INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Pei Xie,Kai Wang,Jisong Zhang,Yunpeng Hu,Guangsheng Luo
To obtain a high quality bromobutyl rubber product, a higher selectivity of brominated secondary allylic structure is necessary, but it is difficult to realize in traditional reaction devices. We developed a microreaction system and used microwater droplets as an extractant to in situ remove HBr, the catalyst of the isomerization side reaction, from the organic reacting solution to prevent converting brominated secondary allyl to brominated primary allyl and degradation of the polymer chain. The microreaction system contains two micromixers, including a membrane dispersion micromixer for dispersing microwater droplets in the butyl rubber solution and a cross-junction micromixer for blending butyl rubber and Br2 solutions. A volume adjustable delayed loop after the micromixers is used to carry out the reaction. The results show that 1 wt % water in the organic phase is satisfied to remove HBr, and 97% selectivity of brominated secondary allyl is successfully obtained under optimized operating conditions.
研究领域:
化学工程
·
聚合物科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Microfluidics and Nanofluidics
·
2015
·Vol. 19
·期 4
·829-836
·
IF 2.528
He Weiqi,Xiao Jingrong,Zhang Zhengtao,Zhang Weiying,Cao Yiping,He Rongxiang,Chen Yong
A cost-effective method that used electroplating to fabricate a 3D polydimethylsiloxane (PDMS) passive micromixer was developed in this work. The mixer fabrication process characteristics were as follows: The chip design was transferred to indium tin oxide (ITO) glass via photolithography; the ITO glass was vertically immersed in a nickel electroplating solution; and the ITO glass was raised up by controlling by the syringe pump, while electroplating was in progress. In this method, the height of the mixing structure could increase gradient from 15 to 30 μm. Compared with a flat structure, this structure could increase mixing efficiency by at least 10 %. The mixing efficiency with this 3D microstructure can reach more than 80 %. This 3D microstructure fabrication method can be easily integrated with other PDMS functional structures for future point-of-care diagnostic applications because of the advantages of this technique.
研究领域:
微流控技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Micromachines
·
2022
·Vol. 14
·期 1
·45
·
IF 3.523
Zhou Lan,Yangcheng Lu
The combination of microstructural units is an effective strategy to improve the micromixing of liquid phase systems, especially viscous systems. However, how the microstructural combination influences micromixing is still not systematically investigated. In this work, the Villermaux/Dushman reaction is used to study the micromixing performance of the viscous system of the glycerol–water in the combination of a T-type micromixer and a micropacked bed. Micromixing performances under various structural parameters and fluid characteristics are determined and summarized, and the micromixing laws are revealed by dimensionless analysis considering the specific spatial characteristics and temporal sequence in the combined microstructures. It achieves good agreement with experimental results and enables guidance for the design and scaling-up of the combined T-type micromixer and micropacked bed towards micromixing intensification in viscous reaction systems.Keywords:micromixing;micropacked bed;microstructual combination;viscous system
研究领域:
化学工程
·
流体力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Jiaying Lu,Yanqing Guo,Yihang Xin,Xiaogang Yang,Jiusheng Li
Achieving a controllable synthesis of metal nanoparticles depends very much on the hydrodynamics of the synthesis process, in particular the local turbulence that has been considered to have a significant impact on the synthesised nano particle size and morphology. This paper reports the study on turbulence induced shear regulatable synthesis of the silver nanoparticles (AgNPs) using a counter axial-swirling impinging jet flow reactor (CASIJR), exploring the effect of turbulent shear stress on the formation of AgNPs. The micro-mixing and turbulence induced shear in the flow inside the CASIJR reactor were evaluated using Reynolds Average Navier-Stokes (RANS) modelling coupled with the Reynolds Stress Model (RSM). It was indicated from the simulations that an increase in the axial-swirling circular pipe flow diameter based Reynolds number from 3300 to 4900 would enhance the mixing and local turbulence induced shear, characterising by an increase in the mixing index. It was also found from the AgNPs synthesis experiments that there exists a strong correlation between the turbulent shear stress u ′ v ′ ¯ and the synthesised AgNPs size. The average synthesised nano particle size, size distribution, and morphology of AgNPs are affected by the micro-mixing and anisotropic turbulence induced shear in the CASIJR.
