ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Hongli Li,Fengyun Li,Lizhi Zhao,Lei Zhao,Ping Sun,Jing Wu,Xiayan Wang,Qiaosheng Pu
Electrophoretic separation in short microchannels is a promising way for rapid analysis of biomolecules, but the pressurized laminar flow may compromise the separation efficiency. In this work, through an electric field, instant formation and removal of a solid chitosan/β-glycerol phosphate (CS/β-GP) hydrogel within microchannels of microchips were realized. In a typical cross-type microchip, the CS/β-GP hydrogel was precisely formed in the separation microchannel within 15 s of the application of a voltage of 2000 V. Highly efficient separation of peptides and proteins was achieved, and theoretical plate numbers of 0.6 to 1.5 × 106/m were attained for proteins in 120 s. The used hydrogel could be swiftly removed also with an electric field, and the whole procedure was achieved on a standard microchip electrophoresis device with no extra accessory or special operation required.
研究领域:
生物化学
·
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Zheng Wang,Feng Xu,Di Wu,Wei Huang,Zhiqin Chu,Yuan Lin
Cells need to migrate through confined spaces during processes such as embryo development and cancer metastasis. However, the fundamental question of how confinement size and surrounding rigidity collectively regulate the migration capability of cells remains unclear. Here, by utilizing maskless photolithography with a digital micromirror device (DMD), a microchannel with precisely controlled width and wall stiffness (similar to those exhibited by natural tissues) is fabricated. We find that increasing the rigidity of the confining wall leads to a more reduced nuclear volume but has no detectable influence on the myosin expression level in the cells. More interestingly, a biphasic trend of the cell speed is observed, with the migration velocity reaching its minimum at an intermediate wall rigidity of ∼10 kPa. A motor-clutch-based pulling race model is then proposed, which suggests that such biphasic dependence is due to the fact that a very soft channel wall will result in small deformation of the nucleus and consequently reduced cell-wall friction, while larger myosin-based crawling force can be triggered by a stiff confining boundary, both leading to a relatively high migration speed. These findings could provide critical insights into novel strategies for controlling the movement of cells and the design of high-performance biological materials.
研究领域:
细胞生物学
·
生物力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED THERMAL ENGINEERING
·
2024
·
IF 6.1
Yaode Li,Yanyu Wu,Mingshuai Qiao,Cong Qi,Zhiguo Zhang
Nanofluid boiling heat transfer in microchannels has the advantages of small size and high heat transfer efficiency, and can meet the requirements of large heat load and high structural integration. In this paper, the enhanced heat transfer characteristics experiment of nanofluids under electro-magnetic co-excitation were studied on a microchannel boiling flow experimental platform. The generation, deformation and motion mechanism of bubbles in nanofluids under electro-magnetic co-excitation were studied by high-speed photography and numerical simulation, achieving microscopic visualization of nanofluids. The experiment shows that the small bubbles are affected by the electric field force and pass through the electrode wire, and perform regular lateral reciprocating motion between the two sides of the wall. This motion of the bubbles can not only strengthen the orderly disturbance inside the fluid, but also will not disrupt the heat transfer mechanism between various media, making the heat transfer enhancement and not chaotic. Magnetic excitation causes the nanoparticles to form a magnetic coupling structure along the direction of the magnetic field, the average strengthening effect increased to 29%. When the current is applied and the electromagnetic coupling field is formed, the heat transfer effect is improved by 36%.
研究领域:
热力学
·
纳米科技
·
传热学
✓ 已验证
产品关联
DOI
高影响因子
Micromachines
·
2021
·Vol. 12
·期 10
·1222
·
IF 2.891
Yin Tang,Yongjie Zheng,Jingzhi Tian,Jing Sun
A micro-channel distillation device was used for the process intensification method to separate boron isotopes,10B and11B. Three-dimensional (3D) printing technology was introduced to manufacture the micro-channel device, which used the chemical exchange method with anisole as the donor to separate the boron isotopes. This device was tested in total reflux mode, and the height of an equivalent theoretical plate of the micro-channel distillation equipment was reduced to 1.56 cm. The accurate control of pressure and temperature, as well as the flow rate of the complex, were factors that affected separation ability. Thus, for process intensification, this micro-channel distillation device can be operated horizontally and connected in series into similar modules to effectively improve separation efficiency and reduce the size of the equipment.Keywords:process intensification;boron isotope;micro-channel;distillation;3D printing
研究领域:
化学工程
·
材料科学
·
分离技术
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Haozhe Yi,Taotao Fu,Chunying Zhu,Youguang Ma
The dynamics of droplet adsorption at the liquid-liquid interface of parallel flow in a microchannel is investigated. The adsorption process is divided into three distinct stages: the liquid bridge expansion stage, the rapid deformation stage and the spreading stage. The dynamic behavior of droplet adsorption is elucidated by quantitatively analyzing the evolution of adsorption length and droplet height over time under different droplet viscosities. This experiment makes a positive contribution to further reveal the droplet adsorption mechanism and expand the application prospect of microfluidic technology.
