ANALYTICAL CHEMISTRY
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2024
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IF 6.7
Chunjiao Qi,Jintao Chen,Yuhui Shang,Yu Yang,Kangyan Wang,Jinyang Chen
Point-of-care (POC) tests increasingly highlight the importance of portable, cost-effective, and visually quantitative detection of biomarkers. Herein, we developed a power-free and visual signal-readout POC sensor based on the target-triggered ultrafast gelation process. In the gelation process, the target triggered the cascade reaction catalyzed by oxidase and ferrous glycinate to produce carbon radicals that immediately initiated the rapid polymerization and cross-linking of acryloylated chondroitin sulfate and dimethylacrylamide. This highly efficient enzymatic polymerization process contributed to the ultrafast generation of chondroitin hydrogel within 1 min at 25 °C. The increase in viscosity of aqueous solution resulted from hydrogel formation was then visually measured according to the distance of solution migration on a tick-labeled pH test strip, which thus realized the quantification of a target. By utilizing glucose oxidase as an oxidase model during the gelation process, this POC sensor was successfully employed in the rapid quantitative detection of glucose without the need for any auxiliary instruments. Benefiting from the specificity and stability of the enzymatic polymerization reaction, the sensor exhibited excellent performance in the detection of glucose in clinical blood samples. Moreover, the sensor was further extended to uric acid detection and enabled accurate assay in clinical urine samples, which indicated the versatility and practicability of this sensor in the POC test.
研究领域:
生物化学
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医学诊断
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材料科学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Nanbin Bao,Kun Wang,Mengxue Duan,Xuhan Gao,Yue Sun,Huan Liu,Zilian Yu,Xinmeng Zhou,Yukai Wu,Huanjun Li
Tough hydrogels capable of achieving instant and strong adhesion to diverse surfaces are highly desirable for various applications such as soft electronics and antifogging coatings. However, existing hydrogel adhesives currently suffer from several limitations including slow adhesion formation, weak bonding, and poor mechanical properties . Herein, we present that strong adhesion of tough nanocomposite hydrogels can be realized instantly by rapid copolymerization of precursor solution within seconds under ambient conditions. Such tough hydrogels possessing ultrashort gelation time were prepared based on self-catalytic Fe 3+ /tannic acid redox pairs, which could activate ammonium persulfate initiator to generate abundant sulfate radicals to trigger ultrafast copolymerization of N, N-dimethylacrylamide (DMAA) and acrylic acid (AA) in the presence of Al(OH) 3 nanoparticles . The resultant hydrogels exhibit excellent mechanical properties including tensile strength of ∼1.0 MPa and compressive strength of ∼15.0 MPa, high adhesion energy of ∼1200 J m − 2 , and good conductivity of 0.72 S/m. Benefiting from these features, the sustainable antifogging hydrogel coatings on diverse transparent substrates can be fabricated easily based on the combined advantages of ultrafast polymerization and instant strong adhesion. Furthermore, the conductive hydrogels can be assembled into flexible strain sensors to monitor various human motions and handwriting recognition. This work provides a promising strategy to design high-performance hydrogels with instant strong adhesion, antifogging properties, and strain sensing.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
ADVANCED MATERIALS
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2024
·Vol. 36
·期 40
·2405290
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IF 27.4
Qiang Luo,Jie Luo,Zhaohui Luan,Kaige Xu,Lixing Tian,Kebin Zhang,Xue Peng,Mengxue Yuan,Chuanhao Zheng,Zhenzhen Shu,Yuchen Zhang,Shali Tan,Ruijue Dan,Kibret Mequanint,Chaoqiang Fan,Malcolm Xing,Shiming Yang
In an emergency, nonvariceal upper gastrointestinal bleeding (NVUGIB), endoscopic hemostasis is considered the gold standard intervention. However, current endoscopic hemostasis is very challenging to manage bleeding in large-diameter or deep lesions highly prone to rebleeding risk. Herein, a novel hemostatic peptide hydrogel (HPH) is reported, consisting of a self-assembly peptide sequence CFLIVIGSIIVPGDGVPGDG (PFV) and gelatin methacryloyl (GelMA), which can be triggered by blue laser endoscopy (BLE) for nonvariceal upper gastrointestinal bleeding treatment without recurring bleeding concerns. Upon contact with GelMA solution, PFV immediately fibrillates into β-sheet nanofiber and solvent-induced self-assembly to form HPH gel. HPH nanofiber networks induced ultrafast coagulation by enveloping blood cells and activating platelets and coagulation factors even to the blood with coagulopathy. Besides its remarkable hemostatic performance in artery and liver injury models, HPH achieves instant bleeding management in porcine NVUGIB models within 60 s by preventing the rebleeding risk. This work demonstrates an extraordinary hemostatic agent for NVUGIB intervention by BLE for the first time, broadening potential application scenarios, including patients with coagulopathy and promising clinical prospects.
