Coatings
·
2022
·Vol. 13
·期 1
·23
·
IF 3.236
Shan Miao,Zheng Chen,Jin Wang,Shanbo Ma,Long Li,Yuhan Chen,Feiyan Wang,Meiling Zheng,Xiaodi Guo,Botao Song,Xiaopeng Shi
Oral instant membranes can be quickly wetted by the patient’s saliva and dissolved/disintegrated in the mouth without the need for drinking water and chewing, exhibiting great promise for patients from children to the elderly who have difficulties with swallowing. However, the reported instant oral membranes can load and release only one single drug, which greatly hinders their potential applications. Herein, we employ a sequential electrospinning approach to fabricate dual drug-loaded bilayered gelatin oral instant membranes. The results indicate that a gelatin membrane with a uniform nanofibrous structure can be successfully prepared, and that both the hydrophilic model drug and hydrophobic model drug can be embedded into the gelatin nanofibers. X-ray diffraction results verify that the two drugs are well distributed in the nanofibrous matrix in an amorphous state. Owing to the excellent water solubility and large surface area of gelatin nanofibers, the hydrophilic model drug can be quickly dissolved in 101 s, while the hydrophobic model drug can be completely released in 100 s. The bilayered gelatin nanofibrous membrane shows promise for simultaneous loading and release of two drugs for fast-dissolving delivery applications.Keywords:electrospinning;dual drug release;fast-dissolving;gelatin;bilayered structure
研究领域:
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 140
·期 3
·e53338
·
IF 3.057
Shenglong Shi,Jinsheng Sun,Kaihe Lv,Qingzhi Wen,Yingrui Bai,Jintang Wang,Jiafeng Jin,Jingping Liu,Xianbin Huang,Jian Li
To prepare the thickener of fracturing fluid with temperature resistance, salt resistance and quick dissolution, an emulsion thickener (ASC) was synthesized by acrylamide, acrylic acid, 2-acrylamide-2-methylpropanesulfonic acid, and acryloyl morpholine. The dissolution, salt resistance and drag reduction of ASC, and the viscoelasticity, temperature resistance and shear resistance and gel breaking properties of fracturing fluid formed by ASC and zirconium crosslinker were investigated. The results showed that the sticky time of ASC was less than 60 s and the drag reduction rate was 72.5% in 100,000 mg/L brine, showing that ASC had thickening ability in high salinity brine and satisfied the requirements of continuous fluid preparation on the fracturing process. The viscosity of ASC fracturing fluid was 98 mPa s after shearing at 200°C and 170 s −1 for 150 min when the salinity was 100,000 mg/L. When the ammonium persulfate concentration was 400 mg/L, the viscosity of the broken fluid was 4.0 mPa s. The temperature resistance, salt resistance and shear resistance of ASC emulsion fracturing fluid could be significantly improved by the introduction of acryloyl morpholine, ASC fracturing fluid had the characteristics of high elasticity and low viscosity, which could meet the application requirements under ultra-high temperature reservoirs.
研究领域:
石油工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 19
·9075-9084
·
IF 3.925
Yanping Li,Ya Liu,Li Wang,Hongsheng Lu
Polyacrylamide and its derivatives are widely used in oilfields due to their efficient viscosity building and drag-reducing properties. At present, the commonly used products of polyacrylamide include two types: polymer powder and polymer emulsions. However, the low dissolution rate of powdered products and the instability of polymer emulsions limit their application. Here, we constructed a pH-sensitive inverse polymer emulsion of poly(acrylamide-co-acrylic acid-co-2-acrylamide-2-methylpropyl sulfonic acid), showing a phase separation and phase inversion from W/O to O/W at pH < 6 and pH > 8 due to a pH-switchable surfactant N,N-dimethylcyclohexylamine/Oleic acid complex (DM–OA). The demulsification or phase inversion of the W/O polymer emulsion can release the polymer that was originally in the aqueous phase, and the released polymer can quickly dissolve in water to perform its function of viscosity building and friction reduction. Therefore, this pH-sensitive modified-polyacrylamide polymer emulsion shows a fast dissolution rate with a dissolution time of about 1 min and a long storage stability. The utilization of stimuli-responsive surfactants to construct pH-responsive water-soluble polymer W/O emulsions provides a new approach to the preparation of water-soluble polymer emulsion additives that can be quickly dissolved and stored for long periods of time in water-treatment, papermaking and oil recovery fields.