研究领域:
流体力学
·
微流控技术
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
·
2017
·
IF 3.458
Chunying Zhu,Yutao Lu,Taotao Fu,Youguang Ma,Huai Z. Li
The gas-liquid two-phase flow and mass transfer with fast chemical reaction in a microchannel were investigated experimentally. Result showed that the bubble volume decreased exponentially with its movement along the channel in a quickly reactable absorbent. The volumetric mass transfer coefficient k L a increased with gas flow rate, while it was insensitive to liquid flow rate under experimental conditions, although the mass transfer coefficient k L increased with liquid flow rate. In slug-bubbly flow regime, the k L decreased when increasing gas flow rate, but inverse tendency was found for slug flow pattern. Both k L and k L a increased with the increase of absorbent concentration. A new correlation for predicting the volumetric mass transfer coefficients k L a was proposed by taking the enhancement factor E of chemical reaction into account.
研究领域:
化学工程
·
传质与反应工程
✓ 已验证
产品关联
DOI
高影响因子
POWDER TECHNOLOGY
·
2022
·
IF 5.64
Jinxin Zhang,Xiaoping Luo,Liangfeng Wang,Zhenfei Feng,Tengfei Li
In this work, electric field and nanofluid are coupled to enhance flow boiling heat transfer in minichannel. Pin electrodes are adopted to create non-uniform electric field. The effects of nanoparticle mass concentration, surfactant type and mass concentration under electric field on nanofluid flow boiling heat transfer are studied. Image analysis technique is used to quantify boiling bubble behaviors. The results demonstrate that without electric field, bubbles for nanofluid flow boiling are smaller and more discrete than R141b. Under electric field, bubble size reduces and the number of bubbles increases, which reveals synergy effect of electric field and nanofluid on bubble behaviors is effective. Besides, electric forces mitigate bubble coalescence and delay transition from bubbly to slug flow. Maximum heat transfer coefficient of nanofluid is 80% higher than R141b. Under electric field, boiling heat transfer of nanofluid modified by anionic surfactant (SDBS) is better than cationic (CTAB) and nonionic (Span80) surfactant.
研究领域:
热力学
·
流体力学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhaolong Wang,Xiaolong Wang,Jinsong Xiong,Mingzhu Xie,Yong Shuai
Water electrolysis offers the advantages of emission-free and highly efficient energy conversion in terms of sustainable energy development and environmental pollution. However, water electrolysis is strongly affected by the detachment of bubbles from the electrodes commonly enabled by buoyancy, thereby reducing the performance of the electrolytic cells in harsh environments like in space. Herein, a bionic Janus microchannels with active gas–liquid separation for water electrolysis is proposed. There is a Janus membrane with superaerophilic top surface and inner micropores over the microchannels, and such a unique type of microchannels can capture and unidirectionally manipulate the hydrogen (H 2 ) bubbles generated on the surface of the electrode during the water electrolysis reaction at high speed with long-term stability. It is worth noting that the gas–liquid separation through the Janus membrane does not hinder the flow of electrolyte in the microchannel due to its hydrophilic inside surfaces, which can maintain the great stability of the electrolysis. Moreover, mimicked leaves and trees for water catalysis are further demonstrated with ultrahigh electrolysis efficiency based on the active detachment of H 2 bubbles enabled by Janus micropores. The present bionic Janus microchannels for high-efficient water electrolysis to produce H 2 is intended to provide a new power supply solution for human space living and exploration.
