SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Qichen Shang,Yu Chang,Junjie Wang,Daiwei Gu,Jian Deng,Chencan Du,Guangsheng Luo
Liquid-liquid extraction can be greatly intensified in microchannel devices. Unfortunately, countercurrent flow is hard to realize at microscale. Meanwhile the microdroplet extraction efficiency is still low when the phase ratio is high. Micro-capillary jetting as a new technology for microdispersion can produce microdroplets with narrow size distribution without the restriction of phase ratio. In this work, an integrated microsystem of the micro-capillary jetting for microdroplet generation with the liquid–liquid countercurrent flow in a millimeter column has been developed, and the countercurrent extraction based on microdroplet under high phase ratio was successfully realized. More than 3 theoretical stages within 40 cm were achieved under the phase ratio of 50 ∼ 90 for H 2 O 2 extraction. This paper systematically reports the microdispersion, flow characteristics and extraction performances of the microsystem. It means a lot for future intensification of the countercurrent extraction with high phase ratio.
研究领域:
化学工程
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微流体技术
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DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Ren Zhihao,Shi Xiaoyu,Yang Qing,Li Chunsheng,Liu Hanqing,Bai Tiesheng,Ma Yuan,Das Pratteek,Liu Haofeng,Yang Endian,Jin Shengye,Feng Liang,Shi Quan,Bao Xinhe,Cheng Hui-Ming,Wu Zhong-Shuai
For electronics to be wearable, contactless charging and overall deformability are necessary pre-conditions. However, the current heterogeneous integration based on different active materials and separate manufacturing often leads to mechanical mismatch. Here, we report an ultrastretchable all-in-one integrated MXene-based microsystem comprising wireless coils, micro-supercapacitors (MSCs) and strain sensors. The seamless configuration without any connecting interface dramatically improves the structural integrity of the microsystem, and a pre-crumpled structure endows it with superior stretchability. Attributed to these, our MSCs can be wirelessly charged in ~20 s under various types of deformation and are capable of powering strain sensors, responding rapidly to body motion signals. Moreover, the MSCs display a high specific capacitance of 76.82 F cm –3 , and superb mechanical stability with 98.5% capacitance retention after biaxial stretching 1000 cycles from 0% to 500% areal strain. Therefore, this work sheds new insights into design and implementation of skin-attachable wireless microelectronics.
研究领域:
材料科学
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电子工程
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生物医学工程
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DOI
PubMed
高影响因子
Fundamental Research
·
2022
·
IF 0
Yuanyuan Zhu,Shuanghao Zheng,Jieqiong Qin,Jiaxin Ma,Pratteek Das,Feng Zhou,Zhong-Shuai Wu
Two-dimensional MXenes are key high-capacitance electrode materials for micro-supercapacitors (MSCs) catering to integrated microsystems. However, the narrow electrochemical voltage windows of conventional aqueous electrolytes (≤ 1.23 V) and symmetric MXene MSCs (typically ≤ 0.6 V) substantially limit their output voltage and energy density. Highly concentrated aqueous electrolytes exhibit lower water molecule activity, which inhibits water splitting and consequently widens the operating voltage window. Herein, we report ultrahigh-voltage aqueous planar asymmetric MSCs (AMSCs) based on a highly concentrated LiCl-gel quasi-solid-state electrolyte with MXene (Ti 3 C 2 T x ) as the negative electrode and MnO 2 nanosheets as the positive electrode (MXene//MnO 2 -AMSCs). The MXene//MnO 2 -AMSCs exhibit a high voltage of up to 2.4 V, attaining an ultrahigh volumetric energy density of 53 mWh cm −3 . Furthermore, the in-plane geometry and the quasi-solid-state electrolyte enabled excellent mechanical flexibility and performance uniformity in the serially/parallel connected packs of our AMSCs. Notably, the MXene//MnO 2 -AMSC-based integrated microsystem, in conjunction with solar cells and consumer electronics, could efficiently realize simultaneous energy harvesting, storage, and conversion. The findings of this study provide insights for constructing high-voltage aqueous MXene-based AMSCs as safe and self-sufficient micropower sources in smart integrated microsystems.