研究领域:
石油工程
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Ze-yu Qin,Xi-Wen Jia,Qian Liu,Bao-hua Kong,Hao Wang
In this study, Chitosan/pullulan composite nanofiber fast dissolving oral films (FDOFs) were prepared via electrospinning technology. The ratio of chitosan/pullulan (C/P) had an influence on solution property and nanofiber morphology, with the increase of chitosan, viscosity and conductivity of solutions increased, the morphology obtained by scanning electron microscopy indicated that the diameter of nanofibers decreased initially then increased. The Fourier transform infrared spectra indicated hydrogen bond interactions between chitosan and pullulan molecules. X-ray diffraction analysis proved that electrospinning process decreased the crystallinity of materials. Thermal analysis showed that melting point, degradation temperature and glass transition temperature increased with the addition of chitosan content in the FDOF. Water solubility test proved that the FDOF can dissolve in water completely within 60 s. Finally, in order to prove its practicability in future, a model drug of aspirin was encapsulated in the FDOF successfully.
研究领域:
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Huimin Dai,Jian Lan,Zou He,Liyin Zhang,Ying Xiong,Shanshan Dai
The development of shear-resistant drag reducer agent (DRA) is crucial for enhancing oil recovery, especially during high-speed pumping and fracturing processes where polymer networks are prone to damage, leading to the reduction of the drag reduction (DR) performance. To address this issue, the introduction of nano-silica into the polymer structure, while maintaining good DR, endows the DRA with better shear resistance and salt resistance through its unique cross-linking mode. In this study, a novel shear-resistant and fast-dissolving drag reducer was synthesized through free-radical polymerization using acrylamide (AM), acrylic acid (AA), 2-acrylamide-2-methylpropyl sulfonic acid (AMPS) and KH570 modified nano-silica. The comprehensive properties of drag reducer were studied using conductivity and dissolution time test, microscopic morphology analysis, thermogravimetric analysis, and rheological test. The results suggestion that the PAPO-10@SiO 2 exhibits outstanding characteristics, including rapid dissolution (4 min), excellent salt resistance (DR rate up to 80.41% at a polymer concentration of 500 mg/L) and nano-silica concentration of 1.5 wt%. Moreover, the mechanism of drag reduction was proposed that nano-silica connects the molecular chains through multiple cross-linking effects of chemical cross-linking and physical adsorption, which enhances the stability of the network structure and prevents the destruction of the molecular chain structure by shear force effectively (viscosity retention of 76.9% after shearing for 40 min at 90°C and 170 s −1 ). In summary, this study provides valuable insights for developing polymers with both shear resistance and dissolution properties in aqueous solutions.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 11
·1602
·
IF 4.7
Jingyi Hu,Xiaojie Chen,Jianmin Jiang,Renbiao Mai,Han Wang,Qiming Xu,Ting Zhang
As the global facial mask market continues to grow, consumers have put forward higher requirements for the functionality and ingredients of mask products. Ordinary facial masks mostly use ordinary non-woven fabrics as the mask base fabric and are used with essence. Preservatives are generally added. At the same time, they are susceptible to the influence of the external environment and are easily oxidized, causing the mask to deteriorate and cause skin allergic reactions. In addition, traditional facial masks have problems such as poor fit with the skin, poor breathability, insufficient absorption of nutrient solutions, and easy dripping. The high specific surface area and high porosity of a nanofiber mask prepared by electrospinning technology are beneficial to the skin’s absorption of nutrients, and it has good fit with the skin and strong breathability. A unique advantage of this nanofiber mask is that it uses spray. After the mask is sprayed with water or essence, the water-soluble polymer within it can be quickly dissolved, saving a lot of time. Nanofiber facial mask products can effectively solve consumer pain points and are conducive to the high-end development of facial masks. Therefore, this article combines needleless electrospinning technology to develop a new solid-state, preservative-free, quick-dissolving nanofiber facial mask that can be prepared on a large scale. Based on needleless electrospinning technology, this article deeply explores the process parameters and their influencing mechanisms for preparing nanofiber, quick-dissolving facial masks to achieve the stable preparation of nanofiber facial masks with the best morphology; a comprehensive analysis of the structure and influence of nanofiber facial masks from micro and macro perspectives demonstrates their performance and allows evaluation of them. The experimental results show that the mask morphology is optimal under the process conditions of using a spinning liquid of 20% collagen peptide solution, a spinning voltage of 30 kV, a collection distance of 19 cm, and a liquid supply speed of 130 mL/h.
