable. In addition, the microfluidic contact lens has good flexibility, light transmittance, and biocompatibility. Finally, we demonstrate through fluorescence experiments that the microfluidic contact lens can be loaded with different types of drugs in different regions. In general, liquid exchange between the eye and the contact lens can be realized through the mechanical action of blinking without using electronic components, meaning more safety and stability. The mechanical characteristics of a blink can be artificially regulated to a large extent; thus, it is also possible to achieve specific, personalized medicine.
研究领域:
生物医学工程
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药物递送系统
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微流控技术
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可穿戴设备
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眼科学
✓ 已验证
DOI
高影响因子
Evidence-based Complementary and Alternative Medicine
·
2021
·Vol. 2021
·期 1
·5574413
·
IF 2.63
Cui He,Lihua Yu,Wenran Dan,Surong Deng,Haidong Ma,Beizhong Liu,Yuan Li
This study aimed to develop a simple microfluidic chip analysis technology to study the inhibitory effect of protocatechuic acid on shear-induced platelet aggregation. The microfluidic chip designed in this study simulates 80% fixed narrow microchannels. This microchannel narrow model uses the finite element analysis module of the three-dimensional modeling software solidwork to analyze fluid dynamic behavior. Blood treated with protocatechuic acid at 1, 2, 4, 8, or 16 µ g/mL was passed through the microchannel stenosis model at a shear rate of 10,000 s −1 . The platelet adhesion and aggregation behaviors were then measured using fluorescence microscopy and observed in real time. Simultaneously, the antiplatelet aggregation effect of protocatechuic acid was analyzed using thromboelastography and photoelectric turbidimetry. The designed stenosis model of the microfluidic chip can produce a gradient of fluid shear rate, and the gradient of fluid shear rate can induce platelet aggregation. Under this model, the degree of platelet adhesion and aggregation increased as the shear rate increased. In the experimental concentration range of 0–8 µ mol/mL, protocatechuic acid exerted a concentration-dependent inhibition of platelet aggregation. In contrast, thromboelastography and photoelectric turbidimetry failed to demonstrate an inhibitory effect. The microfluidic chip analysis technology developed in this study can be used to study the effect of protocatechin in inhibiting platelet aggregation induced by shear rate in vitro. This technology is simple to operate and can be used as a new type of antiplatelet aggregation analysis technology for screening studies of novel potential antiplatelet aggregation drugs.
研究领域:
生物医学工程
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血液学
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药理学
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微流控技术
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2015
·
IF 5.636
Carl Esben Poulsen,Robert C. R. Wootton,Anders Wolff,Andrew J. deMello,Katherine S. Elvira
The determination of pharmacokinetic properties of drugs, such as the distribution coefficient (D) is a crucial measurement in pharmaceutical research. Surprisingly, the conventional (gold standard) technique used for D measurements, the shake-flask method, is antiquated and unsuitable for the testing of valuable and scarce drug candidates. Herein, we present a simple microfluidic platform for the determination of distribution coefficients using droplet-based liquid–liquid extraction. For simplicity, this platform makes use of gravity to enable phase separation for analysis and is 48 times faster and uses 99% less reagents than performing an equivalent measurement using the shake-flask method. Furthermore, the D measurements achieved in our platform are in good agreement with literature values measured using traditional shake-flask techniques. Since D is affected by volume ratios, we use the apparent acid dissociation constant, pK′, as a proxy for intersystem comparison. Our platform determines a pK′ value of 7.24 ± 0.15, compared to 7.25 ± 0.58 for the shake-flask method in our hands and 7.21 for the shake-flask method in the literature. Devices are fabricated using injection molding, the batchwise fabrication time is <2 min per device (at a cost of $1 U.S. per device), and the interdevice reproducibility is high.
研究领域:
药物科学
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微流控技术
·
分析化学
·
药物发现
·
芯片实验室技术
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2014
·
IF 3.583
Haiyun Zhai,Jiangmei Li,Zuanguang Chen,Zihao Su,Zhenping Liu,Xiao Yu
A simple glass/PDMS microfluidic chip for on-line sample pretreatment and contactless conductivity detection, which consisted of a 0.17 mm-thick glass cover and a PDMS substrate embedded with an SPE monolithic column, was presented in this paper. Using this integrated microchip system, sample extraction, injection, separation and detection were automatically performed in sequence. A sample of auramine O was concentrated by molecularly imprinted SPE (MISPE), eluted to sample reservoir, and injected by electromigration into separation channel for electrophoresis separation and contactless conductivity detection, with the calculated detection limit (S/N = 3) being 2.5 μg mL − 1 . The monolithic column was utilized to quantitatively extract auramine O , yielding an on-line enrichment factor of about 12. The microchip system is reliable and applicable to the analysis of auramine O in food sample.