研究领域:
材料科学
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能源存储
·
纳米技术
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DOI
Chemistry-An Asian Journal
·
2019
·Vol. 14
·期 14
·2503-2511
·
IF 3.698
Ming Luo,Yuzhou Jiang,Jingbei Su,Zhuoyi Deng,Fangzhi Mou,Leilei Xu,Jianguo Guan
Graphical A good catch : A simple, versatile and efficient approach to extract nucleic acids in microsystems was demonstrated by developing cationic branched polyethyleneimine (PEI)-functionalized tubular micromotors. The PEI-functionalized tubular micromotor can selectively capture nucleic acids from an acid medium and recover the captured nucleic acids in a basic medium. Extraction of nucleic acids in microsystems is of significance for biomedical applications, but the current extraction methods generally require sophisticated microchannels and external equipment, hindering their practical applications. In this work, we have demonstrated a simple, versatile and efficient approach to extract nucleic acids in microsystems by developing cationic branched polyethyleneimine (PEI)-functionalized tubular micromotors. The as-developed tubular micromotors are fabricated by a two-step process combining the template-assisted electrodeposition and carbodiimide chemistry, and contain an inner catalytic Pt layer, a middle magnetic Ni layer and an outer cationic PEI layer. They exhibit autonomous bubble-propelled motion in aqueous hydrogen peroxide solutions, which can be guided by an external magnetic field, and the surface charges can be reversibly modulated by changing the pH value of the solution. Consequently, the as-developed tubular micromotors can selectively absorb nucleic acids from acidic solutions and desorb them into alkaline solutions, leading to the extraction of nucleic acids with high efficiency without external stirring. Furthermore, they can be operated in a microchannel chip without the aid of a pumping system. Our results indicate that this PEI-functionalized tubular micromotor platform provides a novel, simple and versatile microsystem nucleic acid extraction technology, holding considerable promise for important practical applications.
研究领域:
生物医学工程
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分析化学
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纳米技术
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DOI
PubMed
高影响因子
Journal of Tissue Engineering and Regenerative Medicine
·
2018
·Vol. 12
·期 12
·2266-2276
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IF 4.089
Jing Liu,Chengpan Li,Shaohui Cheng,Shengnan Ya,Dayong Gao,Weiping Ding
In vitro engineering of liver tissue is a rapidly developing field for various biomedical applications. However, liver tissue culture is currently performed on only a small scale with a low density of hepatocytes. In this study, a simple design was introduced in a liver microsystem to enhance the transport of nutrients (e.g., oxygen and glucose) for the three-dimensional large-scale, high-density culture of hepatocytes. In this design, convection across the cell culture zone was generated to mimic sinusoid blood flow (SBF) based on the pressure difference between two fluids flowing in a countercurrent manner on either side of the cell culture zone. First, the distributions of living and dead cells in different culture subzones under various perfusion flow rates were observed, analysed, and compared. Then, the enhanced transport of nutrients was experimentally validated in relation to the viability of cells and theoretically explained by comparing the fluid velocity and oxygen concentration distribution in the cell culture zone in counterflow and coflow modes. Finally, the functions of the SBF-mimicked liver microsystem were assessed on the basis of specific metabolites, synthesized proteins, and bilirubin detoxification of hepatocytes, with collagen and alginate as extracellular matrices. Under this design, the density of hepatocytes cultured at the 3-mm-thickness scale reached ~7 × 10 7 cells/ml on Day 7, and the metabolism and detoxification functions of the cells worked well. In addition, a liver rope-like structure and sphere-like clusters of cells were observed. This work provides insight for the design of a bionic liver microsystem.
研究领域:
组织工程
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生物医学工程
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细胞生物学
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DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 70
·65624-65630
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IF 3.289
Linlin Wang,Jun Chen,Xiaomiao Feng,Wenjin Zeng,Ruiqing Liu,Xiujing Lin,Yanwen Ma,Lianhui Wang
A manganese oxide-based catalytic tubular micromotor (PEDOT/MnO2) is described that displays effective autonomous motion in hydrogen peroxide with high speed (318.80 µm s−1) and can operate in very low levels of fuel, down to 0.4%. The polymer bilayer micromotor also exhibits efficient locomotion in different biological media including bovine serum albumin and bovine serum. Moreover, the micromotor is applied to deliver a chemotherapeutic anticancer drug, camptothecin, using electrostatic interactions, offering considerable potential for diverse clinical and biomedical applications such as drug delivery for theranostic microsystems.