研究领域:
化学工程
·
纳米材料科学
✓ 已验证
产品关联
DOI
高影响因子
Chemical Engineering and Processing-Process Intensification
·
2024
·
IF 3.8
Jun-Ru Bai,Tian-Xiang Cui,Chen-Yang Wang,Guang-Wen Chu,Lei Shao,Yang Xiang
Rotating packed beds (RPBs), as the typical chemical intensification devices, have been widely applied in liquid-phase fast reactions and precipitation processes. In this study, three novel tube-tube premixers were designed, and three-dimensional CFD models of the flow and mixing processes for non-Newtonian fluids in tube-tube premixers were established. Meanwhile, the micromixing efficiency in RPBs with different tube-tube premixers was experimentally investigated. The results show that TG-2 premixer exhibits the best premixing performance. The segregation index decreases as the rotational speed or flow rate increases, indicating the increase in micromixing efficiency. With the increase of CMC mass fraction, the segregation index initially decreases and then increases. Moreover, the micromixing efficiency of TG-0-RPB is the highest in aqueous solution, the micromixing efficiency of TG-4-RPB is the highest in 0.2 wt.% CMC system, and the micromixing efficiency of TG-2-RPB is the highest when the CMC concentrations is equal to or greater than 0.4 wt.%. The micromixing times of non-Newtonian fluid in RPBs range from 2 to 10 ms.
研究领域:
化学工程
·
流体力学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICS OF FLUIDS
·
2024
·Vol. 36
·期 11
·
IF 4.1
Chen Xinkun,Zhai Junlong,Chen Xueye
The traditional lipid preparation methods are complex, time-consuming, and consume a large amount of reagents, increasing costs and difficulties. Although microfluidic technology is considered a promising solution, achieving controllable liposome production with a simple and inexpensive microfluidic mixing device remains an important problem. This paper presents a wall-type micro-mixer based on coastal zone fractals. Four parameters related to the geometric shape of the coastline fractal in the microchannel are used as design variables, and the mixing index is the objective function. Single-objective optimization numerical analysis of the primary wall-type fractal baffle micromixer under four Reynolds numbers conditions yields the optimal structural configuration. Visualization experiments verify the correctness and accuracy of the numerical simulation, and the optimized mixer is used to produce liposomes. The results show that the micro-mixer with the optimal double-sidewall cross arrangement enhances chaotic convection and improves mixing efficiency. At Re = 0.1 and Re = 100, the mixing efficiency reaches 99%, 50.44% higher than the reference design. By changing the relative flow rates of lipid and aqueous solutions, microfluidic blank liposomes with a particle size of 165.12 ± 11.6 nm and a polydispersity index of 0.35± are obtained. This wall-type fractal micro-mixer has broad application prospects due to its high mixing efficiency.
研究领域:
药剂学
·
生物工程
·
化学工程
✓ 已验证
DOI
高影响因子
Materials
·
2021
·Vol. 14
·期 5
·1263
·
IF 3.623
Rui Xu,Shijiao Zhao,Lei Nie,Changsheng Deng,Shaochang Hao,Xingyu Zhao,Jianjun Li,Bing Liu,Jingtao Ma
In this study, we report a novel high-throughput and instant-mixing droplet microfluidic system that can prepare uniformly mixed monodisperse droplets at a flow rate of mL/min designed for rapid mixing between multiple solutions and the preparation of micro-/nanoparticles. The system is composed of a magneton micromixer and a T-junction microfluidic device. The magneton micromixer rapidly mixes multiple solutions uniformly through the rotation of the magneton, and the mixed solution is sheared into monodisperse droplets by the silicone oil in the T-junction microfluidic device. The optimal conditions of the preparation of monodisperse droplets for the system have been found and factors affecting droplet size are analyzed for correlation; for example, the structure of the T-junction microfluidic device, the rotation speed of the magneton, etc. At the same time, through the uniformity of the color of the mixed solution, the mixing performance of the system is quantitatively evaluated. Compared with mainstream micromixers on the market, the system has the best mixing performance. Finally, we used the system to simulate the internal gelation broth preparation of zirconium broth and uranium broth. The results show that the system is expected to realize the preparation of ceramic microspheres at room temperature without cooling by the internal gelation process.Keywords:microfluidic;high-throughput;micromixing;monodisperse droplets;internal gelation process
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYSICS OF FLUIDS
·
2022
·Vol. 34
·期 3
·
IF 4.98
Yuan Shuai,Zhou Mingyong,Peng Tao,Li Qiang,Jiang Fengze
Achieving rapid mixing of different liquids in a short distance is important in various biochemical applications. Herein, a novel planar mixer with staggered Z-shaped baffles is proposed. Numerical investigations are carried out to evaluate its mixing ability based on mixing quality and pressure drop when the Reynolds number (Re) varies from 0.1 to 50. The Lyapunov exponent, the Poincaré map, and the vortex visualization are conducted to comprehensively analyze the chaotic state and the mixing mechanism. Results show that the proposed mixer exceeds 0.9 mixing efficiency when 0.1 ≤ Re and Re ≥ 8. As Re ≥ 8, different vortex patterns appear by changing the inlet configuration. The disturbance for fluids induced by a vortex on the mass transfer surface is not only dependent on its intensity but also related to the position of the vortex/vortex leg. The proposed planar mixer, inducing a single vortex or vortex pair with different directions, presents different mixing performance when the Re varies from 8 to 50, from which the approach of the rotating vortex that can mainly improve the mixing quality is found. This well explains the chaotic mixing behavior observed in the planar mixer with Z-shaped baffles, which to date has not been studied before. Furthermore, the micromixer is fabricated, tested, and applied for luminol–peroxide chemiluminescence detection to characterize its performance.