研究领域:
分析化学
·
微流控技术
·
食品安全
·
分子印迹技术
·
电泳学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Tingliang Xie,Minxuan Chen,Cong Xu,Jing Chen
Microextractors are known to provide high mass transfer rates for the extraction and separation of rare-earth elements (REEs). High-throughput microextractors are essential for industrial-scale production of REEs, but few practical studies have been conducted to date. In this work, a chaotic advection microextractor, i.e., a three-stage microextractor, was designed and demonstrated to extract Pr(III) and Ce(III) efficiently from nitric acid media at high throughputs by using 2-ethylhexyl phosphoric acid-2-ethylhexyl ester (P507) and sulfonated kerosene as an extraction agent and a diluent, respectively. Flow visualization experiments showed that the dispersed phase could be effectively broken into small droplets owing to vortex and recirculation flows. Microextraction experiments performed under optimal extraction conditions indicated that at low throughputs, the concentration ratio D , extraction efficiency E , and separation factor β decreased with an increase in the throughput, whereas at high throughputs, D , E , and β increased with an increase in the throughput. An extraction efficiency close to that of co-current balanced extraction was successfully achieved, even at a high total throughput of 100 mL/min and a rather short residence time of 0.029 s. Thus, the chaotic advection microextractor features a high throughput and high extraction efficiency, which are appropriate for the high-efficiency extraction and separation of REEs.
研究领域:
化学工程
·
分离科学
·
稀土冶金
·
微流控技术
·
过程强化
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Hao Wu,Tianyi Jiang,Wenlong Wu,Shanguo Zhang,Ming Li,Jingzhuo Zhou,Mengya Zhu,Juzheng Chen,Ziyong Li,Yang Lu,Hongyuan Jiang
Water-in-oil-in-water (W/O/W) double emulsion droplets are a typical colloidal system applied in various practical fields. However, certain high-specification applications necessitate exact geometric homogeneity in terms of both shell diameter and thickness. Despite achieving uniformity in shell diameter, on-chip microfluidic emulsification always leads to an eccentric phenomenon due to innate density differences of the droplet solution. At the same time, the current regulation methods have multiple limitations, including their applicability, regulatory scope, and objective restrictions. Herein, we propose an off-chip osmosis-induced hydrodynamic method to accurately regulate the eccentricity of W/O/W double emulsion droplets. The rational selection of hypertonic osmosis can energize the droplets and induce inward transmembrane water flux. This flow helps to reposition the droplet core to align concentrically with the shell, regardless of the initial dimension and eccentricity of the droplets. As the osmotic induction reduces due to the dilution of the inner solute molar concentration , the optimal droplet configuration can be achieved when osmosis-induced hydrodynamic regulation sufficiently counteracts the adverse effects of droplet solution density difference. The microcapsules can thus be produced by instant UV polymerization of the regulated double emulsion droplets, and the silica microspheres with fine geometric homogeneity can be prepared through further heat treatment, which is expected to meet the stringent morphological requirements in practical applications.
研究领域:
胶体与界面化学
·
微流控技术
·
生物材料
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药物递送系统
·
高分子科学
✓ 已验证
DOI
高影响因子
BIOMEDICAL MICRODEVICES
·
2011
·Vol. 13
·期 5
·865-875
·
IF 3.386
He Zhongyuan,Zhang Qinghong,Wang Hongzhi,Li Yaogang
A capillary microchannel (CM) containing TiO 2 -coated ZnO nanorod arrays was applied as a novel microfluidic device to selectively bind and enrich phosphopeptides. The device was prepared by pumping a TiO 2 sol into a CM containing preformed ZnO nanorod arrays. Different thicknesses of the TiO 2 coating were obtained by controlling the flow duration of TiO 2 sol. The modified CM achieved uninterrupted high-throughput introduction, capture and enrichment of phosphopeptides using continuous-flow operation. The microfluidic device based on the modified CM showed great selectivity, sensitivity and durability for the enrichment of phosphopeptides from tryptic protein digests. These results suggest that microfluidic chips employing this strategy can be used for rapid and high-throughput enrichment of phosphopeptides from complex mixtures.
研究领域:
分析化学
·
蛋白质组学
·
微流控技术
·
纳米材料
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Xinlian Zhang,Xi Chen,Yuhan Yao,Xiaona Shang,Huijun Lu,Wang Zhao,Sixiu Liu,Jianmin Chen,Guodong Sui
Acute toxicity assay presents vital significance in modern environmental monitoring, including online detection and in-situ assay for emergency events. Although photobacteria related detection methods were established and verified in the past decades with combination of photomultiplier tube (PMT), the price and size of PMT sensor hampered application of rapid acute toxicity assay and detection system miniaturization, especially in the resource-limited occasions. Wide application of smartphones with great low-light performance cameras could be used in photobacteria-based toxicity assay instead of the PMT methods. Herein a box-type portable detection system had been successfully established, including a disc-chip for detection, detection device, and smartphones with a high-performance camera. The system performed well showing stable temperature and rotation control. Results captured by CMOS-based camera presented a linear relationship with PMT-based detection method. An image progress algorithm was also established and tested by series diluted zinc sulfate solution as a reference substance. The system also performed well for toxicity analysis for real Atmospheric particle matter sample. The system could be used in some environmental monitoring scenarios as an alternative solution.
研究领域:
环境科学
·
毒理学
·
生物传感器
·
微流控技术
·
即时检测
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）