阿拉丁SCI论文搜索工具

JOURNAL OF CHEMICAL RESEARCH · 2019 · IF 0.67

First total synthesis of mariamide A

Yamu Xia,Chenglong Chen,Mengying Li,Weizeng Zhou,Shuyu Sun,Shanpeng Chu,Hui Wang

Mariamide A, a lignanamide isolated from the seeds of Silybum marianum, has demonstrated potential utility as an antioxidant and antidiabetic agent and possesses an 8-O-4′ neolignan skeleton. Herein, a first total synthesis of mariamide A is presented that proceeds in nine steps using vanillin as the starting material. The key steps for the preparation of mariamide A involve an I2-catalyzed bromomethoxylation of an alkene group, a nucleophilic substitution followed by a sequential elimination and a monoacylation reaction.

CAS / MDL: 112926-00-8

研究领域: 有机化学 · 药物化学

✓ 已验证产品关联 DOI 高影响因子

查看原文查看 PubMed

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY · 2014 ·Vol. 2014 ·期 34 ·7572-7576 · IF 3.154

Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A

Lijing Fang,Chunlei Wu,Zaidan Yu,Peng Shang,Yongxian Cheng,Yuefeng Peng,Wu Su

Graphical A highly efficient protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids is developed and applied to the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N -alkylated amino acids, as well as proteinogenic amino acids.

研究领域: 有机化学 · 药物化学 · 生物合成

✓ 已验证 DOI 高影响因子

查看原文查看 PubMed

查找使用阿拉丁产品的科研文献

与阿拉丁产品相关的已发表科研成果

热门产品

First total synthesis of mariamide A

Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A