研究领域:
流体力学
·
生物化学工程
·
微流控技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2021
·
IF 4.311
Zhinan Fu,Yiming Wang,Fen Li,Xiaofeng Niu,Li Li,Dianhua Liu,Zhiyong Liu,Xuhong Guo
Kinetic control over self-assembly may lead to various out-of-equilibrium supramolecular objects with distinctly different functions based on identical building blocks, but the engineering approach towards such goal is still lacking, limiting the practical applications. Here we show how a variety of transient assemblies bearing different architectures can be prepared from the same amphiphilic block copolymer (BCP) using a high-efficiency micromixer. Upon simply tuning the mixing parameters, the self-assembly kinetics of the BCP were effectively interfered, giving rise to a series of kinetically favored assemblies under continuous production. Interestingly, all these different assemblies were capable of converting into thermodynamically more stable state over time, showing typical out-of-equilibrium feature. Importantly, the kinetically favored assemblies loading with gold nanoparticles showed very different catalytic activities from the thermodynamic one, demonstrating their different functionalities. Such engineering approach towards out-of-equilibrium supramolecular assemblies may promote the implementation of flow chemistry technique in supramolecular chemistry for engineering applications.
研究领域:
高分子化学
·
超分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Chen Xu,Rui Feng,Fei Song,Jia-Min Wu,Yu-Qiong Luo,Xiu-Li Wang,Yu-Zhong Wang
Directional transportation of water flow, which is frequently seen in nature, is of not only great importance to organisms but also crucial demand for advanced science and technologies . Numerous contributions have been dedicated to the motion manipulation of single drops on chemically heterogeneous surfaces, which have hydrophilic/superhydrophobic patterns in general. Drop retention is therefore difficult to avoid due to the hydrophilic regions, and continuous transportation of water flow still remains a challenge. Here, a hydrophobic/superhydrophobic patterned surface, featured with chemical homogeneity, is developed via a simple coating on a morphologically heterogeneous surface. Such surface can guide the continuous water motions, and relationship between the surface patterns and the motion controllability is clarified. Additionally, the potential application of the patterned films is explored as a micro-mixing device for different drops. The finding and results are essential for advancing more applications of microfluidics and microchips.
研究领域:
材料科学
·
生物工程
·
流体力学
✓ 已验证
产品关联
DOI
高影响因子
Particuology
·
2018
·
IF 2.785
Xiaojing Liu,Yangcheng Lu
Solvent exchange is widely used to synthesize magnetic nanoclusters (MNCs). However, it remains a challenge to increase the production and decrease the addition of surfactants, both of which are important for the application and functionalization of MNCs. Herein, we use a rapid and tunable mixing method to control the assembly of Fe 3 O 4 nanoparticles. This method involves shear-mixing in a channel of a T-junction micromixer. Smaller and more monodisperse MNCs were synthesized with less surfactant, when compared with conventional bulk synthesis. Varying the mixing rate and the formula of the magnetic suspension allowed for the flexible adjustment of the nanocluster size while maintaining a uniformly sized MNCs. The flow synthesis and ease of scale-up make this method potentially suitable for broad industrial application.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Nano
·
2023
·
IF 10.3
X. Zhao,H. Chen,Y. Xiao,J. Zhang,S. Watanabe,N. Hao
Acoustic microfluidics has a remarkable influence on mixing but still face significant challenges of low throughput. Here, a robust acoustic micromixer with a spiral microchannel and side-wall sharp-edge structures is first proposed for facilitating microscale fluid mixing at wide-range flow rates . A micromixer that integrates acoustics with hydrodynamics enables fast and homogeneous mixing, ranging from 4 μL/min to over 2500 μL/min. the mixing performance shows a transition from acoustics domination at low flow rates to hydrodynamics domination at high flow rates. The increases of transducer amplitude, curvature, and sharp-edge density are positively correlated with mixing performance, while the increase of a tilted angle shows the opposite. The acoustic micromixer is leveraged to synthesize a functional ZnO nanoarray inside glass capillaries as portable microanalytical systems. ZnO nanofiber and nanosheet arrays are developed and their performances are systematically investigated by photodegradation of organic dye and enrichment of a heavy metal ion . Generally, efficiencies in photodegradation and enrichment can be well regulated by residence time, and a ZnO nanofiber shows more outstanding activity and robust stability than a ZnO nanosheet. These findings not only shed new light on the rational design of advanced lab-on-a-chip devices but also provide important guidelines for the controllable synthesis and applications of functional nanomaterials .
研究领域:
微流控技术
·
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）