研究领域:
材料科学
·
生物医学工程
·
化妆品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Yeli Wang,Zian Deng,Xinmiao Wang,Yugang Shi,Ying Lu,Sheng Fang,Xianrui Liang
Improving solubility and administration route of isoflavone formononetin (FMN) are critical factors to improve its bioavailability in the oral cavity. This study fabricated fast-dissolving nanofibers containing FMN/methyl- β -cyclodextrin (FMN/Me- β -CD) inclusion complex. The solubility of FMN could be increased by approximately 50 times at 20 mM aqueous Me- β -CD. Interactions and thermodynamic parameters of the host-guest inclusion complex were studied by a fluorescence quenching method. The structure and mechanisms of the complex were further studied by molecular docking and molecular dynamics. Finally, polyvinyl-alcohol (PVA) nanofibrous webs containing the FMN/Me- β -CD inclusion complex were fabricated by electrospinning. The dissolution test demonstrated that the FMN/Me- β -CD/PVA nanofibers can be dissolved in artificial saliva within approximately 2 s. This study shows the potential of Me- β -CD inclusion and electrospinning to improve solubility and administration route of isoflavones.
研究领域:
药剂学
·
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yang Yang,Caifu Zhi,Yong Zhang,Xin Long,Jie Qi,Yang Wu,Zheng Zhang,Hongsheng Lu
Polymer emulsion drag reducers are vital components in slickwater fracturing fluids used for stimulating shale gas reservoirs. Efficient dissolution rates are crucial for maximizing the performance of friction reducers by enabling rapid friction reduction. However, the stability of W/O-type emulsion is compromised in the presence of hydrophilic surfactants, posing a significant challenge for enhancing the dissolution of friction reducers in continuous fracturing processes. Herein, a dynamic covalent trimeric stabilizer, oleylamine - glycerol triglycidyl ether (OLA-GTE), was designed to construct W/O monomer emulsions. The stabilizer underwent pH-induced cleavage of imine bonds, leading to an increased concentration and enhanced surface activity of the cationic surfactant OLA + , which facilitated the transition to reverse emulsion. The stability parameters of the monomer emulsions consisting of oil-water ratio, stabilizer concentration, and pH level were optimized by storage, centrifugation, and heat treatment. Furthermore, the polyacrylamide-based friction reducer emulsions were synthesized through inverse emulsion polymerization. The stimuli-responsive friction reducer emulsions directly dissolved in water with a pH below 5.0, which was attributed to the breakdown of OLA-GTE at the interface, coupled with the phase transition effect of the cationic surfactant OLA + . The formulation of slickwater using friction-reducer emulsions can be completed within 10 s when stimulated by water at pH 5.0, resulting in a friction-reduction rate of up to 76 %. The rapid dissolution capability is a significant advancement for applications in slickwater fracturing for shale gas reservoirs, offering quick and efficient friction reduction.
研究领域:
材料科学
·
化学工程
·
石油工程
✓ 已验证
产品关联
DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 5
·344
·
IF 5.3
Shenglong Shi,Jinsheng Sun,Shanbo Mu,Kaihe Lv,Yingrui Bai,Jian Li
Aiming at the problem that conventional friction reducers used in fracturing cannot simultaneously possess properties such as temperature resistance, salt resistance, shear resistance, rapid dissolution, and low damage. Under the design concept of “medium-low molecular weight, salt-resistant functional monomer, supramolecular physical crosslinking aggregation, and enhanced chain mechanical strength”, acrylamide, sulfonic acid salt-resistant monomer 2-acrylamide-2-methylpropanesulfonic acid, hydrophobic association monomer, and rigid skeleton functional monomer acryloyl morpholine were introduced into the friction reducer molecular chain by free radical polymerization, and combined with the compound suspension technology to develop a new type of multi-functional viscous friction reducer suspension (SAMD), the comprehensive performance of SAMD was investigated. The results indicated that the critical micelle concentration of SAMD was 0.33 wt%, SAMD could be dissolved in 80,000 mg/L brine within 3.0 min, and the viscosity loss of 0.5 wt% SAMD solution was 24.1% after 10 min of dissolution in 80,000 mg/L brine compared with that in deionized water, the drag reduction rate of 0.1 wt% SAMD solution could exceed 70% at 120 °C and still maintained good drag reduction performance in brine with a salinity of 100,000 mg/L. After three cycles of 170 s −1 and 1022 s −1 variable shear, the SAMD solution restored viscosity quickly and exhibited good shear resistance. The Tan δ (a parameter characterizing the viscoelasticity of the system) of 1.0 wt% SAMD solution was 0.52, which showed a good sand-carrying capacity, and the proppant settling velocity in it could be as low as 0.147 mm/s at 120 °C, achieving the function of high drag reduction at low concentrations and strong sand transportation at high concentrations. The viscosity of 1.4 wt% SAMD was 95.5 mPa s after shearing for 120 min at 140 °C and at 170 s −1 . After breaking a gel, the SAMD solution system had a core permeability harm rate of less than 15%, while the SAMD solution also possessed the performance of enhancing oil recovery. Compared with common friction reducers, SAMD simultaneously possessed the properties of temperature resistance, salt resistance, shear resistance, rapid dissolution, low damage, and enhanced oil recovery. Therefore, the use of this multi-effect friction reducer is suitable for the development of unconventional oil reservoirs with a temperature lower than 140 °C and a salinity of less than 100,000 mg/L.