研究领域:
生物医学工程
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纳米技术
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药物递送系统
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癌症治疗
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产品关联
DOI
高影响因子
JOURNAL OF BIOMEDICAL OPTICS
·
2025
·Vol. 30
·期 4
·046501
·
IF 2.9
Huaiyuan Zhang,Yiting Hu,Xingwei Pu,Shizheng Zhang,Yi He,Kun Chen,Ziji Liu
Significance The multiplexing capabilities of fluorescence imaging are enhanced by its exceptional molecular specificity with diverse fluorescent probes, making it a powerful tool for studying complex biological structures, organization, and functions. Recent advances in super-resolution fluorescence microscopy have further revolutionized our ability to explore biology and related fields. However, current multicolor super-resolution fluorescence imaging systems often come with high costs and bulky designs. Aim We present a multicolor extended resolution fluorescence imaging system that uses light-emitting diode to simplify the optical path, make the design more compact, and reduce system costs. Approach This multicolor extended resolution fluorescence imaging system is based on structured illumination, utilizing a simple diffraction unit positioned between the light source and the sample in a wide-field microscope. Notably, this design could be easily integrated into standard widefield microscopes as a convenient add-on unit, enabling extended resolution imaging. Results Our system demonstrates concurrent extended resolved imaging of three-color microsphere beads and successfully showcases multicolor extended resolution fluorescence imaging of biological tissue samples, revealing intricate structural details. Conclusions This system provides a structurally simple, cost-effective alternative to traditional microscopes, offering flexible multicolor extended resolution fluorescence imaging and potential applications in multimodal imaging.
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DOI
PubMed
高影响因子
ACS Applied Electronic Materials
·
2025
·
IF 4.7
Wenshuai Yang,Haohao Liu,Chenyang Hao,Zhengyong Lyu,Yinhua Jiang,Yuqiao Wang
The convergence of energy storage and sensing functionalities in a single miniaturized device represents a critical advancement for next-generation wearable electronics. Herein, we report an MXene/GO@MnO2 composite with a rationally designed layer-by-layer architecture for planar microsupercapacitors (PMSCs) and capacitive microsensors. By intercalating MnO2-decorated graphene oxide (GO@MnO2) between MXene layers, the interlayer spacing is expanded to 1.47 nm, enabling ultrafast ion diffusion (DLi+ = 3.1 × 10–12 cm2 s–1) and efficient vertical electron transport (σ⊥ = 247.7 S m–1). The resulting PMSCs achieve record-high areal capacitance (39.3 mF cm–2) and energy density (2.0 μWh cm–2) among MXene-based microdevices, with 91.1% capacitance retention after 10,000 cycles. As a wearable sensor, the device demonstrates multisignal detection capability, including temperature (10–40 °C, sensitivity = 6.3% °C–1), pressure (sensitivity >1.0 kPa–1, response time <10 ms), and biomechanical motions. This work provides a paradigm for designing multifunctional microsystems through strategic interlayer engineering of 2D materials.
研究领域:
材料科学
·
纳米技术
·
电化学
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可穿戴传感器
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能量存储
·
柔性电子器件
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产品关联
DOI
高影响因子
Microsystems & Nanoengineering
·
2023
·Vol. 9
·期 1
·1-14
·
IF 7.9
Li Shibo,Li Chengpan,Khan Muhammad Imran,Liu Jing,Shi Zhengdi,Gao Dayong,Qiu Bensheng,Ding Weiping
Hepatic sinusoids play a key role in maintaining high activities of liver cells in the hepatic acinus. However, the construction of hepatic sinusoids has always been a challenge for liver chips, especially for large-scale liver microsystems. Herein, we report an approach for the construction of hepatic sinusoids. In this approach, hepatic sinusoids are formed by demolding a self-developed microneedle array from a photocurable cell-loaded matrix in a large-scale liver-acinus-chip microsystem with a designed dual blood supply. Primary sinusoids formed by demolded microneedles and spontaneously self-organized secondary sinusoids can be clearly observed. Benefiting from significantly enhanced interstitial flows by formed hepatic sinusoids, cell viability is witnessed to be considerably high, liver microstructure formation occurs, and hepatocyte metabolism is enhanced. In addition, this study preliminarily demonstrates the effects of the resulting oxygen and glucose gradients on hepatocyte functions and the application of the chip in drug testing. This work paves the way for the biofabrication of fully functionalized large-scale liver bioreactors.
研究领域:
生物医学工程
·
组织工程
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微流控技术
·
药物发现
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）