研究领域:
能源科学
·
材料科学
·
仿生学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Daofan Ma,Hao Jiang,Guangwei Wang,Youguang Ma,Chunying Zhu,Xiangyang Tang
A novel droplet separation method was proposed by using an array protrusion microchannel, which could divert droplets of different sizes into designated branch channels. The performance and mechanism of droplet sieving were investigated. In this work, three distinct flow patterns were obtained: partial sieving, complete sieving, and main drop loss regimes. The influences of droplet length and operation conditions on the sieving efficiency were studied systematically. It was found that, in the partial sieving flow pattern, the increase of small droplet diameter is not conducive to sieving, and there exists a critical diameter of the small droplet for complete sieving under a constant main droplet size, which relies primarily on the array protrusion height. The operating range of the complete sieving flow pattern extends when increasing the main droplet size, and the critical capillary number for evolving into the main droplet loss flow pattern rises. The sieving efficiency increases with the flow rate of the continuous phase in the regulating channel while decreasing with that in the main channel.
研究领域:
微流控技术
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2024
·
IF 3.7
Min An,Chengxiang Wang,Qing Liu,Mengya Wang,Zhirong Yang,Wenpeng Li,Guoli Zhou,Jingtao Wang,Jinli Zhang
Combining the advantages of high efficiency, low-pressure drop, and large throughput, the pore array-enhanced tube-in-tube microchannel (PA-TMC) is a promising microreactor for industrial applications. However, most of the mass transfer takes place in the upstream pore region, while the contribution of the downstream annulus is limited. In this work, helical wires were introduced into the annulus by adhering to the outer surface of the inner tube. Mixing behavior and mass transfer of liquid–liquid two-phase flow in PA-TMC with different helical wires have been systematically studied by a combination of experiments and volume of fluid (VOF) method. The introduction of helical wires improves the overall volumetric mass transfer coefficient K L a by up to 133% and the mass transfer efficiency E by up to 117%. The simulation results show that the helical wire brings extra phase mixing regions and increases the specific interface area, while accelerating the fluid flow and expanding the area of enhanced turbulent dissipation rate. Influences of helical wires in various configurations are compared by the comprehensive index I concerning the pressure drop and mass transfer performance simultaneously and a new correlation between K L a and specific energy consumption ϕ is proposed. This research deepens the understanding of the mixing behavior and mass transfer in the PA-TMCs and provides practical experience for the process intensification of microchannel reactors.
研究领域:
化学工程
·
传热传质学
·
微流控技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2021
·
IF 4.311
Guanqiu Wang,Chunying Zhu,Taotao Fu,Youguang Ma
In many applications of microdroplets, the high monodispersity of the product is usually an essential requirement, the appearance of undesired satellite droplets needs to be avoided. In this study, the deformation of droplets and the formation of tail satellite droplets in microchannel were investigated experimentally, and the process mechanism was also explored. Three flow regimes of moving droplets were observed: (1) droplet with convex cap; (2) droplet with tip; (3) droplet with satellite. It was found that the rear cap of the droplet was more prone to deformation. The shearing force on the droplet becomes strengthened with the increase of the superficial velocity of the droplet, the flow rate ratio of two phases or the viscosity of the continuous phase, which facilitates the formation of tail satellite droplets. The critical criterion for formation of tail satellite droplets was proposed, which is at good agreement with the experiment result.
研究领域:
微流体学
·
流体力学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2022
·
IF 3.898
Yingjie Fei,Chunying Zhu,Taotao Fu,Xiqun Gao,Youguang Ma
The deformation of moving slug bubbles and its influence on the bubble breakup dynamics in microchannel were studied. Three bubble morphologies were found in the experiment: slug, dumbbell and grenade shapes. The viscosity effect of continuous phase aggravates the velocity difference between the fluid near the wall and the bubble, resulting in that the continuous phase near the bubble head flows towards and squeezes the bubble tail, which causes the deformation of bubbles. Moreover, the experimental results show that the deformation of bubbles could significantly prolong the bubble breakup period at the downstream Y-junction. There exists the critical capillary number Ca Cr for the asymmetric breakup of grenade bubbles, Ca Cr increases with the rise of flow rate and viscosity of the continuous phase.
研究领域:
流体力学
·
微流控技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）