Journal of Advanced Research
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2025
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IF 13
Jin-Long Tian,Nuo Wang,Qin-Fu Zhao,Zhi-Huan Zang,Zhi-Ying Li,Zhen-Yu Wang,Ying Zhou,Bao-Ru Yang,Sergey S. Makarov,Anton I. Chudetsky,Liang Wang,Ying He,Bin Li
Introduction Anthocyanins have various health benefits but are limited by fast elimination and low bioavailability. Many studies have shown that nano delivery systems are effective in improving the intestinal absorption and bioavailability of anthocyanins. However, in the process of selecting anthocyanin nanomaterials, a dilemma is faced: numerous functional nanomaterials lack edible properties, it is difficult to meet the edible and functional requirements of nanomaterials simultaneously. Therefore, it is necessary and inevitable to select nano-anthocyanin carriers that are edible and have certain functional and morphological characteristics. Objectives We aim to provide an efficient, sustained-release and easy to industrialize nanosystem method to solve the problem of low bioavailability of anthocyanins. Methods A succinylated casein-phospholipid-anthocyanin nanosystem (CLS) was designed via computational chemistry-guided one-step self-assembly. Morphological, in vitro/in vivo digestion, pharmacokinetic were conducted. Furthermore, the effects of CLS on intestinal microecology were verified by using enteritis model animals, and the lung-targeting effect of CLS on lung health was verified by using lung injury model animals. Results CLS exhibited 24-hour intestinal sustained release and lung-targeted enrichment. Pharmacokinetic studies showed 25.7-fold higher lung AUC (0-t) and 13.1-fold higher blood AUC (0-t) compared to free anthocyanins. CLS significantly alleviated lung injury and colitis in model rats via the gut-lung axis. Conclusion This study significantly improved the bioavailability of anthocyanins and demonstrated the oral lung-targeting function of anthocyanins for the first time, paving the way for utilizing anthocyanins as dietary supplements and precision nutrition.
研究领域:
食品科学
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药理学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Caixuan Zhang,Ying Shu,Yang Li,Fanyu Wang,Juntian Gan,Yiqian Wang,Xiaojuan Feng,Mingzhu Guo
Clinical research has demonstrated that non-starch polysaccharides from natural sources exhibit protective and therapeutic effects on ulcerative colitis (UC). In this study, a non-starch polysaccharide (CYP-A) with a molecular weight of 1.54 × 10 3 kDa was isolated from a speciality Chinese yam ( Dioscorea ) variety, the Ma yam, consisting mainly of mannose and glucose. The results indicated that CYP-A alleviated colitis symptoms induced by dextran sulfate sodium (DSS), repaired the mucus barrier, and protected the integrity of the intestinal mechanical barrier. Furthermore, CYP-A suppressed pro-inflammatory cytokine production, reduced oxidative stress, and modulated the biological barriers by facilitating the colonization of norank_f-_Muribaculaceae , Dubosella , Faecalibaculum and Enterorhabdus, while reducing Escherichia - Shigella and Bacteroides . Notably, CYP-A reshaped the metabolic pathways related to steroid hormone biosynthesis as well as phenylalanine, tyrosine, and histidine metabolism. These findings highlight the potential of CYP-A as a nutraceutical for targeting UC and improving gut health.
研究领域:
营养学
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肠道微生物组学
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免疫学
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产品关联
DOI
PubMed
高影响因子
Food & Function
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2022
·Vol. 13
·期 5
·2581-2593
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IF 6.317
Panpan Zhang,Jinhui Jia,Pingrui Jiang,Weiyun Zheng,Xiangfei Li,Shuang Song,Chunqing Ai
Brown seaweed is rich in polysaccharides including sulfated polysaccharides and alginate, both of which provide health benefits to the host but whose differences have not received sufficient attention. In this study, alginate from Undaria pinnatifida (UPA) and sulfated polysaccharides from U. pinnatifida (UPSP) were isolated, and their action was analyzed in high fat diet-fed mice. UPA and UPSP improved body composition, fat deposition in body tissues and organs, lipid abnormality and inflammatory response in mice, and compound polysaccharides from U. pinnatifida (UPP: UPA + UPSP) had a better effect on some physiological indexes, which could be attributed to the differences in the gut microbiota. Both UPSP and UPA modulated diet-induced microbiota dysbiosis, and UPP had better effect on changes in the gut microbiota, including an increase in Bacteroidales and reduction in both Clostridiales and Lactobacillales that had positive correlations with the improvement of the physiological status. The in vitro model of bacterial culture revealed that the use of Bacteroides on UPA and UPSP was species dependent, and UPP can better maintain the diversity and stability of the Bacteroidales community. This study indicated that polysaccharides from edible brown seaweed can benefit host health by improving the intestinal microecology, which can be helpful for the application of edible brown seaweed in health foods.