研究领域:
石油工程
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Quanpeng Li,Xueqing Yu,Xiaoyan Zheng,Jing Yang,Junfeng Hui,Daidi Fan
At present, the main clinical methods of oral local anesthesia are direct injection of anesthetic and surface ointment. However, the pain and fear caused by the injection, the discomfort of topical anesthetic creams, and the scour and moist oral environment during the procedure pose great challenges to oral anesthesia. Herein, we designed a Lido-PVP/PVA DMNP microneedle (MN) for oral local anesthesia. The microneedle tip was consisted of Polyvinylpyrrolidone/Polyvinyl alcohol (PVP/PVA), which can quickly dissolve and release the lidocaine hydrochloride (Lido) drug within 5 min to achieve rapid anesthesia. The backing was composed of polyvinyl alcohol/chitosan (PVA/CS), and its excellent adhesion can overcome saliva erosion and anchor firmly to the oral mucosa , significantly improving the utilization rate of drugs, as well as the patient compliance. MNs have good mechanical properties for tissue insertion while possessing high drug loading (3 mg/MNs). Von Frey tests proved that MNs showed a faster and more effective local anesthetic effect (anesthesia takes effect at 5 min) compared to cream (anesthesia takes effect at 30 min). In addition, the excellent biocompatibility and no skin irritation endowed Lido-PVP/PVA DMNP MNs a great potential for oral local anesthesia in the oral cavity.
研究领域:
药学
·
材料科学
·
牙科科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 2
·1012-1021
·
IF 3.361
Qingmiao Zhang,Zhuangsheng Lin,Wenkun Zhang,Ting Huang,Jingjing Jiang,Yu Ren,Ruiqi Zhang,Wen Li,Xiaoli Zhang,Qin Tu
Fast-dissolving drug delivery systems are essential to drug delivery owing to the enhanced drug solubility, controlled drug concentration, target and rapid drug delivery. In this study, we developed fast-dissolving drug delivery systems using honey and acetylsalicylic acid-embedded poly(vinyl alcohol) (PVA) nanofibers based on natural deep eutectic solvent (DES). The efficacy of our fast-dissolving drug delivery system was tested by incorporating honey and acetylsalicylic acid in the PVA nanofibers. Firstly, the morphology and structure of the functional PVA–DES nanofibers (PVA–DES–honey and PVA–DES–ASA) were observed and analyzed, which proved the successful preparation of functional PVA–DES nanofibers. NIH/3T3 and HepG2 cells incubated on the nanofiber had more than 90% of cell viability, suggesting our materials were biocompatible and non-toxic. The nanofiber materials dissolved rapidly in artificial saliva solutions, suggesting potential use of our materials for fast dissolving drug delivery in oral cavities. The honey incorporated PVA nanofiber (PVA–DES–honey) showed a total bacterial reduction of 37.0% and 37.9% against E. coli and S. aureus, respectively, after 6 hour incubation in bacterial cultures. Furthermore, in vivo study proved that the PVA–DES–honey nanofibers accelerated the wound healing process, and they improved the wound healing rate on rat skin to 85.2% after 6 days of surgery, when compared to the control PVA (68.2%) and PVA–DES (76.3%) nanofibers. Overall, the nanofiber materials reported in our study showed potential as a green and biocompatible fast-dissolving drug delivery system and can be used for pharmaceutical fields, such as antibacterial wound dressing and oral ulcer stickers.
研究领域:
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）