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Microfluidics and Nanofluidics · 2016 ·Vol. 20 ·期 9 ·1-10 · IF 2.537

Novel prototyping method for microfluidic devices based on thermoplastic polyurethane microcapillary film

Xu Zheyun,Jiang Feng,Xu Zhongbin,Xu Haoyan,Ruan Xiaodong

Thermoplastic polyurethane microcapillary film (TPU-MCF), as a novel extruded product, inherently contains an array of circular micron-sized capillaries embedded inside the polymer matrix. With the aid of simple laser cutting and conventional sealing technologies, a rapid prototyping method for microfluidic devices is proposed based on the ready-made microstructure of MCFs. Two functionalized microfluidic devices: serpentine micromixer and multi-droplet generator, are rapidly fabricated to demonstrate the advantages and potential of employing this new method. The whole proof-of-concept fabrication process can be completed in 8–10 min in a simple way; each procedure is repeatable with stable performance control of microfluidic devices; and the material cost can be as low as $0.01 for each device. The TPU-MCF and this novel method are expected to provide a new perspective and alternative in microfluidic community with particular requirements.

研究领域: 生物医学工程 · 微流体技术 · 材料科学 · 快速原型制造 · 生物芯片
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Science Advances · 2019 ·Vol. 5 ·期 3 · IF 12.804

Hydrogel 3D printing with the capacitor edge effect

Jikun Wang,Tongqing Lu,Meng Yang,Danqi Sun,Yukun Xia,Tiejun Wang

Recent decades have seen intense developments of hydrogel applications for cell cultures, tissue engineering, soft robotics, and ionic devices. Advanced fabrication techniques for hydrogel structures are being developed to meet user-specified requirements. Existing hydrogel 3D printing techniques place substantial constraints on the physical and chemical properties of hydrogel precursors as well as the printed hydrogel structures. This study proposes a novel method for patterning liquids with a resolution of 100 μm by using the capacitor edge effect. We establish a complete hydrogel 3D printing system combining the patterning and stacking processes. This technique is applicable to a wide variety of hydrogels, overcoming the limitations of existing techniques. We demonstrate printed hydrogel structures including a hydrogel scaffold, a hydrogel composite that responds sensitively to temperature, and an ionic high-integrity hydrogel display device. The proposed technique offers great opportunities in rapid prototyping hydrogel devices using multiple compositions and complex geometries.

研究领域: 生物材料 · 组织工程 · 软体机器人 · 生物医学工程 · 微纳制造 · 转化医学
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