研究领域:
营养学
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微生物学
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食品科学
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药理学
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DOI
PubMed
高影响因子
Systems Microbiology and Biomanufacturing
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2025
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IF 2.9
Cheng Fan,Mei Jie,Wang Jiasheng,Zhang Xian,Miao Yongmei,Si Guanru,Liu Qingtao,Chen Tao,Rao Zhiming,Xue Zhenglian,Zhang Wenqing
Ethyl carbamate (EC) is an endogenous pollutant in traditional fermented foods and has potential carcinogenicity. In this work, a yeast capable of degrading EC was screened from the microecology of Zhimaxiangxing baijiu (ZB). The strain, which exhibited excellent fermentation performance and strong resistance to acids and ethanol, was identified as Pichia manshurica and named Pichia manshurica AHXJ-p4 by homologous alignment analysis of its ITS gene sequence. Then its optimised solid-state fermentation (SSF) culture conditions were determined as follows: the addition ratio of wheat bran to corn meal ranged from 4.6:0.9 to 4.8:0.7 (w/w), the water content was 55% (w/w), the inoculation amount was 10% (v/v), and the pH was 5.0. This study expanded the research on the application of yeast in baijiu brewing and provided a theoretical basis for establishing a production process for Fuqu with an EC-reducing function. Furthermore, this work is significant for enhancing the quality of the baijiu industry and controlling food safety.
研究领域:
食品科学
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微生物学
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生物技术
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发酵技术
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应用微生物学
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产品关联
DOI
高影响因子
Advanced Science
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2024
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IF 14.3
Zilin Zhou,Lizhong Sun,Yuanyuan Tu,Yingming Yang,Ailin Hou,Jiyao Li,Jun Luo,Lei Cheng,Jianshu Li,Kunneng Liang,Jiaojiao Yang
In treating infectious diseases, achieving selective bacterial inhibition is crucial for preserving the microecological equilibrium. The current approaches predominantly rely on synthetic materials tailored to specific bacteria, considering their cell walls or oxygen requirements. Herein, inspired by intricate bacterial communication, a natural implant is proposed coating utilizing bacterial outer membrane vesicles (OMVs), essential components in bacterial signaling, integrated onto diverse implant surfaces through a universal poly (tannic acid) bridging layer. This coating is homogenous and stable, unexpectedly promoting the proliferation of parental bacteria while inhibiting heterologous bacteria both in vitro and in vivo. Through high-throughput sequencing and bioinformatics analysis, the selective bacteriostatic ability arises from OMVs, upregulating anti-oxidative stress genes in heterologous bacteria and activating biofilm-related genes in parental bacteria. This study positions OMVs as an appealing biomaterial for selective bacterial inhibition through a biological approach, showcasing their potential in regulating the microecological balance through a natural interface modification strategy.
研究领域:
生物医学工程
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微生物学
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材料科学
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生物化学
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DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2020
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IF 6.793
Yanluo Xie,Huakang Liu,Hao Li,Hao Tang,He Peng,Heng Xu
Di-(2-ethylhexyl) phthalate (DEHP) has been classified as a priority pollutant which increased the healthy risk to human and animals dramatically. Hence, a novel biochemical system combined by DEHP-resistant bacterial flora (B) and a green oxidant of persulfate (PS) activated by Nano-Fe 3 O 4 was applied to degrade DEHP in contaminated soil. In this study, the resistant bacterial flora was screened from activated sludge and immobilized by sodium alginate (SAB). Nano-Fe 3 O 4 was coated on biochar (BC@Fe 3 O 4 ) to prevent agglomerating in soil. X-ray diffraction (XRD) and scanning electron microscope (SEM) were utilized to characterize BC@Fe 3 O 4 . Results demonstrated that the treatment of biochemical system (SAB + BC@Fe 3 O 4 + PS) presented the maximum degradation rate about 92.56% within 24 days of incubation and improved soil microecology. The 16S rDNA sequences analysis of soil microorganisms showed a significantly different abundance and a similar diversity among different treatments. Kyoto Encyclopedia of Genes and Genomes (KEGG) functional genes difference analysis showed that some metabolic pathways, such as metabolism of cofactors and vitamins, energy metabolism, cell growth and death, replication and repair, were associated with the biodegradation of DEHP. Besides, DEHP was converted to MEHP and PA by biodegradation, while DEHP was converted to DBP and PA by persulfate and BC@Fe 3 O 4 , and then ultimately degraded to CO 2 and H 2 O.
研究领域:
环境科学
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微生物学
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土壤学
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基因组学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
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IF 5.162
Ye Mi,Yao Xian Chin,Wan Xiu Cao,Yao Guang Chang,Phaik Eem Lim,Chang Hu Xue,Qing Juan Tang
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, has gradually emerged as a public health challenge worldwide. Carrageenan is a popular food additive that has been in use for decades. However, controversy exists regarding to the safety of carrageenan due to its exacerbation of colitis in experimental models. In this study, we studied the effects of vehicle and host intestinal microflora on carrageenan inflammatory properties in C57BL/6 J mice. We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects. However, no signs of colitis were observed under low-fat diet regardless of the mode of vehicle used. Moreover, we discovered that carrageenan-induced colitis in high-fat diet model was robustly correlated with changes in the composition of gut microbiota, specifically Alistipes finegoldii and Bacteroides acidifaciens . Hence, we propose that the inflammatory property of carrageenan is influenced greatly by its intake form via modification of host intestinal microecology.
研究领域:
胃肠病学
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微生物学
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营养学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）