CAS / MDL:
研究领域:
生物医学工程
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材料科学
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消化内科
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
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IF 8.128
Yajun Chen,Di Wang,Alfred Mensaha,Qingqing Wang,Yibing Cai,Qufu Wei
Multifunctional hydrogels with transparency, ultraviolet (UV)-blocking, stretchable, self-healing, adhesive, antioxidant and antibacterial properties are promising materials for biomedical and relevant applications. However, preparation of these hydrogels at ambient environment without stimuli is still a challenge. Here, a series of hydrogels possessing ultrashort gelation time (~30 s) at room or cold temperature were fabricated based on self-catalytic Fe 3+ /Tannic acid-cellulose nanofiber (Fe 3+ /TA-CNF). Fe 3+ /TA-CNF formed stable redox pairs to activate ammonium persulfate (initiator), generating abundant free radicals to trigger the ultrafast polymerization of acrylic acid (AA). To improve the antibacterial ability of hydrogel, a bilayer hydrogel composite (NF@HG) composed of tetracycline hydrochloride (TH)-loaded electrospun nanofibers and hydrogel layer was fabricated via a mild casting method. The NF@HG exhibited enhanced antibacterial ability and the sustained release of TH can provide long-term antibacterial activity . Besides, cell viability results demonstrated that NF@HG was non-cytotoxic. Taken together, this strategy based on self-catalytic Fe 3+ /TA-CNF system may inspire new aspects on fast and economical preparation of multifunctional hydrogels or composites, which have attractive industrial applications for biomedical materials .
研究领域:
材料科学
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生物医学工程
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化学工程
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产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
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2024
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IF 5.6
Xie Lijun,Zhang Yan,Cao Binji,Jiao Xiaoyi,Yue Xusong,Xu Yan,Yang Xianyan,Yang Guojing,Wang Yingjie,Shen Jian,Wang Cong,Weng Xisheng,Gou Zhongru
It is known that magnesium phosphate cements (MPCs) show appreciable mechanical strength and biocompatibility, but the hydration reaction processes often lead to intense heat release while the hydration products present weak resistance to mechanical decay and low bioactivity. Herein we developed an MPC-based system, which was low-heat-releasing and fast-curing in this study, by compounding with self-curing calcium silicate cements (CSCs). The MPC composed of magnesium oxide (MgO), potassium dihydrogen phosphate (KH2PO4), disodium hydrogen phosphate (Na2HPO4), magnesium hydrogen phosphate trihydrate (MgHPO4·3H2O) and chitosan were weakly basic, which would be more stable in vivo. The physicochemical properties indicated that the addition of CSCs could increase the final setting time while decrease the heat release. Meanwhile, the CSCs could endow MPC substrate with apatite re-mineralization reactivity, especially, which add 25 wt.% CSCs showed the most significant apatite deposition. What’s more, the mechanical evolution in buffer demonstrated CSCs could enhance and sustain the mechanical strength during degradation, and the internal constructs of cement implants could still be reconstructed by μCT analysis in rabbit femoral bone defect model in vivo. Particularly, appropriate CSCs adjusted the biodegradation and promoted new bone tissue regeneration in vivo. Totally, the MPC/CSCs composite system endows bioactivity and sustain mechanical strength of the MPC, which may be promising for expending the clinical applications of MPC-based bone cements.
研究领域:
材料科学
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生物材料
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生物医学工程
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骨科
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Tingwu Liu,Wen Sun,Changjun Mu,Xu Zhang,Donghua Xu,Qiuyan Yan,Shifang Luan
Injectable adhesive hydrogels combining rapid gelling with robust adhesion to wet tissues are highly required for fast hemostasis in surgical and major trauma scenarios. Inspired by the cross-linking mechanism of mussel adhesion proteins, we developed a bionic double-crosslinked (BDC) hydrogel of poly (γ-glutamic acid) (PGA)/poly (N-(2-hydroxyethyl) acrylamide) (PHEA) fabricated through a combination of photo-initiated radical polymerization and hydrogen bonding cross-linking. The BDC hydrogel exhibited an ultrafast gelling process within 1 s. Its maximum adhesion strength to wet porcine skin reached 254.5 kPa (9 times higher than that of cyanoacrylate (CA) glue) and could withstand an ultrahigh burst pressure of 626.4 mmHg (24 times higher than that of CA glue). Notably, the BDC hydrogel could stop bleeding within 10 s from a rat liver incision 10 mm long and 5 mm deep. The wound treated with the BDC hydrogel healed faster than the control groups, underlining the potential for emergency rescue and wound care scenarios.
研究领域:
材料科学
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生物医学工程
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组织工程
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急诊医学
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外科手术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）